The right place at the right time: chaperoning core histone variants

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The right place at the right time: chaperoning core histone variants is …
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scholarly articleQ13442814

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P356DOI10.15252/EMBR.201540840
P932PMC publication ID4641499
P698PubMed publication ID26459557

P50authorKarolin LugerQ6373153
Sheena D'ArcyQ56992242
P2093author name stringFrancesca Mattiroli
P2860cites workCrystal structure of the nucleosome core particle at 2.8 A resolutionQ22122355
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Histone variant H2A.Bbd is associated with active transcription and mRNA processing in human cellsQ24293198
Structure of human nucleosome containing the testis-specific histone variant TSH2BQ24293590
Dimerization of the CENP-A assembly factor HJURP is required for centromeric nucleosome depositionQ24295179
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Dynamics of histone H3 deposition in vivo reveal a nucleosome gap-filling mechanism for H3.3 to maintain chromatin integrity.Q51543312
Regions of variant histone His2AvD required for Drosophila development.Q52571223
Histone H2A.Z inheritance during the cell cycle and its impact on promoter organization and dynamics.Q53138242
Chromosome-wide nucleosome replacement and H3.3 incorporation during mammalian meiotic sex chromosome inactivation.Q53576128
Expression and prognostic significance of centromere protein A in human lung adenocarcinoma.Q54312442
Histone macroH2A isoforms predict the risk of lung cancer recurrenceQ57263888
HJURP Involvement in De Novo CenH3CENP-A and CENP-C RecruitmentQ57898678
The essential histone variant H2A.Z regulates the equilibrium between different chromatin conformational statesQ77649147
Histone H2A.Z prepares the prostate specific antigen (PSA) gene for androgen receptor-mediated transcription and is upregulated in a model of prostate cancer progressionQ82357114
Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURPQ24299299
Structures of human nucleosomes containing major histone H3 variantsQ24305314
Nucleosome assembly by a complex of CAF-1 and acetylated histones H3/H4Q24313176
H3.3/H2A.Z double variant-containing nucleosomes mark 'nucleosome-free regions' of active promoters and other regulatory regionsQ24317641
Centromere-specific assembly of CENP-a nucleosomes is mediated by HJURP.Q24321321
HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeresQ24321377
ANP32E is a histone chaperone that removes H2A.Z from chromatinQ24323053
The macro domain is an ADP-ribose binding moduleQ24529134
Preferential occupancy of histone variant H2AZ at inactive promoters influences local histone modifications and chromatin remodelingQ24535638
Concerted and birth-and-death evolution of multigene familiesQ24544285
Nucleosomes containing the histone variant H2A.Bbd organize only 118 base pairs of DNAQ24563396
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomasQ24629777
A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatinQ24801790
Every amino acid matters: essential contributions of histone variants to mammalian development and diseaseQ27008522
Chromosomes. CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere.Q27331790
Crystal structure of a nucleosome core particle containing the variant histone H2A.ZQ27628748
Structure of the yeast histone H3-ASF1 interaction: implications for chaperone mechanism, species-specific interactions, and epigeneticsQ27640732
NMR structure of chaperone Chz1 complexed with histones H2A.Z-H2BQ27651273
The nucleosomal core histone octamer at 3.1 A resolution: a tripartite protein assembly and a left-handed superhelixQ27655585
Structural basis for recognition of centromere histone variant CenH3 by the chaperone Scm3Q27667279
Recognition of the centromere-specific histone Cse4 by the chaperone Scm3Q27667962
Crystal structure of the human centromeric nucleosome containing CENP-AQ27670750
Structure of the variant histone H3.3–H4 heterodimer in complex with its chaperone DAXXQ27675056
A Conserved Mechanism for Centromeric Nucleosome Recognition by Centromere Protein CENP-CQ27678426
The Catalytic Subunit of the SWR1 Remodeler Is a Histone Chaperone for the H2A.Z-H2B DimerQ27681627
Anp32e, a higher eukaryotic histone chaperone directs preferential recognition for H2A.ZQ27682061
Structural basis of histone H2A-H2B recognition by the essential chaperone FACTQ27684683
High-resolution profiling of histone methylations in the human genomeQ27860906
ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complexQ27929959
Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sitesQ27931488
Replication-independent histone deposition by the HIR complex and Asf1.Q27931963
Scm3, an essential Saccharomyces cerevisiae centromere protein required for G2/M progression and Cse4 localizationQ27932322
Stepwise Histone Replacement by SWR1 Requires Dual Activation with Histone H2A.Z and Canonical NucleosomeQ27932939
Chz1, a nuclear chaperone for histone H2AZ.Q27933271
A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1.Q27933672
Histone variant H2A.Z marks the 5' ends of both active and inactive genes in euchromatinQ27935829
Nonhistone Scm3 and histones CenH3-H4 assemble the core of centromere-specific nucleosomesQ27936719
DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domainQ27937364
Scm3 is essential to recruit the histone h3 variant cse4 to centromeres and to maintain a functional kinetochoreQ27939322
Cse4 is part of an octameric nucleosome in budding yeastQ27939957
ATRX interacts with H3.3 in maintaining telomere structural integrity in pluripotent embryonic stem cellsQ28114801
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139Q28131715
Overexpression and mistargeting of centromere protein-A in human primary colorectal cancerQ28184405
H2AX: the histone guardian of the genomeQ28274279
Histone macroH2A1 is concentrated in the inactive X chromosome of female mammalsQ28274301
Histone variants--ancient wrap artists of the epigenomeQ28274796
Distinct factors control histone variant H3.3 localization at specific genomic regionsQ28275277
DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumorsQ28303693
Tetrameric structure of centromeric nucleosomes in interphase Drosophila cellsQ28469268
Genomic instability in mice lacking histone H2AXQ28589826
DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognitionQ28658254
Dynamic regulation of nucleosome positioning in the human genomeQ29615046
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastomaQ29616862
The histone variant H3.3 marks active chromatin by replication-independent nucleosome assemblyQ29618256
The RCAF complex mediates chromatin assembly during DNA replication and repairQ29620048
A two-step mechanism for epigenetic specification of centromere identity and functionQ30405362
In vitro centromere and kinetochore assembly on defined chromatin templates.Q30427862
HJURP is a CENP-A chromatin assembly factor sufficient to form a functional de novo kinetochoreQ30428662
Nap1 and Chz1 have separate Htz1 nuclear import and assembly functionsQ30433388
Chromatin assembly at kinetochores is uncoupled from DNA replicationQ30442008
CAL1 is the Drosophila CENP-A assembly factorQ30570646
The Histone Database: a comprehensive resource for histones and histone fold-containing proteinsQ33229210
Histone variants: emerging players in cancer biologyQ33630867
HJURP binds CENP-A via a highly conserved N-terminal domain and mediates its deposition at centromeresQ33667469
H2A.Bbd: an X-chromosome-encoded histone involved in mammalian spermiogenesisQ33760193
Nucleosome stability mediated by histone variants H3.3 and H2A.Z.Q35840889
Towards a mechanism for histone chaperonesQ35861914
Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complexQ35878397
p21 transcription is regulated by differential localization of histone H2A.Z.Q35917048
Stepwise assembly of chromatin during DNA replication in vitroQ35923880
DNA repair factor APLF is a histone chaperoneQ36238038
Centromere protein-A, an essential centromere protein, is a prognostic marker for relapse in estrogen receptor-positive breast cancerQ36245350
The basic linker of macroH2A stabilizes DNA at the entry/exit site of the nucleosomeQ36280768
Topography of the histone octamer surface: repeating structural motifs utilized in the docking of nucleosomal DNAQ36657548
Cell-cycle-dependent structural transitions in the human CENP-A nucleosome in vivoQ36669215
Genomic analysis of estrogen cascade reveals histone variant H2A.Z associated with breast cancer progressionQ36671809
CENP-A confers a reduction in height on octameric nucleosomesQ36912565
Histone H2A.Z is essential for estrogen receptor signalingQ37247116
Nucleosome-free region dominates histone acetylation in targeting SWR1 to promoters for H2A.Z replacementQ37274135
Genome-wide dynamics of Htz1, a histone H2A variant that poises repressed/basal promoters for activation through histone lossQ37458741
The budding yeast Centromere DNA Element II wraps a stable Cse4 hemisome in either orientation in vivoQ37698353
Reconciling the positive and negative roles of histone H2A.Z in gene transcriptionQ37723982
The chaperone-histone partnership: for the greater good of histone traffic and chromatin plasticityQ37952956
The role of the nucleosome acidic patch in modulating higher order chromatin structureQ38085143
Mechanisms and functions of ATP-dependent chromatin-remodeling enzymesQ38126255
Structural biology-based insights into combinatorial readout and crosstalk among epigenetic marksQ38205661
Histone chaperones: assisting histone traffic and nucleosome dynamicsQ38218235
Placing the HIRA histone chaperone complex in the chromatin landscape.Q38607892
Removal of H2A.Z by INO80 promotes homologous recombinationQ38856752
Phosphorylation and DNA binding of HJURP determine its centromeric recruitment and function in CenH3(CENP-A) loadingQ38977427
Mislocalization of the centromeric histone variant CenH3/CENP-A in human cells depends on the chaperone DAXX.Q39023712
Transcription recovery after DNA damage requires chromatin priming by the H3.3 histone chaperone HIRA.Q39090477
FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16.Q39992783
Activation of Holliday junction recognizing protein involved in the chromosomal stability and immortality of cancer cellsQ40083781
Reconstitution of chromatin: assembly of the nucleosomeQ40572714
The histone chaperone Nap1 promotes nucleosome assembly by eliminating nonnucleosomal histone DNA interactionsQ40889167
Chromatin assembly coupled to DNA repair: a new role for chromatin assembly factor I.Q41166774
CENP-A K124 Ubiquitylation Is Required for CENP-A Deposition at the CentromereQ41333170
Cell-cycle-coupled structural oscillation of centromeric nucleosomes in yeastQ41811815
Transcriptional and developmental functions of the H3.3 histone variant in DrosophilaQ41960228
Partitioning of histone H3-H4 tetramers during DNA replication-dependent chromatin assemblyQ43111741
Centromere identity maintained by nucleosomes assembled with histone H3 containing the CENP-A targeting domainQ46132923
Evolution of histone H3: emergence of variants and conservation of post-translational modification sites.Q47266768
A retroviral gene trap insertion into the histone 3.3A gene causes partial neonatal lethality, stunted growth, neuromuscular deficits and male sub-fertility in transgenic miceQ47912968
Dynamic phosphorylation of CENP-A at Ser68 orchestrates its cell-cycle-dependent deposition at centromeresQ48392345
Imaging the fate of histone Cse4 reveals de novo replacement in S phase and subsequent stable residence at centromeresQ33795322
The expression level of HJURP has an independent prognostic impact and predicts the sensitivity to radiotherapy in breast cancerQ33889488
Structural characterization of the histone variant macroH2A.Q33925060
Dual recognition of CENP-A nucleosomes is required for centromere assemblyQ33950286
Automodification switches PARP-1 function from chromatin architectural protein to histone chaperoneQ34144527
Histone variants in metazoan developmentQ34149623
Altered telomeres in tumors with ATRX and DAXX mutationsQ34196696
QKI-mediated alternative splicing of the histone variant MacroH2A1 regulates cancer cell proliferationQ34208257
Structural basis for the histone chaperone activity of Asf1Q34312157
The octamer is the major form of CENP-A nucleosomes at human centromeresQ34342975
Chaperone Nap1 shields histone surfaces used in a nucleosome and can put H2A-H2B in an unconventional tetrameric form.Q34366314
A network of players in H3 histone variant deposition and maintenance at centromeresQ34390431
Purification and characterization of CAF-I, a human cell factor required for chromatin assembly during DNA replication in vitroQ34451628
MacroH2A1.1 and PARP-1 cooperate to regulate transcription by promoting CBP-mediated H2B acetylationQ34458110
Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomesQ34516925
Histone chaperones in nucleosome assembly and human diseaseQ34647041
The histone variant macroH2A suppresses melanoma progression through regulation of CDK8.Q34676833
The nucleosome surface regulates chromatin compaction and couples it with transcriptional repressionQ34707393
Histone mRNA expression: multiple levels of cell cycle regulation and important developmental consequencesQ35021205
Structure and Scm3-mediated assembly of budding yeast centromeric nucleosomesQ35038924
Mislocalization of the Drosophila centromere-specific histone CID promotes formation of functional ectopic kinetochoresQ35335808
Phylogenomics of the nucleosomeQ35570334
Structural transitions of centromeric chromatin regulate the cell cycle-dependent recruitment of CENP-NQ35635462
Acetylation of H2A.Z is a key epigenetic modification associated with gene deregulation and epigenetic remodeling in cancerQ35694399
The Histone Chaperones FACT and Spt6 Restrict H2A.Z from Intragenic LocationsQ35762777
Histone chaperone Anp32e removes H2A.Z from DNA double-strand breaks and promotes nucleosome reorganization and DNA repairQ35764396
P433issue11
P921main subjectmolecular chaperonesQ422496
P304page(s)1454-1466
P577publication date2015-10-12
P1433published inEMBO ReportsQ5323356
P1476titleThe right place at the right time: chaperoning core histone variants
P478volume16

Reverse relations

cites work (P2860)
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