Bench to bedside: the quest for quality in experimental stroke research

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Bench to bedside: the quest for quality in experimental stroke research is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1038/SJ.JCBFM.9600298
P698PubMed publication ID16525413
P5875ResearchGate publication ID7253714

P50authorUlrich DirnaglQ27870042
P2860cites workSystematic evaluation and comparison of statistical tests for publication biasQ81455289
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Statins and strokeQ81623503
Why most published research findings are falseQ21092395
Sifting the evidence-what's wrong with significance tests?Q24524896
Where is the evidence that animal research benefits humans?Q24601393
Publication bias in situQ24801473
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Outcome reporting bias in randomized trials funded by the Canadian Institutes of Health ResearchQ28285027
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Prehospital and in-hospital delays in acute stroke careQ30652175
Beyond mismatch: evolving paradigms in imaging the ischemic penumbra with multimodal magnetic resonance imaging.Q30882783
The therapeutic value of nimodipine in experimental focal cerebral ischemia. Neurological outcome and histopathological findingsQ69065405
Effect sizes and p values: what should be reported and what should be replicated?Q71640170
Neurotransmitter systems involved in learning and memory in the rat: a meta-analysis based on studies of four behavioral tasksQ73187556
For ischemic brain damage, is preclinical evidence of neuroprotection by presynaptic blockade of glutamate release enough?Q73735489
Selective reporting biases in cancer prognostic factor studiesQ80395257
Publication bias and journals as policemenQ80872161
Magnetic resonance imaging in experimental models of brain disordersQ30885751
Pooling of animal experimental data reveals influence of study design and publication biasQ30918723
Mechanisms underlying recovery of motor function after strokeQ30978384
What has diffusion imaging in animals told us about diffusion imaging in patients with ischaemic stroke?Q30985886
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Recovery and rehabilitation in stroke: stem cellsQ31117918
Magnetic resonance imaging criteria for thrombolysis in acute cerebral infarct.Q33210344
Recommendations for standards regarding preclinical neuroprotective and restorative drug developmentQ33785562
Post-randomisation exclusions: the intention to treat principle and excluding patients from analysisQ33812064
Why do neuroprotective drugs work in animals but not humans?Q33887012
Nervous system reorganization following injuryQ34130225
Calcium antagonists for ischemic stroke: a systematic reviewQ34130838
Knockout mice: simple solutions to the problems of genetic background and flanking genesQ34134816
Practical aspects of experimental design in animal researchQ34155516
Emergency medicine animal research: does use of randomization and blinding affect the results?Q34202311
Recommendations for clinical trial evaluation of acute stroke therapies.Q34300670
Identifying outcome reporting bias in randomised trials on PubMed: review of publications and survey of authorsQ34389549
Nimodipine in animal model experiments of focal cerebral ischemia: a systematic reviewQ34392812
The role of leukocytes following cerebral ischemia: pathogenic variable or bystander reaction to emerging infarct?Q34481206
Does animal experimentation inform human healthcare? Observations from a systematic review of international animal experiments on fluid resuscitationQ34540924
Cell transplantation for strokeQ34805823
Systematic reviews of animal experimentsQ34871813
Why do neuroprotective drugs that are so promising in animals fail in the clinic? An industry perspectiveQ34941187
Animal models of focal and global cerebral ischemiaQ35090269
Models of focal cerebral ischemia in the nonhuman primateQ35090273
Mechanisms, challenges and opportunities in strokeQ35120144
Ischemic tolerance and endogenous neuroprotectionQ35126696
Design of future acute-stroke treatment trialsQ35172350
Treatment of neural injury with marrow stromal cellsQ35172499
Why have so many drugs with stellar results in laboratory stroke models failed in clinical trials? A theory based on allometric relationshipsQ35174559
Animal models of stroke: do they have value for discovering neuroprotective agents?Q35198028
Meta-analysis of the effects of endothelin receptor blockade on survival in experimental heart failureQ35570391
Gene expression changes after focal stroke, traumatic brain and spinal cord injuriesQ35587077
The ischemic penumbra: identification, evolution and treatment conceptsQ35615678
Thrombolysis: from the experimental findings to the clinical practiceQ35615748
Neuroprotection in cerebral ischaemia: facts and fancies--the need for new approachesQ35615757
What have genetically engineered mice taught us about ischemic injury?Q35699533
Transplantation for strokeQ35772691
Lost in translation: taking neuroprotection from animal models to clinical trials.Q35832807
Pathophysiology of stroke: lessons from animal modelsQ35956294
Systematic review and meta-analysis of the efficacy of melatonin in experimental strokeQ35992930
Exciting, radical, suicidal: how brain cells die after strokeQ36002053
Systematic review and metaanalysis of the efficacy of FK506 in experimental strokeQ36036681
Neuroprotection for ischemic stroke: two decades of success and failureQ36045217
Cell therapy for strokeQ36045372
A systematic review of nitric oxide donors and L-arginine in experimental stroke; effects on infarct size and cerebral blood flow.Q36083655
Nitric oxide synthase inhibitors in experimental ischemic stroke and their effects on infarct size and cerebral blood flow: a systematic review.Q36182005
Central nervous system injury-induced immune deficiency syndromeQ36257627
Methodological quality of animal studies on neuroprotection in focal cerebral ischaemiaQ36260781
Design and statistical methods in studies using animal models of developmentQ36359731
Empirical assessment of effect of publication bias on meta-analyses.Q38630464
Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemiaQ39133981
Neuroprotection by neuregulin-1 following focal stroke is associated with the attenuation of ischemia-induced pro-inflammatory and stress gene expressionQ40397153
The past is the future: innovative designs in acute stroke therapy trialsQ40424628
Stroke units: the next 10 yearsQ40523795
Knockout miceQ40966754
Transgenic and knockout mice in the study of neurodegenerative diseasesQ41143203
Does effect of a neuroprotective agent on volume of experimental animal cerebral infarct predict effect of the agent on clinical outcome in human stroke?Q41643160
Issues in experimental design and endpoint analysis in the study of experimental cytotoxic agents in vivo in breast cancer and other models.Q41710325
Ten year follow-up of a randomised controlled trial of care in a stroke rehabilitation unitQ42130289
Surveying the literature from animal experiments: systematic review and meta-analysis are important contributionsQ43068321
Stroke unit treatment. 10-year follow-upQ43579028
Local Cerebral Blood Flow and Vascular Reactivity in a Chronic Stable Stroke in BaboonsQ48442721
Can statistics cause brain damage?Q48740885
Use of animal models has not contributed to development of acute stroke therapies: pro.Q48788244
Use of animal models has not contributed to development of acute stroke therapies: con.Q48788262
Pre- and post-treatment with MK-801 but not pretreatment alone reduces neocortical damage after focal cerebral ischemia in the rat.Q48897841
Have randomized controlled trials of neuroprotective drugs been underpowered? An illustration of three statistical principles.Q48960167
Clinical trials in acute stroke: why have they not been successful?Q51501002
Using knockout and transgenic mice to study neurophysiology and behavior.Q51990334
Principles: the need for better experimental design.Q52012369
The use of predicted confidence intervals when planning experiments and the misuse of power when interpreting results.Q52373114
Integrated transcriptional profiling and linkage analysis for identification of genes underlying disease.Q52940189
Stroke neuroimaging.Q53659622
Tissue plasminogen activator reduces neurological damage after cerebral embolism.Q53986915
Intravenous thrombolysis with recombinant tissue plasminogen activator for acute hemispheric stroke. The European Cooperative Acute Stroke Study (ECASS)Q55063586
Ischemia and StrokeQ56969358
Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemiaQ68927696
P433issue12
P304page(s)1465-1478
P577publication date2006-03-08
P1433published inJournal of Cerebral Blood Flow & MetabolismQ14663525
P1476titleBench to bedside: the quest for quality in experimental stroke research
P478volume26

Reverse relations

cites work (P2860)
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