Human embryonic stem cell responses to ionizing radiation exposures: current state of knowledge and future challenges

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Human embryonic stem cell responses to ionizing radiation exposures: current state of knowledge and future challenges is …
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scholarly articleQ13442814

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P356DOI10.1155/2012/579104
P932PMC publication ID3431129
P698PubMed publication ID22966236
P5875ResearchGate publication ID230830737

P2093author name stringMykyta V Sokolov
Ronald D Neumann
P2860cites workA comparative analysis of DNA methylation across human embryonic stem cell linesQ39183470
Pinacidil enhances survival of cryopreserved human embryonic stem cellsQ39452864
Human embryonic stem cells are capable of executing G1/S checkpoint activation.Q39697555
Characterization of human embryonic stem cells with features of neoplastic progression.Q39898745
Recurrent chromosomal abnormalities in human embryonic stem cellsQ39912737
Comprehensive microRNA profiling reveals a unique human embryonic stem cell signature dominated by a single seed sequenceQ39993069
Self-renewal of human embryonic stem cells is supported by a shortened G1 cell cycle phaseQ40232134
Microarray analysis of differentially expressed genes after exposure of normal human fibroblasts to ionizing radiation from an external source and from DNA-incorporated iodine-125 radionuclideQ40250003
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Induction of stress genes by low doses of gamma rays.Q40933805
Radiosensitivity and double-strand break rejoining in tumorigenic and non-tumorigenic human epithelial cell linesQ41101698
Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cellsQ41118001
Human embryonic stem cells have constitutively active Bax at the Golgi and are primed to undergo rapid apoptosisQ41822569
ATM-independent, high-fidelity nonhomologous end joining predominates in human embryonic stem cellsQ42356980
microRNAs regulate human embryonic stem cell divisionQ42529464
Main principles of radiobiologyQ43807842
Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblastsQ46709852
Enrichment and terminal differentiation of striated muscle progenitors in vitroQ48517840
Establishment of histone gene regulation and cell cycle checkpoint control in human embryonic stem cells.Q50919370
Epigenetics of embryonic stem cells.Q51798781
Molecular pathway and cell state responsible for dissociation-induced apoptosis in human pluripotent stem cells.Q51902673
Inherent cellular radiosensitivity as a basic concept for human tumor radiotherapy.Q52737798
Radiation biology: concepts for radiation protection.Q53358094
Adaptation to culture of human embryonic stem cells and oncogenesis in vivoQ59544319
High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosityQ59696431
Regulation of apoptosis and differentiation by p53 in human embryonic stem cellsQ79441696
Microarray analysis of the transcriptional response to single or multiple doses of ionizing radiation in human subcutaneous fibroblastsQ81504550
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathwayQ22065419
Radiation effects on developmentQ22252925
An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cellsQ24293077
Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray dosesQ24677973
DNA repair in human pluripotent stem cells is distinct from that in non-pluripotent human cellsQ27309692
Embryonic stem cell lines derived from human blastocystsQ27861010
ATM phosphorylates histone H2AX in response to DNA double-strand breaksQ28188651
Induction of sister chromatid exchanges by extremely low doses of alpha-particlesQ28201203
MicroRNAs regulate p21(Waf1/Cip1) protein expression and the DNA damage response in human embryonic stem cellsQ28264713
Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesisQ28274000
Repair at single targeted DNA double-strand breaks in pluripotent and differentiated human cellsQ28478289
The architectural organization of human stem cell cycle regulatory machineryQ28609122
A ROCK inhibitor permits survival of dissociated human embryonic stem cellsQ29616183
Epigenetic signatures associated with different levels of differentiation potential in human stem cellsQ30885935
Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendantsQ33549647
Human embryonic stem cells are pre-mitotically committed to self-renewal and acquire a lengthened G1 phase upon lineage programmingQ33584339
Expression of pluripotency-associated genes in the surviving fraction of cultured human embryonic stem cells is not significantly affected by ionizing radiation.Q33747678
Radiation-induced bystander effects in cultured human stem cellsQ33769819
Premature aging and cancer in nucleotide excision repair-disordersQ34025252
Survival responses of human embryonic stem cells to DNA damageQ34078474
Radiation dose associated with common computed tomography examinations and the associated lifetime attributable risk of cancerQ34087987
Subpopulations of human embryonic stem cells with distinct tissue-specific fates can be selected from pluripotent culturesQ34129056
Epigenetic modifications in pluripotent and differentiated cellsQ34143430
Regulation of DNA strand exchange in homologous recombinationQ34145363
Unraveling the global microRNAome responses to ionizing radiation in human embryonic stem cellsQ34162661
Effects of ionizing radiation on self-renewal and pluripotency of human embryonic stem cells.Q34458727
Characterization of human embryonic stem cell lines by the International Stem Cell InitiativeQ34638055
Cyclin D2 and the CDK substrate p220(NPAT) are required for self-renewal of human embryonic stem cellsQ34691366
Reference Maps of human ES and iPS cell variation enable high-throughput characterization of pluripotent cell linesQ34714112
Activation of p53 by nutlin leads to rapid differentiation of human embryonic stem cells.Q34784150
Base excision repair and lesion-dependent subpathways for repair of oxidative DNA damageQ34987124
Dynamics of the transcriptome response of cultured human embryonic stem cells to ionizing radiation exposureQ34994419
Variation in base excision repair capacityQ35004482
Human embryonic stem cells have a unique epigenetic signatureQ35012978
Biological response to radiation therapyQ35151872
DNA methylation in embryonic stem cellsQ35788271
Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instabilityQ35828731
Effects of DNA-targeted ionizing radiation produced by 5-[125I]iodo-2'-deoxyuridine on global gene expression in primary human cellsQ35915738
Ionizing radiation induces ataxia telangiectasia mutated-dependent checkpoint signaling and G(2) but not G(1) cell cycle arrest in pluripotent human embryonic stem cellsQ35924505
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantageQ36266493
The multifaceted mismatch-repair systemQ36448284
Differences between human embryonic stem cell linesQ36579000
Intercellular and intracellular signaling pathways mediating ionizing radiation-induced bystander effects.Q36747077
Derivation of pluripotent stem cells from cultured human primordial germ cellsQ36797341
Cell cycle dependent phosphorylation and subnuclear organization of the histone gene regulator p220(NPAT) in human embryonic stem cells.Q36829835
Radiation exposure and pregnancy: when should we be concerned?Q36874495
The abbreviated pluripotent cell cycle.Q36886887
gamma-H2AX in bystander cells: not just a radiation-triggered event, a cellular response to stress mediated by intercellular communicationQ36946414
Human embryonic stem cells have enhanced repair of multiple forms of DNA damageQ36953410
Staged assembly of histone gene expression machinery at subnuclear foci in the abbreviated cell cycle of human embryonic stem cellsQ36964278
Exposure to low-dose ionizing radiation from medical imaging proceduresQ36999610
CDK inhibitors: cell cycle regulators and beyondQ37081857
Overview of radiosensitivity of human tumor cells to low-dose-rate irradiationQ37327682
Intercellular communication of cellular stress monitored by gamma-H2AX inductionQ37376590
Copy number variant analysis of human embryonic stem cellsQ37513150
Collaboration and competition between DNA double‐strand break repair pathwaysQ37638191
Chromatin plasticity and genome organization in pluripotent embryonic stem cellsQ37708503
Navigating the nucleotide excision repair thresholdQ37748663
Induction and repair of DNA double strand breaks: the increasing spectrum of non-homologous end joining pathwaysQ37844204
Dynamics of mammalian NER proteinsQ37873061
Cell cycle adaptations and maintenance of genomic integrity in embryonic stem cells and induced pluripotent stem cells.Q37883207
Portrait of transcriptional responses to ultraviolet and ionizing radiation in human cellsQ38336923
Genome-wide gene expression changes in normal human fibroblasts in response to low-LET gamma-radiation and high-LET-like 125IUdR exposuresQ38517219
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjecthuman embryonic stem cellQ59626782
P304page(s)579104
P577publication date2012-08-16
P1433published inStem Cells InternationalQ26842114
P1476titleHuman embryonic stem cell responses to ionizing radiation exposures: current state of knowledge and future challenges
P478volume2012

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cites work (P2860)
Q35879279A Genomic Study of DNA Alteration Events Caused by Ionizing Radiation in Human Embryonic Stem Cells via Next-Generation Sequencing
Q37720218Comparison of the early response of human embryonic stem cells and human induced pluripotent stem cells to ionizing radiation.
Q37535491Effects of low doses of ionizing radiation exposures on stress-responsive gene expression in human embryonic stem cells
Q36639903Genetic stability of pluripotent stem cells during anti-cancer therapies
Q37139081Lessons learned about human stem cell responses to ionizing radiation exposures: a long road still ahead of us.
Q27301084Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells
Q60301058Molecular and epigenetic regulatory mechanisms of normal stem cell radiosensitivity
Q26781874New Horizons in Enhancing the Proliferation and Differentiation of Neural Stem Cells Using Stimulatory Effects of the Short Time Exposure to Radiofrequency Radiation
Q52723083Recruitment kinetics of the homologous recombination pathway in procyclic forms of Trypanosoma brucei after ionizing radiation treatment.
Q36247550TP53inp1 Gene Is Implicated in Early Radiation Response in Human Fibroblast Cells
Q38767220The Impact of Epigenetics on Mesenchymal Stem Cell Biology

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