| scholarly article | Q13442814 |
| P356 | DOI | 10.1586/ERC.11.34 |
| P953 | full work available online at | http://www.future-drugs.com/doi/abs/10.1586/erc.11.34 |
| http://www.tandfonline.com/doi/pdf/10.1586/erc.11.34 | ||
| P698 | PubMed publication ID | 21517728 |
| P50 | author | Michael Tymianski | Q91271778 |
| P2093 | author name string | Douglas James Cook | |
| P2860 | cites work | Specific coupling of NMDA receptor activation to nitric oxide neurotoxicity by PSD-95 protein | Q22009972 |
| Heart Disease and Stroke Statistics--2010 Update: A Report From the American Heart Association | Q22306345 | ||
| Rodent models of focal stroke: size, mechanism, and purpose | Q24529165 | ||
| A modified transorbital baboon model of reperfused stroke | Q28139594 | ||
| Reversible middle cerebral artery occlusion without craniectomy in rats | Q28268048 | ||
| NXY-059 for acute ischemic stroke | Q28296316 | ||
| Update of the stroke therapy academic industry roundtable preclinical recommendations | Q29615508 | ||
| 1,026 experimental treatments in acute stroke | Q29615509 | ||
| What are surrogate outcome measures and why do they fail in clinical research? | Q30304060 | ||
| Brain, Mind and Language Functional Architectures | Q30479255 | ||
| Pooling of animal experimental data reveals influence of study design and publication bias | Q30918723 | ||
| A modified transorbital baboon model of reperfused stroke | Q30927285 | ||
| Extending reperfusion therapy for acute ischemic stroke: emerging pharmacological, mechanical, and imaging strategies. | Q31006678 | ||
| Glucose deprivation induces mitochondrial dysfunction and oxidative stress in PC12 cell line. | Q33187153 | ||
| The use of propidium iodide to assess excitotoxic neuronal death in primary mixed cortical cultures | Q33321806 | ||
| Trends in acute ischemic stroke trials through the 20th century | Q46087072 | ||
| Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials | Q46202446 | ||
| Ginsenoside Rb1 reduces neurodegeneration in the peri-infarct area of a thromboembolic stroke model in non-human primates | Q46619596 | ||
| NXY-059 for the treatment of acute stroke: pooled analysis of the SAINT I and II Trials | Q46680379 | ||
| NMDA receptors mediate calcium accumulation in myelin during chemical ischaemia | Q46863665 | ||
| NXY-059: a hopeful sign in the treatment of stroke | Q47590519 | ||
| AMPA receptor mediated excitotoxicity in neocortical neurons is developmentally regulated and dependent upon receptor desensitization. | Q47794810 | ||
| Combination drug therapy and mild hypothermia: a promising treatment strategy for reversible, focal cerebral ischemia | Q48121979 | ||
| Neuroimaging and histopathological evaluation of delayed neurological damage produced by artificial occlusion of the middle cerebral artery in Cynomolgus monkeys: establishment of a monkey model for delayed cerebral ischemia | Q48123852 | ||
| Experimental stroke in gerbils: effect on translation and transcription | Q48138884 | ||
| Serial MRI, functional recovery, and long-term infarct maturation in a non-human primate model of stroke | Q48184297 | ||
| Combined oxygen and glucose deprivation in cortical cell culture: calcium-dependent and calcium-independent mechanisms of neuronal injury | Q48244677 | ||
| Paw-reaching, sensorimotor, and rotational behavior after brain infarction in rats | Q48270063 | ||
| Experimental acute thrombotic stroke in baboons | Q48278183 | ||
| Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for detection and quantification of experimental cerebral infarction in rats | Q48285430 | ||
| An improved functional neurological examination for use in nonhuman primate studies of focal reperfused cerebral ischemia | Q48314626 | ||
| Translational research: moving discovery to practice | Q48333022 | ||
| Therapeutic time window of tacrolimus (FK506) in a nonhuman primate stroke model: comparison with tissue plasminogen activator | Q48337857 | ||
| Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination | Q48347152 | ||
| New light on white matter | Q48392877 | ||
| Preclinical evaluation of the neuroprotective effect of soluble complement receptor type 1 in a nonhuman primate model of reperfused stroke | Q48396079 | ||
| Local Cerebral Blood Flow and Vascular Reactivity in a Chronic Stable Stroke in Baboons | Q48442721 | ||
| HuEP5C7 as a humanized monoclonal anti-E/P-selectin neurovascular protective strategy in a blinded placebo-controlled trial of nonhuman primate stroke | Q48446087 | ||
| Ischemic thresholds for gray and white matter: a diffusion and perfusion magnetic resonance study | Q48598653 | ||
| Middle cerebral artery occlusion in Macaca fascicularis: acute and chronic stroke evolution | Q48607203 | ||
| Optimal outcome measures for detecting clinical benefits of early reperfusion: insights from the DEFUSE Study. | Q45010761 | ||
| Fetal striatal allografts reverse cognitive deficits in a primate model of Huntington disease | Q45296323 | ||
| Cerebrovascular disease and dementia: a primate model of hypertension and cognition. | Q45930662 | ||
| Acute stroke therapy with tissue plasminogen activator (tPA) since it was approved by the U.S. Food and Drug Administration (FDA). | Q45950966 | ||
| Mechanism of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction. | Q46066087 | ||
| Patterns of cognitive decline in aged rhesus monkeys. | Q48641404 | ||
| Preserved learning in monkeys with medial temporal lesions: sparing of motor and cognitive skills | Q48687575 | ||
| The existence and evolution of diffusion-perfusion mismatched tissue in white and gray matter after acute stroke | Q48777694 | ||
| Characterization of a novel thrombotic middle cerebral artery occlusion model in monkeys that exhibits progressive hypoperfusion and robust cortical infarction | Q48870935 | ||
| Mechanisms of H+ and Na+ changes induced by glutamate, kainate, and D-aspartate in rat hippocampal astrocytes. | Q48938350 | ||
| Experimental thromboembolic stroke in cynomolgus monkey | Q49048442 | ||
| Quantitative measurement of neuronal degeneration in organotypic hippocampal cultures after combined oxygen/glucose deprivation | Q50762869 | ||
| Impairment in abstraction and set shifting in aged rhesus monkeys. | Q52008789 | ||
| Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach | Q52920486 | ||
| A Comparison of Long-Term Functional Outcome After 2 Middle Cerebral Artery Occlusion Models in Rats | Q52935689 | ||
| A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. II. Volume of distribution and mean residence time | Q52963243 | ||
| Glutamate neurotoxicity in cortical cell culture | Q54412952 | ||
| PDZ Protein Interactions Underlying NMDA Receptor-Mediated Excitotoxicity and Neuroprotection by PSD-95 Inhibitors | Q57083899 | ||
| EPITHET | Q58619127 | ||
| Rat middle cerebral artery occlusion: Correlations between histopathology, T2-weighted magnetic resonance imaging, and behavioral indices | Q58856660 | ||
| Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia | Q68927696 | ||
| PC12 pheochromocytoma cells: culture, nerve growth factor treatment, and experimental exploitation | Q69429380 | ||
| Experimental primate stroke model | Q69498306 | ||
| The beneficial effect of intracarotid urokinase on acute stroke in a baboon model | Q69581231 | ||
| Selective lenticulostriate occlusion in the primate. A highly focal cerebral ischemia model | Q70988041 | ||
| Changes of relaxation times (T1, T2) and apparent diffusion coefficient after permanent middle cerebral artery occlusion in the rat: temporal evolution, regional extent, and comparison with histology | Q70995064 | ||
| Acute NMR changes during MCA occlusion: a preliminary study in primates | Q71696783 | ||
| Thresholds in cerebral ischemia - the ischemic penumbra | Q72913488 | ||
| T2-weighted MRI correlates with long-term histopathology, neurology scores, and skilled motor behavior in a rat stroke model | Q74233367 | ||
| Heterogeneity of stroke pathophysiology and neuroprotective clinical trial design | Q74254030 | ||
| NXY-059 for the treatment of acute ischemic stroke | Q80768385 | ||
| Intraarterial reteplase and intravenous abciximab for treatment of acute ischemic stroke. A preliminary feasibility and safety study in a non-human primate model | Q81311780 | ||
| Acute studies of a new primate model of reversible middle cerebral artery occlusion | Q81370995 | ||
| Pre-clinical evaluation of an sLe x-glycosylated complement inhibitory protein in a non-human primate model of reperfused stroke | Q81537095 | ||
| Translational medicine for stroke drug discovery: the pharmaceutical industry perspective | Q82876207 | ||
| Effects of intra-arterial urokinase on a non-human primate thromboembolic stroke model | Q82974222 | ||
| Stroke outcomes | Q95822113 | ||
| Rodent models of focal cerebral ischemia: procedural pitfalls and translational problems | Q33647103 | ||
| A new model of cortical stroke in the rhesus macaque. | Q33689444 | ||
| Drug development for stroke: importance of protecting cerebral white matter | Q33709233 | ||
| Pharmacological approaches to stroke recovery | Q33726573 | ||
| Recommendations for standards regarding preclinical neuroprotective and restorative drug development | Q33785562 | ||
| Calcium, ischemia and excitotoxicity. | Q34099560 | ||
| Glutamate receptors, neurotoxicity and neurodegeneration | Q34103957 | ||
| Permanent or transient chronic ischemic stroke in the non-human primate: behavioral, neuroimaging, histological, and immunohistochemical investigations | Q34170787 | ||
| Different strokes for different folks: the rich diversity of animal models of focal cerebral ischemia | Q34171291 | ||
| Unit activity in prefrontal cortex during delayed-response performance: neuronal correlates of transient memory | Q34203998 | ||
| Cognitive and behavioral assessment in experimental stroke research: will it prove useful? | Q34303605 | ||
| The rise and fall of NMDA antagonists for ischemic stroke. | Q34307201 | ||
| Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials | Q34617625 | ||
| Toward wisdom from failure: lessons from neuroprotective stroke trials and new therapeutic directions | Q34770260 | ||
| Neuroprotective gene therapy against acute neurological insults | Q35038275 | ||
| Clinical issues in animal models of stroke and rehabilitation | Q35090267 | ||
| Models of focal cerebral ischemia in the nonhuman primate | Q35090273 | ||
| Assessment of cognitive and motor deficits in a marmoset model of stroke | Q35090292 | ||
| A squirrel monkey model of poststroke motor recovery | Q35090295 | ||
| Why have so many drugs with stellar results in laboratory stroke models failed in clinical trials? A theory based on allometric relationships | Q35174559 | ||
| Evaluation of MCAO stroke models in normotensive rats: standardized neocortical infarction by the 3VO technique | Q35190725 | ||
| Stroke in the female: role of biological sex and estrogen | Q35757557 | ||
| Lost in translation: taking neuroprotection from animal models to clinical trials. | Q35832807 | ||
| Primate phylogeny: molecular evidence from retroposons | Q35951329 | ||
| Pathophysiology of stroke: lessons from animal models | Q35956294 | ||
| Nitrone-related therapeutics: potential of NXY-059 for the treatment of acute ischaemic stroke | Q35974043 | ||
| Mechanisms of neural cell death: implications for development of neuroprotective treatment strategies | Q36045199 | ||
| Neuroprotection for ischemic stroke: two decades of success and failure | Q36045217 | ||
| Organotypic cultures as tools for functional screening in the CNS. | Q36196841 | ||
| Organotypic hippocampal slice cultures for studies of brain damage, neuroprotection and neurorepair | Q36230555 | ||
| Organotypic hippocampal slice cultures: a model system to study basic cellular and molecular mechanisms of neuronal cell death, neuroprotection, and synaptic plasticity | Q36346042 | ||
| Bench to bedside: the quest for quality in experimental stroke research | Q36416843 | ||
| A critical appraisal of the NXY-059 neuroprotection studies for acute stroke: a need for more rigorous testing of neuroprotective agents in animal models of stroke | Q36780257 | ||
| Cell-cell signaling in the neurovascular unit | Q36801092 | ||
| Missing steps in the STAIR case: a Translational Medicine perspective on the development of NXY-059 for treatment of acute ischemic stroke | Q36853648 | ||
| Combination treatment for acute ischemic stroke: A ray of Hope? | Q36951411 | ||
| Neuroprotection does not work! | Q37059566 | ||
| Combined neuroprotective modalities coupled with thrombolysis in acute ischemic stroke: a pilot study of caffeinol and mild hypothermia | Q37168996 | ||
| Do in vivo experimental models reflect human cerebral small vessel disease? A systematic review. | Q37242444 | ||
| Good laboratory practice: preventing introduction of bias at the bench | Q37243686 | ||
| Relationships between infarct growth, clinical outcome, and early recanalization in diffusion and perfusion imaging for understanding stroke evolution (DEFUSE) | Q37252669 | ||
| Efficacy and safety of tissue plasminogen activator 3 to 4.5 hours after acute ischemic stroke: a metaanalysis. | Q37301824 | ||
| The development of stroke therapeutics: promising mechanisms and translational challenges | Q37325124 | ||
| Combination therapy with hypothermia for treatment of cerebral ischemia | Q37392817 | ||
| MAP2 immunostaining in thick sections for early ischemic stroke infarct volume in non-human primate brain | Q37415108 | ||
| In vivo gene regulation using tetracycline-regulatable systems | Q37460085 | ||
| Optimal definition for PWI/DWI mismatch in acute ischemic stroke patients | Q37701383 | ||
| Functional assessments in the rodent stroke model | Q37774041 | ||
| Bioethical considerations in translational research: primate stroke | Q38450837 | ||
| Rodent models of cerebral ischemia | Q38735687 | ||
| Cortical evoked potential and extracellular K+ and H+ at critical levels of brain ischemia | Q39133981 | ||
| Comparison of two blood-brain barrier in vitro systems: cytotoxicity and transfer assessments of malathion/oxon and lead acetate. | Q39753545 | ||
| Optimizing cutoff scores for the Barthel index and the modified Rankin scale for defining outcome in acute stroke trials | Q40399607 | ||
| Calcium, free radicals, and excitotoxic neuronal death in primary cell culture | Q40402386 | ||
| Animal models of acute ischaemic stroke: can they predict clinically successful neuroprotective drugs? | Q40443931 | ||
| Considerations in the design of clinical trials of neuroprotective therapy in acute stroke | Q41092868 | ||
| Ischemia-induced neuronal apoptosis | Q41235586 | ||
| Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate | Q41649639 | ||
| Glutamate and non-glutamate receptor mediated toxicity caused by oxygen and glucose deprivation in organotypic hippocampal cultures | Q41649675 | ||
| Methodological quality of preclinical stroke studies is not required for publication in high-impact journals | Q42124955 | ||
| Correlating tissue outcome with quantitative multiparametric MRI of acute cerebral ischemia in rats | Q42414763 | ||
| Ischaemic brain damage after stroke: new insights into efficient therapeutic strategies. International Symposium on Neurodegeneration and Neuroprotection | Q42645138 | ||
| A matching algorithm to address imbalances in study populations: application to the National Institute of Neurological Diseases and Stroke Recombinant Tissue Plasminogen Activator acute stroke trial. | Q43157267 | ||
| Liposome-encapsulated hemoglobin ameliorates ischemic stroke in nonhuman primates: an acute study | Q43243157 | ||
| NXY-059, a free radical--trapping agent, substantially lessens the functional disability resulting from cerebral ischemia in a primate species | Q43515003 | ||
| Serial changes in cerebral blood flow and flow-metabolism uncoupling in primates with acute thromboembolic stroke | Q43570490 | ||
| Seroprevalence of Toxoplasma gondii in bred cynomolgus monkeys ( Macaca fascicularis ) in China | Q43645494 | ||
| Infarct volume as a surrogate or auxiliary outcome measure in ischemic stroke clinical trials. The RANTTAS Investigators | Q43678233 | ||
| Costs and rehabilitation use of stroke survivors: a retrospective study of Medicare beneficiaries | Q43851976 | ||
| Treatment of ischemic brain damage by perturbing NMDA receptor- PSD-95 protein interactions | Q44193907 | ||
| Oxidative stress and cyclooxygenase-2 induction mediate cyanide-induced apoptosis of cortical cells | Q44235544 | ||
| Chronic ischemic stroke model in cynomolgus monkeys: behavioral, neuroimaging and anatomical study | Q44300705 | ||
| Neuroprotective action of tacrolimus (FK506) in focal and global cerebral ischemia in rodents: dose dependency, therapeutic time window and long-term efficacy | Q44318931 | ||
| Comparison of the neuroprotective effect of clomethiazole, AR-R15896AR and NXY-059 in a primate model of stroke using histological and behavioural measures | Q44413927 | ||
| Functional and histological evidence for the protective effect of NXY-059 in a primate model of stroke when given 4 hours after occlusion | Q44550693 | ||
| Serial magnetic resonance imaging in experimental primate stroke: validation of MRI for pre-clinical cerebroprotective trials | Q44689007 | ||
| A novel in vitro ischemia/reperfusion injury model. | Q44947008 | ||
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 433-449 | |
| P577 | publication date | 2011-04-01 | |
| P13046 | publication type of scholarly work | review article | Q7318358 |
| P1433 | published in | Expert Review of Cardiovascular Therapy | Q15733727 |
| P1476 | title | Translating promising preclinical neuroprotective therapies to human stroke trials | |
| P478 | volume | 9 |
| Q38162801 | Animal migraine models for drug development: status and future perspectives |
| Q36621226 | Arctic ground squirrel neuronal progenitor cells resist oxygen and glucose deprivation-induced death |
| Q48269849 | Characteristics of cerebral ischemia in major rat stroke models of middle cerebral artery ligation through craniectomy |
| Q47770967 | Connexins in Cardiovascular and Neurovascular Health and Disease: Pharmacological Implications |
| Q34291263 | Development of a database for translational spinal cord injury research |
| Q30572344 | High-dose albumin treatment for acute ischaemic stroke (ALIAS) Part 2: a randomised, double-blind, phase 3, placebo-controlled trial |
| Q44702318 | L-theanine administration results in neuroprotection and prevents glutamate receptor agonist-mediated injury in the rat model of cerebral ischemia-reperfusion |
| Q38953864 | Large Animal Stroke Models vs. Rodent Stroke Models, Pros and Cons, and Combination? |
| Q93047721 | Large animal ischemic stroke models: replicating human stroke pathophysiology |
| Q39028991 | Long-term survival and differentiation of human neural stem cells in nonhuman primate brain with no immunosuppression |
| Q38834682 | Neuroprotection in acute stroke: targeting excitotoxicity, oxidative and nitrosative stress, and inflammation |
| Q26859430 | Nonhuman Primate Models of Stroke for Translational Neuroprotection Research |
| Q37715350 | Nonhuman primate models of focal cerebral ischemia. |
| Q54967560 | Refocusing Neuroprotection in Cerebral Reperfusion Era: New Challenges and Strategies. |
| Q26858828 | Stress as necessary component of realistic recovery in animal models of experimental stroke |
| Q47813397 | Susceptibility to oxygen-glucose deprivation is reduced in acute hippocampal slices from euthermic Syrian golden hamsters relative to slices from Sprague-Dawley rats |
| Q38683402 | TRPC Channels and Stroke |
| Q27028040 | The importance of early brain injury after subarachnoid hemorrhage |
| Q38775856 | The need for new approaches in CNS drug discovery: Why drugs have failed, and what can be done to improve outcomes |
| Q43620885 | Validation of organotypical hippocampal slice cultures as an ex vivo model of brain ischemia: different roles of NMDA receptors in cell death signalling after exposure to NMDA or oxygen and glucose deprivation |
Search more.