A selective sigma-2 receptor ligand antagonizes cocaine-induced hyperlocomotion in mice.

scientific article published on 24 October 2013

A selective sigma-2 receptor ligand antagonizes cocaine-induced hyperlocomotion in mice. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/SYN.21717
P698PubMed publication ID24123353

P50authorDennis MillerQ73109550
P2093author name stringJohn R Lever
Kuo-Hsien Fan
Susan Z Lever
Lisa D Watkinson
Emily A Fergason-Cantrell
Terry L Carmack
Caroline L Green
P2860cites workA novel substituted piperazine, CM156, attenuates the stimulant and toxic effects of cocaine in miceQ24611779
Reinforcing effects of sigma-receptor agonists in rats trained to self-administer cocaineQ24656937
Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromersQ27325489
Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reactionQ27860958
Conformationally restricted analogs of BD1008 and an antisense oligodeoxynucleotide targeting sigma1 receptors produce anti-cocaine effects in miceQ28203832
Sigma receptors: potential medications development target for anti-cocaine agentsQ28208121
Involvement of sigma receptors in the behavioral effects of cocaine: evidence from novel ligands and antisense oligodeoxynucleotidesQ28215345
Development of molecular probes for imaging sigma-2 receptors in vitro and in vivoQ33574808
The σ2 receptor: a novel protein for the imaging and treatment of cancerQ33782364
Medicinal chemical properties of successful central nervous system drugsQ33946968
Radiosynthesis and biological evaluation of a promising sigma(2)-receptor ligand radiolabeled with fluorine-18 or iodine-125 as a PET/SPECT probe for imaging breast cancerQ34117565
[3H]nisoxetine: a new radioligand for norepinephrine uptake sites in brainQ34139619
Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site.Q34197697
S2R(Pgrmc1): the cytochrome-related sigma-2 receptor that regulates lipid and drug metabolism and hormone signalingQ34250906
Direct involvement of sigma-1 receptors in the dopamine D1 receptor-mediated effects of cocaineQ34276531
Sigma-2 receptors are specifically localized to lipid rafts in rat liver membranesQ34326129
The sigma-1 receptor chaperone as an inter-organelle signaling modulatorQ34356970
Sigma receptor agonists: receptor binding and effects on mesolimbic dopamine neurotransmission assessed by microdialysis.Q34462194
SA 4503 attenuates cocaine-induced hyperactivity and enhances methamphetamine substitution for a cocaine discriminative stimulusQ34502987
Cocaine binding at sigma receptors.Q34555132
Effect of structural modification in the amine portion of substituted aminobutyl-benzamides as ligands for binding σ1 and σ2 receptorsQ34721365
Cocaine-conditioned locomotion in dopamine transporter, norepinephrine transporter and 5-HT transporter knockout miceQ35157705
Synthesis and pharmacological evaluation of 6-acetyl-3-(4-(4-(4-fluorophenyl)piperazin-1-yl)butyl)benzo[d]oxazol-2(3H)-one (SN79), a cocaine antagonist, in rodentsQ35176885
A Role for Sigma Receptors in Stimulant Self Administration and Addiction.Q35197016
Synthesis and pharmacological evaluation of indole-based sigma receptor ligandsQ35738067
Effects of UMB24 and (+/-)-SM 21, putative sigma2-preferring antagonists, on behavioral toxic and stimulant effects of cocaine in miceQ35842629
Self-administration of cocaine induces dopamine-independent self-administration of sigma agonists.Q36610032
Synthesis and in vitro evaluation of tetrahydroisoquinolinyl benzamides as ligands for sigma receptorsQ37137418
Mechanisms of acute cocaine toxicityQ37244290
Transgenic mice in the study of drug addiction and the effects of psychostimulant drugsQ37702364
Sigma-1 receptors: potential targets for the treatment of substance abuseQ37979827
Cocaine up-regulates Fra-2 and sigma-1 receptor gene and protein expression in brain regions involved in addiction and rewardQ38326623
Conformationally-flexible benzamide analogues as dopamine D3 and sigma 2 receptor ligands.Q40606027
Relationship between brain serotonin transporter binding, plasma concentration and behavioural effect of selective serotonin reuptake inhibitorsQ43261539
Substitution on the Phe3 aromatic ring in cyclic .delta. opioid receptor-selective dermorphin/deltorphin tetrapeptide analogs: electronic and lipophilic requirements for receptor affinityQ44330953
Indium-labeled macrocyclic conjugates of naltrindole: high-affinity radioligands for in vivo studies of peripheral delta opioid receptorsQ44334563
A role for mu opioid receptors in cocaine-induced activity, sensitization, and reward in the rat.Q44335927
The kappa-opioid receptor agonist U-69593 attenuates cocaine-induced behavioral sensitization in the rat.Q44340372
Intrastriatal administration of sigma ligands inhibits basal dopamine release in vivo.Q44628387
Fluoxetine, but not sertraline or citalopram, potentiates the locomotor stimulant effect of cocaine: possible pharmacokinetic effectsQ44739798
The distribution of cocaine in mice differs by age and strainQ45080384
Relationship between in vivo occupancy at the dopamine transporter and behavioral effects of cocaine, GBR 12909 [1-{2-[bis-(4-fluorophenyl)methoxy]ethyl}-4-(3-phenylpropyl)piperazine], and benztropine analogsQ46598719
CB-64D and CB-184: ligands with high σ2 receptor affinity and subtype selectivityQ46698599
Sigma2 (sigma2) receptors as a target for cocaine action in the rat striatumQ46946366
Effects of N-phenylpropyl-N'-substituted piperazine sigma receptor ligands on cocaine-induced hyperactivity in miceQ47922008
Occupancy of striatal D(2)-like dopamine receptors after treatment with the sigma ligand EMD 57445, a putative atypical antipsychoticQ48113634
Fluorine-18-labeled benzamide analogues for imaging the sigma2 receptor status of solid tumors with positron emission tomography.Q48131617
Possible involvement of a sigma receptor subtype in the neck dystonia in ratsQ48286606
Relationship between subjective effects of cocaine and dopamine transporter occupancyQ48725518
Synthesis, radioiodination and in vitro and in vivo sigma receptor studies of N-1-allyl-N´-4-phenethylpiperazine analogsQ48775139
Synthesis and in vivo studies of a selective ligand for the dopamine transporter: 3 beta-(4-[125I]iodophenyl) tropan-2 beta-carboxylic acid isopropyl ester ([125I]RTI-121).Q49023806
Pharmacological identification of SM-21, the novel sigma(2) antagonistQ49059458
Selective sigma ligands block stimulant effects of cocaine.Q51707499
P433issue2
P304page(s)73-84
P577publication date2013-10-24
P1433published inSynapseQ7662025
P1476titleA selective sigma-2 receptor ligand antagonizes cocaine-induced hyperlocomotion in mice
P478volume68

Reverse relations

cites work (P2860)
Q35977409Characterization of pulmonary sigma receptors by radioligand binding
Q50323703Cocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma-1 and Sigma-2 Receptor Expression
Q36494168Cocaine occupancy of sigma1 receptors and dopamine transporters in mice
Q34451737Ether modifications to 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine (SA4503): effects on binding affinity and selectivity for sigma receptors and monoamine transporters
Q28392148Potential Molecular Mechanisms on the Role of the Sigma-1 Receptor in the Action of Cocaine and Methamphetamine
Q34186286Relationship between cerebral sigma-1 receptor occupancy and attenuation of cocaine's motor stimulatory effects in mice by PD144418
Q57284829Sigma-1 Receptor Antagonist (BD1047) Decreases Cathepsin B Secretion in HIV-Infected Macrophages Exposed to Cocaine
Q38984519Tactics for preclinical validation of receptor-binding radiotracers
Q42700435The Sigma-2 Receptor Selective Agonist Siramesine (Lu 28-179) Decreases Cocaine-Reinforced Pavlovian Learning and Alters Glutamatergic and Dopaminergic Input to the Striatum

Search more.