Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes

scientific article published in September 2002

Fibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/ART.10502
P8608Fatcat IDrelease_iqwo7vssgzax3nl2l47mcchhku
P698PubMed publication ID12355484
P5875ResearchGate publication ID11100987

P50authorRichard F LoeserQ88623051
P2093author name stringChristopher B Forsyth
Judit Pulai
P2860cites workRole of Rac1 and oxygen radicals in collagenase-1 expression induced by cell shape changeQ24313072
Biochemical characterization of human collagenase-3Q24318765
Cloning, expression, and type II collagenolytic activity of matrix metalloproteinase-13 from human osteoarthritic cartilageQ24562729
The extracellular matrix ligands fibronectin and tenascin collaborate in regulating collagenase gene expression in fibroblastsQ24620542
Integrin signalingQ28142010
Cellular mechanisms for human procollagenase-3 (MMP-13) activation. Evidence that MT1-MMP (MMP-14) and gelatinase a (MMP-2) are able to generate active enzymeQ28282027
c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritisQ28343409
Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinaseQ28609377
The ?5?1 integrin provides matrix survival signals for normal and osteoarthritic human articular chondrocytes in vitroQ29544119
RGD and other recognition sequences for integrinsQ29616331
Evidence for metalloproteinase and metalloproteinase inhibitor imbalance in human osteoarthritic cartilageQ33848759
Human chondrocyte expression of growth-arrest-specific gene 6 and the tyrosine kinase receptor axl: potential role in autocrine signaling in cartilageQ34435728
Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expressionQ36221364
Activation of distinct alpha5beta1-mediated signaling pathways by fibronectin's cell adhesion and matrix assembly domainsQ36255267
The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritisQ37354475
Enhanced cleavage of type II collagen by collagenases in osteoarthritic articular cartilageQ37365557
Postnatal expression in hyaline cartilage of constitutively active human collagenase-3 (MMP-13) induces osteoarthritis in miceQ39904130
PD98059 attenuates hydrogen peroxide-induced cell death through inhibition of Jun N-Terminal Kinase in HT29 cells.Q40815749
Integrin expression by primary and immortalized human chondrocytes: evidence of a differential role for alpha1beta1 and alpha2beta1 integrins in mediating chondrocyte adhesion to types II and VI collagenQ40885811
Integrin signaling: specificity and control of cell survival and cell cycle progressionQ41612555
Integrins and anoikisQ41612562
Integrin alpha2beta1 is a receptor for the cartilage matrix protein chondroadherinQ42111152
Induction of matrix metalloproteinase activation cascades based on membrane-type 1 matrix metalloproteinase: associated activation of gelatinase A, gelatinase B and collagenase 3.Q42259003
Focal adhesion kinase and mitogen-activated protein kinases are involved in chondrocyte activation by the 29-kDa amino-terminal fibronectin fragmentQ43777353
Cytokine control of interstitial collagenase and collagenase-3 gene expression in human chondrocytes.Q46412153
1997 William J. Stickel Gold Award. Morphological and biochemical properties of metatarsophalangeal joint cartilageQ48383572
Expression of beta 1 integrins by cultured articular chondrocytes and in osteoarthritic cartilage.Q52507678
Disruption of fibronectin binding to the alpha 5 beta 1 integrin stimulates the expression of cyclin-dependent kinases and DNA synthesis through activation of extracellular signal-regulated kinase.Q52528748
P433issue9
P921main subjectantibodyQ79460
P304page(s)2368-2376
P577publication date2002-09-01
P1433published inArthritis & RheumatologyQ4797636
P1476titleFibronectin fragments and blocking antibodies to alpha2beta1 and alpha5beta1 integrins stimulate mitogen-activated protein kinase signaling and increase collagenase 3 (matrix metalloproteinase 13) production by human articular chondrocytes
P478volume46

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