The effect of the pyridyl nitrogen position in pyridylpiperazine sigma ligands

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The effect of the pyridyl nitrogen position in pyridylpiperazine sigma ligands is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.BMCL.2010.02.087
P932PMC publication ID3401592
P698PubMed publication ID20338757
P5875ResearchGate publication ID42588881

P2093author name stringRae R Matsumoto
Michael J Seminerio
Andrew Coop
Lidiya Stavitskaya
Marilyn M Matthews-Tsourounis
P2860cites workExon-intron structure, analysis of promoter region, and chromosomal localization of the human type 1 sigma receptor geneQ24336001
Regulating ankyrin dynamics: Roles of sigma-1 receptorsQ24548145
A novel substituted piperazine, CM156, attenuates the stimulant and toxic effects of cocaine in miceQ24611779
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionQ27860958
Sigma receptors: potential medications development target for anti-cocaine agentsQ28208121
Involvement of sigma receptors in the behavioral effects of cocaine: evidence from novel ligands and antisense oligodeoxynucleotidesQ28215345
Involvement of sigma (sigma) receptors in the acute actions of methamphetamine: receptor binding and behavioral studiesQ28254901
The effects of morphine- and nalorphine- like drugs in the nondependent and morphine-dependent chronic spinal dogQ28260862
Sigma receptors: biology and therapeutic potentialQ28266963
Involvement of the sigma1 receptor in the cocaine-induced conditioned place preferenceQ31440672
N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in miceQ31869459
Effects of UMB24 and (+/-)-SM 21, putative sigma2-preferring antagonists, on behavioral toxic and stimulant effects of cocaine in miceQ35842629
The role of sigma receptors in depressionQ36063076
Intracellular sigma1 receptor modulates phospholipase C and protein kinase C activities in the brainstemQ36418374
New N-substituted 9-azabicyclo[3.3.1]nonan-3alpha-yl phenylcarbamate analogs as sigma2 receptor ligands: synthesis, in vitro characterization, and evaluation as PET imaging and chemosensitization agents.Q37161130
Attenuation of methamphetamine-induced effects through the antagonism of sigma (sigma) receptors: Evidence from in vivo and in vitro studiesQ37208188
DTG-induced circling behaviour in rats may involve the interaction between σ sites and nigro-striatal dopaminergic pathwaysQ41678370
A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brainQ41721321
Autoradiographic localization of sigma receptor binding sites in guinea pig and rat central nervous system with (+)3H-3-(3-hydroxyphenyl)-N-(1-propyl)piperidineQ42205824
Characterization of two novel sigma receptor ligands: antidystonic effects in rats suggest sigma receptor antagonismQ42557456
(+/-)-SM 21 attenuates the convulsive and locomotor stimulatory effects of cocaine in miceQ43574377
Molecular cloning and pharmacological characterization of the rat sigma1 receptorQ43659980
N-arylalkylpiperidines as high-affinity sigma-1 and sigma-2 receptor ligands: phenylpropylamines as potential leads for selective sigma-2 agentsQ43869049
The sigma1 (sigma1) receptor activation is a key step for the reactivation of cocaine conditioned place preference by drug primingQ44777838
Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activityQ46751107
Biochemical characterization of a 22-kDa high affinity antiischemic drug-binding polypeptide in the endoplasmic reticulum of guinea pig liver: potential common target for antiischemic drug action.Q48339377
Repeated methamphetamine-treatment alters brain sigma receptorsQ48347089
(+)-6,7-Benzomorphan sigma ligands stimulate dopamine synthesis in rat corpus striatum tissueQ48670734
Stimulation of rat striatal tyrosine hydroxylase activity following intranigral administration of sigma receptor ligands.Q51610642
Rat liver and kidney contain high densities of sigma 1 and sigma 2 receptors: characterization by ligand binding and photoaffinity labeling.Q55065614
A proposal for the classification of sigma binding sitesQ67487993
Ca(2+) signaling via sigma(1)-receptors: novel regulatory mechanism affecting intracellular Ca(2+) concentrationQ73929999
P433issue8
P407language of work or nameEnglishQ1860
P1104number of pages2
P304page(s)2564-2565
P577publication date2010-03-01
P1433published inBioorganic & Medicinal Chemistry LettersQ2709483
P1476titleThe effect of the pyridyl nitrogen position in pyridylpiperazine sigma ligands
P478volume20

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cites work (P2860)
Q34383909Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands.
Q33782364The σ2 receptor: a novel protein for the imaging and treatment of cancer

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