Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes

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Galectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes is …
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scholarly articleQ13442814

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P356DOI10.1084/JEM.185.10.1851
P932PMC publication ID2196320
P698PubMed publication ID9151710
P5875ResearchGate publication ID273559074

P2093author name stringJ T Nguyen
C H Uittenbogaart
L G Baum
N L Perillo
P2860cites workGalectins. Structure and function of a large family of animal lectinsQ28246794
p53 is required for radiation-induced apoptosis in mouse thymocytesQ29620281
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Induction of a retinoblastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosisQ33879990
Bclx regulates the survival of double-positive thymocytesQ34261390
Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28Q36362727
Human thymic epithelial cells express an endogenous lectin, galectin-1, which binds to core 2 O-glycans on thymocytes and T lymphoblastoid cellsQ36364533
p53 prevents maturation to the CD4+CD8+ stage of thymocyte differentiation in the absence of T cell receptor rearrangement.Q36366527
Molecular cloning, characterization, and expression of a human 14-kDa lectinQ36416851
Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.Q37355656
Cell death via apoptosis and its relationship to growth, development and differentiation of both tumour and normal cellsQ37992854
Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes.Q38321834
Overexpression of a beta-galactoside binding protein causes transformation of BALB3T3 fibroblast cellsQ38333726
The S-type lectin from calf heart tissue binds selectively to the carbohydrate chains of lamininQ38339692
Specificity of binding of three soluble rat lung lectins to substituted and unsubstituted mammalian beta-galactosidesQ38350646
Thymic emigration: conveyor belts or lucky dips?Q40475281
Selective events in T cell developmentQ40661180
Positive selection of lymphocytesQ40807424
Adhesive interactions in thymic development: does selective expression of CD45 isoforms promote stage-specific microclustering in the assembly of functional adhesive complexes on differentiating T lineage lymphocytes?Q40878182
Cellular interactions in thymocyte development.Q41039662
Rescue of thymocytes and T cell hybridomas from glucocorticoid-induced apoptosis by stimulation via the T cell receptor/CD3 complex: a possiblein vitro model for positive selection of the T cell repertoireQ41152049
Cellular and biochemical requirements for thymocyte negative selectionQ41214764
Thymic stromal cells in culture. I. Establishment and characterization of a line which is cytotoxic for normal thymocytes and produces hematopoietic growth factor(s).Q41686479
LAMP-1 in CHO cells is a primary carrier of poly-N-acetyllactosamine chains and is bound preferentially by a mammalian S-type lectinQ41709873
Establishment of a murine thymic epithelial cell line capable of inducing both thymic nurse cell formation and thymocyte apoptosisQ41748706
Studies on T cell maturation on defined thymic stromal cell populations in vitroQ42034172
Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitroQ42136342
Precursors of CD3+CD4+CD8+ cells in the human thymus are defined by expression of CD34. Delineation of early events in human thymic developmentQ42941830
Regulation of pre-T cell receptor (pT alpha-TCR beta) gene expression during human thymic development.Q42943666
Recombinant human β-galactoside binding lectin suppresses clinical and histological signs of experimental autoimmune encephalomyelitisQ43820997
Role of TCR specificity in CD4 versus CD8 lineage commitment.Q46082518
Two signals are required for negative selection of CD4+CD8+ thymocytesQ46168371
Apoptosis of T cells mediated by galectin-1.Q46356564
Thymocyte apoptosis induced by p53-dependent and independent pathways.Q54242475
A death in the life of p53Q59062854
T-cell apoptosis detected in situ during positive and negative selection in the thymusQ59087078
Tolerance induction by clonal deletion of CD4+8+ thymocytes in vitro does not require dedicated antigen-presenting cellsQ61454446
Expression of the Bcl-2 protein in murine and human thymocytes and in peripheral T lymphocytesQ61716209
Programmed T lymphocyte death. Cell activation- and steroid-induced pathways are mutually antagonisticQ68163837
Delimitation of the proliferative stages in the human thymus indicates that cell expansion occurs before the expression of CD3 (T cell receptor)Q70522097
Prevention and therapy with electrolectin of experimental autoimmune myasthenia gravis in rabbitsQ71763169
Tissue fibronectin is an endogenous ligand for galectin-1Q72310370
CD69 cell surface expression identifies developing thymocytes which audition for T cell antigen receptor-mediated positive selectionQ72658265
Normal development of mice carrying a null mutation in the gene encoding the L14 S-type lectinQ72770432
The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agentsQ72800599
Interleukin-7 promotes the generation of phenotypically mature CD45RA positive human thymocytes in vitroQ72838727
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectthymocyteQ7799635
apoptotic processQ14599311
P304page(s)1851-1858
P577publication date1997-05-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleGalectin-1, an endogenous lectin produced by thymic epithelial cells, induces apoptosis of human thymocytes
P478volume185

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