A nuclear export signal in Kap95p is required for both recycling the import factor and interaction with the nucleoporin GLFG repeat regions of Nup116p and Nup100p

scientific article

A nuclear export signal in Kap95p is required for both recycling the import factor and interaction with the nucleoporin GLFG repeat regions of Nup116p and Nup100p is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1083/JCB.137.4.797
P932PMC publication ID2139834
P698PubMed publication ID9151683
P5875ResearchGate publication ID14066242

P2093author name stringS R Wente
M K Iovine
P2860cites workA nuclear export signal in hnRNP A1: a signal-mediated, temperature-dependent nuclear protein export pathwayQ24309825
The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complexQ24316128
Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62Q24317417
Identification of hSRP1 alpha as a functional receptor for nuclear localization sequencesQ24318457
Sequence and characterization of cytoplasmic nuclear protein import factor p97Q24318868
Two different subunits of importin cooperate to recognize nuclear localization signals and bind them to the nuclear envelopeQ24320769
Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteinsQ24321880
A human nucleoporin-like protein that specifically interacts with HIV RevQ24322635
Identification of different roles for RanGDP and RanGTP in nuclear protein importQ24561933
Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporinsQ24563707
Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexesQ24563814
Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 RevQ24568152
Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathwayQ24568233
Nuclear protein import: Ran-GTP dissociates the karyopherin alphabeta heterodimer by displacing alpha from an overlapping binding site on betaQ24617416
Isolation of the yeast nuclear pore complexQ24651185
Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteinsQ24671748
Transformation of intact yeast cells treated with alkali cationsQ24672708
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiaeQ27860636
A novel genetic system to detect protein-protein interactionsQ27860915
NUP145 encodes a novel yeast glycine-leucine-phenylalanine-glycine (GLFG) nucleoporin required for nuclear envelope structureQ27930563
The GLFG repetitive region of the nucleoporin Nup116p interacts with Kap95p, an essential yeast nuclear import factorQ27931303
Kap104p: a karyopherin involved in the nuclear transport of messenger RNA binding proteinsQ27932702
Nup120p: a yeast nucleoporin required for NPC distribution and mRNA transportQ27932741
GLE2, a Saccharomyces cerevisiae homologue of the Schizosaccharomyces pombe export factor RAE1, is required for nuclear pore complex structure and functionQ27933501
Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeastQ27933981
Identification of a yeast karyopherin heterodimer that targets import substrate to mammalian nuclear pore complexesQ27934056
A new family of yeast nuclear pore complex proteinsQ27934086
Nup145p is required for nuclear export of mRNA and binds homopolymeric RNA in vitro via a novel conserved motifQ27934225
Functional interaction of Nic96p with a core nucleoporin complex consisting of Nsp1p, Nup49p and a novel protein Nup57pQ27934383
Defining the essential functional regions of the nucleoporin Nup145p.Q27935376
Purification of NSP1 reveals complex formation with ‘GLFG’ nucleoporins and a novel nuclear pore protein NIC96Q27937202
The essential yeast nucleoporin NUP159 is located on the cytoplasmic side of the nuclear pore complex and serves in karyopherin-mediated binding of transport substrateQ27937661
Characterization of nuclear localizing sequences derived from yeast ribosomal protein L29.Q27939511
The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAsQ28131708
Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporinsQ28131733
Isolation of a protein that is essential for the first step of nuclear protein importQ28243173
Ran binding domains promote the interaction of Ran with p97/beta-karyopherin, linking the docking and translocation steps of nuclear importQ28274296
Nucleocytoplasmic transportQ28275907
A G protein involved in nucleocytoplasmic transport: the role of RanQ28286483
HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAsQ28289718
Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporinsQ28573887
The HIV-1 Rev trans-activator shuttles between the nucleus and the cytoplasmQ28646841
Identification of a signal for rapid export of proteins from the nucleusQ29547742
Identification and characterization of a nuclear pore complex proteinQ29616069
An RNA-export mediator with an essential nuclear export signalQ29617266
Regulation of the yeast HO geneQ29618279
A temperature-sensitive NUP116 null mutant forms a nuclear envelope seal over the yeast nuclear pore complex thereby blocking nucleocytoplasmic trafficQ29618710
Shuttling of pre-mRNA binding proteins between nucleus and cytoplasmQ29618907
Distinct functions for the two importin subunits in nuclear protein importQ29620112
The GTP-binding protein Ran/TC4 is required for protein import into the nucleusQ29620192
Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factorQ29620193
Nuclear protein import in permeabilized mammalian cells requires soluble cytoplasmic factorsQ29620194
Cytosolic proteins that specifically bind nuclear location signals are receptors for nuclear importQ29620195
Components of the yeast spindle and spindle pole bodyQ29620925
Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelopeQ29622845
The yeast nuclear import receptor is required for mitosisQ33995362
Nuclear import can be separated into distinct steps in vitro: nuclear pore binding and translocationQ34175285
An N-ethylmaleimide-sensitive cytosolic factor necessary for nuclear protein import: requirement in signal-mediated binding to the nuclear poreQ36222719
Reconstituted nuclei depleted of a vertebrate GLFG nuclear pore protein, p97, import but are defective in nuclear growth and replicationQ36235386
Dynamic localization of the nuclear import receptor and its interactions with transport factorsQ36237107
RanBP1 stabilizes the interaction of Ran with p97 nuclear protein importQ36237637
GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein importQ36685432
Nucleotide-specific interaction of Ran/TC4 with nuclear transport factors NTF2 and p97.Q37432537
The nuclear transport factor karyopherin beta binds stoichiometrically to Ran-GTP and inhibits the Ran GTPase activating proteinQ38360627
Characterization of an essential Orc2p-associated factor that plays a role in DNA replicationQ40018637
Nucleocytoplasmic transport: factors and mechanismsQ40403309
Nuclear export signals and the fast track to the cytoplasmQ40459787
Mechanisms of nuclear protein import.Q40475438
Cytosolic factors in nuclear transport: what's importin?Q40655599
In vivo evidence for involvement of a 58 kDa component of nuclear pore-targeting complex in nuclear protein importQ40788934
A karyophilic protein forms a stable complex with cytoplasmic components prior to nuclear pore bindingQ41350466
Role of the nuclear transport factor p10 in nuclear importQ48064951
The nuclear pore‐targeting complex binds to nuclear pores after association with a karyophileQ48072038
The two steps of nuclear import, targeting to the nuclear envelope and translocation through the nuclear pore, require different cytosolic factorsQ49486533
Nuclear protein migration involves two steps: rapid binding at the nuclear envelope followed by slower translocation through nuclear poresQ70378768
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)797-811
P577publication date1997-05-01
P1433published inJournal of Cell BiologyQ1524550
P1476titleA nuclear export signal in Kap95p is required for both recycling the import factor and interaction with the nucleoporin GLFG repeat regions of Nup116p and Nup100p
P478volume137

Reverse relations

cites work (P2860)
Q39318117A subset of FG-nucleoporins is necessary for efficient Msn5-mediated nuclear protein export
Q27937963Accelerating the rate of disassembly of karyopherin.cargo complexes
Q33964950Assembly and preferential localization of Nup116p on the cytoplasmic face of the nuclear pore complex by interaction with Nup82p
Q27931219Binding of the Mex67p/Mtr2p heterodimer to FXFG, GLFG, and FG repeat nucleoporins is essential for nuclear mRNA export.
Q36376892Calcineurin-dependent nuclear import of the transcription factor Crz1p requires Nmd5p
Q37813021Controlling Subcellular Delivery to Optimize Therapeutic Effect
Q36592228Controlling protein compartmentalization to overcome disease
Q77323192Cse1p functions as the nuclear export receptor for importin alpha in yeast
Q39576650Cse1p is involved in export of yeast importin alpha from the nucleus
Q27939696Exportin 1 (Crm1p) is an essential nuclear export factor
Q27933306Facilitated transport and diffusion take distinct spatial routes through the nuclear pore complex
Q36932768Functional characterization of a Nup159p-containing nuclear pore subcomplex
Q47926605Functions of the GTPase Ran in RNA export from the nucleus
Q24310348GLFG and FxFG nucleoporins bind to overlapping sites on importin-beta
Q28143781GTP hydrolysis links initiation and termination of nuclear import on the nucleoporin nup358
Q36816824Inhibition of mRNA export in vertebrate cells by nuclear export signal conjugates
Q27937378Interactions between a nuclear transporter and a subset of nuclear pore complex proteins depend on Ran GTPase
Q27933578Karyopherin-mediated import of integral inner nuclear membrane proteins
Q47721363Karyopherins and kissing cousins
Q24683280Major binding sites for the nuclear import receptor are the internal nucleoporin Nup153 and the adjacent nuclear filament protein Tpr
Q27931250Minimal nuclear pore complexes define FG repeat domains essential for transport
Q27931616Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Npl3p
Q24291848Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export
Q24644057Npp106p, a Schizosaccharomyces pombe nucleoporin similar to Saccharomyces cerevisiae Nic96p, functionally interacts with Rae1p in mRNA export
Q42792243Nuclear envelope irregularity is induced by RET/PTC during interphase
Q74084072Nuclear localization of the Saccharomyces cerevisiae HMG protein NHP6A occurs by a Ran-independent nonclassical pathway
Q27934517Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores.
Q27933063Nup116p and nup100p are interchangeable through a conserved motif which constitutes a docking site for the mRNA transport factor gle2p.
Q73763113Nup116p associates with the Nup82p-Nsp1p-Nup159p nucleoporin complex
Q27931388Nup2p, a yeast nucleoporin, functions in bidirectional transport of importin alpha
Q56687975Peering through the Pore
Q42715997Purification of the vertebrate nuclear pore complex by biochemical criteria
Q41075696Ran-unassisted nuclear migration of a 97-kD component of nuclear pore-targeting complex
Q24644181RanGTP-mediated nuclear export of karyopherin alpha involves its interaction with the nucleoporin Nup153
Q37477637Reconstitution of HIV-1 rev nuclear export: independent requirements for nuclear import and export
Q33937097Regulation of nuclear import and export.
Q52545634Role of importin-beta in the control of nuclear envelope assembly by Ran.
Q44792760Separate nuclear import pathways converge on the nucleoporin Nup153 and can be dissected with dominant-negative inhibitors
Q57809839Septin-associated proteins Aim44 and Nis1 traffic between the bud neck and the nucleus in the yeast Saccharomyces cerevisiae
Q37325778Simple rules for passive diffusion through the nuclear pore complex.
Q41980902Size-dependent leak of soluble and membrane proteins through the yeast nuclear pore complex
Q27931940Specific binding of the karyopherin Kap121p to a subunit of the nuclear pore complex containing Nup53p, Nup59p, and Nup170p.
Q27625995Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear trafficking
Q28283466The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review
Q27935647The GLFG regions of Nup116p and Nup100p serve as binding sites for both Kap95p and Mex67p at the nuclear pore complex
Q41173696The Ty1 integrase protein can exploit the classical nuclear protein import machinery for entry into the nucleus
Q24323008The human homologue of Saccharomyces cerevisiae Gle1p is required for poly(A)+ RNA export
Q28254641The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export
Q27939968The integral membrane protein snl1p is genetically linked to yeast nuclear pore complex function
Q27938827The karyopherin Kap95 regulates nuclear pore complex assembly into intact nuclear envelopes in vivo
Q77304445The nuclear pore complex
Q33912881The nuclear pore complex: a protein machine bridging the nucleus and cytoplasm
Q27939919The yeast hnRNP-Like proteins Yra1p and Yra2p participate in mRNA export through interaction with Mex67p
Q27934181The yeast nucleoporin rip1p contributes to multiple export pathways with no essential role for its FG-repeat region.
Q29615611Transport into and out of the nucleus
Q47926615Transport routes through the nuclear pore complex
Q25257693Yeast phosphatidylinositol 4-kinase, Pik1, has essential roles at the Golgi and in the nucleus
Q40975251beta-subunit of nuclear pore-targeting complex (importin-beta) can be exported from the nucleus in a Ran-independent manner

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