Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system

scientific article

Type 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.20052448
P8608Fatcat IDrelease_2hj65s7ka5e7bbcjk7xkbp3qpq
P932PMC publication ID2118302
P698PubMed publication ID16702603
P5875ResearchGate publication ID7078219

P2093author name stringDavid Voehringer
Tiffany A Reese
Richard M Locksley
Xiaozhu Huang
Kanade Shinkai
P2860cites workNew fluorescent dyes for lymphocyte migration studies. Analysis by flow cytometry and fluorescence microscopyQ28254277
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Peripheral CD4 T cells rapidly accumulate at the host: parasite interface during an inflammatory Th2 memory response.Q31041185
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The instructive role of innate immunity in the acquired immune responseQ34375203
Mice lacking all conventional MHC class II genesQ35620743
Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasitesQ35884218
IL-2 and autocrine IL-4 drive the in vivo development of antigen-specific Th2 T cells elicited by nematode parasitesQ35995946
Complement-mediated killing of schistosomula of Schistosoma mansoni by rat eosinophils in vitroQ36339847
Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivoQ36369717
Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasiteQ36399604
Basophils initiate IL-4 production during a memory T-dependent responseQ36403845
Requirements for allergen-induced airway hyperreactivity in T and B cell-deficient miceQ36438370
An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice.Q36596732
Accumulation of Peribronchial Mast Cells in a Mouse Model of Ovalbumin Allergen Induced Chronic Airway Inflammation: Modulation by Immunostimulatory DNA SequencesQ38348928
The role of L3T4+ and Lyt-2+ T cells in the IgE response and immunity to Nippostrongylus brasiliensisQ39287203
IL-4 treatment can cure established gastrointestinal nematode infections in immunocompetent and immunodeficient mice.Q39379202
Stat6 regulation of in vivo IL-4 responsesQ39529330
Cutting edge: IL-4 receptor expression by non-bone marrow-derived cells is required to expel gastrointestinal nematode parasites.Q39586138
T cells are required for host protection against Brugia malayi but need not produce or respond to interleukin-4.Q39755218
Expulsion of Nippostrongylus brasiliensis from mice lacking antibody production potentialQ40788631
Requirement for IL-13 independently of IL-4 in experimental asthmaQ41881960
Simultaneous disruption of interleukin (IL)-4 and IL-13 defines individual roles in T helper cell type 2-mediated responsesQ42944667
Multiple pathways for the initiation of T helper 2 (Th2) responsesQ42947603
Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivoQ43687301
Th2 activities induced during virgin T cell priming in the absence of IL-4, IL-13, and B cells.Q44129501
Mutations in T-cell antigen receptor genes alpha and beta block thymocyte development at different stagesQ44151375
Parasite antigen-driven basophils are a major source of IL-4 in human filarial infectionsQ44757017
Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporterQ46062240
Activation of the integrated stress response during T helper cell differentiationQ46290572
Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthmaQ46413344
Type 2 immunity reflects orchestrated recruitment of cells committed to IL-4 productionQ46528021
Interleukin-13 in asthma pathogenesisQ47894967
Differences between IL-4R alpha-deficient and IL-4-deficient mice reveal a role for IL-13 in the regulation of Th2 responsesQ47946081
Mast cells, basophils, and eosinophils acquire constitutive IL-4 and IL-13 transcripts during lineage differentiation that are sufficient for rapid cytokine production.Q50781666
Mast-cell infiltration of airway smooth muscle in asthma.Q51715332
Stat6 is required for mediating responses to IL-4 and for development of Th2 cells.Q55066450
Interleukin-5 deficient mice exhibit impaired host defence against challenge Trichinella spiralis infectionsQ58061417
Constitutive production of IL-4 and IL-10 and stimulated production of IL-8 by normal peripheral blood eosinophilsQ71120610
Kinetics of expulsion of the nematode, Nippostrongylus brasiliensis, in mast-cell deficient W/WV miceQ71243604
Enhanced helminthotoxic capacity of eosinophils from patients with eosinophiliaQ71338652
Secretion of IL-4 from human basophils. The relationship between IL-4 mRNA and protein in resting and stimulated basophilsQ72332704
Expression of IL-5 in thymocytes/T cells leads to the development of a massive eosinophilia, extramedullary eosinophilopoiesis, and unique histopathologiesQ73025983
Conventional, naive CD4+ T cells provide an initial source of IL-4 during Th2 differentiationQ73084699
Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profileQ73520544
Identification of basophils by immunohistochemistry in the airways of post-mortem cases of fatal asthmaQ73708145
Protective roles of eosinophils in Nippostrongylus brasiliensis infectionQ73863391
Immunohistochemical detection of human basophils in postmortem cases of fatal asthmaQ74595730
Accelerated intestinal epithelial cell turnover: a new mechanism of parasite expulsionQ81810291
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)1435-1446
P577publication date2006-05-15
P1433published inJournal of Experimental MedicineQ3186912
P1476titleType 2 immunity is controlled by IL-4/IL-13 expression in hematopoietic non-eosinophil cells of the innate immune system
P478volume203

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