The dominant-negative inhibition of double-stranded RNA-dependent protein kinase PKR increases the efficacy of Rift Valley fever virus MP-12 vaccine

scientific article

The dominant-negative inhibition of double-stranded RNA-dependent protein kinase PKR increases the efficacy of Rift Valley fever virus MP-12 vaccine is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.00778-12
P932PMC publication ID3416293
P698PubMed publication ID22573861

P50authorShigeru MorikawaQ88820659
Shuetsu FukushiQ89375432
Alexander N. FreibergQ93156043
Sabarish V IndranQ117536105
Nandadeva LokugamageQ117812116
Birte KalveramQ121296437
Olga LihoradovaQ121296444
Terry L JuelichQ121296446
Tetsuro IkegamiQ40311693
P2093author name stringBin Gong
Chien-Te K Tseng
Terence E Hill
P2860cites workImpact of protein kinase PKR in cell biology: from antiviral to antiproliferative actionQ24672548
Chemotactic and inflammatory responses in the liver and brain are associated with pathogenesis of Rift Valley fever virus infection in the mouseQ27305612
Complete Genome Analysis of 33 Ecologically and Biologically Diverse Rift Valley Fever Virus Strains Reveals Widespread Virus Movement and Low Genetic Diversity due to Recent Common AncestryQ27478367
Rift Valley fever virus (family Bunyaviridae, genus Phlebovirus). Isolations from Diptera collected during an inter-epizootic period in KenyaQ27482900
RNA polymerase I-mediated expression of viral RNA for the rescue of infectious virulent and avirulent Rift Valley fever virusesQ27487321
Rapid Accumulation of Virulent Rift Valley Fever Virus in Mice from an Attenuated Virus Carrying a Single Nucleotide Substitution in the M RNAQ27491320
Evaluation of the efficacy and safety of the Rift Valley Fever Clone 13 vaccine in sheepQ40358602
Rift Valley fever virus: an unrecognized emerging threat?Q40360325
Potential for North American mosquitoes to transmit Rift Valley fever virusQ40398345
Rift Valley fever virus lacking NSm proteins retains high virulence in vivo and may provide a model of human delayed onset neurologic disease.Q40453546
Immunoglobulin G enzyme-linked immunosorbent assay using truncated nucleoproteins of Reston Ebola virusQ40556157
Pathogenicity and neurovirulence of a mutagen-attenuated Rift Valley fever vaccine in rhesus monkeysQ40557158
Teratogenicity of a mutagenised Rift Valley fever virus (MVP 12) in sheep.Q40579610
Defects in translational regulation mediated by the alpha subunit of eukaryotic initiation factor 2 inhibit antiviral activity and facilitate the malignant transformation of human fibroblastsQ40589545
Improved Recovery of Rabies Virus from Cloned cDNA Using a Vaccinia Virus‐Free Reverse Genetics SystemQ40629273
Immunogenicity of an inactivated Rift Valley fever vaccine in humans: a 12-year experience.Q40632227
Mapping of the mutations present in the genome of the Rift Valley fever virus attenuated MP12 strain and their putative role in attenuationQ40642621
Safety of a mutagen-attenuated Rift Valley fever virus vaccine in fetal and neonatal bovidsQ40645618
Safety and efficacy of a mutagen-attenuated Rift Valley fever virus vaccine in cattleQ40645625
Characterization of clone 13, a naturally attenuated avirulent isolate of Rift Valley fever virus, which is altered in the small segment.Q40679919
Further evaluation of a mutagen-attenuated Rift Valley fever vaccine in sheepQ40753243
Use of reassortant viruses to map attenuating and temperature-sensitive mutations of the Rift Valley fever virus MP-12 vaccineQ40759549
Vector Competence of Senegalese Aedes fowleri (Diptera: Culicidae) for Rift Valley Fever Virus1Q40784948
Pathogenicity and immunogenicity of a mutagen-attenuated Rift Valley fever virus immunogen in pregnant ewesQ40795447
Mutagen-directed attenuation of Rift Valley fever virus as a method for vaccine developmentQ40814834
The development of a formalin-killed Rift Valley fever virus vaccine for use in man.Q40987065
Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinaseQ41602853
Langerhans cells: not your average dendritic cellQ42281644
The Homingbac baculovirus cloning system: An alternative way to introduce foreign DNA into baculovirus genomesQ43168948
Dominant negative function by an alternatively spliced form of the interferon-inducible protein kinase PKR.Q43559384
Expression of double-stranded RNA-activated protein kinase in small-size peripheral adenocarcinoma of the lungQ47362441
Double-hexahistidine tag with high-affinity binding for protein immobilization, purification, and detection on ni-nitrilotriacetic acid surfaces.Q50732326
Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR.Q52533947
Human general transcription factor IIH phosphorylates the C-terminal domain of RNA polymerase IIQ59098636
Neoplastic progression in melanoma and colon cancer is associated with increased expression and activity of the interferon-inducible protein kinase, PKRQ78666553
TFIIH plays an essential role in RNA polymerase I transcriptionQ27934158
Structure and function of the spleenQ28264813
A new, tenth subunit of TFIIH is responsible for the DNA repair syndrome trichothiodystrophy group AQ28268795
Cloning and characterization of murine p16INK4a and p15INK4b genesQ28512180
Molecular structure of human TFIIHQ28611504
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinaseQ29620280
TFIIH transcription factor, a target for the Rift Valley hemorrhagic fever virus.Q33198557
A SAP30 complex inhibits IFN-beta expression in Rift Valley fever virus infected cells.Q33316823
Double-stranded RNA-activated protein kinase PKR of fishes and amphibians: varying the number of double-stranded RNA binding domains and lineage-specific duplicationsQ33321981
Rift Valley fever virus NSs protein promotes post-transcriptional downregulation of protein kinase PKR and inhibits eIF2alpha phosphorylationQ33406230
Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivityQ33787696
Translational control of viral gene expression in eukaryotesQ33935121
Rift Valley fever virus(Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and preventionQ33960690
Anti-nucleocapsid protein immune responses counteract pathogenic effects of Rift Valley fever virus infection in miceQ34031858
Tissue tropism and target cells of NSs-deleted rift valley fever virus in live immunodeficient mice.Q34097995
Hemorrhagic fever viruses as biological weapons: medical and public health managementQ34126496
The pathogenesis of Rift Valley feverQ34191969
Rift Valley fever virus vaccine lacking the NSs and NSm genes is safe, nonteratogenic, and confers protection from viremia, pyrexia, and abortion following challenge in adult and pregnant sheepQ34221766
Origin, homeostasis and function of Langerhans cells and other langerin-expressing dendritic cellsQ34887778
Rift Valley fever virusQ34971963
Rift valley fever virus lacking the NSs and NSm genes is highly attenuated, confers protective immunity from virulent virus challenge, and allows for differential identification of infected and vaccinated animalsQ36484009
Lymph node mapping in the mouseQ36590616
Rift valley fever vaccinesQ37393780
NSs protein of rift valley fever virus induces the specific degradation of the double-stranded RNA-dependent protein kinaseQ39195523
NSs protein of rift valley fever virus promotes posttranslational downregulation of the TFIIH subunit p62.Q39547955
The S segment of rift valley fever phlebovirus (Bunyaviridae) carries determinants for attenuation and virulence in miceQ39588385
Genetic evidence for an interferon-antagonistic function of rift valley fever virus nonstructural protein NSsQ39601913
Transfection of insect cell lines using polyethylenimineQ39918460
NSs protein of Rift Valley fever virus blocks interferon production by inhibiting host gene transcriptionQ39960501
Antigen-capture ELISA for the detection of Rift Valley fever virus nucleoprotein using new monoclonal antibodiesQ40299380
Rescue of infectious rift valley fever virus entirely from cDNA, analysis of virus lacking the NSs gene, and expression of a foreign geneQ40311587
Mucosal immunization of rhesus macaques with Rift Valley Fever MP-12 vaccineQ40317212
DC-SIGN as a receptor for phlebovirusesQ40318139
Protection of MP-12-vaccinated rhesus macaques against parenteral and aerosol challenge with virulent rift valley fever virusQ40321756
Genetic evidence for Rift Valley fever outbreaks in Madagascar resulting from virus introductions from the East African mainland rather than enzootic maintenanceQ40327417
The pathogenesis of Rift Valley fever virus in the mouse modelQ40348320
P433issue14
P407language of work or nameEnglishQ1860
P921main subjectRift Valley feverQ326638
Rift Valley fever virusQ14276794
Rift Valley fever phlebovirusQ24809101
P1104number of pages12
P304page(s)7650-7661
P577publication date2012-05-09
P1433published inJournal of VirologyQ1251128
P1476titleThe dominant-negative inhibition of double-stranded RNA-dependent protein kinase PKR increases the efficacy of Rift Valley fever virus MP-12 vaccine
P478volume86

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cites work (P2860)
Q59335452A single-cycle replicable Rift Valley fever phlebovirus vaccine carrying a mutated NSs confers full protection from lethal challenge in mice
Q43167996Attenuation and protective efficacy of Rift Valley fever phlebovirus rMP12-GM50 strain
Q37509225Attenuation of pathogenic Rift Valley fever virus strain through the chimeric S-segment encoding sandfly fever phlebovirus NSs or a dominant-negative PKR.
Q56881173Bunyaviruses: from transmission by arthropods to virus entry into the mammalian host first-target cells
Q28486276Characterization of Rift Valley fever virus MP-12 strain encoding NSs of Punta Toro virus or sandfly fever Sicilian virus
Q33705717Countermeasure development for Rift Valley fever: deletion, modification or targeting of major virulence factor NSs
Q35126733Development of a novel, single-cycle replicable rift valley Fever vaccine
Q44170263Genetic stability of Rift Valley fever virus MP-12 vaccine during serial passages in culture cells
Q35792819MP-12 virus containing the clone 13 deletion in the NSs gene prevents lethal disease when administered after Rift Valley fever virus infection in hamsters
Q36489477Modifying the NSs gene to improve live-attenuated vaccine for Rift Valley fever.
Q27027003Novel approaches to develop Rift Valley fever vaccines
Q36816140Novel vaccine strategies against emerging viruses
Q36879979Post-exposure vaccination with MP-12 lacking NSs protects mice against lethal Rift Valley fever virus challenge
Q39251803Rift Valley fever vaccines: an overview of the safety and efficacy of the live-attenuated MP-12 vaccine candidate.
Q37006803Rift Valley fever virus MP-12 vaccine encoding Toscana virus NSs retains neuroinvasiveness in mice
Q36501737Rift Valley fever virus NSs inhibits host transcription independently of the degradation of dsRNA-dependent protein kinase PKR.
Q36326847Single-cycle replicable Rift Valley fever virus mutants as safe vaccine candidates
Q37509231The two faces of Rift Valley fever virus virulence factor NSs: The development of a vaccine and the elucidation of pathogenesis

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