Rho kinase signaling pathways during stretch in primary alveolar epithelia

scientific article

Rho kinase signaling pathways during stretch in primary alveolar epithelia is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPLUNG.00175.2011
P8608Fatcat IDrelease_5g5oin5amfcjfmrzrt52iirzn4
P932PMC publication ID3362254
P698PubMed publication ID22287611

P2093author name stringSusan S Margulies
Brian C DiPaolo
P2860cites workRho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loopQ22011174
Specific activation of LIM kinase 2 via phosphorylation of threonine 505 by ROCK, a Rho-dependent protein kinaseQ24290361
Rocks: multifunctional kinases in cell behaviourQ24303641
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)Q24319737
Rho protein regulates tight junctions and perijunctional actin organization in polarized epitheliaQ24563849
Regulation of cell motility by mitogen-activated protein kinaseQ24678874
Reinforcement versus fluidization in cytoskeletal mechanoresponsivenessQ27349353
The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinaseQ28117594
Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphataseQ28140582
The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeletonQ28287040
Phosphorylation of smooth muscle myosin at two distinct sites by myosin light chain kinaseQ28609799
Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)Q28609825
Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphataseQ29615195
Cooperative effects of Rho and mechanical stretch on stress fiber organizationQ30446661
Actin depolymerization disrupts tight junctions via caveolae-mediated endocytosisQ30476106
Diphosphorylation of the myosin regulatory light chain enhances the tension acting on stress fibers in fibroblasts.Q33254767
Quantifying myosin light chain phosphorylation in single adherent cells with automated fluorescence microscopyQ33302971
Effectors for the Rho GTPasesQ33536478
Lung endothelial barrier protection by iloprost in the 2-hit models of ventilator-induced lung injury (VILI) involves inhibition of Rho signalingQ33621771
'Putting the squeeze' on the tight junction: understanding cytoskeletal regulationQ34019639
Differential effects of shear stress and cyclic stretch on focal adhesion remodeling, site-specific FAK phosphorylation, and small GTPases in human lung endothelial cellsQ45262325
Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunctionQ45871451
Intestinal absorptive cell tight junctions are linked to cytoskeletonQ46186998
Identification of three genes of known function expressed by alveolar epithelial type I cellsQ46546948
Alveolar epithelial type I cells express beta2-adrenergic receptors and G-protein receptor kinase 2.Q46560691
Defined medium for primary culture de novo of adult rat alveolar epithelial cellsQ46691052
Cyclic strain-mediated regulation of vascular endothelial occludin and ZO-1: influence on intercellular tight junction assembly and functionQ46790580
Na+-K+-2Cl- cotransport in Ehrlich cells: regulation by protein phosphatases and kinases.Q47747884
Cadherins, RhoA, and Rac1 are differentially required for stretch-mediated proliferation in endothelial versus smooth muscle cells.Q50930088
Quantifying Western blots: pitfalls of densitometry.Q51822227
Rho kinase regulates tight junction function and is necessary for tight junction assembly in polarized intestinal epithelia.Q52543811
Enteropathogenic Escherichia coli dephosphorylates and dissociates occludin from intestinal epithelial tight junctions.Q54021246
PKC-dependent regulation of transepithelial resistance: roles of MLC and MLC kinase.Q54079243
Effects of lung inflation on alveolar epithelial solute and water transport properties.Q54516771
Blebbistatin, a novel inhibitor of myosin II ATPase activity, increases aqueous humor outflow facility in perfused enucleated porcine eyes.Q54634122
Myosin light chain phosphorylation regulates barrier function by remodeling tight junction structureQ57179984
Light-chain phosphorylation controls the conformation of vertebrate non-muscle and smooth muscle myosin moleculesQ59053614
An improved method for isolating type II cells in high yield and purityQ69303198
Calyculin A and okadaic acid: inhibitors of protein phosphatase activityQ69337324
An improved procedure for identifying and quantitating protein phosphatases in mammalian tissuesQ69353149
Type I cell-like morphology in tight alveolar epithelial monolayersQ69781655
Phosphorylation of the 20,000-dalton light chain of smooth muscle myosin by the calcium-activated, phospholipid-dependent protein kinase. Phosphorylation sites and effects of phosphorylationQ70183097
Lung inflation, lung solute permeability, and alveolar edemaQ72951119
Physiological regulation of epithelial tight junctions is associated with myosin light-chain phosphorylationQ73847660
Deformation-induced injury of alveolar epithelial cells. Effect of frequency, duration, and amplitudeQ74139134
Keratinocyte growth factor reduces alveolar epithelial susceptibility to in vitro mechanical deformationQ74614130
Equibiaxial deformation-induced injury of alveolar epithelial cells in vitroQ77649794
Measurement of stretch-induced loss of alveolar epithelial barrier integrity with a novel in vitro methodQ78396074
Frequency and peak stretch magnitude affect alveolar epithelial permeabilityQ81611581
Cytoskeletal remodelling and slow dynamics in the living cellQ81816339
Beta-actin is not a reliable loading control in Western blot analysisQ83319008
Specificity of endothelial cell reorientation in response to cyclic mechanical stretchingQ94029350
Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cellsQ34071220
Stretch magnitude and frequency-dependent actin cytoskeleton remodeling in alveolar epitheliaQ34085706
Dedicated myosin light chain kinases with diverse cellular functionsQ34092402
Stretch increases alveolar epithelial permeability to uncharged micromoleculesQ34307317
Rho family proteins: coordinating cell responsesQ34446303
Angiotensin II and myosin light-chain phosphorylation contribute to the stretch-induced slow force response in human atrial myocardiumQ34781733
Mammalian nonsarcomeric myosin regulatory light chains are encoded by two differentially regulated and linked genesQ34892124
TrkBT1 induces liver metastasis of pancreatic cancer cells by sequestering Rho GDP dissociation inhibitor and promoting RhoA activationQ34925405
Stimulated calcium entry and constitutive RhoA kinase activity cause stretch-induced detrusor contractionQ35224547
Factors influencing the expression of stress fibers in vascular endothelial cells in situQ36207697
Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts.Q36328730
Molecular cloning and sequencing of the chicken smooth muscle myosin regulatory light chainQ36453511
Phosphorylation of myosin-II regulatory light chain by cyclin-p34cdc2: a mechanism for the timing of cytokinesisQ36531692
Cytoskeleton dynamics: fluctuations within the network.Q36726870
Universal physical responses to stretch in the living cellQ36737346
Myosin II isoforms in smooth muscle: heterogeneity and functionQ36809519
Macromolecular composition of stress fiber-plasma membrane attachment sites in endothelial cells in situQ36829197
Myosin phosphorylation triggers actin polymerization in vascular smooth muscleQ37038985
Long-term cyclic stretch controls pulmonary endothelial permeability at translational and post-translational levelsQ37089150
Isozymes of the Na+/K+-ATPaseQ38270644
Cytoskeletal rearrangements and transcriptional activation of c-fos serum response element by Rho-kinase.Q38342846
Fluorescent antibody localization of myosin in the cytoplasm, cleavage furrow, and mitotic spindle of human cellsQ39408251
Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motilityQ39714519
Activation of ROCK by RhoA is regulated by cell adhesion, shape, and cytoskeletal tensionQ39754336
Regulation of cellular contractile force in response to mechanical stretch by diphosphorylation of myosin regulatory light chain via RhoA signaling cascade.Q39851060
High tidal volume mechanical ventilation with hyperoxia alters alveolar type II cell adhesionQ40113514
Functional diversity between Rho-kinase- and MLCK-mediated cytoskeletal actions in a myofibroblast-like hepatic stellate cell line.Q40648177
Mechanical stretching of alveolar epithelial cells increases Na(+)-K(+)-ATPase activityQ40935933
Reactivity of alveolar epithelial cells in primary culture with type I cell monoclonal antibodiesQ41113053
Expression of the catalytic domain of myosin light chain kinase increases paracellular permeabilityQ41151632
Structural basis for physiological regulation of paracellular pathways in intestinal epitheliaQ41442657
Cellular control lies in the balance of forcesQ41750971
Enhanced interaction between focal adhesion and adherens junction proteins: involvement in sphingosine 1-phosphate-induced endothelial barrier enhancementQ41828281
RhoA, Rac1, and Cdc42 exert distinct effects on epithelial barrier via selective structural and biochemical modulation of junctional proteins and F-actinQ42459171
Differential effect of MLC kinase in TNF-alpha-induced endothelial cell apoptosis and barrier dysfunctionQ43606149
Protein phosphatase 2B inhibitor potentiates endothelial PKC activity and barrier dysfunctionQ43706752
Role of stretch on tight junction structure in alveolar epithelial cellsQ43802262
Shear stress-mediated cytoskeletal remodeling and cortactin translocation in pulmonary endothelial cellsQ43936976
Isoforms of the alpha subunit of Na,K-ATPase and their significanceQ44026384
Endothelial contraction and monolayer hyperpermeability are regulated by Src kinaseQ44232451
Magnitude-dependent regulation of pulmonary endothelial cell barrier function by cyclic stretchQ44363886
Role of heat shock protein 27 in cytoskeletal remodeling of the airway smooth muscle cellQ44732930
Stretch of the vascular wall induces smooth muscle differentiation by promoting actin polymerizationQ44927212
P4510describes a project that usesImageJQ1659584
P433issue10
P304page(s)L992-1002
P577publication date2012-01-27
P1433published inAmerican Journal of Physiology - Lung Cellular and Molecular PhysiologyQ4352992
P1476titleRho kinase signaling pathways during stretch in primary alveolar epithelia
P478volume302

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cites work (P2860)
Q36876137Activation of Vascular Endothelial Growth Factor (VEGF) Receptor 2 Mediates Endothelial Permeability Caused by Cyclic Stretch
Q37234860Biophysical determinants of alveolar epithelial plasma membrane wounding associated with mechanical ventilation.
Q36122885Coming to terms with tissue engineering and regenerative medicine in the lung
Q37056453Cyclic stretch-induced oxidative stress increases pulmonary alveolar epithelial permeability
Q51832919Fluctuation-driven mechanotransduction regulates mitochondrial-network structure and function.
Q30578909Folliculin controls lung alveolar enlargement and epithelial cell survival through E-cadherin, LKB1, and AMPK.
Q35056389Hyperoxia increases the elastic modulus of alveolar epithelial cells through Rho kinase
Q41474435Ibuprofen protects ventilator-induced lung injury by downregulating Rho-kinase activity in rats.
Q38794244Local influence of cell viability on stretch-induced permeability of alveolar epithelial cell monolayers
Q38138015Novel concepts of acute lung injury and alveolar-capillary barrier dysfunction
Q33775159Paxillin mediates stretch-induced Rho signaling and endothelial permeability via assembly of paxillin-p42/44MAPK-GEF-H1 complex
Q43069129Rac1 pathway mediates stretch response in pulmonary alveolar epithelial cells
Q39028601Role of MicroRNA in the Lung's Innate Immune Response.
Q34313951Sepsis enhances epithelial permeability with stretch in an actin dependent manner.
Q37734257Targeting the mevalonate cascade as a new therapeutic approach in heart disease, cancer and pulmonary disease
Q47811859The newborn rat gastric emptying rate is volume and not developmentally dependent

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