Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury

scientific article

Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1016/S0014-2999(01)01175-X
P698PubMed publication ID11525764

P50authorRussel J ReiterQ89645924
P2093author name stringCuzzocrea S
P2860cites workRegulation of prostaglandin production in carrageenan-induced pleurisy by melatoninQ78139312
Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxideQ29547245
Superoxide radical and superoxide dismutasesQ29614204
Nitric oxide as a secretory product of mammalian cellsQ29620372
NMDA receptors increase OH radicals in vivo by using nitric oxide synthase and protein kinase C.Q30463806
Reduction of MPP(+)-induced hydroxyl radical formation and nigrostriatal MPTP toxicity by inhibiting nitric oxide synthase.Q30463956
The oxidant/antioxidant network: role of melatoninQ33543307
Copper, zinc superoxide dismutase catalyzes hydroxyl radical production from hydrogen peroxideQ33657113
Selective regulation of cellular cyclooxygenase by dexamethasone and endotoxin in miceQ34262516
A review of the evidence supporting melatonin's role as an antioxidantQ34312720
Melatonin: a peroxyl radical scavenger more effective than vitamin E.Q34323905
Melatonin, hydroxyl radical-mediated oxidative damage, and aging: a hypothesisQ34335212
Evaluation of the antioxidant activity of melatonin in vitroQ34401507
Nitric oxide: a mediator in rat tubular hypoxia/reoxygenation injuryQ35067646
Peroxynitrite decomposition catalysts: therapeutics for peroxynitrite-mediated pathologyQ35933719
Inhibition of the activity of poly(ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscleQ35960752
Peroxynitrite induces both vasodilatation and impaired vascular relaxation in the isolated perfused rat heartQ35980011
Protection against peroxynitrite-induced fibroblast injury and arthritis development by inhibition of poly(ADP-ribose) synthaseQ36011589
Inhibition of poly (ADP-ribose) synthetase attenuates neutrophil recruitment and exerts antiinflammatory effectsQ36380660
Exploratory laser flash photolysis study of free radical reactions and magnetic field effects in melatonin chemistry.Q36817571
Prostaglandin endoperoxide synthase: regulation of enzyme expressionQ37335647
Melatonin: the chemical expression of darknessQ37443826
Mechanisms of oxidant injury of cellsQ37781539
Free radicals and antioxidants in sepsis.Q38568109
Down's syndrome: a pathology involving the lack of balance of reactive oxygen speciesQ39485617
Mechanisms of lipid peroxidationQ39843060
The Pineal and Its Hormones in the Control of Reproduction in Mammals*Q40124874
Nitric oxide: role in neurotoxicityQ40403994
New insights into the mode of action of anti-inflammatory drugsQ40476391
The significance of the metabolism of the neurohormone melatonin: antioxidative protection and formation of bioactive substancesQ40796347
Cellular defenses against damage from reactive oxygen speciesQ40808542
Free radicals as mediators of tissue injury and diseaseQ40895574
Functional aspects of the pineal hormone melatonin in combating cell and tissue damage induced by free radicalsQ40992973
Melatonin is a scavenger of peroxynitriteQ41140748
Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicityQ41488356
Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice.Q41664189
Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammationQ41827670
Drug modulation of antigen-induced paw oedema in guinea-pigs: effects of lipopolysaccharide, tumour necrosis factor and leucocyte depletionQ41884742
Involvement of superoxide and xanthine oxidase in neutrophil-independent rat gastric damage induced by NO donorsQ41921333
Evidence for nitric oxide-mediated oxidative damage in chronic inflammation. Nitrotyrosine in serum and synovial fluid from rheumatoid patientsQ42283943
Beneficial effects of Mn(III)tetrakis (4-benzoic acid) porphyrin (MnTBAP), a superoxide dismutase mimetic, in carrageenan-induced pleurisyQ42536751
Potent protective effect of melatonin on chromium(VI)-induced DNA single-strand breaks, cytotoxicity, and lipid peroxidation in primary cultures of rat hepatocytesQ42549059
Beneficial effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase in a rat model of splanchnic artery occlusion and reperfusionQ43173946
Beneficial effects of raxofelast (IRFI 016), a new hydrophilic vitamin E-like antioxidant, in carrageenan-induced pleurisyQ43188677
Production of nitric oxide and peroxynitrite in the lung during acute endotoxemia.Q43806157
Altered immune responses in mice lacking inducible nitric oxide synthaseQ44662136
Sustained inhibition of nitric oxide by NG-nitro-L-arginine improves myocardial function following ischemia/reperfusion in isolated perfused rat heartQ45083961
Free radical scavenging effects of melatonin and serotonin: possible mechanism.Q46189045
The importance of vitamin E in human nutritionQ46208753
Role of inducible nitric oxide synthase expression and peroxynitrite formation in guinea pig ileitisQ46575678
Mechanisms of nitric oxide-mediated neurotoxicity in primary brain culturesQ48281625
Superoxide and nitric oxide cooperation in hypoxia/reoxygenation-induced neuron injuryQ48316742
N-acetyl-serotonin (normelatonin) and melatonin protect neurons against oxidative challenges and suppress the activity of the transcription factor NF-kappaB.Q48485930
Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemiaQ48616927
Melatonin protects neurons from singlet oxygen-induced apoptosis.Q50761811
Vitamin E protects human skeletal muscle from damage during surgical ischemia-reperfusion.Q51546825
Endotoxin-induced oxidative stress in the rat small intestine: role of nitric oxide.Q54592867
Melatonin-A Highly Potent Endogenous Radical Scavenger and Electron Donor: New Aspects of the Oxidation Chemistry of this Indole Accessed in vitroaQ56212000
Scavenging of reactive oxygen species by melatoninQ64132511
Peroxynitrite formation from macrophage-derived nitric oxideQ67505344
Release of 15-hydroxy-5,8,11,13-eicosatetraenoic acid and cysteinyl-leukotrienes in carrageenin-induced inflammation: effect of non-steroidal anti-inflammatory drugsQ68263104
Anti-Shock Effects of Human Superoxide Dismutase in Splanchnic Artery Occlusion (SAO) ShockQ68441569
Phenyl-T-butyl-nitrone is active against traumatic shock in ratsQ68845719
Pharmacological demonstration of inflammatory mediators using experimental inflammatory models: rat pleurisy induced by carrageenin and phorbol myristate acetateQ69535584
H2O2-induced lipid peroxidation in rat brain homogenates is greatly reduced by melatoninQ70958064
Red-light-induced suppression of melatonin synthesis is mediated by N-methyl-D-aspartate receptor activation in retinally normal and retinally degenerate ratsQ70965497
Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide and peroxynitriteQ71089423
Melatonin as a therapeutic agent in experimental endotoxic shockQ71551522
Role of oxygen-derived metabolites in the rat gastric mucosal injury induced by nitric oxide donorsQ71572745
Induction of nitric oxide synthase and concomitant suppression of superoxide dismutases in experimental colitis in ratsQ71598244
Characterization of the antioxidant effects of melatonin and related indoleamines in vitroQ71605718
Melatonin reduces nitric oxide synthase activity in rat hypothalamusQ71605727
Nitric oxide, superoxide and peroxynitrite: putative mediators of NMDA-induced cell death in cerebellar granule cellsQ71611092
Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide SynthaseQ71647466
Physiological concentrations of melatonin inhibit nitric oxide synthase in rat cerebellumQ71661526
The role of free radicals in NMDA-dependent neurotoxicityQ71679694
Endotoxin triggers the expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in the rat aorta in vivoQ71691440
NMDA Receptor Activation Produces Concurrent Generation of Nitric Oxide and Reactive Oxygen Species: Implications for Cell DeathQ71832406
3-Nitropropionic acid neurotoxicity is attenuated in copper/zinc superoxide dismutase transgenic miceQ71894886
Desferrioxamine inhibition of the hydroxyl radical-like reactivity of peroxynitrite: Role of the hydroxamic groupsQ71958549
Poly(ADP‐Ribose) Synthetase Activation: An Early Indicator of Neurotoxic DNA DamageQ71978528
Poly(ADP-ribose) polymerase: early involvement in glutamate-induced neurotoxicity in cultured cerebellar granule cellsQ72374996
Endotoxin-stimulated nitric oxide production increases injury and reduces rat liver chemiluminescence during reperfusionQ72460791
Peroxynitrite-induced rat colitis--a new model of colonic inflammationQ72638580
The pineal hormone melatonin inhibits DNA-adduct formation induced by the chemical carcinogen safrole in vivoQ72828716
A nonpeptidyl mimic of superoxide dismutase with therapeutic activity in ratsQ73066471
Augmentation of indices of oxidative damage in life-long melatonin-deficient ratsQ73215103
Protective effect of melatonin in carrageenan-induced models of local inflammation: relationship to its inhibitory effect on nitric oxide production and its peroxynitrite scavenging activityQ73929017
Antiinflammatory effects of mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, in carrageenan-induced models of inflammationQ74075555
Peroxynitrite-mediated DNA strand breakage activates poly (ADP-ribose) synthetase and causes cellular energy depletion in carrageenan-induced pleurisyQ74425068
Protective effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthase in a carrageenan-induced model of local inflammationQ74449667
Protective effect of melatonin in a non-septic shock model induced by zymosan in the ratQ77051513
Alloxan acts as a prooxidant only under reducing conditions: influence of melatoninQ77401000
Prevention of immune dysfunction and vitamin E loss by dehydroepiandrosterone and melatonin supplementation during murine retrovirus infectionQ77419217
A novel melatonin metabolite, cyclic 3-hydroxymelatonin: a biomarker of in vivo hydroxyl radical generationQ77905838
P433issue1-2
P407language of work or nameEnglishQ1860
P921main subjectpharmacologyQ128406
melatoninQ180912
reperfusion injuryQ1413991
P304page(s)1-10
P577publication date2001-08-01
P1433published inEuropean Journal of PharmacologyQ1376712
P1476titlePharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury
P478volume426

Reverse relations

cites work (P2860)
Q44789810(-)-Epicatechin 3-O-gallate ameliorates the damages related to peroxynitrite production by mechanisms distinct from those of other free radical inhibitors
Q54367778A case-control study of melatonin receptor type 1A polymorphism and acute myocardial infarction in a Spanish population.
Q51515734A rapid and sensitive method for hydroxyl radical detection on a microfluidic chip using an N-doped porous carbon nanofiber modified pencil graphite electrode.
Q46692847Alleviation of maternal hyperthermia-induced early embryonic death by administration of melatonin to mice
Q46946118Alpha-lipoic acid protects against renal ischaemia-reperfusion injury in rats
Q44256911Amelioration of hepatic ischemia/reperfusion injury using indolepropionic acid
Q36790186Analysis of the mechanism by which melatonin inhibits human eosinophil peroxidase
Q34602426Beneficial effects of rutin and L-arginine coadministration in a rat model of liver ischemia-reperfusion injury.
Q34533540Clinical Pharmacokinetics of Antioxidants and Their Impact on Systemic Oxidative Stress
Q44026420Determination of melatonin in galenic preparations by LC and voltammetry
Q35640162Do solar cycles influence giant cell arteritis and rheumatoid arthritis incidence?
Q38560692Effects of aminoguanidine and melatonin on intestinal ischemia/reperfusion injury in rats: An assessor-blinded, controlled experimental study.
Q43136654Effects of caffeic acid phenethyl ester and melatonin on distraction osteogenesis: an experimental study
Q41904590Effects of melatonin on the expression of iNOS and COX-2 in rat models of colitis
Q36182062Free radical scavengers in anaesthesiology and critical care
Q46374561Glycyrrhizae Radix attenuates peroxynitrite-induced renal oxidative damage through inhibition of protein nitration
Q42242564Green Tea Polyphenols for the Protection against Renal Damage Caused by Oxidative Stress
Q46583445Green tea polyphenol extract attenuates ischemia/reperfusion injury of the gut.
Q48097088Hibernation-based blood loss therapy increases survivability of lethal hemorrhagic shock in rats
Q39241072Hydrogen-rich saline protects against ischemia/reperfusion injury in grafts after pancreas transplantations by reducing oxidative stress in rats
Q35008854Hydroxyl radical in living systems and its separation methods
Q35688862Lipopolysaccharide induces inducible nitric oxide synthase-dependent podocyte dysfunction via a hypoxia-inducible factor 1α and cell division control protein 42 and Ras-related C3 botulinum toxin substrate 1 pathway
Q35817388Melatonin Attenuates Oxidative Damage Induced by Acrylamide In Vitro and In Vivo
Q44558485Melatonin ameliorates oxidative organ damage induced by acute intra-abdominal compartment syndrome in rats.
Q44392612Melatonin and N-acetylcysteine have beneficial effects during hepatic ischemia and reperfusion
Q45955801Melatonin and its potential biological functions in the fruits of sweet cherry.
Q47098709Melatonin as an Anti-Inflammatory Agent Modulating Inflammasome Activation
Q50996967Melatonin counteracts the loss of agonist-evoked contraction of aortic rings induced by incubation.
Q47608127Melatonin expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic-acid-induced colitis in rats.
Q39377382Melatonin improves sleep in asthma: a randomized, double-blind, placebo-controlled study
Q46970991Melatonin inhibits free radical-mediated mitochondrial-dependent hepatocyte apoptosis and liver damage induced during malarial infection
Q44530232Melatonin protects against lipid peroxidation and membrane rigidity in erythrocytes from patients undergoing cardiopulmonary bypass surgery
Q44604272Melatonin protects against myocardial doxorubicin toxicity in rats: role of physiological concentrations
Q46742288Melatonin protects from the long-term consequences of a neonatal hypoxic-ischemic brain injury in rats
Q44275611Melatonin protects the central nervous system of rats against toluene-containing thinner intoxication by reducing reactive gliosis
Q24790971Melatonin reduces TNF-a induced expression of MAdCAM-1 via inhibition of NF-kappaB
Q37203835Melatonin reduces bacterial translocation and apoptosis in trinitrobenzene sulphonic acid-induced colitis of rats
Q28194026Melatonin: reducing the toxicity and increasing the efficacy of drugs
Q44187161Myocardial ischemia-reperfusion in rats: reduction of infarct size by either supplemental physiological or pharmacological doses of melatonin
Q38188467Novel therapeutic strategies for traumatic brain injury: acute antioxidant reinforcement
Q44744697Octreotide improves reperfusion-induced oxidative injury in acute abdominal hypertension in rats
Q44530217Orally administered melatonin reduces oxidative stress and proinflammatory cytokines induced by amyloid-beta peptide in rat brain: a comparative, in vivo study versus vitamin C and E.
Q37693921Pharmacological strategies against cold ischemia reperfusion injury
Q33657662Protective Effects of N-acetylcysteine and a Prostaglandin E1 Analog, Alprostadil, Against Hepatic Ischemia: Reperfusion Injury in Rats
Q46565400Protective effect of MESNA (2-mercaptoethane sulfonate) against hepatic ischemia/reperfusion injury in rats
Q46679535Protective effect of melatonin against ischemia/reperfusion-induced oxidative remote organ injury in the rat.
Q52578514Protective effect of melatonin in acetic acid induced colitis in rats.
Q46703459Protective effect of melatonin on Ca2+ homeostasis and contractility in acute cholecystitis
Q87320677Protective effect of melatonin on infrarenal aortic occlusion: this effect is related to anti-inflammatory effect and antioxidant effect
Q42167174Protective effects of Nigella sativa on the neuronal injury in frontal cortex and brain stem after chronic toluene exposure
Q46888694Protective effects of exogenously administered or endogenously produced melatonin on hyperbaric oxygen-induced oxidative stress in the rat brain
Q44489328Protective effects of melatonin, vitamin E and N-acetylcysteine against acetaminophen toxicity in mice: a comparative study
Q43265106Protective effects of pycnogenol against ischemia reperfusion-induced oxidative renal injury in rats
Q42710741Quercetin treatment against ischemia/reperfusion injury in rat corpus cavernosum tissue: a role on apoptosis and oxidative stress.
Q46566164Seasonality of pineal gland activity and immune functions in chickens
Q37181164Standardized Extract of Bacopa monniera Attenuates Okadaic Acid Induced Memory Dysfunction in Rats: Effect on Nrf2 Pathway
Q38816026The antioxidative property of melatonin against brain ischemia
Q54449722The effect of melatonin on endotoxemia-induced intestinal apoptosis and oxidative stress in infant rats.
Q45085699The effect of melatonin on plasma oxidant-antioxidant skeletal muscle reperfusion injury in rats
Q50914431The transition from day-to-night activity is a risk factor for the development of CNS oxygen toxicity in the diurnal fat sand rat (Psammomys obesus).
Q35076749The utility of melatonin in reducing cerebral damage resulting from ischemia and reperfusion
Q30490890Time-of-day determines neuronal damage and mortality after cardiac arrest
Q26991796Tissue damage and oxidant/antioxidant balance
Q79722158Vitamin E and selenium supplementation reduces plasma cortisol and oxidative stress in dystocia-affected buffaloes
Q36021253When melatonin gets on your nerves: its beneficial actions in experimental models of stroke

Search more.