Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts.

scientific article

Distinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.150.4.797
P932PMC publication ID2175273
P698PubMed publication ID10953004
P5875ResearchGate publication ID12367984

P50authorFumio MatsumuraQ37388206
Shigeko YamashiroQ55206548
Go TotsukawaQ55416311
P2093author name stringY Sasaki
D J Hartshorne
Y Yamakita
P2860cites workRegulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)Q24319737
The p160 RhoA-binding kinase ROK alpha is a member of a kinase family and is involved in the reorganization of the cytoskeletonQ24648481
Rho-stimulated contractility drives the formation of stress fibers and focal adhesionsQ24671788
Differential subcellular localization of protein phosphatase-1 alpha, gamma1, and delta isoforms during both interphase and mitosis in mammalian cellsQ24680202
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphataseQ28140582
Interaction of smooth muscle myosin phosphatase with phospholipidsQ28242107
Myosin light chain phosphatase: subunit composition, interactions and regulationQ28274342
Rho-associated kinase of chicken gizzard smooth muscleQ28295444
Cooperation between mDia1 and ROCK in Rho-induced actin reorganizationQ28587275
Phosphorylation and activation of myosin by Rho-associated kinase (Rho-kinase)Q28609825
Protein phosphatase type 1 in mammalian cell mitosis: chromosomal localization and involvement in mitotic exitQ28755173
Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertensionQ29614247
A major role for the rho-associated coiled coil forming protein kinase in G-protein-mediated Ca2+ sensitization through inhibition of myosin phosphatase in rabbit tracheaQ30443946
Signal transduction and regulation in smooth muscleQ30465812
Purification and characterization of the mammalian myosin light chain phosphatase holoenzyme. The differential effects of the holoenzyme and its subunits on smooth muscle.Q30465871
Activation of myosin phosphatase targeting subunit by mitosis-specific phosphorylationQ34502458
Characterization of antibodies to smooth muscle myosin kinase and their use in localizing myosin kinase in nonmuscle cellsQ35453267
Microinjection of nonmuscle and smooth muscle caldesmon into fibroblasts and muscle cells.Q36224225
In vivo phosphorylation of regulatory light chain of myosin II during mitosis of cultured cellsQ36233630
Specific localization of serine 19 phosphorylated myosin II during cell locomotion and mitosis of cultured cellsQ36254887
Association of the myosin-binding subunit of myosin phosphatase and moesin: dual regulation of moesin phosphorylation by Rho-associated kinase and myosin phosphataseQ36289185
Characterization of the myosin-binding subunit of smooth muscle myosin phosphatase.Q36729109
Regulation of cytoplasmic and smooth muscle myosinQ37188229
p160ROCK, a Rho-associated coiled-coil forming protein kinase, works downstream of Rho and induces focal adhesionsQ38347826
Interactions and properties of smooth muscle myosin phosphatase.Q38357666
The function of myosin and myosin light chain kinase phosphorylation in smooth muscleQ39494677
Phosphorylation of vertebrate nonmuscle and smooth muscle myosin heavy chains and light chainsQ40637237
Phosphorylation of myosin-binding subunit (MBS) of myosin phosphatase by Rho-kinase in vivoQ40915136
Dynamics of myosin light chain phosphorylation at Ser19 and Thr18/Ser19 in smooth muscle cells in culture.Q41037496
Regulation of the association of adducin with actin filaments by Rho-associated kinase (Rho-kinase) and myosin phosphataseQ41052407
Formation of actin stress fibers and focal adhesions enhanced by Rho-kinaseQ41126637
Clostridium difficile toxin B acts on the GTP-binding protein Rho.Q42799847
The control of protein phosphatase-1 by targetting subunits. The major myosin phosphatase in avian smooth muscle is a novel form of protein phosphatase-1.Q44724692
Regulatory light chain phosphorylation and the assembly of myosin II into the cytoskeleton of microcapillary endothelial cells.Q52535723
Identification of the regions on the M110 subunit of protein phosphatase 1M that interact with the M21 subunit and with myosin.Q54569086
Interactions of the subunits of smooth muscle myosin phosphatase.Q54570849
Phosphorylation of glial fibrillary acidic protein at the same sites by cleavage furrow kinase and Rho-associated kinase.Q55478553
Selective inhibition of catalytic activity of smooth muscle myosin light chain kinaseQ70341558
Immunological properties of myosin light-chain kinasesQ70348124
Phosphorylation of the large subunit of myosin phosphatase and inhibition of phosphatase activityQ71048930
Production and characterization of an antibody to myosin light chain kinase and intracellular localization of the enzymeQ72417644
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectphosphorylationQ242736
P1104number of pages10
P304page(s)797-806
P577publication date2000-08-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleDistinct roles of ROCK (Rho-kinase) and MLCK in spatial regulation of MLC phosphorylation for assembly of stress fibers and focal adhesions in 3T3 fibroblasts
P478volume150

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Q83587061Rho kinase inhibitors stimulate the migration of human cultured osteoblastic cells by regulating actomyosin activity
Q35994798Rho kinase signaling pathways during stretch in primary alveolar epithelia
Q30477845Rho kinase, myosin-II, and p42/44 MAPK control extracellular matrix-mediated apical bile canalicular lumen morphogenesis in HepG2 cells
Q44859639Rho modulates hepatic sinusoidal endothelial fenestrae via regulation of the actin cytoskeleton in rat endothelial cells
Q40162264Rho plays a central role in regulating local cell-matrix mechanical interactions in 3D culture
Q46900605Rho signaling in Entamoeba histolytica modulates actomyosin-dependent activities stimulated during invasive behavior
Q33968841Rho-associated coiled-coil containing kinases (ROCK): structure, regulation, and functions
Q38100279Rho-associated coiled-coil kinase (ROCK) signaling and disease
Q91959468Rho-associated kinase and zipper-interacting protein kinase, but not myosin light chain kinase, are involved in the regulation of myosin phosphorylation in serum-stimulated human arterial smooth muscle cells
Q37786442Rho-associated kinase-dependent contraction of stress fibres and the organization of focal adhesions
Q39583935Rho-dependent agonist-induced spatio-temporal change in myosin phosphorylation in smooth muscle cells
Q52096698Rho-dependent contractile responses in the neuronal growth cone are independent of classical peripheral retrograde actin flow.
Q44107653Rho-kinase contributes to diphosphorylation of myosin II regulatory light chain in nonmuscle cells
Q40126648Rho-kinase dependent organization of stress fibers and focal adhesions in cultured fibroblasts.
Q62805859Rho-kinase inhibitor coupled to peptide-modified albumin carrier reduces portal pressure and increases renal perfusion in cirrhotic rats
Q40775912Rho-kinase regulates myosin II activation in MDCK cells during recovery after ATP depletion
Q33252503Rho-kinase regulates tissue morphogenesis via non-muscle myosin and LIM-kinase during Drosophila development
Q28609762Rho-kinase--mediated contraction of isolated stress fibers
Q33663771Rho-kinase-mediated Ca2+-independent contraction in rat embryo fibroblasts
Q30489647Rho-regulated myosin phosphatase establishes the level of protrusive activity required for cell movements during zebrafish gastrulation
Q35949016Rho/Rho-associated kinase-II signaling mediates disassembly of epithelial apical junctions
Q34504042Rho1 regulates adherens junction remodeling by promoting recycling endosome formation through activation of myosin II.
Q34646834RhoA Inactivation Prevents Photoreceptor Axon Retraction in an In Vitro Model of Acute Retinal Detachment
Q39029939RhoA and Rac1 play independent roles in lysophosphatidic acid-induced ovarian cancer chemotaxis
Q48880526RhoA-ROCK-Myosin pathway regulates morphological plasticity of cultured olfactory ensheathing cells.
Q30477696RhoA-kinase and myosin II are required for the maintenance of growth cone polarity and guidance by nerve growth factor
Q35759021RhoA/ROCK-dependent moesin phosphorylation regulates AGE-induced endothelial cellular response
Q24303641Rocks: multifunctional kinases in cell behaviour
Q46863306Roles for Rho/ROCK and vinculin in parietal endoderm migration
Q39177650S100A4 downregulates filopodia formation through increased dynamic instability
Q51812956SNARE-mediated membrane traffic modulates RhoA-regulated focal adhesion formation.
Q36838919STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis.
Q27340417Senescent stromal cells induce cancer cell migration via inhibition of RhoA/ROCK/myosin-based cell contractility
Q42917027Shear stress-induced endothelial cell polarization is mediated by Rho and Rac but not Cdc42 or PI 3-kinases
Q36057903Signaling and cytoskeletal requirements in erythroblast enucleation
Q30480418Slit and Netrin-1 guide cranial motor axon pathfinding via Rho-kinase, myosin light chain kinase and myosin II.
Q35608039Sodium-calcium exchanger 1 regulates epithelial cell migration via calcium-dependent extracellular signal-regulated kinase signaling
Q40019043Softening of the actin cytoskeleton by inhibition of myosin II.
Q37780682Spatial organization of adhesion: force-dependent regulation and function in tissue morphogenesis
Q34033134Specific isoforms of drosophila shroom define spatial requirements for the induction of apical constriction
Q37361115Sphingosine-1-phosphate induced contraction of bladder smooth muscle
Q36301849Staurosporine and cytochalasin D induce chondrogenesis by regulation of actin dynamics in different way.
Q37378697Substrate Stiffness Regulates PDGF-Induced Circular Dorsal Ruffle Formation Through MLCK.
Q30484812Substrate rigidity regulates Ca2+ oscillation via RhoA pathway in stem cells.
Q55182324Suppression of focal adhesion formation may account for the suppression of cell migration, invasion and growth of non-small cell lung cancer cells following treatment with polyisoprenylated cysteinyl amide inhibitors.
Q93052871Switch-like enhancement of epithelial-mesenchymal transition by YAP through feedback regulation of WT1 and Rho-family GTPases
Q48061178TRPV4 mediates the Ca2+ influx required for the interaction between flightless-1 and non-muscle myosin, and collagen remodeling
Q37984123Targeting Rho GTPase signaling for cancer therapy
Q42264053The Abl and Arg non-receptor tyrosine kinases regulate different zones of stress fiber, focal adhesion, and contractile network localization in spreading fibroblasts.
Q92126895The Cytoskeleton of the Retinal Pigment Epithelium: from Normal Aging to Age-Related Macular Degeneration
Q24652634The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway
Q27341833The Novel Antitubulin Agent TR-764 Strongly Reduces Tumor Vasculature and Inhibits HIF-1α Activation.
Q48573737The Rho-GTPase effector ROCK regulates meiotic maturation of the bovine oocyte via myosin light chain phosphorylation and cofilin phosphorylation
Q37170851The actin cytoskeleton in cancer cell motility
Q34045733The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.
Q40684957The bovine lactoferrin region responsible for promoting the collagen gel contractile activity of human fibroblasts.
Q35568886The effects of knockdown of rho-associated kinase 1 and zipper-interacting protein kinase on gene expression and function in cultured human arterial smooth muscle cells
Q35551752The endocytic protein GRAF1 is directed to cell-matrix adhesion sites and regulates cell spreading
Q29620375The microenvironment of the tumour-host interface
Q36173910The phosphorylation of myosin II at the Ser1 and Ser2 is critical for normal platelet-derived growth factor induced reorganization of myosin filaments
Q34501695The phosphorylation state of MRLC is polyamine dependent in intestinal epithelial cells
Q39869490The planar cell polarity pathway directs parietal endoderm migration
Q36222798The role of Rho/Rho-kinase pathway and the neuroprotective effects of fasudil in chronic cerebral ischemia.
Q34111432The switchable integrin adhesome.
Q39699837The transcription factor EGR1 regulates metastatic potential of v-src transformed sarcoma cells
Q36598629Timothy syndrome is associated with activity-dependent dendritic retraction in rodent and human neurons
Q42128424Traction forces of fibroblasts are regulated by the Rho-dependent kinase but not by the myosin light chain kinase
Q29547894Tumour-cell invasion and migration: diversity and escape mechanisms
Q42834338Uncoordinated regulation of stress fibers and focal adhesions by DAP kinase
Q42582162Unraveling the determinants of protrusion formation
Q30477150Viscoelastic retraction of single living stress fibers and its impact on cell shape, cytoskeletal organization, and extracellular matrix mechanics.
Q35088197Weak power frequency magnetic field acting similarly to EGF stimulation, induces acute activations of the EGFR sensitive actin cytoskeleton motility in human amniotic cells
Q35491880Wound contraction is attenuated by fasudil inhibition of Rho-associated kinase
Q28588545ZIP kinase is responsible for the phosphorylation of myosin II and necessary for cell motility in mammalian fibroblasts
Q33568853ZIPK is critical for the motility and contractility of VSMCs through the regulation of nonmuscle myosin II isoforms
Q39474004aPKCζ affects directed cell migration through the regulation of myosin light chain phosphorylation
Q59791911p73 regulates ependymal planar cell polarity by modulating actin and microtubule cytoskeleton

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