Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis

scientific article

Fibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.141.7.1659
P932PMC publication ID2132998
P698PubMed publication ID9647657
P5875ResearchGate publication ID13636431

P2093author name stringS Patel
D B Rifkin
R L Shapiro
C J Ren
P Mignatti
G Pintucci
A C Galloway
G Seghezzi
A Gualandris
E S Robbins
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The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicingQ34582371
Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrixQ34613112
Molecular and biological properties of the vascular endothelial growth factor family of proteinsQ35313427
The FGF family of growth factors and oncogenesQ35335377
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A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membraneQ35818217
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Biological roles of fibroblast growth factor-2.Q41349632
Vascular endothelial growth factor is induced in response to transforming growth factor-beta in fibroblastic and epithelial cells.Q41481649
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Indirect angiogenic cytokines upregulate VEGF and bFGF gene expression in vascular smooth muscle cells, whereas hypoxia upregulates VEGF expression onlyQ42495897
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Vascular endothelial growth factor in human glioma cell lines: induced secretion by EGF, PDGF-BB, and bFGF.Q42805196
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectendotheliumQ111140
angiogenesisQ539568
P1104number of pages15
P304page(s)1659-1673
P577publication date1998-06-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleFibroblast growth factor-2 (FGF-2) induces vascular endothelial growth factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis
P478volume141

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Q39305373Pentraxin 3 (PTX3) inhibits plasma cell/stromal cell cross-talk in the bone marrow of multiple myeloma patients
Q37053858Peritubular capillary rarefaction: a new therapeutic target in chronic kidney disease
Q35562693Perlecan and tumor angiogenesis
Q33391125Phase I and pharmacokinetic study of TSU-68, a novel multiple receptor tyrosine kinase inhibitor, by twice daily oral administration between meals in patients with advanced solid tumors
Q34981292Phenotypic and gene expression modification with normal brain aging in GFAP-positive astrocytes and neural stem cells
Q64103615Phytochemicals Targeting VEGF and VEGF-Related Multifactors as Anticancer Therapy
Q50091134Placental growth throughout the last two thirds of pregnancy in sheep: vascular development and angiogenic factor expression
Q33703845Possible role of transforming growth factor-β1 and vascular endothelial growth factor in Fabry disease nephropathy
Q42153567Pressuromodulation at the cell membrane as the basis for small molecule hormone and peptide regulation of cellular and nuclear function
Q33675114Profilin-1 phosphorylation directs angiocrine expression and glioblastoma progression through HIF-1α accumulation
Q35177011Prognostic significance of angiogenesis and angiogenic growth factors in nonsmall cell lung cancer
Q36228311Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis
Q64110061Proteomic analysis of human mesenchymal stromal cell secretomes: a systematic comparison of the angiogenic potential
Q89843928Quantitative assessment and clinical relevance of VEGFRs-positive tumor cells in refractory brain tumors
Q46429748Rapamycin reduces VEGF expression in retinal pigment epithelium (RPE) and inhibits RPE-induced sprouting angiogenesis in vitro
Q42528044Rapid tumor development and potent vascularization are independent events in carcinoma producing FGF-1 or FGF-2.
Q36785331Rebuilding the coronary vasculature: hedgehog as a new candidate for pharmacologic revascularization.
Q53955419Release Kinetics and in vitro Bioactivity of Basic Fibroblast Growth Factor: Effect of the Thickness of Fibrous Matrices
Q58323579Response of bovine endothelial cells to FGF-2 and VEGF is dependent on their site of origin: Relevance to the regulation of angiogenesis
Q39221209Response of the cerebral vasculature following traumatic brain injury
Q40730311Retinal expression, regulation, and functional bioactivity of prostacyclin-stimulating factor
Q39068605Role of M2-like macrophage recruitment during angiogenic growth factor therapy
Q54487345Role of fibroblast growth factor signaling in vascular formation and maintenance: orchestrating signaling networks as an integrated system.
Q51941355Role of repulsive factors in vascularization dynamics.
Q27025540Roles of FGF signaling in stem cell self-renewal, senescence and aging
Q33899574S100A13 is a new angiogenic marker in human melanoma
Q50895931S1P Synergizes with Wall Shear Stress and Other Angiogenic Factors to Induce Endothelial Cell Sprouting Responses.
Q39350876SU6668, a multiple tyrosine kinase inhibitor, inhibits progression of human malignant pleural mesothelioma in an orthotopic model
Q37551794Serum levels of three angiogenic factors in systemic lupus erythematosus and their clinical significance
Q35990029Serum uPAR as Biomarker in Breast Cancer Recurrence: A Mathematical Model
Q37380465Shared circuitry: developmental signaling cascades regulate both embryonic and adult coronary vasculature
Q37400353Spatiotemporal tracking of cells in tissue-engineered cardiac organoids
Q36180591Spider angiomas in patients with liver cirrhosis: role of vascular endothelial growth factor and basic fibroblast growth factor
Q52632502Sprouty2 expression controls endothelial monolayer integrity and quiescence.
Q36845727Statistical platform to discern spatial and temporal coordination of endothelial sprouting.
Q46834835Structure Activity Relationship of Heparin Mimicking Polymer p(SS-co-PEGMA): Effect of Sulfonation and Polymer Size on FGF2-Receptor Binding
Q55472739Structure and inhibitory effects on angiogenesis and tumor development of a new vascular endothelial growth inhibitor.
Q46676094Subchoroidal Release of VEGF and bFGF Produces Choroidal Neovascularization in Rabbit
Q43933934Synergistic effect of basic fibroblast growth factor and vascular endothelial growth factor in murine hepatocellular carcinoma
Q41593699TGF-beta1 induces rearrangement of FLK-1-VE-cadherin-beta-catenin complex at the adherens junction through VEGF-mediated signaling.
Q42175314TGF-β1 induces endothelial cell apoptosis by shifting VEGF activation of p38(MAPK) from the prosurvival p38β to proapoptotic p38α.
Q36614139TRAIL inhibits angiogenesis stimulated by VEGF expression in human glioblastoma cells
Q33912018Target molecules for anti-angiogenic therapy: from basic research to clinical trials
Q34062422Targeted decorin gene therapy delivered with adeno-associated virus effectively retards corneal neovascularization in vivo
Q37412392Targeted disruption of the Fgf2 gene does not affect vascular growth in the mouse ischemic hindlimb
Q28344662Targeted expression of a human pituitary tumor-derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis
Q52624116Temporal Dynamics of Gene Expression During Endothelial Cell Differentiation From Human iPS Cells: A Comparison Study of Signalling Factors and Small Molecules.
Q44319291Temporal changes in regeneration-associated gene expression in cryopreserved rat vascular grafts
Q42561804Temporally expressed PDGF and FGF-2 regulate embryonic coronary artery formation and growth
Q34805055The Effect of Fibroblast Co-culture on In Vitro Maturation of Mouse Preantral Follicles
Q90232767The Interactivity between TGFβ and BMP Signaling in Organogenesis, Fibrosis, and Cancer
Q59335689The Platelet Response to Tissue Injury
Q37690651The Pleiotropic Role of L1CAM in Tumor Vasculature
Q36601812The Shc adaptor protein is critical for VEGF induction by Met/HGF and ErbB2 receptors and for early onset of tumor angiogenesis
Q38252537The angiogenic asset of soft tissue sarcomas: a new tool to discover new therapeutic targets.
Q40022803The angiogenic variation of skeletal site-specific human BMSCs from same alveolar cleft patients: a comparative study.
Q43202381The constitutive level of vascular endothelial growth factor (VEGF) is more important than hypoxia-induced VEGF up-regulation in the angiogenesis of human melanoma xenografts
Q33940874The effect of leptin on luteal angiogenic factors during the luteal phase of the estrous cycle in goats
Q47120527The effect of low intensity shockwave treatment (Li-SWT) on human myoblasts and mouse skeletal muscle
Q40875944The first peak of the UVB irradiation-dependent biphasic induction of vascular endothelial growth factor (VEGF) is due to phosphorylation of the epidermal growth factor receptor and independent of autocrine transforming growth factor alpha.
Q38208062The ins and outs of fibroblast growth factor receptor signalling.
Q34658478The pathogenesis of diabetic retinopathy: old concepts and new questions
Q38540713The potential of fibroblast growth factor/fibroblast growth factor receptor signaling as a therapeutic target in tumor angiogenesis.
Q38840344The role of FGF2 in migration and tubulogenesis of endothelial progenitor cells in relation to pro-angiogenic growth factor production
Q37512303The role of fibroblast growth factors in tumor growth
Q78384186The role of fibroblast growth factors in vascular development
Q37308157The role of vascular endothelial growth factor in wound healing
Q36314802The use of tyrosine kinase inhibitors in modifying the response of tumor microvasculature to radiotherapy
Q50048638Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.
Q44518833Thrombin induces angiogenesis and vascular endothelial growth factor expression in human endothelial cells: possible relevance to HIF-1alpha
Q77359737Thrombospondin-1, vascular endothelial growth factor and fibroblast growth factor-2 are key functional regulators of angiogenesis in the prostate
Q73124809Tissue engineering
Q37386687Tissue-engineered endothelial cell layers on surface-modified Ti for inhibiting in vitro platelet adhesion.
Q36915712Towards comprehensive cardiac repair and regeneration after myocardial infarction: Aspects to consider and proteins to deliver.
Q48524593Transcriptomic analysis of gene cascades involved in protein kinase A and C signaling in the KGN line of human ovarian granulosa tumor cells†.
Q42562736Transforming growth factor-beta 1 (TGF-beta1) induces angiogenesis through vascular endothelial growth factor (VEGF)-mediated apoptosis
Q50104779Transforming growth factor-β in stem cells and tissue homeostasis
Q34704214Treatment of retinopathy of prematurity: a review of conventional and promising new therapeutic options
Q35786008Tumor growth of FGF or VEGF transfected MCF-7 breast carcinoma cells correlates with density of specific microvessels independent of the transfected angiogenic factor
Q38988571Tumor targeting RGD conjugated bio-reducible polymer for VEGF siRNA expressing plasmid delivery
Q73787163Two distinct signalling pathways are involved in FGF2-stimulated proliferation of choriocapillary endothelial cells: a comparative study with VEGF
Q33989013Ultrastructural immunolocalization of basic fibroblast growth factor in endothelial cells: morphologic evidence for unconventional secretion of a novel protein
Q91893478Up-regulation of pro-angiogenic pathways and induction of neovascularization by an acute retinal light damage
Q37004659VEGF Trap(R1R2) suppresses experimental corneal angiogenesis.
Q28375509VEGF expression in an osteoblast-like cell line is regulated by a hypoxia response mechanism
Q48358455VEGF expression is developmentally regulated during human brain angiogenesis
Q35768578VEGF, a prosurvival factor, acts in concert with TGF-beta1 to induce endothelial cell apoptosis
Q58765708VEGF-A/VEGFR-2 and FGF-2/FGFR-1 but not PDGF-BB/PDGFR-β play important roles in promoting immature and inflammatory intraplaque angiogenesis
Q52601468Vascular endothelial growth factor (VEGF-A) and fibroblast growth factor (FGF-2) as potential regulators of seasonal reproductive processes in male European bison (Bison bonasus, Linnaeus 1758).
Q52767251Vascular endothelial growth factor causally contributes to the angiogenic response upon ultraviolet B irradiation in vivo.
Q42130349Vascular endothelial growth factor expression and vascular density in oral squamous cell carcinoma (OSCC): A study on clinical and histopathologic significance
Q44319020Vascular endothelial growth factor increases the migration and proliferation of smooth muscle cells through the mediation of growth factors released by endothelial cells
Q35087955Vascular endothelial growth factor localization in the adult.
Q43850088Vascular endothelial growth factor modulates neutrophil transendothelial migration via up-regulation of interleukin-8 in human brain microvascular endothelial cells
Q47429370Vascular endothelial growth factor synthesis by human omental mesothelial cells is augmented by fibroblast growth factor-2: possible role of mesothelial cell on the development of peritoneal metastasis
Q36807993Vascular endothelial-cadherin stimulates syndecan-1-coupled insulin-like growth factor-1 receptor and cross-talk between αVβ3 integrin and vascular endothelial growth factor receptor 2 at the onset of endothelial cell dissemination during angiogenes
Q50773041Vascular leakage in chick embryos after expression of a secreted binding protein for fibroblast growth factors.
Q33292668Vasculogenic mimicry by bone marrow macrophages in patients with multiple myeloma.
Q59400995Xueshuantong Injection (Lyophilized) Attenuates Cerebral Ischemia/Reperfusion Injury by the Activation of Nrf2–VEGF Pathway
Q38712092Zebrafish Caudal Haematopoietic Embryonic Stromal Tissue (CHEST) Cells Support Haematopoiesis
Q54600919[Advanced research of fibroblast growth factor receptor in non-small cell lung cancer].
Q53677535[Angiogenic factors in external auditory canal cholesteatoma-fibroblast cell culture].
Q83775208[Antiangiogenic treatment for neovascular glaucoma and after filtering surgery]
Q40083516alpha-Tocopheryl succinate inhibits angiogenesis by disrupting paracrine FGF2 signalling
Q36429702c-fos-induced growth factor/vascular endothelial growth factor D induces angiogenesis in vivo and in vitro.
Q95847957siVEGF-loaded nanoparticle uptake by tumor-associated vascular endothelial cells for hepatocellular carcinoma

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