Chronic centrosome amplification without tumorigenesis

scientific article

Chronic centrosome amplification without tumorigenesis is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2015PNAS..112E6321V
P356DOI10.1073/PNAS.1519388112
P932PMC publication ID4655534
P698PubMed publication ID26578792
P5875ResearchGate publication ID283509984

P50authorElaine FuchsQ516846
Don W. ClevelandQ24004784
Benjamin VitreQ42809378
Lino TessarolloQ67472644
P2093author name stringYin Wang
Sylvia M Evans
Jihane Boubaker
Deborah A Swing
Andrew J Holland
Anita Kulukian
Ofer Shoshani
Marcus Maldonado
Maretoshi Hirai
Thomas Cho
P2860cites workThe Polo kinase Plk4 functions in centriole duplicationQ24292705
Centrosome amplification drives chromosomal instability in breast tumor developmentQ24534950
RNA-dependent integrin alpha3 protein localization regulated by the Muscleblind-like protein MLP1Q24647775
p19Arf suppresses growth, progression, and metastasis of Hras-driven carcinomas through p53-dependent and -independent pathwaysQ24799059
Centrosomes, chromosome instability (CIN) and aneuploidyQ26865035
p53 protects against genome instability following centriole duplication failureQ27310018
Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cellsQ27345177
A new mathematical model for relative quantification in real-time RT-PCRQ27860781
Generalized lacZ expression with the ROSA26 Cre reporter strainQ27860837
Centrioles, centrosomes, and cilia in health and diseaseQ29615173
A mechanism linking extra centrosomes to chromosomal instabilityQ29617923
Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cellsQ29617924
Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouseQ29620355
Persistent telomere damage induces bypass of mitosis and tetraploidyQ30494078
Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesisQ30514031
Oncogene-like induction of cellular invasion from centrosome amplificationQ30580976
Loss of heterozygosity frequency at the Trp53 locus in p53-deficient (+/-) mouse tumors is carcinogen-and tissue-dependentQ31835388
The ploidy conveyor of mature hepatocytes as a source of genetic variation.Q34259413
Abnormal centrosome amplification in the absence of p53.Q34374717
'Green mice' as a source of ubiquitous green cells.Q34428099
SAK/PLK4 is required for centriole duplication and flagella developmentQ34472675
Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4.Q34474551
Mechanisms of procentriole formationQ34795065
A clinical overview of centrosome amplification in human cancersQ35479894
Multi-stage chemical carcinogenesis in mouse skin: fundamentals and applicationsQ35542147
The magical touch: genome targeting in epidermal stem cells induced by tamoxifen application to mouse skinQ35555290
Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice.Q35600328
Overexpressing centriole-replication proteins in vivo induces centriole overduplication and de novo formation.Q35830134
Cytokinetic Failure-induced Tetraploidy Develops into Aneuploidy, Triggering Skin Aging in Phosphovimentin-deficient MiceQ35860907
Epidermal development, growth control, and homeostasis in the face of centrosome amplificationQ36305968
The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycleQ36496562
Centrosome amplification can initiate tumorigenesis in flies.Q37123357
Boveri revisited: chromosomal instability, aneuploidy and tumorigenesisQ37527786
The causes and consequences of polyploidy in normal development and cancerQ37908119
Moesin is a major regulator of centrosome behavior in epithelial cells with extra centrosomesQ39254368
The C. elegans zyg-1 gene encodes a regulator of centrosome duplication with distinct maternal and paternal roles in the embryoQ39750041
Centrosome aberrations in chronic myeloid leukemia correlate with stage of disease and chromosomal instabilityQ40427115
Centrosome amplification causes microcephalyQ41932064
p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylationQ44853379
Somatic mutation of p53 leads to estrogen receptor alpha-positive and -negative mouse mammary tumors with high frequency of metastasisQ46557073
A role for endothelial NO synthase in LTP revealed by adenovirus-mediated inhibition and rescue.Q46933897
Centrosome dysfunction in Drosophila neural stem cells causes tumors that are not due to genome instabilityQ49037799
Epiblast-restricted Cre expression in MORE mice: a tool to distinguish embryonic vs. extra-embryonic gene function.Q52169994
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.Q52544495
Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instabilityQ72130906
Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomasQ73154777
Correlation between centrosome abnormalities and chromosomal instability in human pancreatic cancer cellsQ73852548
P4510describes a project that usesImageJQ1659584
P433issue46
P407language of work or nameEnglishQ1860
P304page(s)E6321-30
P577publication date2015-11-02
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleChronic centrosome amplification without tumorigenesis
P478volume112

Reverse relations

cites work (P2860)
Q47248840Building the right centriole for each cell type
Q41968646Cdk1 Phosphorylates Drosophila Sas-4 to Recruit Polo to Daughter Centrioles and Convert Them to Centrosomes.
Q38798554Centrosomal clustering contributes to chromosomal instability and cancer.
Q38993086Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals
Q92763230Centrosome Amplification and Tumorigenesis: Cause or Effect?
Q58132668Centrosome aberrations and chromosome instability contribute to tumorigenesis and intra-tumor heterogeneity
Q64950616Centrosome amplification disrupts renal development and causes cystogenesis.
Q38780267Centrosome amplification: a suspect in breast cancer and racial disparities
Q93064621Centrosome loss results in an unstable genome and malignant prostate tumors
Q92265592Cep131 overexpression promotes centrosome amplification and colon cancer progression by regulating Plk4 stability
Q90318091Cytokinesis defects and cancer
Q39363632Dividing with Extra Centrosomes: A Double Edged Sword for Cancer Cells.
Q38929880Emerging links among Chromosome Instability (CIN), cancer, and aging
Q36305968Epidermal development, growth control, and homeostasis in the face of centrosome amplification
Q98513690FAM46C/TENT5C functions as a tumor suppressor through inhibition of Plk4 activity
Q47140345HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development
Q57292651Inactivation of PLK4-STIL Module Prevents Self-Renewal and Triggers p53-Dependent Differentiation in Human Pluripotent Stem Cells
Q39044653Living in CIN: Mitotic Infidelity and Its Consequences for Tumor Promotion and Suppression
Q49831825Once and only once: mechanisms of centriole duplication and their deregulation in disease
Q47368506PLK4: a link between centriole biogenesis and cancer
Q33654342Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1.
Q57115037Targeting the cell cycle in breast cancer: towards the next phase
Q91823882The Emerging Link between Centrosome Aberrations and Metastasis
Q37618954The PIDDosome activates p53 in response to supernumerary centrosomes
Q64056446The emerging links between chromosomal instability (CIN), metastasis, inflammation and tumour immunity
Q88866802The impact of mitotic errors on cell proliferation and tumorigenesis
Q99571918p53 is not required for cell death and tumor suppression caused by high chromosomal instability

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