Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects

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Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects is …
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scholarly articleQ13442814

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P356DOI10.1084/JEM.186.7.1041
P932PMC publication ID2199068
P698PubMed publication ID9314553
P5875ResearchGate publication ID13907034

P50authorRoderick FlowerQ7356612
Lina LimQ73741775
Mauro PerrettiQ60976463
P2093author name stringA L Salzman
C Szabó
S Cuzzocrea
B Zingarelli
S J Getting
P2860cites workInteraction between neutrophil-derived elastase and reactive oxygen species in cartilage degradationQ70631366
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Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitriteQ71089423
Evidence of peroxynitrite involvement in the carrageenan-induced rat paw edemaQ71546642
Mobilizing lipocortin 1 in adherent human leukocytes downregulates their transmigrationQ71739795
Leukocyte transmigration, but not rolling or adhesion, is selectively inhibited by dexamethasone in the hamster post-capillary venule. Involvement of endogenous lipocortin 1Q71848072
Molecular determinants of lipid mediator-induced leukocyte adherence and emigration in rat mesenteric venulesQ72370042
Poly(ADP-ribose) polymerase: early involvement in glutamate-induced neurotoxicity in cultured cerebellar granule cellsQ72374996
Role of nitric oxide in a nonseptic shock model induced by zymosan in the ratQ73371424
Screens for anti-inflammatory drugsQ93700979
Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin diseaseQ28298870
Molecular mechanisms of leukocyte recruitment in the inflammatory processQ30469636
Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferaseQ34340947
Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscleQ35960752
Poly(ADP-ribose) polymerase enhances activator-dependent transcription in vitroQ36035454
Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitriteQ37370840
DNA strand breakage, activation of poly (ADP-ribose) synthetase, and cellular energy depletion are involved in the cytotoxicity of macrophages and smooth muscle cells exposed to peroxynitriteQ37700756
Mechanisms of oxidant injury of cellsQ37781539
H2O2 and Tumor Necrosis Factor-α Activate Intercellular Adhesion Molecule 1 (ICAM-1) Gene Transcription through Distinct cis-Regulatory Elements within the ICAM-1 PromoterQ38292712
Neutrophil-mediated tissue injury and its modulation.Q40550415
The microcirculation and inflammation: modulation of leukocyte-endothelial cell adhesion.Q40752165
Common pathway of endothelial-leukocyte interaction in shock, ischemia, and reperfusionQ40779406
Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotideQ40922454
Mediators of injury and inflammationQ41004733
Peroxynitrite causes energy depletion and increases permeability via activation of poly (ADP-ribose) synthetase in pulmonary epithelial cellsQ41130890
Modification of growth related enzymatic pathways and apparent loss of tumorigenicity of a ras-transformed bovine endothelial cell line by treatment with 5-iodo-6-amino-1,2-benzopyrone (INH2BP).Q41230111
Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicityQ41488356
Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammationQ41827670
Inhibition of neutrophil and monocyte recruitment by endogenous and exogenous lipocortin 1.Q41890683
Evidence that endogenous interleukin-1 is involved in leukocyte migration in acute experimental inflammation in rats and miceQ45303701
Inactivation of the poly(ADP-ribose) polymerase gene affects oxygen radical and nitric oxide toxicity in islet cells.Q54172665
Nitric oxide toxicity in islet cells involves poly(ADP-ribose) polymerase activation and concomitant NAD+ depletion.Q64882857
Lipid peroxidation, protein thiol oxidation and DNA damage in hydrogen peroxide-induced injury to endothelial cells: role of activation of poly(ADP-ribose)polymeraseQ67990314
Neutrophil enzyme activities in carrageenan-induced inflammation in ratsQ69356550
Neutrophil function and lipid peroxidation in a rat model of multiple organ failureQ69360237
Multiple-organ failure and sepsis without bacteria. An experimental modelQ69563681
Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardiumQ70106808
Polymorphonuclear leukocyte collagenase in carrageenin-induced inflammation: effect of nonsteroidal antiinflammatory drugsQ70146173
Pathway to carrageenan-induced inflammation in the hind limb of the ratQ70321562
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectneutrophil recruitmentQ106615276
P304page(s)1041-1049
P577publication date1997-10-01
P1433published inJournal of Experimental MedicineQ3186912
P1476titleInhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effects
P478volume186

Reverse relations

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