Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression

scientific article

Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.109.2.877
P932PMC publication ID2115739
P698PubMed publication ID2547805
P5875ResearchGate publication ID20607958

P2093author name stringZ Werb
C H Damsky
E Crowley
O Behrendtsen
P M Tremble
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Transcription from the stromelysin promoter is induced by interleukin-1 and repressed by dexamethasoneQ48333589
Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors.Q48376448
Fibronectin and laminin promote in vitro attachment and outgrowth of mouse blastocystsQ58803698
Cryptic chemotactic activity of fibronectin for human monocytes resides in the 120-kDa fibroblastic cell-binding fragmentQ68468687
Inhibition by human recombinant tissue inhibitor of metalloproteinases of human amnion invasion and lung colonization by murine B16-F10 melanoma cellsQ68502549
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The participation of a putative cell surface receptor for laminin and fibronectin in peripheral neurite extensionQ69995008
Biosynthesis of tissue inhibitor of metalloproteinases by human fibroblasts in culture. Stimulation by 12-O-tetradecanoylphorbol 13-acetate and interleukin 1 in parallel with collagenaseQ70079368
Tumor invasion through the human amniotic membrane: requirement for a proteinase cascadeQ70153486
Retardation of fading and enhancement of intensity of immunofluorescence by p-phenylenediamineQ70251591
Occupation of the extracellular matrix receptor, integrin, is a control point for myogenic differentiationQ70358907
Stromelysin, a connective tissue-degrading metalloendopeptidase secreted by stimulated rabbit synovial fibroblasts in parallel with collagenase. Biosynthesis, isolation, characterization, and substratesQ34564649
Coordinate regulation of stromelysin and collagenase genes determined with cDNA probesQ34616419
A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma cellsQ34691910
Biologically active synthetic peptides as probes of embryonic development: a competitive peptide inhibitor of fibronectin function inhibits gastrulation in amphibian embryos and neural crest cell migration in avian embryosQ34710476
The extracellular matrix of normal chick embryo fibroblasts: its effect on transformed chick fibroblasts and its proteolytic degradation by the transformantsQ36213680
The cell substrate attachment (CSAT) antigen has properties of a receptor for laminin and fibronectinQ36213913
Reorganization of polymerized actin: a possible trigger for induction of procollagenase in fibroblasts cultured in and on collagen gelsQ36215422
A cell surface receptor complex for collagen type I recognizes the Arg-Gly-Asp sequenceQ36216437
Embryonic neural retinal cell response to extracellular matrix proteins: developmental changes and effects of the cell substratum attachment antibody (CSAT)Q36216465
Integrin (the CSAT antigen): functionality requires oligomeric integrityQ36216818
Interactions of a neuronal cell line (PC12) with laminin, collagen IV, and fibronectin: identification of integrin-related glycoproteins involved in attachment and process outgrowthQ36217781
Expression and function of cell surface extracellular matrix receptors in mouse blastocyst attachment and outgrowthQ36218490
Inhibition of in vitro tumor cell invasion by Arg-Gly-Asp-containing synthetic peptidesQ36218753
Purification and characterization of mammalian integrins expressed by a rat neuronal cell line (PC12): evidence that they function as alpha/beta heterodimeric receptors for laminin and type IV collagenQ36219476
Induction of chondrogenesis in limb mesenchymal cultures by disruption of the actin cytoskeletonQ36510296
Phosphorylation of the fibronectin receptor complex in cells transformed by oncogenes that encode tyrosine kinasesQ37397390
Stabilized complexes of epidermal growth factor and its receptor on the cell surface stimulate RNA synthesis but not mitogenesisQ37539880
Proteases induce secretion of collagenase and plasminogen activator by fibroblastsQ37583731
Cell surface receptors for extracellular matrix moleculesQ39160059
The platelet membrane glycoprotein IIb-IIIa complex.Q39195582
Biochemical interactions of tumor cells with the basement membraneQ39503917
Cell migration in the vertebrate embryo: role of cell adhesion and tissue environment in pattern formationQ39844008
Cytochalasin B increases collagenase production by cells in vitroQ39949110
Purification of pig synovial collagenase to high specific activityQ40291518
Rapid induction of morphological changes in human carcinoma cells A-431 by epidermal growth factorsQ40728994
Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitorQ41343795
Changes in cell shape correlate with collagenase gene expression in rabbit synovial fibroblastsQ41456294
Collagenase is a major gene product of induced rabbit synovial fibroblastsQ41456592
Influence of stereochemistry of the sequence Arg-Gly-Asp-Xaa on binding specificity in cell adhesionQ41467300
Distribution of the cell substratum attachment (CSAT) antigen on myogenic and fibroblastic cells in cultureQ41486608
Commitment to expression of the metalloendopeptidases, collagenase and stromelysin: relationship of inducing events to changes in cytoskeletal architectureQ41501387
The platelet fibrinogen receptor: an immunogold-surface replica study of agonist-induced ligand binding and receptor clusteringQ41517769
Ultrastructural localization of plasma membrane-associated urokinase-type plasminogen activator at focal contactsQ41543313
Fibronectin and vitronectin regulate the organization of their respective Arg-Gly-Asp adhesion receptors in cultured human endothelial cellsQ41561676
Cleavage of a 135 kD cell surface glycoprotein correlates with loss of fibroblast adhesion to fibronectinQ41840054
Comparison of human stromelysin and collagenase by cloning and sequence analysisQ42128842
Fibronectin modulation of cell shape and lipogenic gene expression in 3T3-adipocytesQ42820082
Fibronectin receptor of human macrophages recognizes the sequence Arg-Gly-Asp-SerQ42937517
Cell surface glycoproteins mediate compaction, trophoblast attachment, and endoderm formation during early mouse developmentQ43804389
Regulation of the fibronectin receptor affinity by divalent cations.Q44461951
Tenascin: an extracellular matrix protein involved in tissue interactions during fetal development and oncogenesisQ46128262
Collagenase expression and endogenous activation in rabbit synovial fibroblasts stimulated by the calcium ionophore A23187.Q46726097
An antibody to a receptor for fibronectin and laminin perturbs cranial neural crest development in vivoQ48296891
The Drosophila PS2 antigen is an invertebrate integrin that, like the fibronectin receptor, becomes localized to muscle attachmentsQ48332817
P433issue2
P407language of work or nameEnglishQ1860
P304page(s)877-889
P577publication date1989-08-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleSignal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression
P478volume109

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Q46058032Identification and characterization of novel airway epithelial integrins
Q28291781Identification of an interaction between the m-band protein skelemin and beta-integrin subunits. Colocalization of a skelemin-like protein with beta1- and beta3-integrins in non-muscle cells
Q90317081Identification of matrix physicochemical properties required for renal epithelial cell tubulogenesis by using synthetic hydrogels
Q24651203Identification of sequences required for the efficient localization of the focal adhesion kinase, pp125FAK, to cellular focal adhesions
Q30851875Image-guided genomics of phenotypically heterogeneous populations reveals vascular signalling during symbiotic collective cancer invasion.
Q36289473Immunoglobulin superfamily: Structure, function and relationship to other receptor molecules
Q35831087Immunohistochemical localization of integrins in the normal, hyperplastic, and neoplastic breast. Correlations with their functions as receptors and cell adhesion molecules
Q73727601Immunolocalization of integrins in the normal lung and in pulmonary carcinomas
Q42483434Immunoloealization of integrins in the normal and neoplastic colonic epithelium
Q41593571In vitro model of angiogenesis using a human endothelium‐derived permanent cell line: Contributions of induced gene expression, G‐proteins, and integrins
Q43053802Increased expression of integrins on fibroblast-like synoviocytes from rheumatoid arthritis in vitro correlates with enhanced binding to extracellular matrix proteins
Q41142229Induced PAI-1 mRNA expression and targeted protein accumulation are early G1 events in serum-stimulated rat kidney cells
Q42443216Induction and repression of collagenase-1 by keratinocytes is controlled by distinct components of different extracellular matrix compartments
Q72075544Induction of macrophage metalloproteinases by extracellular matrix. Evidence for enzyme- and substrate-specific responses involving prostaglandin-dependent mechanisms
Q73186898Induction of nonspecific cross-reacting antigen mRNA by interferon-gamma and anti-fibronectin receptor antibody in colon cancer cells
Q31886420Inflammatory cytokines stimulate vascular smooth muscle cells locomotion and growth by enhancing alpha5beta1 integrin expression and function.
Q43204140Inhibition of neutrophil migration by a selective inhibitor of matrix metalloproteinase: analysis by intravital microscopy
Q43636939Inhibition of proprotein convertases is associated with loss of growth and tumorigenicity of HT-29 human colon carcinoma cells: importance of insulin-like growth factor-1 (IGF-1) receptor processing in IGF-1-mediated functions
Q37588910Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape
Q35915588Integrin Ligation Results in Nephrin Tyrosine Phosphorylation In Vitro
Q37383350Integrin alpha 3 beta 1 participates in the phagocytosis of extracellular matrix molecules by human breast cancer cells
Q34449319Integrin alpha 5 beta 1 expression negatively regulates cell growth: reversal by attachment to fibronectin
Q34447949Integrin alpha 8 beta 1 promotes attachment, cell spreading, and neurite outgrowth on fibronectin
Q36236656Integrin alpha subunit ratios, cytoplasmic domains, and growth factor synergy regulate muscle proliferation and differentiation
Q36382983Integrin alpha v beta 3 differentially regulates adhesive and phagocytic functions of the fibronectin receptor alpha 5 beta 1.
Q42075812Integrin alpha2beta1 mediates isoform-specific activation of p38 and upregulation of collagen gene transcription by a mechanism involving the alpha2 cytoplasmic tail
Q41564910Integrin beta 1- and beta 3-mediated endothelial cell migration is triggered through distinct signaling mechanisms.
Q36235842Integrin beta 3 cytoplasmic tail is necessary and sufficient for regulation of alpha 5 beta 1 phagocytosis by alpha v beta 3 and integrin-associated protein
Q36615726Integrin beta1 is required for the invasive behaviour but not proliferation of squamous cell carcinoma cells in vivo
Q34445039Integrin binding and cell spreading on extracellular matrix act at different points in the cell cycle to promote hepatocyte growth
Q36233869Integrin cytoplasmic domains mediate inside-out signal transduction
Q41730133Integrin dependence of brain natriuretic peptide gene promoter activation by mechanical strain
Q42172605Integrin distributions in renal cell carcinomas of various grades of malignancy
Q36079635Integrin expression and ability to adhere to extracellular matrix proteins and endothelial cells in human lung cancer lines
Q41638856Integrin expression in human melanoma cells with differing invasive and metastatic properties
Q40939392Integrin mediated signal transduction in oncogenesis: an overview
Q36604045Integrin overexpression induced by high glucose and by human diabetes: potential pathway to cell dysfunction in diabetic microangiopathy
Q24679036Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8
Q38200064Integrin signaling in skeletal development and function.
Q24678607Integrin-associated protein: a 50-kD plasma membrane antigen physically and functionally associated with integrins
Q37359182Integrin-dependent induction of functional urokinase receptors in primary T lymphocytes
Q41111698Integrin-dependent signal transduction
Q71808987Integrin-mediated entry into S phase of human gastric adenocarcinoma cells
Q40769921Integrin-type extracellular matrix receptors in cancer and inflammation
Q34174032Integrins
Q41238988Integrins and cancer
Q36425948Integrins and chondrocyte-matrix interactions in articular cartilage
Q41724010Integrins and oral cancer
Q37955301Integrins and their ligands in rheumatoid arthritis
Q37219576Integrins as a primary signal transduction molecule regulating monocyte immediate-early gene induction
Q71919458Integrins in human anterior chamber angle
Q42485822Integrins of normal human epidermis: differential expression, synthesis and molecular structure
Q37367146Integrins β1 and β3 are biomarkers of uterine condition for embryo transfer
Q33850089Integrins: a role as cell signalling molecules
Q58249847Interaction and Immunological Effect of Very Late Antigen-4, 5, and Fibronectin in Tonsillar Lymphocytes and Their Relation to Age
Q24301112Interaction of TRAF6 with MAST205 regulates NF-kappaB activation and MAST205 stability
Q52229205Interaction of endothelial cells with a laminin A chain peptide (SIKVAV) in vitro and induction of angiogenic behavior in vivo
Q41586180Interaction of fibronectin with integrin receptors: evidence by use of synthetic peptides
Q37139057Interaction of monocarboxylate transporter 4 with beta1-integrin and its role in cell migration
Q37352075Intercellular adhesion molecule-1-deficient mice are protected against ischemic renal injury
Q36233172Interference with endogenous ras function inhibits cellular responses to wounding
Q37398724Interleukin 1 beta induces rapid phosphorylation and redistribution of talin: a possible mechanism for modulation of fibroblast focal adhesion
Q42439499Interleukin 1-induced calcium signalling in chondrocytes requires focal adhesions
Q74301158Intermittent cyclic loading of cartilage explants modulates fibronectin metabolism
Q42805301Invasion by cultured human follicular thyroid cancer correlates with increased beta 1 integrins and production of proteases
Q44441105Involvement of CD44 in induction of matrix metalloproteinases by a COOH‐terminal heparin‐binding fragment of fibronectin in human articular cartilage in culture
Q41379067Involvement of alpha v beta 3 integrin in mediating fibrin gel retraction
Q28116229IκB kinase complex (IKK) triggers detachment-induced autophagy in mammary epithelial cells independently of the PI3K-AKT-MTORC1 pathway
Q42771254Lack of beta 1 integrin gene in embryonic stem cells affects morphology, adhesion, and migration but not integration into the inner cell mass of blastocysts
Q37129361Laminin binding proteins
Q42452875Laminin isoforms in human embryonic stem cells: synthesis, receptor usage and growth support
Q24338710Laminin-10 and Lutheran blood group glycoproteins in adhesion of human endothelial cells
Q41269122Lateral mobility of Fc gamma RIIa is reduced by protein kinase C activation
Q30479586Ligand density dramatically affects integrin alpha IIb beta 3-mediated platelet signaling and spreading
Q41132432Ligation of integrin alpha5beta1 is required for internalization of vitronectin by integrin alphavbeta3.
Q42458507Localization of focal adhesion kinase in differentiating Schwann cell/neuron cultures
Q55058076Loss of VLA-2 collagen receptor in breast carcinoma, facilitating invasion and metastasis.
Q27314967Loss of the α2β1 integrin alters human papilloma virus-induced squamous carcinoma progression in vivo and in vitro
Q64086638Low Density Receptor-Related Protein 1 Interactions With the Extracellular Matrix: More Than Meets the Eye
Q34413051Mammary gland ECM remodeling, stiffness, and mechanosignaling in normal development and tumor progression
Q40242164Mapping in vivo associations of cytoplasmic proteins with integrin beta 1 cytoplasmic domain mutants.
Q41670855Mast cell adhesion to fibronectin.
Q44163344Matrix metalloproteinase-1 activates a pertussis toxin-sensitive signaling pathway that stimulates the release of matrix metalloproteinase-9.
Q42498979Matrix metalloproteinases and their inhibitors in oral lichen planus
Q36712749Matrix metalloproteinases in lung: multiple, multifarious, and multifaceted
Q30175136Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase
Q40606999Matrix-degrading proteases in hormone-dependent breast cancer
Q35766403Mechanical strain of rat vascular smooth muscle cells is sensed by specific extracellular matrix/integrin interactions
Q36298393Melanoma cells undergo aggressive coalescence in a 3D Matrigel model that is repressed by anti-CD44.
Q30539640MicroRNA 9-3p targets β1 integrin to sensitize claudin-low breast cancer cells to MEK inhibition
Q36743563Microenvironment of the involuting mammary gland mediates mammary cancer progression
Q36847018Modulation of cell proliferation and differentiation through substrate-dependent changes in fibronectin conformation
Q70978774Modulation of the catabolic effects of interleukin-1 beta on human articular chondrocytes by transforming growth factor-beta
Q37073348Molecular basis of new approaches to the therapy of rheumatoid arthritis
Q55066366Molecular basis of sun-induced premature skin ageing and retinoid antagonism.
Q34995545Molecular control of capillary growth in skeletal muscle
Q34920476Molecular determinants of metalloproteinase substrate specificity: matrix metalloproteinase substrate binding domains, modules, and exosites
Q36530834Motility of fibronectin receptor-deficient cells on fibronectin and vitronectin: collaborative interactions among integrins
Q40861327Myocardial extracellular matrix remodeling with the development of pacing induced congestive heart failure contributory mechanisms
Q33992822NF-kappa B mediates the stimulation of cytokine and chemokine expression by human articular chondrocytes in response to fibronectin fragments
Q36901472Na-H exchange acts downstream of RhoA to regulate integrin-induced cell adhesion and spreading
Q73486198Neuronal differentiation in SH-SY5Y human neuroblastoma cells induces synthesis and secretion of tenascin and upregulation of ?v integrin receptors
Q41701308Novel ecto-tagged integrins reveal their trafficking in live cells
Q40146962Oscillatory behavior of a simple kinetic model for proteolysis during cell invasion.
Q48125956Osteoactivin regulates head and neck squamous cell carcinoma invasion by modulating matrix metalloproteases.
Q47676690Osteoblasts induce osteopontin expression in response to attachment on fibronectin: demonstration of a common role for integrin receptors in the signal transduction processes of cell attachment and mechanical stimulation.
Q24646895Overexpressed Csk tyrosine kinase is localized in focal adhesions, causes reorganization of alpha v beta 5 integrin, and interferes with HeLa cell spreading
Q37267940Par1b links lumen polarity with LGN-NuMA positioning for distinct epithelial cell division phenotypes.
Q34275992Pathogenesis of rheumatoid arthritis: the role of synoviocytes
Q40795795Phenotypic alterations in Caki-1 cells as a consequence of TIMP-1 overexpression.
Q34287068Phenotypic reversion or death of cancer cells by altering signaling pathways in three-dimensional contexts
Q35224533Plasminogen Activators and Plasminogen Activator Inhibitors in Neural Developmenta
Q36223980Plasminogen activator inhibitor type I stabilizes vitronectin-dependent adhesions in HT-1080 cells
Q48075139Platelet-Rich Plasma Attenuates 30-kDa Fibronectin Fragment-Induced Chemokine and Matrix Metalloproteinase Expression by Meniscocytes and Articular Chondrocytes
Q73025730Pleural mesotheliomas have an integrin profile distinct from visceral carcinomas
Q35833724Post-cardiac transplant arteriopathy in piglets is associated with fragmentation of elastin and increased activity of a serine elastase.
Q34504760Pregnancy-associated breast cancer and metastasis.
Q68070352Presence of functionally active cytochrome P-450IIE1 in the plasma membrane of rat hepatocytes
Q92256627Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin
Q47995122Prolidase in human breast cancer MCF-7 cells.
Q42466658Proliferating Oral Epithelial Cells in Culture are Capable of Both Extracellular and Intracellular Degradation of Interstitial Collagen
Q34679398Proprotein convertases in tumor progression and malignancy: novel targets in cancer therapy
Q46096320Prostaglandins increase proMMP-1 and proMMP-3 secretion by human ciliary smooth muscle cells
Q46229313Protease repertoires of cells adherent to membranes recovered after guided tissue regeneration
Q37230129Proteinase-mediated cartilage degradation in osteoarthritis
Q34632691Proteolytic events of wound-healing--coordinated interactions among matrix metalloproteinases (MMPs), integrins, and extracellular matrix molecules
Q35092086Proteolytic host cell enzymes in gingival crevice fluid
Q41052471Psoriasiform architecture of murine epidermis overlying human psoriatic dermis transplanted onto SCID mice
Q46320302Purified staphylococcal culture medium stimulates neutral metalloprotease secretion from human articular cartilage
Q41119226Quantification of integrin subunits on human prostatic cell lines--comparison of nontumorigenic and tumorigenic lines
Q68841945RGD peptides may only temporarily inhibit cell adhesion to fibronectin
Q42487976Re-epithelialization rate and protein expression in the suction-induced wound model: comparison between intact blisters, open wounds and calcipotriol-pretreated open wounds
Q68257918Recruitment of Peripheral Mononuclear Cells by Mammalian Collagenase Digests of Type I Collagen
Q43680073Regulated expression and binding of three VLA (beta 1) integrin receptors on T cells
Q42155711Regulated expression and function of CD11c/CD18 integrin on human B lymphocytes. Relation between attachment to fibrinogen and triggering of proliferation through CD11c/CD18.
Q41895419Regulation of cell surface beta 1 integrin levels during keratinocyte terminal differentiation
Q41035046Regulation of endothelial cell motility by complexes of tetraspan molecules CD81/TAPA-1 and CD151/PETA-3 with alpha3 beta1 integrin localized at endothelial lateral junctions
Q40865497Regulation of fibronectin matrix assembly by activated Ras in transformed cells
Q36233262Regulation of in vitro capillary tube formation by anti-integrin antibodies
Q67765307Regulation of integrin-type cell adhesion receptors by cytokines
Q35563066Regulation of macrophage infiltration and activation in sites of chronic inflammation
Q41209328Regulation of matrix metalloproteinases following cellular transformation
Q41909450Regulation of the VLA integrin-ligand interactions through the beta 1 subunit
Q71996824Release from quiescence stimulates the expression of integrin α5β1 which regulates DNA synthesis in human fibrosarcoma HT1080 cells
Q41920449Release of cardiac troponin I from viable cardiomyocytes is mediated by integrin stimulation
Q37158335Retinal pigment epithelial cells promote spatial reorganization and differentiation of retina photoreceptors
Q29614313Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies
Q42755431Role of beta 1-integrins in epidermotropism of malignant T cells.
Q41672451Role of focal adhesion kinase in integrin signaling
Q38254774Role of integrins and their ligands in osteoarthritic cartilage
Q41349193Role of intermediate filaments in migration, invasion and metastasis
Q40745849Role of mechanical stimulation in the establishment and maintenance of muscle cell differentiation
Q36847392Role of the alpha v beta 3 integrin in human melanoma cell invasion
Q41813666Role of the beta3 integrin subunit in human primary melanoma progression: multifunctional activities associated with alpha(v)beta3 integrin expression
Q40511441Role of the extracellular matrix in the degradation of connective tissue
Q77579546Roles of the matrix metalloproteinases in mammary gland development and cancer
Q36232953SPARC, a secreted protein associated with morphogenesis and tissue remodeling, induces expression of metalloproteinases in fibroblasts through a novel extracellular matrix-dependent pathway
Q42715356Secretion of latent type IV procollagenase and active type IV collagenase by testicular cells in culture
Q34594621Sensing the environment: a historical perspective on integrin signal transduction
Q40733262Signal transduction by integrins and its role in the regulation of tumor growth
Q37597345Signal transduction by integrins: increased protein tyrosine phosphorylation caused by clustering of beta 1 integrins
Q24598414Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes
Q40241371Signal transduction by the platelet integrin alpha IIb beta 3: induction of calcium oscillations required for protein-tyrosine phosphorylation and ligand-induced spreading of stably transfected cells
Q24675031Signal transduction from the extracellular matrix
Q45769683Simian virus 40 transformation alters the actin cytoskeleton, expression of matrix metalloproteinases and inhibitors of metalloproteinases, and invasive behavior of normal and ataxia-telangiectasia human skin fibroblasts
Q77425619Soluble Arg-Gly-Asp peptides reduce collagen accumulation in cultured rat hepatic stellate cells
Q46557302Specific fibronectin fragments as markers of periodontal disease status
Q55066384Specific induction of cell motility on laminin by alpha 7 integrin.
Q43463708Spontaneous expression of immediately-early response genes c-fos and egr-1 in collagenase-producing rheumatoid synovial fibroblasts
Q36487024Stromal regulation of epithelial function
Q36238993Structural and Biologic Properties of Integrin-Mediated Cell Adhesion
Q45328083Substrate stiffness regulates temporary NF-κB activation via actomyosin contractions.
Q40745830Substratum mechanics and cell differentiation.
Q44531149Surface chemistry modulates fibronectin conformation and directs integrin binding and specificity to control cell adhesion
Q74527923Syndecan-1 expression suppresses the level of myeloma matrix metalloproteinase-9
Q36236564Syndecan-1 mediates cell spreading in transfected human lymphoblastoid (Raji) cells
Q41435232Synergy between basic fibroblast growth factor and HIV-1 Tat protein in induction of Kaposi's sarcoma
Q33816362Synoviocyte-derived angiopoietin-like protein 2 contributes to synovial chronic inflammation in rheumatoid arthritis
Q45767748T-antigen inhibits metalloproteinase expression and invasion in human placental cells transformed with temperature-sensitive simian virus 40.
Q35167525Tales from the crypt[ic] sites of the extracellular matrix
Q39510504Targeted disruption of fibronectin-integrin interactions in human gingival fibroblasts by the RI protease of Porphyromonas gingivalis W50.
Q46889961The 120 kDa cell-binding fragment of fibronectin up-regulates migration of alphavbeta6-expressing cells by increasing matrix metalloproteinase-2 and -9 secretion.
Q41881350The 45 kDa collagen-binding fragment of fibronectin induces matrix metalloproteinase-13 synthesis by chondrocytes and aggrecan degradation by aggrecanases.
Q35707924The Walter Herbert Lecture. Control of cell motility and tumour invasion by extracellular matrix interactions
Q42160122The alpha 1-alpha 6 subunits of integrins are characteristically expressed in distinct segments of developing and adult human nephron
Q36223031The alpha 1/beta 1 and alpha 6/beta 1 integrin heterodimers mediate cell attachment to distinct sites on laminin
Q33324178The alpha 5 beta 1 fibronectin receptor. Characterization of the alpha 5 gene promoter
Q41984711The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases
Q42436161The differential regulation and secretion of proteinases from fetal and neonatal fibroblasts by growth factors
Q51536291The effect of basic fibroblast growth factor on delayed-replanted monkey teeth.
Q40412671The extracellular matrix during heart development
Q24620542The extracellular matrix ligands fibronectin and tenascin collaborate in regulating collagenase gene expression in fibroblasts
Q41712024The extracellular matrix of the human fetal membranes: structure and function
Q36234250The induction of 72-kD gelatinase in T cells upon adhesion to endothelial cells is VCAM-1 dependent
Q36531324The integrin alpha 6 beta 4 is a laminin receptor
Q28137622The integrin alpha v beta 6 binds and activates latent TGF beta 1: a mechanism for regulating pulmonary inflammation and fibrosis
Q28257562The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line
Q28508336The major laminin receptor of mouse embryonic stem cells is a novel isoform of the alpha 6 beta 1 integrin
Q53990149The platelet cytoskeleton stabilizes the interaction between alphaIIbbeta3 and its ligand and induces selective movements of ligand-occupied integrin.
Q46125742The response of periodontal ligament cells to fibronectin
Q40729411The role of adhesion molecules in the pathogenesis of rheumatoid arthritis
Q33380192The role of alpha 6 integrin in prostate cancer migration and bone pain in a novel xenograft model
Q40442587The role of growth factors in proliferative diabetic retinopathy
Q41904505The role of integrins in the maintenance of endothelial monolayer integrity
Q36494108The role of metalloproteinases in tumor cell metastasis
Q42519636The role of proteases in fibronectin matrix remodeling in thyroid epithelial cell monolayer cultures.
Q40939420The role of the integrin vitronectin receptor, alpha v beta 3 in melanoma metastasis
Q41481767The roles of adhesion molecules and proteinases in lymphocyte transendothelial migration
Q43984586The selective regulation of alpha Vbeta 1 integrin expression is based on the hierarchical formation of alpha V-containing heterodimers
Q41469726The solid state environment orchestrates embryonic development and tissue remodeling
Q41890468The tumor microenvironment: possible role of integrins and the extracellular matrix in tumor biological behavior of intratubular germ cell neoplasia and testicular seminomas.
Q36224126The vitronectin receptor alpha v beta 3 binds fibronectin and acts in concert with alpha 5 beta 1 in promoting cellular attachment and spreading on fibronectin
Q36229813The vitronectin receptor serves as an accessory molecule for the activation of a subset of gamma/delta T cells
Q34428911The α₂β₁ integrin is a metastasis suppressor in mouse models and human cancer
Q36254949Thyroid hormone induces apoptosis in primary cell cultures of tadpole intestine: cell type specificity and effects of extracellular matrix
Q73811973Time, stress, and location dependent chondrocyte death and collagen damage in cyclically loaded articular cartilage
Q40365762Translational suppression of syndecan-1 expression in Ha-ras transformed mouse mammary epithelial cells
Q36708059Transmembrane neural cell-adhesion molecule (NCAM), but not glycosyl-phosphatidylinositol-anchored NCAM, down-regulates secretion of matrix metalloproteinases
Q33901970Tumor cell adhesion and migration supported by interaction of a receptor-protease complex with its inhibitor
Q55024516Tumor cell attachment to laminin promotes degradation of the extracellular matrix and cell migration in high-metastatic clone cells of RCT sarcoma in vitro.
Q42478267Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling
Q46130698Tumoral invasion in the central nervous system
Q46340962Type I collagen is overexpressed in medulloblastoma as a component of tumor microenvironment
Q68273498UVA irradiation induces collagenase in human dermal fibroblasts in vitro and in vivo
Q35581806Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo.
Q41955991VLA‐4 Molecules on Tumor Cells Initiate an Adhesive Interaction with VCAM‐1 Molecules on Endothelial Cell Surface
Q35224488Vascular Permeability Factor, Fibrin, and the Pathogenesis of Tumor Stroma Formationa
Q44924809Vascular cell adhesion molecule-1 (VCAM-1) expression in murine lupus nephritis
Q35764980Vitronectin enhances internalization of crocidolite asbestos by rabbit pleural mesothelial cells via the integrin alpha v beta 5
Q41771195Wingless/Wnt signal transduction requires distinct initiation and amplification steps that both depend on Arrow/LRP.
Q36532366Zyxin and cCRP: two interactive LIM domain proteins associated with the cytoskeleton
Q36838444alpha1 and alpha2 integrins mediate invasive activity of mouse mammary carcinoma cells through regulation of stromelysin-1 expression
Q38478561beta1 integrins regulate keratinocyte adhesion and differentiation by distinct mechanisms
Q36863689beta1-integrin cytoplasmic subdomains involved in dominant negative function
Q28361828p38 mitogen-activated kinase is a bidirectional regulator of human fibroblast collagenase-1 induction by three-dimensional collagen lattices
Q71807379α v β 3 Integrin Expression in Normal and Atherosclerotic Artery
Q30427521β₁Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy

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