Haplotypes of the endothelial protein C receptor (EPCR) gene are not associated with severe malaria in Tanzania

scientific article

Haplotypes of the endothelial protein C receptor (EPCR) gene are not associated with severe malaria in Tanzania is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1025983789
P356DOI10.1186/S12936-015-1007-6
P932PMC publication ID4666078
P698PubMed publication ID26620701
P5875ResearchGate publication ID285392501

P50authorIb C BygbjergQ40444031
Louise TurnerQ43240630
Thor G. TheanderQ54802168
Michael AlifrangisQ54802182
Christian W. WangQ55182133
Helle H HanssonQ56418835
Thomas LavstsenQ80377133
Bruno P MmbandoQ85689358
John LusinguQ90228924
P2093author name stringSamwel Gesase
Daniel T R Minja
Line Møller
P2860cites workActivated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotectiveQ24293646
Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptorQ24323189
Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT): an open-label, randomised trialQ24630683
Protein C anticoagulant and cytoprotective pathwaysQ26999113
Structural and functional implications of the intron/exon organization of the human endothelial cell protein C/activated protein C receptor (EPCR) gene: comparison with the structure of CD1/major histocompatibility complex alpha1 and alpha2 domainsQ28139081
Characterization of protein C receptor expression in monocytesQ28204704
The cytoprotective protein C pathwayQ28274500
Gaps in the childhood malaria burden in Africa: cerebral malaria, neurological sequelae, anemia, respiratory distress, hypoglycemia, and complications of pregnancyQ30681939
A progressive declining in the burden of malaria in north-eastern TanzaniaQ34060866
Plasmodium falciparum erythrocyte membrane protein 1 domain cassettes 8 and 13 are associated with severe malaria in childrenQ34276755
Severe malaria is associated with parasite binding to endothelial protein C receptorQ34348881
Structural conservation despite huge sequence diversity allows EPCR binding by the PfEMP1 family implicated in severe childhood malariaQ34452432
Human genetic polymorphisms in the Knops blood group are not associated with a protective advantage against Plasmodium falciparum malaria in Southern GhanaQ34481349
Levels of plasma immunoglobulin G with specificity against the cysteine-rich interdomain regions of a semiconserved Plasmodium falciparum erythrocyte membrane protein 1, VAR4, predict protection against malarial anemia and febrile episodesQ34601747
Endothelial protein C receptor gene variants not associated with severe malaria in ghanaian childrenQ35534205
Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African childrenQ37065724
The endothelial cell protein C receptor augments protein C activation by the thrombin-thrombomodulin complex.Q37331775
Association of the endothelial protein C receptor (PROCR) rs867186-G allele with protection from severe malariaQ37731569
Protein C anticoagulant system--anti-inflammatory effectsQ37913122
The endothelial cell protein C receptor: cell surface conductor of cytoprotective coagulation factor signaling.Q37942050
Modulation of monocyte function by activated protein C, a natural anticoagulantQ40247922
The Ser219-->Gly dimorphism of the endothelial protein C receptor contributes to the higher soluble protein levels observed in individuals with the A3 haplotypeQ40330593
High plasma levels of soluble endothelial protein C receptor are associated with increased mortality among children with cerebral malaria in BeninQ41647824
Circulating endothelial cell protein C receptor: endothelial regulation and cumulative impact of gender and A3 haplotypeQ42483140
Activated protein C alters cytosolic calcium flux in human brain endothelium via binding to endothelial protein C receptor and activation of protease activated receptor-1.Q44315236
Expression and function of the endothelial protein C receptor in human neutrophilsQ44417143
First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African childrenQ46182948
Contribution of polymorphisms in the endothelial protein C receptor gene to soluble endothelial protein C receptor and circulating activated protein C levels, and thrombotic risk.Q50889046
The endothelial cell protein C receptor. Inhibition of activated protein C anticoagulant function without modulation of reaction with proteinase inhibitorsQ71144269
The endothelial cell protein C receptor. Cell surface expression and direct ligand binding by the soluble receptorQ71144272
Characterization of dysfunctional protein S-Tokushima (K155-->E) in relation to the molecular interactions required for the regulation of blood coagulationQ73252112
A haplotype of the EPCR gene is associated with increased plasma levels of sEPCR and is a candidate risk factor for thrombosisQ79202743
Haplotypes of the EPCR gene, plasma sEPCR levels and the risk of deep venous thrombosisQ80435690
Haplotypes of the EPCR gene, prothrombin levels, and the risk of venous thrombosis in carriers of the prothrombin G20210A mutationQ81057638
Influence of the 4600A/G and 4678G/C polymorphisms in the endothelial protein C receptor (EPCR) gene on the risk of venous thromboembolism in carriers of factor V LeidenQ81094216
P921main subjectTanzaniaQ924
malariaQ12156
endotheliumQ111140
P304page(s)474
P577publication date2015-12-01
P1433published inMalaria JournalQ15749954
P1476titleHaplotypes of the endothelial protein C receptor (EPCR) gene are not associated with severe malaria in Tanzania
P478volume14

Reverse relations

cites work (P2860)
Q90176965Association of EPCR Polymorphism rs867186-GG With Severity of Human Malaria
Q90341629Cerebral Plasmodium falciparum malaria: The role of PfEMP1 in its pathogenesis and immunity, and PfEMP1-based vaccines to prevent it
Q50095537Natural and vaccine-induced acquisition of cross-reactive IgG inhibiting ICAM-1-specific binding of a PfEMP1 subtype associated specifically with cerebral malaria
Q37370672Plasma Ang2 and ADAM17 levels are elevated during clinical malaria; Ang2 level correlates with severity and expression of EPCR-binding PfEMP1.
Q36965217The endothelial protein C receptor rs867186-GG genotype is associated with increased soluble EPCR and could mediate protection against severe malaria

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