The effect of ketoconazole on the jejunal permeability and CYP3A metabolism of (R/S)-verapamil in humans

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The effect of ketoconazole on the jejunal permeability and CYP3A metabolism of (R/S)-verapamil in humans is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1046/J.1365-2125.1999.00999.X
P932PMC publication ID2014302
P698PubMed publication ID10417494
P5875ResearchGate publication ID12881040

P2093author name stringH Lennernäs
B Jansson
L Knutson
T W Knutson
R Sandström
P2860cites workPredictability of the in vivo metabolism of verapamil from in vitro data: contribution of individual metabolic pathways and stereoselective aspectsQ30966752
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The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitorsQ34065800
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Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and manQ35580014
Limited oral bioavailability and active epithelial excretion of paclitaxel (Taxol) caused by P-glycoprotein in the intestineQ36031211
Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expressionQ37367800
Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.Q40449494
Kinetics of the multidrug transporter (P-glycoprotein) and its reversalQ41441350
Ketoconazole effectively reverses multidrug resistance in highly resistant KB cellsQ41492388
Pharmacokinetics of felodipine in patients with liver diseaseQ42646696
Differentiation of absorption and first-pass gut and hepatic metabolism in humans: Studies with cyclosporine*Q44872539
Oral first-pass elimination of midazolam involves both gastrointestinal and hepatic CYP3A-mediated metabolismQ51030961
Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolismQ51530623
First-pass metabolism of midazolam by the human intestine.Q51568384
Regional rectal perfusion: a new in vivo approach to study rectal drug absorption in man.Q52349665
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Regional jejunal perfusion, a new in vivo approach to study oral drug absorption in manQ67591105
A new technique for segmental jejunal perfusion in manQ69768583
Digoxin-verapamil interaction: reduction of biliary but not renal digoxin clearance in humansQ70123371
Comparison of ketoconazole and fluconazole as cytochrome P450 inhibitors. Use of steady-state infusion approach to achieve plasma concentration-response relationshipsQ71350714
Differential induction of prehepatic and hepatic metabolism of verapamil by rifampinQ71650801
Enantioselective distribution of verapamil and norverapamil into human and rat erythrocytes: the role of plasma protein bindingQ71730856
Jejunal permeability and hepatic extraction of fluvastatin in humansQ71828066
Simultaneous analysis of verapamil and norverapamil enantiomers in human plasma by high-performance liquid chromatographyQ72032420
Enantiometric separation of verapamil and norverapamil using Chiral-AGP as the stationary phaseQ73509050
Tacrolimus oral bioavailability doubles with coadministration of ketoconazole*Q73562532
Role of intestinal P-glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine*Q73794585
Sequences of intestinal and hepatic cytochrome P450 3A4 cDNAs are identicalQ74144243
Jejunal absorption and metabolism of R/S-verapamil in humansQ74731555
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)180-189
P577publication date1999-08-01
P1433published inBritish Journal of Clinical PharmacologyQ176044
P1476titleThe effect of ketoconazole on the jejunal permeability and CYP3A metabolism of (R/S)-verapamil in humans
P478volume48

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cites work (P2860)
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