Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma.

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Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/NG.950
P932PMC publication ID3376644
P698PubMed publication ID21946352
P5875ResearchGate publication ID51673435

P50authorSteven RosenbergQ2347448
Elliott H. MarguliesQ5365658
Katherine Stemke-HaleQ52353554
Yardena SamuelsQ55130355
Jamie K TeerQ80095848
Jared J GartnerQ91623672
P2093author name stringVijay Walia
Xiaomu Wei
Jeffrey E Gershenwald
Praveen F Cherukuri
Michael A Davies
Alfredo Molinolo
Jimmy C Lin
Todd D Prickett
Jiji Jiang
Isabel Cardenas-Navia
P2860cites workAnalysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4.Q27851483
Inhibition of Mutated, Activated BRAF in Metastatic MelanomaQ27860458
Multiplex amplification of large sets of human exonsQ28253118
SIFT: Predicting amino acid changes that affect protein functionQ29547211
Cancer statistics, 2009Q29547625
Patterns of somatic mutation in human cancer genomesQ29547841
BRAF mutation predicts sensitivity to MEK inhibitionQ29614281
Modelling G-protein-coupled receptors for drug designQ33766736
Expression and functional role of mGluR3 and mGluR5 in human astrocytes and glioma cells: opposite regulation of glutamate transporter proteinsQ34202874
G-protein-coupled receptors and cancer.Q34606002
Mutational and functional analysis reveals ADAMTS18 metalloproteinase as a novel driver in melanomaQ34682013
Estrogen promotes the survival and pulmonary metastasis of tuberin-null cellsQ37087123
G-protein-coupled receptors and melanomaQ37200841
Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanomaQ37356835
Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancerQ38445646
Comparative effect of L-CCG-I, DCG-IV and gamma-carboxy-L-glutamate on all cloned metabotropic glutamate receptor subtypes.Q40991782
Integrated Molecular and Clinical Analysis of AKT Activation in Metastatic MelanomaQ42723115
Pharmacological characterization of metabotropic glutamate receptor-mediated high-affinity GTPase activity in rat cerebral cortical membranesQ43264619
Lysophosphatidic Acid Stimulates Ovarian Cancer Cell Migration via a Ras-MEK Kinase 1 PathwayQ43461747
Double-blind randomized phase II study of the combination of sorafenib and dacarbazine in patients with advanced melanoma: a report from the 11715 Study GroupQ46619788
Genetic inactivation of ADAMTS15 metalloprotease in human colorectal cancer.Q47756832
Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasiaQ48250298
P4510describes a project that usesImageJQ1659584
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectG protein-coupled receptorQ38173
P304page(s)1119-1126
P577publication date2011-09-25
P1433published inNature GeneticsQ976454
P1476titleExon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma
P478volume43

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cites work (P2860)
Q49954335-The a-arrestin ARRDC3 suppresses breast carcinoma invasion by regulating G protein-coupled receptor lysosomal sorting and signaling
Q33917519A highly recurrent RPS27 5'UTR mutation in melanoma
Q34253185Abrogation of BRAFV600E-induced senescence by PI3K pathway activation contributes to melanomagenesis
Q33560677Activation of the glutamate receptor GRM1 enhances angiogenic signaling to drive melanoma progression
Q38091649Advances in personalized targeted treatment of metastatic melanoma and non-invasive tumor monitoring
Q36021702BRAFV600E remodels the melanocyte transcriptome and induces BANCR to regulate melanoma cell migration
Q28544919Clonal architectures and driver mutations in metastatic melanomas
Q34420417Comparative exome sequencing of metastatic lesions provides insights into the mutational progression of melanoma
Q34737562Comprehensive genomic characterization of cutaneous malignant melanoma cell lines derived from metastatic lesions by whole-exome sequencing and SNP array profiling
Q36030770Delving into somatic variation in sporadic melanoma
Q35828069Detecting false-positive signals in exome sequencing
Q37626431Disruption of GRM1-mediated signalling using riluzole results in DNA damage in melanoma cells
Q37162578DrGaP: a powerful tool for identifying driver genes and pathways in cancer sequencing studies
Q42012553ERBB4 mutation analysis: emerging molecular target for melanoma treatment.
Q37028299Exome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas
Q37576033Exploiting the curative potential of adoptive T-cell therapy for cancer
Q33845217FBXW7 mutations in melanoma and a new therapeutic paradigm
Q35705859Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing
Q36409682Functional effects of GRM1 suppression in human melanoma cells
Q37659860G-protein-coupled receptor GPR161 is overexpressed in breast cancer and is a promoter of cell proliferation and invasion.
Q62884236GPCRs in Cancer: Protease-Activated Receptors, Endocytic Adaptors and Signaling
Q34411505GRM1 is upregulated through gene fusion and promoter swapping in chondromyxoid fibroma.
Q37406812Genetics and epigenetics of melanoma
Q36563659Genetics of melanoma
Q88552258Genetics of metastasis: melanoma and other cancers
Q34048497Glutamate and its receptors in cancer
Q37121338Glutamate signaling in benign and malignant disorders: current status, future perspectives, and therapeutic implications
Q37978409Glutamatergic signaling in cellular transformation
Q47169465Glutaminolysis drives membrane trafficking to promote invasiveness of breast cancer cells.
Q26861766Harnessing the genome for characterization of G-protein coupled receptors in cancer pathogenesis
Q42773490High-throughput sequencing of the melanoma genome
Q33819083Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.
Q33624972Human melanoma metastases demonstrate nonstochastic site-specific antigen heterogeneity that correlates with T-cell infiltration
Q34619124Hypoxia-inducible factors enhance glutamate signaling in cancer cells
Q36762520Illuminating the activation mechanisms and allosteric properties of metabotropic glutamate receptors
Q30528247Increased platelet activation and thrombosis in transgenic mice expressing constitutively active P2Y12.
Q37361741Integration of mechanical and chemical signals by YAP and TAZ transcription coactivators
Q33880126Location, location, location: The relationship of anatomic site, antigen expression, and T-cell infiltration in human melanoma metastases
Q33704699MUG-Mel2, a novel highly pigmented and well characterized NRAS mutated human melanoma cell line
Q34971850Melanoma brain colonization involves the emergence of a brain-adaptive phenotype
Q38111220Melanoma metastasis: new concepts and evolving paradigms
Q38710970Melanoma-associated GRM3 variants dysregulate melanosome trafficking and cAMP signaling.
Q34083191Melanoma: clinical features and genomic insights.
Q27024061Melanoma: from mutations to medicine
Q43090167MelanomaDB: A Web Tool for Integrative Analysis of Melanoma Genomic Information to Identify Disease-Associated Molecular Pathways
Q30570451Metabotropic glutamate receptor 1 (Grm1) is an oncogene in epithelial cells
Q37540105Metabotropic glutamate receptor 1 disrupts mammary acinar architecture and initiates malignant transformation of mammary epithelial cells
Q33769639Metabotropic glutamate receptor 1 mediates melanocyte transformation via transactivation of insulin-like growth factor 1 receptor
Q33591900Metabotropic glutamate receptors as a new therapeutic target for malignant gliomas
Q38741884Metabotropic glutamate receptors in cancer
Q78271812Modelling of Protein Kinase Signaling Pathways in Melanoma and Other Cancers
Q36170150Molecular pathways: dysregulated glutamatergic signaling pathways in cancer
Q39519769Multicolor FISH with improved sensitivity and specificity in the diagnosis of malignant melanoma.
Q88637038Multifaceted regulation and functions of YAP/TAZ in tumors (Review)
Q24298571Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP
Q42180596Mutational analysis of the GNA11, MMP27, FGD1, TRRAP and GRM3 genes in thyroid cancer
Q102141804Mutational drivers of cancer cell migration and invasion
Q39007737Near-genomewide RNAi screening for regulators of BRAF(V600E) -induced senescence identifies RASEF, a gene epigenetically silenced in melanoma
Q26853582New developments in dermatological oncogenetics
Q34450728Non-canonical Smads phosphorylation induced by the glutamate release inhibitor, riluzole, through GSK3 activation in melanoma
Q59137905Participation of xCT in melanoma cell proliferation in vitro and tumorigenesis in vivo
Q26865736Pathways and therapeutic targets in melanoma
Q38907413Patient-derived tumor xenograft models for melanoma drug discovery
Q98475181Prediction of drug response in multilayer networks based on fusion of multiomics data
Q26744512Protease-Activated Receptors and other G-Protein-Coupled Receptors: the Melanoma Connection
Q38833742Protein kinase C inhibitor AEB071 targets ocular melanoma harboring GNAQ mutations via effects on the PKC/Erk1/2 and PKC/NF-κB pathways
Q37274872Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma
Q38700311Reduction in Migratory Phenotype in a Metastasized Breast Cancer Cell Line via Downregulation of S100A4 and GRM3.
Q39318208Regulation of mGluR1 expression in human melanocytes and melanoma cells
Q24294906Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling
Q92786732SMARC-B1 deficient sinonasal carcinoma metastasis to the brain with next generation sequencing data: a case report of perineural invasion progressing to leptomeningeal invasion
Q37243181SOX10 ablation arrests cell cycle, induces senescence, and suppresses melanomagenesis
Q37990969Selumetinib (AZD6244; ARRY-142886) in the treatment of metastatic melanoma
Q49386947Targeted sequencing of cancer-associated genes in hepatocellular carcinoma using next-generation sequencing
Q38087215The Hippo pathway and human cancer.
Q38083640The Hippo pathway: regulators and regulations
Q30410176The Hippo signaling pathway in stem cell biology and cancer
Q38532696The current management of brain metastasis in melanoma: a focus on riluzole
Q33799070The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer.
Q38756275The impact of melanoma genetics on treatment response and resistance in clinical and experimental studies
Q42081827The miR-487b-3p/GRM3/TGFβ signaling axis is an important regulator of colon cancer tumorigenesis
Q36833326Transposon mutagenesis identifies genetic drivers of Braf(V600E) melanoma
Q34213994What are we learning from the cancer genome?
Q39060449Whole-genome landscapes of major melanoma subtypes.
Q52312423[The cancer paradigm in pulmonary arterial hypertension: towards anti-remodeling therapies targeting metabolic dysfunction?]

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