Pathophysiology of acute graft-versus-host disease: recent advances

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Pathophysiology of acute graft-versus-host disease: recent advances is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/J.TRSL.2007.06.003
P932PMC publication ID2084257
P698PubMed publication ID17900507
P5875ResearchGate publication ID5943283

P2093author name stringYaping Sun
Isao Tawara
Pavan Reddy
Tomomi Toubai
P2860cites workThe receptor for the cytotoxic ligand TRAILQ24310481
Signal transduction by DR3, a death domain-containing receptor related to TNFR-1 and CD95Q24314819
KIR ligands and prediction of relapse after unrelated donor hematopoietic cell transplantation for hematologic malignancyQ79973289
Ex vivo rapamycin generates Th1/Tc1 or Th2/Tc2 Effector T cells with enhanced in vivo function and differential sensitivity to post-transplant rapamycin therapyQ80141484
Paradoxical effects of interleukin-18 on the severity of acute graft-versus-host disease mediated by CD4+ and CD8+ T-cell subsets after experimental allogeneic bone marrow transplantationQ80388681
Both perforin and Fas ligand are required for the regulation of alloreactive CD8+ T cells during acute graft-versus-host diseaseQ80825838
Target antigens determine graft-versus-host disease phenotypeQ80884497
Distinct roles for donor- and host-derived antigen-presenting cells and costimulatory molecules in murine chronic graft-versus-host disease: requirements depend on target organQ80952289
Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHDQ81014631
Protective conditioning for acute graft-versus-host diseaseQ81279975
Regulatory T cellsQ81342301
Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cellsQ81357564
A crucial role for antigen-presenting cells and alloantigen expression in graft-versus-leukemia responsesQ81357571
Cytokine expanded myeloid precursors function as regulatory antigen-presenting cells and promote tolerance through IL-10-producing regulatory T cellsQ81377803
TRAIL-transduced dendritic cells protect mice from acute graft-versus-host disease and leukemia relapseQ81546508
Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontaminationQ82312167
Expression of chemokines in GVHD target organs is influenced by conditioning and genetic factors and amplified by GVHRQ83885898
CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host diseaseQ34525987
The B7-CD28 superfamilyQ34575331
Perforin-mediated target-cell death and immune homeostasisQ34584322
Cytolytic pathways in haematopoietic stem-cell transplantationQ34632083
Graft-versus-host disease can be separated from graft-versus-lymphoma effects by control of lymphocyte trafficking with FTY720.Q34834459
The complementary roles of deletion and regulation in transplantation toleranceQ35058547
Contrasting alloreactive CD4+ and CD8+ T cells: there's more to it than MHC restrictionQ35072094
T cell anergy and costimulationQ35096703
Th1 and Th2 mediate acute graft-versus-host disease, each with distinct end-organ targetsQ35158939
Umbilical-cord blood transplantation for the treatment of cancerQ35166819
Immunobiology of acute graft-versus-host diseaseQ35558501
Antigen presentation in graft-vs-host diseaseQ35602916
Nitric oxide production in host-versus-graft and graft-versus-host reactions in the ratQ35605951
Cytokine dysregulation and acute graft-versus-host diseaseQ35607602
Pathophysiology of acute graft-versus-host diseaseQ35634710
Selective targeting of the LIGHT-HVEM costimulatory system for the treatment of graft-versus-host disease.Q35804422
How I treat refractory acute GVHD.Q35828633
Missing KIR ligands are associated with less relapse and increased graft-versus-host disease (GVHD) following unrelated donor allogeneic HCT.Q35828810
Improved outcome in HLA-identical sibling hematopoietic stem-cell transplantation for acute myelogenous leukemia predicted by KIR and HLA genotypes.Q35847425
New approaches for preventing and treating chronic graft-versus-host diseaseQ35847596
In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsetsQ35847952
Critical role of host gammadelta T cells in experimental acute graft-versus-host diseaseQ35847964
Reduced frequency of FOXP3+ CD4+CD25+ regulatory T cells in patients with chronic graft-versus-host diseaseQ35848361
Peyer patches are not required for acute graft-versus-host disease after myeloablative conditioning and murine allogeneic bone marrow transplantationQ35848487
Absence of beta7 integrin results in less graft-versus-host disease because of decreased homing of alloreactive T cells to intestineQ35848654
Vasoactive intestinal peptide induces regulatory dendritic cells that prevent acute graft-versus-host disease while maintaining the graft-versus-tumor responseQ35849658
New spectrum of allorecognition pathways: implications for graft rejection and transplantation toleranceQ35876745
Interleukin-18: recent advancesQ35953062
Genetic polymorphisms predicting the outcome of bone marrow transplantsQ35964779
Graft-versus-host-disease-associated lymphoid hypoplasia and B cell dysfunction is dependent upon donor T cell-mediated Fas-ligand function, but not perforin functionQ35996711
IL-7 enhances peripheral T cell reconstitution after allogeneic hematopoietic stem cell transplantationQ36001183
Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organsQ36072414
Non-HLA immunogenetics in hematopoietic stem cell transplantationQ36221377
Cytolytic pathways used by effector cells derived from recipient naive and memory T cells and natural killer cells in resistance to allogeneic hematopoietic cell transplantationQ36336443
Dendritic cells and the control of immunityQ27860918
The multifaceted role of Fas signaling in immune cell homeostasis and autoimmunityQ28139188
CD95's deadly mission in the immune systemQ28142072
The danger model: a renewed sense of selfQ28214633
The B7 family revisitedQ28240070
TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosisQ28257134
Host-reactive CD8+ memory stem cells in graft-versus-host diseaseQ28281894
Interleukin-18 regulates acute graft-versus-host disease by enhancing Fas-mediated donor T cell apoptosisQ28591879
Toll-like receptor control of the adaptive immune responsesQ29547305
Signalling pathways of the TNF superfamily: a double-edged swordQ29616428
Nitric oxide and the immune responseQ29617591
Effectiveness of donor natural killer cell alloreactivity in mismatched hematopoietic transplantsQ29619458
Successful adoptive transfer and in vivo expansion of human haploidentical NK cells in patients with cancerQ29619483
Role of endogenous peptide in human alloreactive cytotoxic T cell responsesQ30311400
Leukocyte migration and graft-versus-host diseaseQ30479618
A uniform genomic minor histocompatibility antigen typing methodology and database designed to facilitate clinical applicationsQ33267303
Interleukin 2 prevents graft-versus-host disease while preserving the graft-versus-leukemia effect of allogeneic T cellsQ33707814
Homeostatic proliferation is a barrier to transplantation toleranceQ33731951
Pathophysiologic mechanisms of acute graft-vs.-host diseaseQ33793177
Differential roles of IL-1 and TNF-alpha on graft-versus-host disease and graft versus leukemiaQ33857573
The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantationQ33898254
Th2 and Tc2 cells in the regulation of GVHD, GVL, and graft rejection: considerations for the allogeneic transplantation therapy of leukemia and lymphomaQ33929802
The role of chemokine receptors in primary, effector, and memory immune responsesQ33932742
New strategies for bone marrow transplantationQ34046829
Fas and perforin pathways as major mechanisms of T cell-mediated cytotoxicityQ34057782
NKT cell-dependent leukemia eradication following stem cell mobilization with potent G-CSF analogs.Q34078681
T cells require TRAIL for optimal graft-versus-tumor activityQ34158517
Dendritic cells in transplantation--friend or foe?Q34241103
Mixed chimerism and transplant toleranceQ34241143
Haematopoietic cell transplantation as immunotherapyQ34253590
The role of peripheral T-cell deletion in transplantation toleranceQ34262660
Importance of minor histocompatibility antigen expression by nonhematopoietic tissues in a CD4+ T cell-mediated graft-versus-host disease modelQ34265880
Molecules and mechanisms of the graft-versus-leukaemia effectQ34318010
Role of adhesion molecules in activation signaling in T lymphocytesQ34337765
The molecular and functional characterization of a dominant minor H antigen, H60.Q34473903
Interferon-gamma-mediated prevention of graft-versus-host disease: development of immune competent and allo-tolerant T cells in chimeric miceQ36851990
Perforin/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantationQ37371294
Fas ligand- mediated killing by intestinal intraepithelial lymphocytes. Participation in intestinal graft-versus-host diseaseQ37377818
The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritisQ37385249
Interleukin-11 promotes T cell polarization and prevents acute graft-versus-host disease after allogeneic bone marrow transplantation.Q37387081
Tumor necrosis factor- alpha production to lipopolysaccharide stimulation by donor cells predicts the severity of experimental acute graft-versus-host diseaseQ37388077
Donor-derived interferon gamma is required for inhibition of acute graft-versus-host disease by interleukin 12.Q37388260
T-lymphocyte-antigen interactions in transplant rejectionQ38139921
Antileukemic Effect of Graft-versus-Host Disease in Human Recipients of Allogeneic-Marrow GraftsQ39244446
Th1 cytokines, programmed cell death, and alloreactive T cell clone size in transplant tolerance.Q39737971
Memory CD4+ T cells do not induce graft-versus-host diseaseQ39778135
The potential immunogenicity of the TK suicide gene does not prevent full clinical benefit associated with the use of TK-transduced donor lymphocytes in HSCT for hematologic malignanciesQ40165690
Effector cells derived from host CD8 memory T cells mediate rapid resistance against minor histocompatibility antigen-mismatched allogeneic marrow grafts without participation of perforin, Fas ligand, and the simultaneous inhibition of 3 tumor necroQ40393771
Transfer of allogeneic CD62L- memory T cells without graft-versus-host diseaseQ40627364
Interferon-gamma and interleukin-6 gene polymorphisms associate with graft-versus-host disease in HLA-matched sibling bone marrow transplantationQ40689796
Human minor histocompatibility antigensQ40700412
The immunological synapse and CD28-CD80 interactions.Q40767962
T-lymphocyte production of macrophage inflammatory protein-1alpha is critical to the recruitment of CD8(+) T cells to the liver, lung, and spleen during graft-versus-host disease.Q40846424
Active participation of CCR5(+)CD8(+) T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease.Q40851124
Activation of macrophage cytostatic effector mechanisms during acute graft-versus-host disease: release of intracellular iron and nitric oxide-mediated cytostasis.Q40858697
Class I-restricted alloreactive cytotoxic T lymphocytes recognize a complex array of specific MHC-associated peptides.Q41046602
Role of indirect allorecognition in allograft rejectionQ41091908
Induction of apoptosis in mature T cells by tumour necrosis factorQ41293478
Macrophage priming and lipopolysaccharide-triggered release of tumor necrosis factor alpha during graft-versus-host diseaseQ41640832
Graft-versus-host disease: the influence of type 1 and type 2 T cell cytokinesQ41699354
Inhibition of CD4+CD25+ regulatory T-cell function by calcineurin-dependent interleukin-2 productionQ41908710
Features of T cells causing H-2-restricted lethal graft-vs.-host disease across minor histocompatibility barriersQ42143820
Negative selection of T cells causing lethal graft-versus-host disease across minor histocompatibility barriers. Role of the H-2 complexQ42259756
Phase III study comparing methotrexate and tacrolimus (prograf, FK506) with methotrexate and cyclosporine for graft-versus-host disease prophylaxis after HLA-identical sibling bone marrow transplantationQ42539543
Clonable T lymphocytes in T cell-depleted bone marrow transplants correlate with development of graft-v-host disease.Q43605522
Pretreatment of donors with interleukin-18 attenuates acute graft-versus-host disease via STAT6 and preserves graft-versus-leukemia effectsQ43852100
Regulation of alloresponses after bone marrow transplantation using donor T cells expressing a thymidine kinase suicide geneQ44248916
Murine graft-versus-host disease in an F1-hybrid model using IFN-gamma gene knockout donors.Q44329356
CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantationQ44408941
Outcomes after transplantation of cord blood or bone marrow from unrelated donors in adults with leukemiaQ44499780
FTY720 does not abrogate acute graft-versus-host disease in the dog leukocyte antigennonidentical unrelated canine model1Q44632260
IL-12-independent LIGHT signaling enhances MHC class II disparate CD4+ T cell alloproliferation, IFN-gamma responses, and intestinal graft-versus-host diseaseQ44892232
Association of Foxp3 regulatory gene expression with graft-versus-host diseaseQ44917891
Interleukin-2 inhibits graft-versus-host disease-promoting activity of CD4+ cells while preserving CD4- and CD8-mediated graft-versus-leukemia effects.Q45009365
Induced SHIP deficiency expands myeloid regulatory cells and abrogates graft-versus-host diseaseQ45018029
Host conditioning is a primary determinant in modulating the effect of IL-7 on murine graft-versus-host diseaseQ45053959
Transfer of the HSV-tk gene into donor peripheral blood lymphocytes for in vivo modulation of donor anti-tumor immunity after allogeneic bone marrow transplantationQ45866646
HSV-TK gene transfer into donor lymphocytes for control of allogeneic graft-versus-leukemiaQ45882160
Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytesQ45888667
Pilot trial on the use of etanercept and methylprednisolone as primary treatment for acute graft-versus-host disease.Q46672540
Ex vivo rapamycin generates donor Th2 cells that potently inhibit graft-versus-host disease and graft-versus-tumor effects via an IL-4-dependent mechanismQ46763980
Differential roles for CCR5 expression on donor T cells during graft-versus-host disease based on pretransplant conditioningQ47231959
Impact of HLA class I and class II high-resolution matching on outcomes of unrelated donor bone marrow transplantation: HLA-C mismatching is associated with a strong adverse effect on transplantation outcomeQ47359749
Host dendritic cells alone are sufficient to initiate acute graft-versus-host diseaseQ47371499
IL-13 production by donor T cells is prognostic of acute graft-versus-host disease following unrelated donor stem cell transplantationQ47602546
Phenotype, function and chimaerism of monocyte‐derived blood dendritic cells after allogeneic haematopoietic stem cell transplantationQ47604670
Blockade of CD40 ligand-CD40 interaction impairs CD4+ T cell-mediated alloreactivity by inhibiting mature donor T cell expansion and function after bone marrow transplantationQ71929801
Interleukin-12 inhibits murine graft-versus-host diseaseQ72030978
Cytokine gene expression in peripheral blood mononuclear cells during graft-versus-host disease after allogeneic bone marrow transplantationQ72311523
Effect of total body irradiation, busulfan-cyclophosphamide, or cyclophosphamide conditioning on inflammatory cytokine release and development of acute and chronic graft-versus-host disease in H-2-incompatible transplanted SCID miceQ72372127
Interleukin-10 administration decreases survival in murine recipients of major histocompatibility complex disparate donor bone marrow graftsQ72446561
Interferon-gamma prevents graft-versus-host disease after allogeneic bone marrow transplantation in miceQ72620596
Interleukin-1 is a critical effector molecule during cytokine dysregulation in graft versus host disease to minor histocompatibility antigensQ72700860
Donor CD4-enriched cells of Th2 cytokine phenotype regulate graft-versus-host disease without impairing allogeneic engraftment in sublethally irradiated miceQ72776658
Dose and timing of interleukin (IL)-12 and timing and type of total-body irradiation: effects on graft-vs.-host disease inhibition and toxicity of exogenous IL-12 in murine bone marrow transplant recipientsQ73113896
Association of HLA-C disparity with graft failure after marrow transplantation from unrelated donorsQ73126126
Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapseQ73153290
Enhancement of MHC class I-stimulated alloresponses by TNF/TNF receptor (TNFR)1 interactions and of MHC class II-stimulated alloresponses by TNF/TNFR2 interactionsQ73166203
Recipient tumor necrosis factor-alpha and interleukin-10 gene polymorphisms associate with early mortality and acute graft-versus-host disease severity in HLA-matched sibling bone marrow transplantsQ73205710
Fas-deficient lpr mice are more susceptible to graft-versus-host diseaseQ73289694
The p55 TNF-alpha receptor plays a critical role in T cell alloreactivityQ73330338
Ligation of 4-1BB (CDw137) regulates graft-versus-host disease, graft-versus-leukemia, and graft rejection in allogeneic bone marrow transplant recipientsQ73509907
Fas-mediated cholangiopathy in the murine model of graft versus host diseaseQ73584922
Granulocyte-colony stimulating factor mobilizes T helper 2-inducing dendritic cellsQ73642913
Interleukin-12 preserves the graft-versus-leukemia effect of allogeneic CD8 T cells while inhibiting CD4-dependent graft-versus-host disease in miceQ73886957
Total body irradiation and acute graft-versus-host disease: the role of gastrointestinal damage and inflammatory cytokinesQ73894705
Adoptive transfer of minor histocompatibility antigen-specific T lymphocytes eradicates leukemia cells without causing graft-versus-host diseaseQ74122363
Soluble Fas levels in sera of bone marrow transplantation recipients are increased during acute graft-versus-host disease but not during infectionsQ74138254
Acute graft-versus-host disease does not require alloantigen expression on host epitheliumQ74221421
Association of TLR4 mutations and the risk for acute GVHD after HLA-matched-sibling hematopoietic stem cell transplantationQ74444949
Role of the passive apoptotic pathway in graft-versus-host diseaseQ74500191
Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host diseaseQ74541853
Differential effects of anti-Fas ligand and anti-tumor necrosis factor alpha antibodies on acute graft-versus-host disease pathologiesQ74576875
NK cells: a lesson from mismatched hematopoietic transplantationQ74675080
Interleukin 7 worsens graft-versus-host diseaseQ74805797
High-producer interleukin-2 genotype increases risk for acute graft-versus-host disease after unrelated donor bone marrow transplantationQ75197654
Involvement of donor T-cell cytotoxic effector mechanisms in preventing allogeneic marrow graft rejectionQ77218507
Levels of soluble FasL and FasL gene expression during the development of graft-versus-host disease in DLT-treated patientsQ77228239
Mechanisms of tolerance induced by PG490-88 in a bone marrow transplantation modelQ77493969
Rapid establishment of dendritic cell chimerism in allogeneic hematopoietic cell transplant recipientsQ77601922
In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigensQ77859052
Prevention of graft-versus-host disease while preserving graft-versus-leukemia effect after selective depletion of host-reactive T cells by photodynamic cell purging processQ77975018
Prevention of graft versus host disease by inactivation of host antigen-presenting cellsQ78016071
Evaluation of KIR ligand incompatibility in mismatched unrelated donor hematopoietic transplants. Killer immunoglobulin-like receptorQ78409932
Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host diseaseQ78409988
Interleukin-1 blockade does not prevent acute graft-versus-host disease: results of a randomized, double-blind, placebo-controlled trial of interleukin-1 receptor antagonist in allogeneic bone marrow transplantationQ78410438
Immunodominance of H60 is caused by an abnormally high precursor T cell pool directed against its unique minor histocompatibility antigen peptideQ78518647
CD25+ immunoregulatory T-cells of donor origin suppress alloreactivity after BMTQ78523396
Ligation of OX40 (CD134) regulates graft-versus-host disease (GVHD) and graft rejection in allogeneic bone marrow transplant recipientsQ78773723
Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reactionQ78782071
Role of CXCR3-induced donor T-cell migration in acute GVHDQ79149798
T-cell subsets: the more the merrierQ79616741
Lymphopenia-induced proliferation of donor T cells reduces their capacity for causing acute graft-versus-host diseaseQ79674881
In vivo administration of interleukin 2 plus T cell-depleted syngeneic marrow prevents graft-versus-host disease mortality and permits alloengraftmentQ36350708
Stem cell mobilization with G-CSF analogs: a rational approach to separate GVHD and GVL?Q36354616
Tumor necrosis factor/cachectin is an effector of skin and gut lesions of the acute phase of graft-vs.-host diseaseQ36357597
A revision of Billingham's tenets: the central role of lymphocyte migration in acute graft-versus-host diseaseQ36363382
Adoptive transfer of allogeneic antigen-specific T cells.Q36363385
Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host diseaseQ36366324
The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in miceQ36366817
Bone marrow NK1.1(-) and NK1.1(+) T cells reciprocally regulate acute graft versus host diseaseQ36368026
Pathophysiology of graft-versus-host diseaseQ36368101
Genetics of risk factors for graft-versus-host diseaseQ36368106
A human minor histocompatibility antigen resulting from differential expression due to a gene deletionQ36370375
Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantationQ36370863
Unequal death in T helper cell (Th)1 and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosisQ36377260
Extrathymic T cell deletion and allogeneic stem cell engraftment induced with costimulatory blockade is followed by central T cell toleranceQ36401145
FOXP3: of mice and men.Q36427333
Minor histocompatibility antigens: from transplantation problems to therapy of cancerQ36489688
Induction of tumor immunity following allogeneic stem cell transplantationQ36490755
Depletion of host Langerhans cells before transplantation of donor alloreactive T cells prevents skin graft-versus-host diseaseQ36505142
Immunogenomics of unrelated hematopoietic cell transplantationQ36548014
The role of CD4+CD25hi regulatory T cells in the physiopathogeny of graft-versus-host disease.Q36552462
Nod-like proteins in immunity, inflammation and diseaseQ36655897
Immunobiology of allogeneic hematopoietic stem cell transplantationQ36665305
T cell-directed therapies: lessons learned and future prospectsQ36688370
New directions in the genomics of allogeneic hematopoietic stem cell transplantationQ36714821
Thymic development and peripheral homeostasis of regulatory T cells.Q36738380
CD25 expression on donor CD4+ or CD8+ T cells is associated with an increased risk for graft-versus-host disease after HLA-identical stem cell transplantation in humansQ47704184
Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-gamma-dependent mechanismQ47745301
The biology of graft-versus-host reactionsQ47809350
Inhibition of graft-versus-host disease by double-negative regulatory T cellsQ47817030
Endothelial apoptosis as the primary lesion initiating intestinal radiation damage in mice.Q49165929
L-Selectin(hi) but not the L-selectin(lo) CD4+25+ T-regulatory cells are potent inhibitors of GVHD and BM graft rejection.Q50796687
Detection of nitric oxide by electron paramagnetic resonance spectroscopy during rejection and graft-versus-host disease after small-bowel transplantation in the ratQ51685233
Alloreactive memory T cells are responsible for the persistence of graft-versus-host disease.Q51994114
Dendritic cell-activated CD44hiCD8+ T cells are defective in mediating acute graft-versus-host disease but retain graft-versus-leukemia activity.Q52002812
TNF-TNFR2 interactions are critical for the development of intestinal graft-versus-host disease in MHC class II-disparate (C57BL/6J-->C57BL/6J x bm12)F1 mice.Q52014017
A major role for the Fas pathway in acute graft-versus-host disease.Q52045436
In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation.Q53589050
Requirement for T-cell apoptosis in the induction of peripheral transplantation tolerance.Q54073234
Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancyQ56777948
Differential TCR Signaling Regulates Apoptosis and Immunopathology during Antigen Responses In VivoQ56880742
Allogeneic bone marrow transplantation with co-stimulatory blockade induces macrochimerism and tolerance without cytoreductive host treatmentQ56906119
Coblockade of the LFA1:ICAM and CD28/CTLA4:B7 pathways is a highly effective means of preventing acute lethal graft-versus-host disease induced by fully major histocompatibility complex-disparate donor graftsQ56909451
In vivo blockade of CD28/CTLA4: B7/BB1 interaction with CTLA4-Ig reduces lethal murine graft-versus-host disease across the major histocompatibility complex barrier in miceQ56909694
Identification of a graft versus host disease-associated human minor histocompatibility antigenQ56929110
Effector and regulatory T-cell function is differentially regulated by RelB within antigen-presenting cells during GVHDQ57252628
IFN differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tractQ57252630
Host B cells produce IL-10 following TBI and attenuate acute GVHD after allogeneic bone marrow transplantationQ57252633
TGF- in allogeneic stem cell transplantation: friend or foe?Q57252637
Relation of an Interleukin-10 Promoter Polymorphism to Graft-versus-Host Disease and Survival after Hematopoietic-Cell TransplantationQ58814550
Foxp3-dependent programme of regulatory T-cell differentiationQ59084714
Influence of SHIP on the NK Repertoire and Allogeneic Bone Marrow TransplantationQ59280520
Nitric oxide formation as predictive parameter for acute graft-versus-host disease after human allogeneic bone marrow transplantationQ61906319
Tissue distribution of human minor histocompatibility antigens. Ubiquitous versus restricted tissue distribution indicates heterogeneity among human cytotoxic T lymphocyte-defined non-MHC antigensQ67898770
Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevents graft-versus-host diseaseQ67903035
Different types of allospecific CTL clones identified by their ability to recognize peptide loading-defective target cellsQ68036519
Phase I-II trial of a monoclonal anti-tumor necrosis factor alpha antibody for the treatment of refractory severe acute graft-versus-host diseaseQ68140704
Risk factors for acute graft-versus-host diseaseQ68218218
Allogeneic marrow transplantation in patients with acute myeloid leukemia in first remission: a randomized trial of two irradiation regimensQ68578028
Increased serum levels of tumor necrosis factor alpha precede major complications of bone marrow transplantationQ68928908
Effect of HLA compatibility on engraftment of bone marrow transplants in patients with leukemia or lymphomaQ69482387
Surface markers of T cells causing lethal graft-vs-host disease to class I vs class II H-2 differencesQ69873475
T cell subsets and graft-versus-host diseaseQ70037088
Antileukemic effect of chronic graft-versus-host disease: contribution to improved survival after allogeneic marrow transplantationQ70149552
Rapid analysis of tumor necrosis factor-alpha mRNA expression during venoocclusive disease of the liver after allogeneic bone marrow transplantationQ70563647
Role of tumor necrosis factor alpha in acute graft-versus-host disease and complications following allogeneic bone marrow transplantationQ70582290
High frequencies of cytotoxic T cell precursors against minor histocompatibility antigens after HLA-identical BMT: absence of correlation with GVHDQ70742852
Mismatches of minor histocompatibility antigens between HLA-identical donors and recipients and the development of graft-versus-host disease after bone marrow transplantationQ70812614
Pretreatment of donor mice with granulocyte colony-stimulating factor polarizes donor T lymphocytes toward type-2 cytokine production and reduces severity of experimental graft-versus-host diseaseQ70837443
The role of granzyme B in murine models of acute graft-versus-host disease and graft rejectionQ71017487
Suppression of B-cell proliferation to lipopolysaccharide is mediated through induction of the nitric oxide pathway by tumor necrosis factor-alpha in mice with acute graft-versus-host diseaseQ71100113
Interferon-gamma suppresses T-cell proliferation to mitogen via the nitric oxide pathway during experimental acute graft-versus-host diseaseQ71249479
Polarized type 2 alloreactive CD4+ and CD8+ donor T cells fail to induce experimental acute graft-versus-host diseaseQ71870327
P433issue4
P921main subjectpathophysiologyQ1135939
P304page(s)197-214
P577publication date2007-07-03
P1433published inTranslational ResearchQ15761127
P1476titlePathophysiology of acute graft-versus-host disease: recent advances
P478volume150

Reverse relations

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Q36380188Immunotherapy following hematopoietic stem cell transplantation: potential for synergistic effects
Q37086953In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations
Q36788495In vivo maturation of allo-specific CD8 CTL and prevention of lupus-like graft-versus-host disease is critically dependent on T cell signaling through the TNF p75 receptor but not the TNF p55 receptor
Q34683729Interleukin-6 Modulates Graft-versus-Host Responses after Experimental Allogeneic Bone Marrow Transplantation
Q33619021Kinetics of IFN-γ and IL-17 Production by CD4 and CD8 T Cells during Acute Graft-versus-Host Disease
Q87458801Mesenchymal stem cells suppress CD8+ T cell-mediated activation by suppressing natural killer group 2, member D protein receptor expression and secretion of prostaglandin E2, indoleamine 2, 3-dioxygenase and transforming growth factor-β
Q54936066Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS): protocol for a randomised, double-blind, parallel-arm, placebo-controlled trial.
Q39445130Mismatch for the minor histocompatibility antigen HA-2 and GVHD occurrence in HLA-A*0201-positive Tunisian recipients of HSCs.
Q37414672Nonabsorbable corticosteroids use in the treatment of gastrointestinal graft-versus-host disease
Q36932886Oral graft-versus-host disease.
Q34077479Pathogenesis and management of graft-versus-host disease.
Q37761297Progress and prospects: graft-versus-host disease
Q33396969Renal thrombotic microangiopathy associated with chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
Q45954189Sclerodermatous chronic graft-versus-host disease induced by host T-cell-mediated autoimmunity.
Q33685495Separating graft-versus-leukemia from graft-versus-host disease in allogeneic hematopoietic stem cell transplantation
Q37776504Solid Organ Transplant-Associated Acute Graft-Versus-Host Disease
Q28554554Spatiotemporal Dynamics of Dexmedetomidine-Induced Electroencephalogram Oscillations
Q37729354TLR4 inactivation protects from graft-versus-host disease after allogeneic hematopoietic stem cell transplantation
Q52971841The Role of B Cell Targeting in Chronic Graft-Versus-Host Disease.
Q57538743The Use of Human Mesenchymal Stem Cells as Therapeutic Agents for the Treatment of Immune-Related Diseases: A Systematic Review
Q91664568The gut microbiota and graft-versus-host disease
Q41831790Transplantation with bone marrow stromal cells promotes wound healing under chemotherapy through altering phenotypes

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