Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology.

scientific article published in May 2004

Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1074-7613(04)00107-4
P698PubMed publication ID15142530

P50authorHorst MossmannQ80227790
Christoph HölscherQ91743109
Irmgard FörsterQ37837842
Magdalena RadwanskaQ57082742
P2093author name stringDe'Broski R Herbert
Anita Schwegmann
Frank Brombacher
Markus Mohrs
Richard Kirsch
Björn Claussen
Berenice Arendse
Pauline Hall
Mosiuoa Leeto
P2860cites workIL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasisQ73869153
SOCS-1 participates in negative regulation of LPS responsesQ78518680
IL-4 dependent alternatively-activated macrophages have a distinctive in vivo gene expression phenotypeQ24798167
Alternative activation of macrophagesQ27860939
Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytesQ29547633
An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrowQ29615498
Other functions, other genes: alternative activation of antigen-presenting cellsQ33540045
Immunology of hepatosplenic schistosomiasis mansoni: a human perspectiveQ33798189
An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory responseQ33853821
Interleukin-4 receptor alpha-deficient BALB/c mice show an unimpaired T helper 2 polarization in response to Leishmania major infectionQ34003756
Central role for interleukin-4 in regulating nitric oxide-mediated inhibition of T-cell proliferation and gamma interferon production in schistosomiasisQ34115626
Somatostatin and intestinal schistosomiasis: therapeutic and neuropathological implications in host-parasite interactionsQ34459692
The immunobiology of schistosomiasisQ34718128
Novel IL-12 family members shed light on the orchestration of Th1 responsesQ35107889
SOCS3 negatively regulates IL-6 signaling in vivoQ38354512
An improved chromogenic substrate endotoxin assay for clinical useQ39517802
Cutting edge: IL-4 receptor expression by non-bone marrow-derived cells is required to expel gastrointestinal nematode parasites.Q39586138
IL-10 is critical for host resistance and survival during gastrointestinal helminth infection.Q39594770
Two different IL-13 receptor chains are expressed in normal human skin fibroblasts, and IL-4 and IL-13 mediate signal transduction through a common pathwayQ41011905
IL-10 induces gene expression in macrophages: partial overlap with IL-5 but not with IL-4 induced genesQ42451430
Differential regulation of nitric oxide synthase-2 and arginase-1 by type 1/type 2 cytokines in vivo: granulomatous pathology is shaped by the pattern of L-arginine metabolismQ43803694
Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils.Q44021327
IL-4 receptor signaling is required for mannose receptor expression by macrophages recruited to granulomata but not resident cells in mice infected with Schistosoma mansoniQ44550687
Conditional gene targeting in macrophages and granulocytes using LysMcre mice.Q44554898
Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: IL-13 is a profibrotic agentQ44826352
A protective and agonistic function of IL-12p40 in mycobacterial infection.Q46435226
Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responsesQ47946081
Regulation of protective immunity against Leishmania major in miceQ61313284
Superoxide production by stimulated neutrophils: temperature effectQ68244788
Reciprocal regulation of the nitric oxide synthase/arginase balance in mouse bone marrow-derived macrophages by TH1 and TH2 cytokinesQ71691379
Determination of arginase activity in macrophages: a micromethodQ72182280
IL-4 plays a crucial role in regulating oxidative damage in the liver during schistosomiasisQ73400795
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectmacrophageQ184204
schistosomiasisQ221159
P304page(s)623-635
P577publication date2004-05-01
P1433published inImmunityQ6005457
P1476titleAlternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology
P478volume20

Reverse relations

cites work (P2860)
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Q34875797Macrophage-derived human resistin is induced in multiple helminth infections and promotes inflammatory monocytes and increased parasite burden.
Q29614354Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
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Q91569404Macrophages assemble! But do they need IL-4R during schistosomiasis?
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Q37604634MicroR-146 blocks the activation of M1 macrophage by targeting signal transducer and activator of transcription 1 in hepatic schistosomiasis
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Q59280514Myeloid cell-specific expression of Ship1 regulates IL-12 production and immunity to helminth infection
Q41106752Myeloid expression of the AP-1 transcription factor JUNB modulates outcomes of type 1 and type 2 parasitic infections.
Q37808167Myeloid-derived suppressor cells in parasitic infections
Q83293334Neither interleukin-4 receptor alpha expression on CD4+ T cells, or macrophages and neutrophils is required for protective immunity to Trichinella spiralis
Q37361936New insights into the roles of dendritic cells in intestinal immunity and tolerance
Q34533347Nippostrongylus-induced intestinal hypercontractility requires IL-4 receptor alpha-responsiveness by T cells in mice
Q35607506Novel effector molecules in type 2 inflammation: lessons drawn from helminth infection and allergy
Q35917062Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense
Q34683631Obstacles and opportunities for understanding macrophage polarization
Q30601730Omega-1 knockdown in Schistosoma mansoni eggs by lentivirus transduction reduces granuloma size in vivo
Q37174214On the hunt for helminths: innate immune cells in the recognition and response to helminth parasites
Q59806954Origin, Differentiation, and Function of Intestinal Macrophages
Q24682128Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation
Q59357241PSTPIP2 connects DNA methylation to macrophage polarization in CCL4-induced mouse model of hepatic fibrosis
Q44857079PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils
Q43631328Paired immunoglobulin-like receptor-B inhibits pulmonary fibrosis by suppressing profibrogenic properties of alveolar macrophages
Q37695081Parasitic helminths: new weapons against immunological disorders
Q24669864Parasitic worms and inflammatory diseases
Q93075393Pathogenesis of fibrostenosing Crohn's disease
Q37695084Peroxisome proliferator-activated receptor (PPAR): balance for survival in parasitic infections
Q39308787Pneumocystis infection alters the activation state of pulmonary macrophages
Q28274980Polarization of host immune responses by helminth-expressed glycans
Q41935070Porcine alveolar macrophage polarization is involved in inhibition of porcine reproductive and respiratory syndrome virus (PRRSV) replication
Q41911191Possible role for Toll-like receptors in interaction of Fasciola hepatica excretory/secretory products with bovine macrophages
Q35208353Preexisting helminth infection induces inhibition of innate pulmonary anti-tuberculosis defense by engaging the IL-4 receptor pathway
Q36247356Priming of the immune response by schistosome eggs
Q47674870Protection from EAE by IL-4Ralpha(-/-) macrophages depends upon T regulatory cell involvement
Q44830476Protection of cattle against a natural infection of Fasciola hepatica by vaccination with recombinant cathepsin L1 (rFhCL1).
Q35925405Protective Effect of Chronic Schistosomiasis in Baboons Coinfected with Schistosoma mansoni and Plasmodium knowlesi
Q38096294Protective and pathological roles of mast cells and basophils
Q36481763Protective immune mechanisms in helminth infection
Q36023909Protein kinase C delta is essential for optimal macrophage-mediated phagosomal containment of Listeria monocytogenes.
Q28073072Purinergic signaling in schistosomal infection
Q41890902Quantification and localization of M2 macrophages in human kidneys with acute tubular injury.
Q33796715Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype
Q90236078Recombinant Sj16 protein with novel activity alleviates hepatic granulomatous inflammation and fibrosis induced by Schistosoma japonicum associated with M2 macrophages in a mouse model
Q35637946Recombinant adeno-associated virus-mediated inhibition of microRNA-21 protects mice against the lethal schistosome infection by repressing both IL-13 and transforming growth factor beta 1 pathways
Q38785193Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy
Q92668520Recruitment of hepatic macrophages from monocytes is independent of IL-4Rα but is associated with ablation of resident macrophages in schistosomiasis
Q35961926Redefining the transcriptional regulatory dynamics of classically and alternatively activated macrophages by deepCAGE transcriptomics.
Q47414963Regnase-1 and Roquin Nonredundantly Regulate Th1 Differentiation Causing Cardiac Inflammation and Fibrosis.
Q38411808Regulation of immunity by Taeniids: lessons from animal models and in vitro studies
Q31141885Regulation of innate responses during pre-patent schistosome infection provides an immune environment permissive for parasite development
Q30434189Regulation of learning and memory by meningeal immunity: a key role for IL-4
Q42846090Regulation of the development of the hepatic B cell compartment during Schistosoma mansoni infection
Q40664477Regulatory parameters of the lung immune response during the early phase of experimental trichinellosis
Q37103941Reverse genetics and the study of the immune response to schistosomes
Q36373253Reversibility of Stricturing Crohn's Disease-Fact or Fiction?
Q35207665Rhinovirus infection induces interleukin-13 production from CD11b-positive, M2-polarized exudative macrophages
Q27010514Role of IL-4Rα during acute schistosomiasis in mice
Q28067627Role of Macrophages in the Repair Process during the Tissue Migrating and Resident Helminth Infections
Q34700777Role of arginase 1 from myeloid cells in th2-dominated lung inflammation.
Q34346340SPI-1 encoded genes of Salmonella Typhimurium influence differential polarization of porcine alveolar macrophages in vitro
Q59127674Schistosoma "Eggs-Iting" the Host: Granuloma Formation and Egg Excretion
Q37373127Schistosoma mansoni arginase shares functional similarities with human orthologs but depends upon disulphide bridges for enzymatic activity.
Q36974469Schistosoma mansoni egg antigen-mediated modulation of Toll-like receptor (TLR)-induced activation occurs independently of TLR2, TLR4, and MyD88
Q36506127Schistosoma mansoni hemozoin modulates alternative activation of macrophages via specific suppression of Retnla expression and secretion.
Q54787200Selective induction of the Notch ligand Jagged-1 in macrophages by soluble egg antigen from Schistosoma mansoni involves ERK signalling.
Q36635594Signal transducer and activator of transcription factor 6 signaling contributes to control host lung pathology but favors susceptibility against Toxocara canis infection.
Q34166632Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin
Q33633305Similarity and diversity in macrophage activation by nematodes, trematodes, and cestodes.
Q36743554Suppression of TH2-type allergic reactions by helminth infection.
Q35930499Surfactant Protein-D Is Essential for Immunity to Helminth Infection.
Q90055083T Lymphocyte-Mediated Liver Immunopathology of Schistosomiasis
Q35928348T helper1/t helper2 cells and resistance/susceptibility to leishmania infection: is this paradigm still relevant?
Q42110315T-bet protects against exacerbation of schistosome egg-induced immunopathology by regulating Th17-mediated inflammation
Q36606601T-helper 17 cells are associated with pathology in human schistosomiasis
Q42825944TGF-β limits IL-33 production and promotes the resolution of colitis through regulation of macrophage function
Q36204162TGF-β-responsive myeloid cells suppress type 2 immunity and emphysematous pathology after hookworm infection
Q35607342TH1-dominant granulomatous pathology does not inhibit fibrosis or cause lethality during murine schistosomiasis
Q81245724TLR9 activation is a key event for the maintenance of a mycobacterial antigen-elicited pulmonary granulomatous response
Q36093909TPL-2 Regulates Macrophage Lipid Metabolism and M2 Differentiation to Control TH2-Mediated Immunopathology.
Q55315292Targeting Macrophages in Cancer: From Bench to Bedside.
Q37143365Th2 cell hyporesponsiveness during chronic murine schistosomiasis is cell intrinsic and linked to GRAIL expression
Q35884210Th2 response polarization during infection with the helminth parasite Schistosoma mansoni
Q38058759Th2 responses in schistosomiasis.
Q35565153Th2-associated alternative Kupffer cell activation promotes liver fibrosis without inducing local inflammation
Q61805993The C-type Lectin Receptor-Driven, Th17 Cell-Mediated Severe Pathology in Schistosomiasis: Not All Immune Responses to Helminth Parasites Are Th2 Dominated
Q41915030The C-type lectin SIGNR1 binds Schistosoma mansoni antigens in vitro, but SIGNR1-deficient mice have normal responses during schistosome infection
Q37346633The CCL7-CCL2-CCR2 axis regulates IL-4 production in lungs and fungal immunity
Q58090901The Foxp3+ regulatory T-cell population requires IL-4Rα signaling to control inflammation during helminth infections
Q43082287The IL-13/IL-4Rα axis is involved in tuberculosis-associated pathology
Q34682153The IL-21 receptor augments Th2 effector function and alternative macrophage activation
Q36659528The Metabolic Prospective and Redox Regulation of Macrophage Polarization
Q35222060The Schistosoma mansoni hepatic egg granuloma provides a favorable microenvironment for sustained growth of Leishmania donovani
Q34072227The absence of MyD88 has no effect on the induction of alternatively activated macrophage during Fasciola hepatica infection
Q37016241The divergent roles of alternatively activated macrophages in helminthic infections.
Q50692950The immunity of splenic and peritoneal F4/80(+) resident macrophages in mouse mixed allogeneic chimeras.
Q40108993The immunomodulatory glycan LNFPIII initiates alternative activation of murine macrophages in vivo
Q26851643The impact of the myeloid response to radiation therapy
Q36576209The linkage of innate and adaptive immune response during granulomatous development
Q36843026The pathogenic Th17 cell response to major schistosome egg antigen is sequentially dependent on IL-23 and IL-1β
Q53083007The protective effect of the recombinant 53-kDa protein of Trichinella spiralis on experimental colitis in mice.
Q33358673The role of B-cells and IgM antibodies in parasitemia, anemia, and VSG switching in Trypanosoma brucei-infected mice
Q92332665The role of microRNAs in the pathogenesis, grading and treatment of hepatic fibrosis in schistosomiasis
Q36764281The schistosoma granuloma: friend or foe?
Q34485066The schistosome glutathione S-transferase P28GST, a unique helminth protein, prevents intestinal inflammation in experimental colitis through a Th2-type response with mucosal eosinophils
Q36850831The schistosome in the mammalian host: understanding the mechanisms of adaptation
Q60910445The state of art of neutrophil extracellular traps in protozoan and helminthic infections
Q35833768Tim-3 induces Th2-biased immunity and alternative macrophage activation during Schistosoma japonicum infection
Q38003021Tissue microenvironments define and get reinforced by macrophage phenotypes in homeostasis or during inflammation, repair and fibrosis.
Q39116477Tissue tolerance: a distinct concept to control acute GVHD severity.
Q38068399Tissues use resident dendritic cells and macrophages to maintain homeostasis and to regain homeostasis upon tissue injury: the immunoregulatory role of changing tissue environments.
Q42949359Toll-like receptor 9 activation is a key mechanism for the maintenance of chronic lung inflammation
Q38772394Toxoplasma gondii GRA15II effector-induced M1 cells ameliorate liver fibrosis in mice infected with Schistosomiasis japonica
Q42836798Toxoplasma gondii peroxiredoxin promotes altered macrophage function, caspase-1-dependent IL-1β secretion enhances parasite replication
Q54224374Transcriptional landscape of Mycobacterium tuberculosis infection in macrophages.
Q37949245Transcriptional regulation of macrophage polarization: enabling diversity with identity
Q60912266Transplantation of bone marrow mesenchymal stromal cells attenuates liver fibrosis in mice by regulating macrophage subtypes
Q38943102Triggering receptor expressed on myeloid cells (TREM)-1 participates in Schistosoma mansoni inflammatory responses.
Q35052425Tumors induce a subset of inflammatory monocytes with immunosuppressive activity on CD8+ T cells
Q36946566Tuning sensitivity to IL-4 and IL-13: differential expression of IL-4Ralpha, IL-13Ralpha1, and gammac regulates relative cytokine sensitivity
Q38424752Type 2 cytokines: mechanisms and therapeutic strategies
Q56834653Type 2 immune response associated with silicosis is not instrumental in the development of the disease
Q37238286Type 2 innate lymphoid cells constitutively express arginase-I in the naive and inflamed lung
Q37102222Umbilical cord-derived mesenchymal stem cells alleviate liver fibrosis in rats
Q37217252Unique functions of the type II interleukin 4 receptor identified in mice lacking the interleukin 13 receptor alpha1 chain
Q28082281Unraveling the Hygiene Hypothesis of helminthes and autoimmunity: origins, pathophysiology, and clinical applications
Q34395286Upregulation of retinal dehydrogenase 2 in alternatively activated macrophages during retinoid-dependent type-2 immunity to helminth infection in mice
Q40462535Vanin-1 controls granuloma formation and macrophage polarization in Coxiella burnetii infection.
Q40240298Vitamin A mediates conversion of monocyte-derived macrophages into tissue-resident macrophages during alternative activation
Q92523630hUCMSC-extracellular vesicles downregulated hepatic stellate cell activation and reduced liver injury in S. japonicum-infected mice
Q34924612mTOR inhibition rescues osteopenia in mice with systemic sclerosis
Q90189626ncRNAs in Type-2 Immunity
Q36916423p16INK4a deficiency promotes IL-4-induced polarization and inhibits proinflammatory signaling in macrophages.

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