A novel substituted piperazine, CM156, attenuates the stimulant and toxic effects of cocaine in mice

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A novel substituted piperazine, CM156, attenuates the stimulant and toxic effects of cocaine in mice is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1124/JPET.109.161398
P932PMC publication ID2872963
P698PubMed publication ID20100904
P5875ResearchGate publication ID41139218

P2093author name stringRae R Matsumoto
Christopher R McCurdy
Nidhi Kaushal
Christophe Mésangeau
Jamaluddin Shaikh
Lisa L Wilson
Yan-Tong Xu
P2860cites workRegulating ankyrin dynamics: Roles of sigma-1 receptorsQ24548145
The sigma receptor: evolution of the concept in neuropsychopharmacologyQ24651621
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Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in miceQ28203832
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Involvement of sigma receptors in the behavioral effects of cocaine: evidence from novel ligands and antisense oligodeoxynucleotidesQ28215345
Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survivalQ28255981
Two novel sigma receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activityQ28376445
Involvement of the sigma1 receptor in the cocaine-induced conditioned place preferenceQ31440672
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Alterations in fos-related antigen 2 and sigma1 receptor gene and protein expression are associated with the development of cocaine-induced behavioral sensitization: time course and regional distribution studiesQ34656615
Sigma(1) (sigma(1)) receptor antagonists represent a new strategy against cocaine addiction and toxicityQ34804462
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Neuroplasticity mediated by altered gene expressionQ36922912
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Attenuation of methamphetamine-induced effects through the antagonism of sigma (sigma) receptors: Evidence from in vivo and in vitro studiesQ37208188
Cocaine up-regulates Fra-2 and sigma-1 receptor gene and protein expression in brain regions involved in addiction and rewardQ38326623
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Effects of the selective sigma receptor ligand, 6-[6-(4-hydroxypiperidinyl)hexyloxy]-3-methylflavone (NPC 16377), on behavioral and toxic effects of cocaineQ42288285
Characterization of two novel sigma receptor ligands: antidystonic effects in rats suggest sigma receptor antagonismQ42557456
Involvement of the sigma(1) receptor in cocaine-induced conditioned place preference: possible dependence on dopamine uptake blockadeQ43942925
Intracellular Dynamics of σ-1 Receptors (σ1Binding Sites) in NG108-15 CellsQ44429454
The sigma1 (sigma1) receptor activation is a key step for the reactivation of cocaine conditioned place preference by drug primingQ44777838
Conversion of a highly selective sigma-1 receptor-ligand to sigma-2 receptor preferring ligands with anticocaine activityQ46751107
Substituted benzylaminoalkylindoles with preference for the sigma2 binding site.Q46858454
Novel sigma receptor ligands attenuate the locomotor stimulatory effects of cocaineQ46887506
NE-100, a novel potent sigma ligand, preferentially binds to sigma 1 binding sites in guinea pig brainQ48191450
Ca(2+) signaling via sigma(1)-receptors: novel regulatory mechanism affecting intracellular Ca(2+) concentrationQ73929999
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectcocaineQ41576
P304page(s)491-500
P577publication date2010-05-01
P1433published inJournal of Pharmacology and Experimental TherapeuticsQ1500272
P1476titleA novel substituted piperazine, CM156, attenuates the stimulant and toxic effects of cocaine in mice
P478volume333

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cites work (P2860)
Q396331911-Cyclohexyl-4-(4-arylcyclohexyl)piperazines: Mixed σ and human Δ(8)-Δ(7) sterol isomerase ligands with antiproliferative and P-glycoprotein inhibitory activity
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Q36738623CM156, a high affinity sigma ligand, attenuates the stimulant and neurotoxic effects of methamphetamine in mice
Q37052590CM156, a sigma receptor ligand, reverses cocaine-induced place conditioning and transcriptional responses in the brain.
Q34383909Chlorophenylpiperazine analogues as high affinity dopamine transporter ligands.
Q41774030Cocaine-Mediated Autophagy in Astrocytes Involves Sigma 1 Receptor, PI3K, mTOR, Atg5/7, Beclin-1 and Induces Type II Programed Cell Death
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