Dendritic cell IL-23 and IL-1 production in response to schistosome eggs induces Th17 cells in a mouse strain prone to severe immunopathology

scientific article published on December 2008

Dendritic cell IL-23 and IL-1 production in response to schistosome eggs induces Th17 cells in a mouse strain prone to severe immunopathology is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.181.12.8559
P932PMC publication ID2663362
P698PubMed publication ID19050275
P5875ResearchGate publication ID23563312

P2093author name stringLaura I Rutitzky
Lindsey E Bazzone
Mara G Shainheit
Miguel J Stadecker
Patrick M Smith
Andrew C Wang
P2860cites workReciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsQ27860460
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsQ27860620
STAT3 and NF-kappaB signal pathway is required for IL-23-mediated IL-17 production in spontaneous arthritis animal model IL-1 receptor antagonist-deficient miceQ28235220
Transforming growth factor-beta induces development of the T(H)17 lineageQ28237370
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cellsQ28296956
Abnormal T cell activation caused by the imbalance of the IL-1/IL-1R antagonist system is responsible for the development of experimental autoimmune encephalomyelitisQ28507389
CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response developmentQ28594824
IL-23 drives a pathogenic T cell population that induces autoimmune inflammationQ29547525
A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17Q29547855
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesQ29547871
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brainQ29614225
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathwaysQ29614839
Essential autocrine regulation by IL-21 in the generation of inflammatory T cellsQ29616147
IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cellsQ29616148
Development, cytokine profile and function of human interleukin 17-producing helper T cellsQ29617131
Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cellsQ29618163
DC-SIGN mediates binding of dendritic cells to authentic pseudo-LewisY glycolipids of Schistosoma mansoni cercariae, the first parasite-specific ligand of DC-SIGN.Q33223117
Schistosome glysoconjugatesQ33778475
Th1-polarizing immunization with egg antigens correlates with severe exacerbation of immunopathology and death in schistosome infectionQ33949267
Cytokines secreted in response to Toll-like receptor ligand stimulation modulate differentiation of human Th17 cellsQ34011616
Hepatic schistosomiasis.Q34033201
Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniaeQ34450323
IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6Q34521302
Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitisQ34575334
TGF-beta and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain T(H)-17 cell-mediated pathologyQ34712326
The immunobiology of schistosomiasisQ34718128
IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonistQ35022575
Natural versus adaptive regulatory T cellsQ35092554
The immune response to parasitic helminths: insights from murine models.Q35124241
Dendritic-cell control of pathogen-driven T-cell polarizationQ35597117
Th2 response polarization during infection with the helminth parasite Schistosoma mansoniQ35884210
Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoniQ36229789
Schistosome glycans and innate immunityQ36247352
Dendritic cells in a mature age.Q36475977
Myeloid C-type lectins in innate immunityQ36655901
Differential regulation of interleukin 12 and interleukin 23 production in human dendritic cellsQ36699809
Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammationQ36732543
Regulatory T cells - a brief history and perspectiveQ36986732
LacdiNAc-glycans constitute a parasite pattern for galectin-3-mediated immune recognitionQ38338674
The dendritic cell-specific C-type lectin DC-SIGN is a receptor for Schistosoma mansoni egg antigens and recognizes the glycan antigen Lewis x.Q38356935
Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1.Q38594831
A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarizationQ40700194
Disruption of interleukin-27 signaling results in impaired gamma interferon production but does not significantly affect immunopathology in murine schistosome infectionQ41963983
The effect of advanced glycation end-products and aminoguanidine on TNFalpha production by rat peritoneal macrophagesQ42503662
A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis.Q42767100
Variation of hepatic fibrosis and granuloma size among mouse strains infected with Schistosoma mansoniQ44970501
Requirement of interleukin-17A for systemic anti-Candida albicans host defense in miceQ45876568
Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology.Q46899191
Cutting edge: dendritic cells copulsed with microbial and helminth antigens undergo modified maturation, segregate the antigens to distinct intracellular compartments, and concurrently induce microbe-specific Th1 and helminth-specific Th2 responsesQ47218007
Maturation of dendritic cell 2 phenotype by a helminth glycan uses a Toll-like receptor 4-dependent mechanismQ47368677
The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells.Q51024754
Severe CD4 T cell-mediated immunopathology in murine schistosomiasis is dependent on IL-12p40 and correlates with high levels of IL-17.Q51989028
A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells.Q55045567
Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17Q56880713
Interleukins 27 and 6 induce STAT3-mediated T cell production of interleukin 10Q56930023
Toll-like receptor (TLR)2 and TLR3 sensing is required for dendritic cell activation, but dispensable to control Schistosoma mansoni infection and pathologyQ57158211
LPS induces altered phosphate labeling of proteins in murine peritoneal macrophagesQ70281116
Apoptosis by neglect of CD4+ Th cells in granulomas: a novel effector mechanism involved in the control of egg-induced immunopathology in murine schistosomiasisQ73765196
CD8- dendritic cell activation status plays an integral role in influencing Th2 response developmentQ74321435
Interleukin-1Q74629939
Suppression of immune induction of collagen-induced arthritis in IL-17-deficient miceQ79317500
IL-23 is required for the development of severe egg-induced immunopathology in schistosomiasis and for lesional expression of IL-17Q80633636
Regulatory T cell responses develop in parallel to Th responses and control the magnitude and phenotype of the Th effector populationQ83276308
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectdendritic cellQ506253
P304page(s)8559-8567
P577publication date2008-12-01
P1433published inJournal of ImmunologyQ3521441
P1476titleDendritic cell IL-23 and IL-1 production in response to schistosome eggs induces Th17 cells in a mouse strain prone to severe immunopathology
P478volume181

Reverse relations

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