Reduction of disulfide bonds during antigen processing: evidence from a thiol-dependent insulin determinant

scientific article

Reduction of disulfide bonds during antigen processing: evidence from a thiol-dependent insulin determinant is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1084/JEM.174.5.1121
P932PMC publication ID2119004
P698PubMed publication ID1940793
P5875ResearchGate publication ID21214787

P2093author name stringP E Jensen
P2860cites workInsulin degradation: mechanisms, products, and significanceQ28289497
ThioredoxinQ29619691
Protein disulfide-isomerase is a substrate for thioredoxin reductase and has thioredoxin-like activity.Q34213308
A cysteine-specific lysosomal transport system provides a major route for the delivery of thiol to human fibroblast lysosomes: possible role in supporting lysosomal proteolysisQ36222502
Enhanced binding of peptide antigen to purified class II major histocompatibility glycoproteins at acidic pH.Q36230523
Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognitionQ36344766
Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processingQ36348935
Regulation of antigen presentation by acidic pH.Q36351024
Flexibility of the T cell repertoire. Self tolerance causes a shift of T cell receptor gene usage in response to insulinQ36351053
Photoaffinity labeling demonstrates binding between Ia molecules and nominal antigen on antigen-presenting cellsQ37392832
Intracellular class II HLA antigens are accessible to transferrin-neuraminidase conjugates internalized by receptor-mediated endocytosisQ37557662
Antigen conformation determines processing requirements for T-cell activationQ37576188
Specific binding of antigenic peptides to separate alpha and beta chains of class II molecules of the major histocompatibility complexQ37666665
The basis for the immunoregulatory role of macrophages and other accessory cellsQ38174608
Protein disulfide isomerase: multiple roles in the modification of nascent secretory proteinsQ38274381
Immune response gene control of determinant selection. II. Genetic control of the murine T lymphocyte proliferative response to insulinQ39548996
Antigen processing and the human T cell receptor repertoire for insulinQ41254325
The molecular basis of the requirement for antigen processing of pigeon cytochrome c prior to T cell activationQ41279676
Processing without proteolytic cleavage is required for recognition of insulin by T cellsQ41711445
Cleavage of disulfide bonds in endocytosed macromolecules. A processing not associated with lysosomes or endosomesQ41715127
Cycling of cell-surface MHC glycoproteins through primaquine-sensitive intracellular compartmentsQ41724706
Development of T cell clones reactive to two defined restriction elements in conjunction with two defined epitopes of antigenQ41934641
Protein synthesis in antigen processing.Q41947029
Role of thiols, pH and cathepsin D in the lysosomal catabolism of serum albuminQ42093504
Disulphide reduction in lysosomes. The role of cysteineQ42200276
Establishment of B cell hybridomas with B cell surface antigens.Q42799227
Differential requirements for antigen processing by macrophages for lysozyme-specific T cell hybridomas.Q42823565
Processing by accessory cells for presentation to murine T cells of apamin, a disulfide-bonded 18 amino acid peptideQ43703469
Disulfide spacer between methotrexate and poly(D-lysine). A probe for exploring the reductive process in endocytosisQ43882742
T cells from nonresponder mice. MHC restricted and unrestricted recognition of insulinQ43993541
Processing and presentation of insulin. I. Analysis of immunogenic peptides and processing requirements for insulin A loop-specific T cells.Q44763280
Purification and characterization of class II histocompatibility antigens from a homozygous human B cell lineQ44802945
Regions of allelic hypervariability in the murine Aα immune response geneQ48397143
Murine I-A beta chain polymorphism: nucleotide sequences of three allelic I-A beta genesQ48397403
Isolation and characterization of antigen-la complexes involved in T cell recognitionQ57000170
Binding of immunogenic peptides to Ia histocompatibility moleculesQ59070314
Immunology: The ins and outs of antigen processing and presentationsQ59073630
Evidence for lysosomal reduction of cystine residuesQ66938676
Immunogenicity of B chain in insulin responder and nonresponder miceQ67669955
High-affinity binding of an influenza hemagglutinin-derived peptide to purified HLA-DRQ68717435
Stable association of processed antigen with antigen-presenting cell membranesQ69740308
Capacity of intact proteins to bind to MHC class II moleculesQ69741058
Studies on monoclonal antibodies to mouse MHC productsQ72642947
Epitope specificity and Ia restriction of T cell responses to insulin in a system of complementing Ir genes: analysis with primed lymph node T cells and a long-term cultured T cell lineQ72711826
Fine specificity of cloned insulin-specific T cell hybridomas: evidence supporting a role for tertiary conformationQ72717995
Studies on the reaction of sulfite with proteinsQ78734313
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectpreproinsulinQ7240673
P304page(s)1121-1130
P577publication date1991-11-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleReduction of disulfide bonds during antigen processing: evidence from a thiol-dependent insulin determinant
P478volume174

Reverse relations

cites work (P2860)
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Q52006255Amino acid residue substitution at T-cell determinant-flanking sites in beta-lactoglobulin modulates antigen presentation to T cells through subtle conformational change
Q58323370Antigen Presentation--Losing Its Shine in the Absence of GILT
Q36232748Antigen presentation: lysoyme, autoimmune diabetes, and Listeria--what do they have in common?
Q34129315Antigen processing in the endocytic compartment
Q28344126Bcl-2-dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis
Q40901299Cellular and molecular aspects of antigen processing and the function of class II MHC molecules
Q46512462Characterisation of the antibody response to a totally synthetic immunocontraceptive peptide vaccine based on LHRH.
Q40202675Crucial role of lysosomal iron in the formation of dinitrosyl iron complexes in vivo
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Q41147813Defective antigen processing correlates with a low level of intracellular glutathione
Q35884189Dendritic cells, pro-inflammatory responses, and antigen presentation in a rodent malaria infection
Q56395856Determination of a Predictive Cleavage Motif for Eluted Major Histocompatibility Complex Class II Ligands
Q28343874Differing processing requirements of four recombinant antigens containing a single defined T-cell epitope for presentation by major histocompatibility complex class II
Q37867108Disulfide Reduction in the Endocytic Pathway: Immunological Functions of Gamma-Interferon-Inducible Lysosomal Thiol Reductase
Q43926217Disulfide bonds in merozoite surface protein 1 of the malaria parasite impede efficient antigen processing and affect the in vivo antibody response
Q77745561Disulfide reduction in major histocompatibility complex class II-restricted antigen processing by interferon-gamma-inducible lysosomal thiol reductase
Q34579769Diversity in MHC class II antigen presentation
Q35058921Drug delivery strategy utilizing conjugation via reversible disulfide linkages: role and site of cellular reducing activities
Q77965788Drug-induced inhibition of insulin recognition by T-cells: the antirheumatic drug aurothiomalate inhibits MHC binding of insulin peptide
Q40165086Endogenous and exogenous pathways maintain the reductive capacity of the phagosome
Q39319598Evaluating the intrinsic cysteine redox-dependent states of the A-chain of human insulin using NMR spectroscopy, quantum chemical calculations, and mass spectrometry
Q58199442Exploring the mechanisms of antigen processing by cell fractionation
Q40729404Factors governing the binding and recognition of foreign and self-peptides by MHC class II.
Q33650907Folding of matrix metalloproteinase-2 prevents endogenous generation of MHC class-I restricted epitope
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Q54082354Importance of thioredoxin in the proteolysis of an immunoglobulin G as antigen by lysosomal Cys-proteases
Q33264116Increased proteolysis of diphtheria toxin by human monocytes after heat shock: a subsidiary role for heat-shock protein 70 in antigen processing
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Q42800203Lysosomal handling of cystine residues: stoichiometry of cysteine involvement
Q81312026Major histocompatibility class II molecules prevent destructive processing of exogenous peptides at the cell surface of macrophages for presentation to CD4 T cells
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Q57372149Molecular Interaction and Enzymatic Activity of Macrophage Migration Inhibitory Factor with Immunorelevant Peptides
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Q77586745Oxidation of defined antigens allows protein unfolding and increases both proteolytic processing and exposes peptide epitopes which are recognized by specific T cells
Q34162875Oxidizing potential of endosomes and lysosomes limits intracellular cleavage of disulfide-based antibody-drug conjugates
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Q36403698The insulin A-chain epitope recognized by human T cells is posttranslationally modified
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