Lessons from genetic forms of osteoarthritis for the pathogenesis of the disease

scientific article

Lessons from genetic forms of osteoarthritis for the pathogenesis of the disease is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/J.JOCA.2007.04.013
P932PMC publication ID2062521
P698PubMed publication ID17572112
P5875ResearchGate publication ID6265330

P2093author name stringL Xu
Y Li
B R Olsen
P2860cites workThe discoidin domain receptor tyrosine kinases are activated by collagenQ24313329
Autosomal dominant and recessive osteochondrodysplasias associated with the COL11A2 locusQ24313449
A family with Stickler syndrome type 2 has a mutation in the COL11A1 gene resulting in the substitution of glycine 97 by valine in alpha 1 (XI) collagenQ24314597
A mutation in COL9A1 causes multiple epiphyseal dysplasia: further evidence for locus heterogeneityQ24536139
Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilageQ24562729
A mutation in the alpha 3 chain of type IX collagen causes autosomal dominant multiple epiphyseal dysplasia with mild myopathyQ24671376
Spondylo-epi-metaphyseal dysplasia (SEMD) matrilin 3 type: homozygote matrilin 3 mutation in a novel form of SEMDQ24675483
Clinical and Molecular genetics of Stickler syndromeQ24681792
The role of structural genes in the pathogenesis of osteoarthritic disordersQ24793861
Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factorsQ24806147
Molecular cloning and expression of collagenase-3, a novel human matrix metalloproteinase produced by breast carcinomasQ28116247
AP-1 and Cbfa/runt physically interact and regulate parathyroid hormone-dependent MMP13 expression in osteoblasts through a new osteoblast-specific element 2/AP-1 composite elementQ28207292
Structural analysis and promoter characterization of the human collagenase-3 gene (MMP13)Q28236176
Molecular cloning of trkE, a novel trk-related putative tyrosine kinase receptor isolated from normal human keratinocytes and widely expressed by normal human tissuesQ28255837
Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domainQ28256857
Stickler syndrome without eye involvement is caused by mutations in COL11A2, the gene encoding the alpha2(XI) chain of type XI collagenQ28264950
A mutation in the gene encoding the alpha 2 chain of the fibril-associated collagen IX, COL9A2, causes multiple epiphyseal dysplasia (EDM2)Q28270822
An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptorsQ28276070
Ultrastructural localization of collagen types II, IX, and XI in the growth plate of human rib and fetal bovine epiphyseal cartilage: type XI collagen is restricted to thin fibrilsQ28289636
The D2 period of collagen II contains a specific binding site for the human discoidin domain receptor, DDR2Q28293395
Mutations in exon 17B of cartilage oligomeric matrix protein (COMP) cause pseudoachondroplasiaQ28297153
The collagen receptor DDR2 regulates proliferation and its elimination leads to dwarfismQ28365928
A new chondrodystrophic mutant in mice. Electron microscopy of normal and abnormal chondrogenesisQ28505144
Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint diseaseQ28509200
A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesisQ28586684
Fibronectin fragment activation of proline-rich tyrosine kinase PYK2 mediates integrin signals regulating collagenase-3 expression by human chondrocytes through a protein kinase C-dependent pathwayQ30433820
Osteoarthritis: new insights. Part 1: the disease and its risk factors.Q33921631
Age-dependent increase of discoidin domain receptor 2 and matrix metalloproteinase 13 expression in temporomandibular joint cartilage of type IX and type XI collagen-deficient miceQ37301301
The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritisQ37354475
The biology of osteoarthritisQ38627467
IL-1 induces collagenase-3 (MMP-13) promoter activity in stably transfected chondrocytic cells: requirement for Runx-2 and activation by p38 MAPK and JNK pathwaysQ39227819
Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in miceQ39904130
The AP-1 site and MMP gene regulation: what is all the fuss about?Q41460650
Ultrastructure of adult human articular cartilage matrix after cryotechnical processingQ41499360
Both AP-1 and Cbfa1-like factors are required for the induction of interstitial collagenase by parathyroid hormoneQ42467906
Matrix metalloproteinase and proinflammatory cytokine production by chondrocytes of human osteoarthritic cartilage: associations with degenerative changesQ43550723
Inhibition of interleukin-1-stimulated MAP kinases, activating protein-1 (AP-1) and nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytesQ43992050
Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytesQ44159758
Relative messenger RNA expression profiling of collagenases and aggrecanases in human articular chondrocytes in vivo and in vitroQ44183277
Structure, expression, and activity of Tyro 3, a neural adhesion-related receptor tyrosine kinase.Q46943661
The type XI collagenopathies.Q50503590
Identification of col2a1 gene mutations in patients with chondrodysplasias and familial osteoarthritisQ57137534
Genetic linkage of a polymorphism in the type II procollagen gene (COL2A1) to primary osteoarthritis associated with mild chondrodysplasiaQ68702209
NEP: a novel receptor-like tyrosine kinase expressed in proliferating neuroepitheliaQ70476499
Early-onset osteoarthritis linked to the type II procollagen gene. Detailed clinical phenotype and further analyses of the geneQ70607971
Osteoarthritis-like changes and decreased mechanical function of articular cartilage in the joints of mice with the chondrodysplasia gene (cho)Q73401298
Absence of the alpha1(IX) chain leads to a functional knock-out of the entire collagen IX protein in miceQ73575439
Interleukin-1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c-Jun N-terminal kinase, and nuclear factor kappaB: differential regulation of collagenase 1 and collagenase 3Q73678522
Linkage analysis of candidate genes as susceptibility loci for osteoarthritis-suggestive linkage of COL9A1 to female hip osteoarthritisQ73731506
Osteoarthritic lesions: involvement of three different collagenasesQ73867207
Effect of collagen turnover on the accumulation of advanced glycation end productsQ74281392
Pathogenesis of osteoarthritis-like changes in the joints of mice deficient in type IX collagenQ80201579
Increased expression of the collagen receptor discoidin domain receptor 2 in articular cartilage as a key event in the pathogenesis of osteoarthritisQ80707124
Activation of the discoidin domain receptor 2 induces expression of matrix metalloproteinase 13 associated with osteoarthritis in miceQ80918755
P433issue10
P921main subjectosteoarthritisQ62736
P304page(s)1101-1105
P577publication date2007-06-14
P1433published inOsteoarthritis and CartilageQ7107605
P1476titleLessons from genetic forms of osteoarthritis for the pathogenesis of the disease
P478volume15

Reverse relations

cites work (P2860)
Q33645936A missense mutation in the aggrecan C-type lectin domain disrupts extracellular matrix interactions and causes dominant familial osteochondritis dissecans
Q85178335A secreted variant of cartilage oligomeric matrix protein carrying a chondrodysplasia‐causing mutation (p.H587R) disrupts collagen fibrillogenesis
Q37730947Beta-catenin, cartilage, and osteoarthritis
Q37270714Cartilage homeostasis in health and rheumatic diseases
Q37331102Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism
Q37310621Immunomodulatory and anti-inflammatory effects of chondroitin sulphate
Q35167937Intact pericellular matrix of articular cartilage is required for unactivated discoidin domain receptor 2 in the mouse model
Q34955182Interaction between extracellular matrix molecules and microbial pathogens: evidence for the missing link in autoimmunity with rheumatoid arthritis as a disease model.
Q26750960Matrilin-3 Role in Cartilage Development and Osteoarthritis
Q38317248Matrix-embedded cytokines to simulate osteoarthritis-like cartilage microenvironments
Q36960089Notch Signaling and the Skeleton
Q26865318Osteoarthritis pathogenesis: a review of molecular mechanisms
Q37980346Participation in athletic activities may be associated with later development of hip and knee osteoarthritis
Q37816952The bone-cartilage unit in osteoarthritis
Q42561581The link between structural damage and pain in a genetic model of osteoarthritis and intervertebral disc degeneration: a joint misadventure

Search more.