Concurrent bacterial stimulation alters the function of helminth-activated dendritic cells, resulting in IL-17 induction.

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Concurrent bacterial stimulation alters the function of helminth-activated dendritic cells, resulting in IL-17 induction. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.1101642
P932PMC publication ID3378507
P698PubMed publication ID22287718
P5875ResearchGate publication ID221789321

P50authorLauren M WebbQ56875600
Georgia Perona-WrightQ78470415
Andrew S MacDonaldQ80897528
P2093author name stringRichard K Grencis
Rachel J Lundie
Stephen J Jenkins
P2860cites workNovel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12Q24290619
Interleukin-10 and the interleukin-10 receptorQ24290912
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunityQ24630261
IL25 elicits a multipotent progenitor cell population that promotes T(H)2 cytokine responsesQ24630608
Helminth infections: the great neglected tropical diseasesQ24648324
Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestineQ24648636
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsQ27860460
Induction of intestinal Th17 cells by segmented filamentous bacteriaQ28131638
Transforming growth factor-beta induces development of the T(H)17 lineageQ28237370
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cellsQ28296956
Dendritic cell expression of OX40 ligand acts as a costimulatory, not polarizing, signal for optimal Th2 priming and memory induction in vivoQ28512204
CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response developmentQ28594824
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17Q29547855
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesQ29547871
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brainQ29614225
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathwaysQ29614839
An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrowQ29615498
Essential autocrine regulation by IL-21 in the generation of inflammatory T cellsQ29616147
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cellsQ29616148
Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cellsQ29619771
Quantification of clinical morbidity associated with schistosome infection in sub-Saharan AfricaQ29620602
Exploitation of the intestinal microflora by the parasitic nematode Trichuris murisQ30524457
Schistosoma mansoni: genetic restriction and cytokine profile of the CD4 + T helper cell response to dominant epitope peptide of major egg antigen Sm-p40.Q32037356
Programming dendritic cells to induce T(H)2 and tolerogenic responsesQ33349475
An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory responseQ33853821
Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node.Q33957034
Chronic mucocutaneous candidiasis in humans with inborn errors of interleukin-17 immunityQ34025875
Hepatic schistosomiasis.Q34033201
CD11c depletion severely disrupts Th2 induction and development in vivoQ34161501
Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B.Q34674471
Coactivation of Syk kinase and MyD88 adaptor protein pathways by bacteria promotes regulatory properties of neutrophils.Q54709609
Dendritic cell expression of the Notch ligandjagged2 is not essential for Th2 response inductionin vivoQ56880711
IL-10 regulates liver pathology in acute murine Schistosomiasis mansoni but is not required for immune down-modulation of chronic diseaseQ57339957
Selective maturation of dendritic cells byNippostrongylus brasiliensis-secreted proteins drives Th2 immune responsesQ58843220
IL-10 permits transient activation of dendritic cells to tolerize T cells and protect from central nervous system autoimmune diseaseQ61971077
Kinetics of egg production and egg excretion by Schistosoma mansoni and S. japonicum in mice infected with a single pair of wormsQ72339097
Role of IL-6 in directing the initial immune response to schistosome eggsQ73458414
IL-4 protects against TNF-alpha-mediated cachexia and death during acute schistosomiasisQ73500970
IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasisQ73869153
CD8- dendritic cell activation status plays an integral role in influencing Th2 response developmentQ74321435
Cutting edge: polarized Th cell response induction by transferred antigen-pulsed dendritic cells is dependent on IL-4 or IL-12 production by recipient cellsQ77800961
Suppression of immune induction of collagen-induced arthritis in IL-17-deficient miceQ79317500
IL-23 is required for the development of severe egg-induced immunopathology in schistosomiasis and for lesional expression of IL-17Q80633636
Helminth antigens modulate TLR-initiated dendritic cell activationQ81111451
Role of gut commensal microflora in the development of experimental autoimmune encephalomyelitisQ84749218
TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathologyQ34712326
The immunobiology of schistosomiasisQ34718128
Dendritic cells at the host-pathogen interface.Q34765258
Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammationQ34936014
Inhibition of interleukin-17 prevents the development of arthritis in vaccinated mice challenged with Borrelia burgdorferiQ35011581
Regulation of innate and adaptive immunity by the commensal microbiotaQ35028444
Enhanced protection to Mycobacterium tuberculosis infection in IL-10-deficient mice is accompanied by early and enhanced Th1 responses in the lungQ36043946
Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoniQ36229789
Dendritic cell activation and function in response to Schistosoma mansoni.Q36476868
Protective immune mechanisms in helminth infectionQ36481763
In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cellsQ36699777
The pathogenic Th17 cell response to major schistosome egg antigen is sequentially dependent on IL-23 and IL-1βQ36843026
IL-6 promotes NK cell production of IL-17 during toxoplasmosisQ37132980
IL-10: the master regulator of immunity to infectionQ37143028
Dendritic cell IL-23 and IL-1 production in response to schistosome eggs induces Th17 cells in a mouse strain prone to severe immunopathologyQ37145507
IL-23 promotes maintenance but not commitment to the Th17 lineageQ37183888
Critical regulation of early Th17 cell differentiation by interleukin-1 signalingQ37250727
IL-10 deficiency unleashes an influenza-specific Th17 response and enhances survival against high-dose challengeQ37297787
Gut commensal bacteria direct a protective immune response against Toxoplasma gondii.Q37353312
Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cellsQ37484974
Current concepts of the intestinal microbiota and the pathogenesis of infectionQ37838789
Up-regulation of IL-17 is associated with bioactive IL-8 expression in Helicobacter pylori-infected human gastric mucosaQ40846579
Immunologic basis of disease and disease regulation in schistosomiasis.Q41431678
Posttranscriptional regulation of II10 gene expression allows natural killer cells to express immunoregulatory function.Q42074930
Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent mannerQ42107193
A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis.Q42767100
Interleukin-1 and IL-23 induce innate IL-17 production from gammadelta T cells, amplifying Th17 responses and autoimmunity.Q43291517
Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo.Q43420803
A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivoQ43629857
Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agentQ44826352
Variation of hepatic fibrosis and granuloma size among mouse strains infected with Schistosoma mansoniQ44970501
Full development of Th2 immunity requires both innate and adaptive sources of CD154.Q45770822
Requirement of interleukin-17A for systemic anti-Candida albicans host defense in miceQ45876568
Skin and peripheral lymph node invariant NKT cells are mainly retinoic acid receptor-related orphan receptor (gamma)t+ and respond preferentially under inflammatory conditions.Q45935220
T cells use two directionally distinct pathways for cytokine secretion.Q45948164
Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology.Q46899191
Cutting edge: dendritic cells copulsed with microbial and helminth antigens undergo modified maturation, segregate the antigens to distinct intracellular compartments, and concurrently induce microbe-specific Th1 and helminth-specific Th2 responsesQ47218007
Transcription of the IL10 gene reveals allele-specific regulation at the mRNA levelQ47334707
IL-10 is crucial for the transition from acute to chronic disease state during infection of mice with Schistosoma mansoniQ47997804
The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells.Q51024754
Severe CD4 T cell-mediated immunopathology in murine schistosomiasis is dependent on IL-12p40 and correlates with high levels of IL-17.Q51989028
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectdendritic cellQ506253
P304page(s)2350-2358
P577publication date2012-01-27
P1433published inJournal of ImmunologyQ3521441
P1476titleConcurrent bacterial stimulation alters the function of helminth-activated dendritic cells, resulting in IL-17 induction
P478volume188

Reverse relations

cites work (P2860)
Q36755254A central role for hepatic conventional dendritic cells in supporting Th2 responses during helminth infection
Q35549617A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells
Q40653441Ellagic acid reduces murine schistosomiasis mansoni immunopathology via up-regulation of IL-10 and down-modulation of pro-inflammatory cytokines production.
Q34393281Increased IL-17, a Pathogenic Link between Hepatosplenic Schistosomiasis and Amyotrophic Lateral Sclerosis: A Hypothesis
Q36949600Induction and regulation of pathogenic Th17 cell responses in schistosomiasis
Q35429782Not all parasites are protective
Q36389513Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response
Q27005837Protection and pathology during parasite infection: IL-10 strikes the balance
Q27329934S. mansoni bolsters anti-viral immunity in the murine respiratory tract
Q61805993The C-type Lectin Receptor-Driven, Th17 Cell-Mediated Severe Pathology in Schistosomiasis: Not All Immune Responses to Helminth Parasites Are Th2 Dominated
Q38674915Type I interferon is required for T helper (Th) 2 induction by dendritic cells

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