Transfection and overexpression of the calcium binding protein calbindin-D28k results in a stimulatory effect on insulin synthesis in a rat beta cell line (RIN 1046-38)

scientific article

Transfection and overexpression of the calcium binding protein calbindin-D28k results in a stimulatory effect on insulin synthesis in a rat beta cell line (RIN 1046-38) is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1997PNAS...94.1961R
P356DOI10.1073/PNAS.94.5.1961
P932PMC publication ID20025
P698PubMed publication ID9050887
P5875ResearchGate publication ID14160345

P2093author name stringA F Stewart
S Christakos
A S Pollock
S A Clark
D Reddy
T Honeyman
K Sooy
R C Vasavada
P2860cites workA rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionQ25938986
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Role of facilitated diffusion of calcium by calbindin in intestinal calcium absorptionQ28284173
Two Related Helix-Loop-Helix Proteins Participate in Separate Cell-Specific Complexes That Bind the Insulin EnhancerQ33263393
A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancerQ34375782
Molecular cloning of mammalian 28,000 Mr vitamin D-dependent calcium binding protein (calbindin-D28K): expression of calbindin-D28K RNAs in rodent brain and kidneyQ35128427
Pancreatic beta-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteinsQ36961228
Vitamin D-dependent calcium binding proteins: chemistry, distribution, functional considerations, and molecular biologyQ38667657
Metabolic coupling factors in pancreatic beta-cell signal transductionQ40422075
Inhibition of insulin secretion: A fail-safe systemQ40488907
Regulation of cytoplasmic free Ca2+ in insulin-secreting cellsQ40784525
Calbindin expression in renal tubular epithelial cells. Altered sodium phosphate co-transport in association with cytoskeletal rearrangementQ41326668
GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity.Q41474070
1,25-Dihydroxyvitamin D3 and pancreatic beta-cell function: vitamin D receptors, gene expression, and insulin secretionQ41476591
Insulin secretion, insulin content and glucose phosphorylation in RINm5F insulinoma cells after transfection with human GLUT2 glucose-transporter cDNA.Q41513949
Overexpression of glucose transporter modulates insulin biosynthesis in insulin producing cell lineQ41721314
Calmodulin-induced early-onset diabetes in transgenic miceQ41840125
Calcium buffering properties of calbindin D28k and parvalbumin in rat sensory neuronesQ42499459
The insulin gene contains multiple transcriptional elements that respond to glucoseQ42501381
Pancreatic beta cells cultured from individual preneoplastic foci in a multistage tumorigenesis pathway: a potentially general technique for isolating physiologically representative cell linesQ42809831
Glucose regulates preproinsulin messenger RNA levels in a clonal cell line of simian virus 40-transformed B cellsQ45835116
Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancer motifsQ46718044
Regulation of insulin gene expression by glucose and calcium in transfected primary islet culturesQ46757812
Vitamin D-dependent rat renal calcium-binding protein: development of a radioimmunoassay, tissue distribution, and immunologic identificationQ48640536
Evidence for calcium-reducing and excitoprotective roles for the calcium-binding protein calbindin-1328k in cultured hippocampal neuronsQ48827363
Analysis of rat vitamin D-dependent calbindin-D28k gene expression.Q52250946
Protein kinase C modulates the insulin secretory process by maintaining a proper function of the beta-cell voltage-activated Ca2+ channels.Q53725724
Calcium-binding protein: its cellular localization in jejunum, kidney and pancreasQ67510078
Measurement of rat insulin. Enzyme-linked immunosorbent assay with increased sensitivity, high accuracy, and greater practicability than established radioimmunoassayQ68139530
Theophylline inhibits active Ca transport in rat intestine by inhibiting Ca binding by CaBPQ68279372
Phorbol ester-stimulated insulin secretion by RINm5F insulinoma cells is linked with membrane depolarization and an increase in cytosolic free Ca2+ concentrationQ69327711
CaBPr facilitates intracellular diffusion for Ca pumping in distal convoluted tubuleQ70060490
Defective glycolysis and calcium signaling underlie impaired insulin secretion in a transgenic mouseQ71585872
Target cells for 1,25 dihydroxyvitamin D3 in the pancreasQ72148019
A role of calcyclin, a Ca(2+)-binding protein, on the Ca(2+)-dependent insulin release from the pancreatic beta cellQ72272643
Localization of calcium signals by a mobile calcium buffer in frog saccular hair cellsQ72418257
Oscillations of secretion driven by oscillations of cytoplasmic Ca2+ as evidences in single pancreatic isletsQ72571167
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectoverexpressionQ61643320
P304page(s)1961-1966
P577publication date1997-03-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleTransfection and overexpression of the calcium binding protein calbindin-D28k results in a stimulatory effect on insulin synthesis in a rat beta cell line (RIN 1046-38)
P478volume94

Reverse relations

cites work (P2860)
Q22254086Cloning and expression of secretagogin, a novel neuroendocrine- and pancreatic islet of Langerhans-specific Ca2+-binding protein
Q30461438Cytosolic Ca2+ Buffers
Q84533972Distribution patterns of calcium-binding proteins in pancreatic tissue of non-diabetic as well as type 2 diabetic rats and in rat insulinoma beta-cells (INS-1)
Q47718742Effects of chronic nimodipine on working memory of old rats in relation to defects in synaptosomal calcium homeostasis
Q34992302Gene targeting and Calcium handling efficiencies in mouse embryonic stem cell lines.
Q40687757Intracellular calcium ion response to glucose in beta-cells of calbindin-D28k nullmutant mice and in betaHC13 cells overexpressing calbindin-D28k
Q38359562Overexpression of the Pdx-1 homeodomain transcription factor impairs glucose metabolism in cultured rat hepatocytes.
Q38804461PTH and Vitamin D.
Q35885637Sphingosine kinase 1 knockdown reduces insulin synthesis and secretion in a rat insulinoma cell line
Q44865859Structural insights into the calcium-dependent interaction between calbindin-D28K and caspase-3.
Q38910863The Presence of Human Chorionic Gonadotropin/Luteinizing Hormone Receptors in Pancreatic β-Cells
Q41689708The dynamic plasticity of insulin production in β-cells.
Q36106466The role of vitamin D in protecting type 1 diabetes mellitus

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