Myocardial ischemia-reperfusion injury: a neglected therapeutic target.

scientific article

Myocardial ischemia-reperfusion injury: a neglected therapeutic target. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1172/JCI62874
P932PMC publication ID3533275
P698PubMed publication ID23281415

P50authorDerek M. YellonQ33528795
Derek HausenloyQ42409890
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Transient Limb Ischemia Induces Remote Preconditioning and Remote Postconditioning in Humans by a K ATP Channel–Dependent MechanismQ59401736
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Free radicals and reperfusion-induced arrhythmias: protection by spin trap agent PBN in the rat heartQ69018468
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P433issue1
P407language of work or nameEnglishQ1860
P921main subjectreperfusion injuryQ1413991
P304page(s)92-100
P577publication date2013-01-02
P1433published inJournal of Clinical InvestigationQ3186904
P1476titleMyocardial ischemia-reperfusion injury: a neglected therapeutic target
P478volume123

Reverse relations

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Q50085056Exosomes and cardioprotection - A critical analysis
Q64074434Exosomes from adipose-derived mesenchymal stem cells prevent cardiomyocyte apoptosis induced by oxidative stress
Q51440774Exposure to cigarette smoke abrogates the beneficial effect of ischemic postconditioning.
Q38693302Extracellular Ubiquitin: Role in Myocyte Apoptosis and Myocardial Remodeling
Q101464325Extracellular Vesicles Enriched with miR-150 Released by Macrophages Regulates the TP53-IGF-1 Axis to Alleviate Myocardial Infarction
Q90380756FPR1 gene silencing suppresses cardiomyocyte apoptosis and ventricular remodeling in rats with ischemia/reperfusion injury through the inhibition of MAPK signaling pathway
Q50958710Fenofibrate protects against acute myocardial I/R injury in rat by suppressing mitochondrial apoptosis as decreasing cleaved caspase-9 activation.
Q90248086Ferulic Acid Attenuates Hypoxia/Reoxygenation Injury by Suppressing Mitophagy Through the PINK1/Parkin Signaling Pathway in H9c2 Cells
Q54116621Fisetin Confers Cardioprotection against Myocardial Ischemia Reperfusion Injury by Suppressing Mitochondrial Oxidative Stress and Mitochondrial Dysfunction and Inhibiting Glycogen Synthase Kinase 3β Activity.
Q64240515Follistatin-Like 1 Attenuates Ischemia/Reperfusion Injury in Cardiomyocytes via Regulation of Autophagy
Q30970322Future directions of acute ischaemic stroke therapy
Q38129528Future treatment strategies in ST-segment elevation myocardial infarction
Q33604042G protein-coupled Receptor Kinase 2 as a Therapeutic Target for Heart Failure
Q57283285German Cardiac Society Working Group on Cellular Electrophysiology state-of-the-art paper: impact of molecular mechanisms on clinical arrhythmia management
Q94464138Gerontoxanthone I and Macluraxanthone Induce Mitophagy and Attenuate Ischemia/Reperfusion Injury
Q32180674Ghrelin protected neonatal rat cardiomyocyte against hypoxia/reoxygenation injury by inhibiting apoptosis through Akt-mTOR signal
Q37015531Ginsenoside RK3 Prevents Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes via AKT and MAPK Pathway
Q41112302GsMTx4-D is a cardioprotectant against myocardial infarction during ischemia and reperfusion.
Q47101148Guanxin Danshen Formulation Protects against Myocardial Ischemia Reperfusion Injury-Induced Left Ventricular Remodeling by Upregulating Estrogen Receptor β.
Q49917885Guidelines for Experimental Models of Myocardial Ischemia and Infarction
Q54978892Heart-type fatty acid binding protein (H-FABP) as a biomarker for acute myocardial injury and long-term post-ischemic prognosis.
Q58557456Heme oxygenase-1 ameliorates hypoxia/reoxygenation via suppressing apoptosis and enhancing autophagy and cell proliferation though Sirt3 signaling pathway in H9c2 cells
Q54985056Hexarelin treatment preserves myocardial function and reduces cardiac fibrosis in a mouse model of acute myocardial infarction.
Q92588566High cystatin C levels predict long-term mortality in patients with ST-segment elevation myocardial infarction undergoing late percutaneous coronary intervention: A retrospective study
Q38231258High density lipoproteins and ischemia reperfusion injury: the therapeutic potential of HDL to modulate cell survival pathways
Q64055071Human cardiac progenitor cell activation and regeneration mechanisms: exploring a novel myocardial ischemia/reperfusion in vitro model
Q52141416Humanin prevents brain mitochondrial dysfunction in a cardiac ischaemia-reperfusion injury model.
Q35860938Hydroxychloroquine Protects against Cardiac Ischaemia/Reperfusion Injury In Vivo via Enhancement of ERK1/2 Phosphorylation
Q41431093Hydroxysafflor yellow A alleviates myocardial ischemia/reperfusion in hyperlipidemic animals through the suppression of TLR4 signaling
Q53353117Icaritin Attenuates Myocardial Ischemia and Reperfusion Injury Via Anti-Inflammatory and Anti-Oxidative Stress Effects in Rats.
Q92814938Identification of lncRNA and mRNA expression profiles in rat spinal cords at various time‑points following cardiac ischemia/reperfusion
Q92011613Imbalance of ER and Mitochondria Interactions: Prelude to Cardiac Ageing and Disease?
Q49888772Immune responsive resolvin D1 programs myocardial infarction-induced cardiorenal syndrome in heart failure
Q64054632Immunometabolism of Phagocytes and Relationships to Cardiac Repair
Q35155185Impact of metformin on endothelial ischemia-reperfusion injury in humans in vivo: a prospective randomized open, blinded-endpoint study
Q34982390Increased cardiac distribution of mono-PEGylated Radix Ophiopogonis polysaccharide in both myocardial infarction and ischemia/reperfusion rats
Q52655081Indolylmaleimide Derivative IM-17 Shows Cardioprotective Effects in Ischemia-Reperfusion Injury.
Q90100481Induced cardiac pacemaker cells survive metabolic stress owing to their low metabolic demand
Q98778869Inhibition of Rho-kinase is involved in the therapeutic effects of atorvastatin in heart ischemia/reperfusion
Q61449103Inhibition of cardiomyocyte Sprouty1 protects from cardiac ischemia-reperfusion injury
Q90115057Inhibition of miR-153 ameliorates ischemia/reperfusion-induced cardiomyocytes apoptosis by regulating Nrf2/HO-1 signaling in rats
Q50105884Inhibition of nuclear factor kappa B pathway protects myocardial ischemia/reperfusion injury in rats under treatment with abnormal savda munziq
Q35019445Inhibition of the cardiomyocyte-specific kinase TNNI3K limits oxidative stress, injury, and adverse remodeling in the ischemic heart
Q92309402Inhibitor 1 of Protein Phosphatase 1 Regulates Ca2+/Calmodulin-Dependent Protein Kinase II to Alleviate Oxidative Stress in Hypoxia-Reoxygenation Injury of Cardiomyocytes
Q98226408Innate Immune Receptors, Key Actors in Cardiovascular Diseases
Q38438100Inorganic nitrite modulates miRNA signatures in acute myocardial in vivo ischemia/reperfusion
Q92637241Intermittent Hypoxia Prevents Myocardial Mitochondrial Ca2+ Overload and Cell Death during Ischemia/Reperfusion: The Role of Reactive Oxygen Species
Q88171503Intermittent hypoxia-generated ROS contributes to intracellular zinc regulation that limits ischemia/reperfusion injury in adult rat cardiomyocyte
Q41838401Intermittent pacing therapy favorably modulates infarct remodeling
Q89964439Intracellular Chloride Channels: Novel Biomarkers in Diseases
Q41890906Intracoronary hypothermia for acute myocardial infarction in the isolated beating pig heart
Q38268870Intramyocardial haemorrhage after acute myocardial infarction
Q100391104Irisin attenuates myocardial ischemia/reperfusion-induced cardiac dysfunction by regulating ER-mitochondria interaction through a mitochondrial ubiquitin ligase-dependent mechanism
Q28072918Ischaemic conditioning and targeting reperfusion injury: a 30 year voyage of discovery
Q34654008Ischemia and reperfusion induce differential expression of calpastatin and its homologue high molecular weight calmodulin-binding protein in murine cardiomyocytes
Q39109413Ischemia/Reperfusion
Q37668843Ischemia/Reperfusion Injury following Acute Myocardial Infarction: A Critical Issue for Clinicians and Forensic Pathologists
Q38386304Ischemic Postconditioning After Routine Thrombus Aspiration During Primary Percutaneous Coronary Intervention: Rationale and Design of the POstconditioning Rotterdam Trial
Q38731870Keto acid metabolites of branched-chain amino acids inhibit oxidative stress-induced necrosis and attenuate myocardial ischemia-reperfusion injury
Q55008053Knockdown of KLF11 attenuates hypoxia/reoxygenation injury via JAK2/STAT3 signaling in H9c2.
Q57126620L. Improved Heart Function and Inhibited Myocardial Apoptosis in Isolated Rat Heart Following Ischemia-Reperfusion Injury
Q90745602Lack of a Sense of Threat and Higher Emotional Lability in Patients With Chronic Microvascular Ischemia as Measured by Non-linear EEG Parameters
Q98895747Large Animal Models of Heart Failure: A Translational Bridge to Clinical Success
Q90512666Left Ventricular Unloading Before Reperfusion Promotes Functional Recovery After Acute Myocardial Infarction
Q91735378Light-emitting diode therapy protects against ventricular arrhythmias by neuro-immune modulation in myocardial ischemia and reperfusion rat model
Q37670940Liraglutide directly protects cardiomyocytes against reperfusion injury possibly via modulation of intracellular calcium homeostasis.
Q91025971LncRNA MALAT1 knockdown alleviates oxygen-glucose deprivation and reperfusion induced cardiomyocyte apoptotic death by regulating miR-122
Q92319477Long noncoding RNA-MEG3 contributes to myocardial ischemia-reperfusion injury through suppression of miR-7-5p expression
Q64084650Low Density Lipoprotein Receptor-Related Protein-1 in Cardiac Inflammation and Infarct Healing
Q55383720Low-Dose 4-Hydroxy-2-Nonenal (HNE) Reperfusion Therapy Displays Cardioprotective Effects in Mice After Myocardial Infarction That Are Abrogated by Genipin.
Q51176986Luteolinidin Protects the Postischemic Heart through CD38 Inhibition with Preservation of NAD(P)(H).
Q39340752MIF family cytokines in cardiovascular diseases and prospects for precision-based therapeutics.
Q48630021Mapping immune cell infiltration using restricted diffusion MRI.
Q33800230Mdivi-1 induced acute changes in the angiogenic profile after ischemia-reperfusion injury in female mice
Q35591986Mechanisms Involved in Exercise-Induced Cardioprotection: A Systematic Review.
Q38326656Mechanisms of myocardial ischemia-reperfusion injury and the cytoprotective role of minocycline: scope and limitations
Q93173172Melatonin elicits protective effects on OGD/R‑insulted H9c2 cells by activating PGC‑1α/Nrf2 signaling
Q55253083Melatonin-Induced Protective Effects on Cardiomyocytes Against Reperfusion Injury Partly Through Modulation of IP3R and SERCA2a Via Activation of ERK1.
Q89807074Mesenchymal Stem Cells Promote the Resolution of Cardiac Inflammation After Ischemia Reperfusion Via Enhancing Efferocytosis of Neutrophils
Q64275072Mesenchymal stromal cell-derived exosomes attenuate myocardial ischaemia-reperfusion injury through miR-182-regulated macrophage polarization
Q92602951Metabolomic characterization of myocardial ischemia-reperfusion injury in ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention
Q37508043Metformin in Diabetic Patients with Heart Failure: Safe and Effective?
Q59138339Metformin: An Old Drug with New Applications
Q58699159MiR-320 regulates cardiomyocyte apoptosis induced by ischemia-reperfusion injury by targeting AKIP1
Q92036851MiR-484 Protects Rat Myocardial Cells from Ischemia-Reperfusion Injury by Inhibiting Caspase-3 and Caspase-9 during Apoptosis
Q90642848MicroRNA-138 attenuates myocardial ischemia reperfusion injury through inhibiting mitochondria-mediated apoptosis by targeting HIF1-α
Q61799147MicroRNA-144 attenuates cardiac ischemia/reperfusion injury by targeting FOXO1
Q33702159MicroRNA-15a inhibition protects against hypoxia/reoxygenation-induced apoptosis of cardiomyocytes by targeting mothers against decapentaplegic homolog 7.
Q49474782MicroRNA-206 Protects against Myocardial Ischaemia-Reperfusion Injury in Rats by Targeting Gadd45β.
Q99630341MicroRNA-214-5p protects against myocardial ischemia reperfusion injury through targeting the FAS ligand
Q35190448MicroRNA-92a inhibition attenuates hypoxia/reoxygenation-induced myocardiocyte apoptosis by targeting Smad7.
Q64242876MicroRNAs as Potential Pharmaco-targets in Ischemia-Reperfusion Injury Compounded by Diabetes
Q55509396MicroRNA‑20b‑5p promotes ventricular remodeling by targeting the TGF‑β/Smad signaling pathway in a rat model of ischemia‑reperfusion injury.
Q60056507Microvesicles and Exosomes in Local and Distant Communication with the Heart
Q26770233Microvesicles and exosomes: new players in metabolic and cardiovascular disease
Q41472664Mitigation of myocardial ischemia-reperfusion injury via HIF-1α-frataxin signaling
Q58611546Mitochondria as a therapeutic target for common pathologies
Q90963905Mitochondrial LonP1 protects cardiomyocytes from ischemia/reperfusion injury in vivo
Q64886537Mitochondrial Membrane Permeability Inhibitors in Acute Myocardial Infarction: Still Awaiting Translation.
Q92733130Mitochondrial Quality Control: Role in Cardiac Models of Lethal Ischemia-Reperfusion Injury
Q90187491Mitochondrial and mitochondrial-independent pathways of myocardial cell death during ischaemia and reperfusion injury
Q39220742Mitochondrial permeability transition in cardiac ischemia-reperfusion: whether cyclophilin D is a viable target for cardioprotection?
Q46368801Modeling oxygen requirements in ischemic cardiomyocytes.
Q63459835Modelling ischemia-reperfusion injury (IRI) in vitro using metabolically matured induced pluripotent stem cell-derived cardiomyocytes
Q58561894Models of Ischemia-Reperfusion Injury
Q34999159Modulation of mononuclear phagocyte inflammatory response by liposome-encapsulated voltage gated sodium channel inhibitor ameliorates myocardial ischemia/reperfusion injury in rats
Q34547638Modulation of signaling mechanisms in the heart by thioredoxin 1.
Q26778211Molecular Characterization of Reactive Oxygen Species in Myocardial Ischemia-Reperfusion Injury
Q89052824Molecular Mechanisms Underlying the Cardiovascular Benefits of SGLT2i and GLP-1RA
Q37052474Molecular basis of cardioprotective effect of antioxidant vitamins in myocardial infarction
Q52680128Molecular mechanism and therapy application of necrosis during myocardial injury.
Q92541680Molecular mechanisms underlying gallic acid effects against cardiovascular diseases: An update review
Q38760245Moving Forwards by Blocking Back-Flow: The Yin and Yang of MI Therapy
Q54978972Mst1: function and mechanism in brain and myocardial ischemia reperfusion injury.
Q64101459Multifunctional PLGA-based nanoparticles as a controlled release drug delivery system for antioxidant and anticoagulant therapy
Q91594685Myocardial Injury After Ischemia/Reperfusion Is Attenuated By Pharmacological Galectin-3 Inhibition
Q97069866Myocardial ischaemia-reperfusion injury and cardioprotection in perspective
Q38827123NDUFA4L2 protects against ischaemia/reperfusion-induced cardiomyocyte apoptosis and mitochondrial dysfunction by inhibiting complex I.
Q58792489Na/K-ATPase Signaling and Cardiac Pre/Postconditioning with Cardiotonic Steroids
Q37081749Nanoparticle-Mediated Delivery of Irbesartan Induces Cardioprotection from Myocardial Ischemia-Reperfusion Injury by Antagonizing Monocyte-Mediated Inflammation.
Q57116116Nanoparticles for diagnosis and therapy of atherosclerosis and myocardial infarction: evolution toward prospective theranostic approaches
Q26799750Netrin-1 as a novel therapeutic target in cardiovascular disease: to activate or inhibit?
Q99717148Neuraminidase-1 promotes heart failure after ischemia/reperfusion injury by affecting cardiomyocytes and invading monocytes/macrophages
Q33587119Neutrophil stunning by metoprolol reduces infarct size
Q41097787Nicotinic acetylcholine receptor-mediated protection of the rat heart exposed to ischemia reperfusion.
Q38184206Nitrite reduction and cardiovascular protection
Q91642265Novel Molecular Targets Participating in Myocardial Ischemia-Reperfusion Injury and Cardioprotection
Q58730374Novel Roles of Non-Coding RNAs in Opioid Signaling and Cardioprotection
Q33812924Novel adjunctive treatments of myocardial infarction
Q42290403Oleuropein Protects Cardiomyocyte against Apoptosis via Activating the Reperfusion Injury Salvage Kinase Pathway In Vitro.
Q38177382Optimising cardioprotection during myocardial ischaemia: targeting potential intracellular pathways with glucagon-like peptide-1
Q50568281Orally active epoxyeicosatrienoic acid analog does not exhibit antihypertensive and reno- or cardioprotective actions in two-kidney, one-clip Goldblatt hypertensive rats.
Q58557149Out-of-hospital initiation of hypothermia in ST-segment elevation myocardial infarction: a randomised trial
Q38838459Overexpression of microRNA-133a inhibits ischemia-reperfusion-induced cardiomyocyte apoptosis by targeting DAPK2.
Q91956212Overexpression of microRNA-202-3p protects against myocardial ischemia-reperfusion injury through activation of TGF-β1/Smads signaling pathway by targeting TRPM6
Q88058263Oxidative cross-linking of proteins to DNA following ischemia-reperfusion injury
Q38172089Oxidative stress-related biomarkers in essential hypertension and ischemia-reperfusion myocardial damage
Q90307761PCSK9 inhibitor improves cardiac function and reduces infarct size in rats with ischaemia/reperfusion injury: Benefits beyond lipid-lowering effects
Q39347543PET measurements of myocardial blood flow post myocardial infarction: Relationship to invasive and cardiac magnetic resonance studies and potential clinical applications
Q59127320PIAS1 protects against myocardial ischemia-reperfusion injury by stimulating PPARγ SUMOylation
Q37721711PTPIP51 regulates mouse cardiac ischemia/reperfusion through mediating the mitochondria-SR junction
Q55390520Panax ginseng Polysaccharide Protected H9c2 Cardiomyocyte From Hypoxia/Reoxygenation Injury Through Regulating Mitochondrial Metabolism and RISK Pathway.
Q91891589Paraoxonase 2 protects against acute myocardial ischemia-reperfusion injury by modulating mitochondrial function and oxidative stress via the PI3K/Akt/GSK-3β RISK pathway
Q26781796Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection
Q89012656Pathological Roles of Iron in Cardiovascular Disease
Q38596702Pathophysiology of Myocardial Infarction
Q57116150Pepducin-mediated cardioprotection via β-arrestin-biased β2-adrenergic receptor-specific signaling
Q49684124Pericytes constrict blood vessels after myocardial ischemia
Q38137849Pharmacologic therapy that simulates conditioning for cardiac ischemic/reperfusion injury
Q58702398Pharmacological preconditioning with inhaled nitric oxide (NO): Organ-specific differences in the lifetime of blood and tissue NO metabolites
Q37736155Phellinus linteus Mycelium Alleviates Myocardial Ischemia-Reperfusion Injury through Autophagic Regulation
Q64970706Platelet Contributions to Myocardial Ischemia/Reperfusion Injury.
Q36975889Platelets activation is associated with elevated plasma mitochondrial DNA during cardiopulmonary bypass
Q64274965Platelets in cardiac ischaemia/reperfusion injury: a promising therapeutic target
Q39343342Platelets, diabetes and myocardial ischemia/reperfusion injury.
Q92399833Poly (ADP-ribose) polymerase inhibition protects against myocardial ischaemia/reperfusion injury via suppressing mitophagy
Q48231806Postconditioning with metformin attenuates apoptotic events in cardiomyoblasts associated with ischemic reperfusion injury.
Q47162467Potential of Bioactive Glasses for Cardiac and Pulmonary Tissue Engineering
Q64085300Potential role of exosomes in the pathophysiology, diagnosis, and treatment of hypoxic diseases
Q42348056Potential therapeutics for myocardial ischemia-reperfusion injury. Focus on "Induction of cardioprotection by small netrin-1-derived peptides".
Q64084254Pre-treatment with a combination of Shenmai and Danshen injection protects cardiomyocytes against hypoxia/reoxygenation- and HO-induced injury by inhibiting mitochondrial permeability transition pore opening
Q36850078Preconditioning c-Kit-positive Human Cardiac Stem Cells with a Nitric Oxide Donor Enhances Cell Survival through Activation of Survival Signaling Pathways
Q104064750Primidone blocks RIPK1-driven cell death and inflammation
Q46255610Propofol Prevents Oxidative Stress by Decreasing the Ischemic Accumulation of Succinate in Focal Cerebral Ischemia-Reperfusion Injury
Q98623182Propofol-induced MiR-20b expression initiates endogenous cellular signal changes mitigating hypoxia/re-oxygenation-induced endothelial autophagy in vitro
Q91943586Prostacyclin Analogue-Loaded Nanoparticles Attenuate Myocardial Ischemia/Reperfusion Injury in Rats
Q26748618Prostaglandin E Receptor Subtype 4 Signaling in the Heart: Role in Ischemia/Reperfusion Injury and Cardiac Hypertrophy
Q37701229Prostaglandin E2 reduces swine myocardial ischemia reperfusion injury via increased endothelial nitric oxide synthase and vascular endothelial growth factor expression levels
Q64085447Protection against cardiac ischemia-reperfusion injury by hypothermia and by inhibition of succinate accumulation and oxidation is additive
Q48264897Protection from Reperfusion Injury with Intracoronary N-Acetylcysteine in Patients with STEMI Undergoing Primary Percutaneous Coronary Intervention in a Cardiac Tertiary Center
Q91705325Protective Effect Of Vasicine Against Myocardial Infarction In Rats Via Modulation Of Oxidative Stress, Inflammation, And The PI3K/Akt Pathway
Q64250714Protective Effects of Extract against Cardiac Ischemia/Reperfusion Injury in Spontaneously Hypertensive Rats
Q48880463Protective Effects of Pterostilbene Against Myocardial Ischemia/Reperfusion Injury in Rats
Q54280898Protective effect of berberine against myocardial ischemia reperfusion injury: role of Notch1/Hes1-PTEN/Akt signaling.
Q47277096Protective effect of celastrol on myocardial ischemia-reperfusion injury.
Q89341498Protective effect of morin on myocardial ischemia‑reperfusion injury in rats
Q49852588Protective effects of GV1001 on myocardial ischemia‑reperfusion injury.
Q37736291Protective effects of tanshinone IIA sodium sulfonate on ischemia-reperfusion-induced myocardial injury in rats
Q49738106Protective role of STVNa in myocardial ischemia reperfusion injury by inhibiting mitochondrial fission
Q94601282Protective role of silibinin against myocardial ischemia/reperfusion injury-induced cardiac dysfunction
Q28256472Protein quality control and metabolism: bidirectional control in the heart
Q64935249Proteomics Research on the Protective Effect of Mangiferin on H9C2 Cell Injury Induced by H2O2.
Q50955954Punicalagin Pretreatment Attenuates Myocardial Ischemia-Reperfusion Injury via Activation of AMPK.
Q52353629Purinergic Regulation of Neutrophil Function.
Q90111757Quantification of intramyocardial hemorrhage volume using magnetic resonance imaging with three-dimensional T1-weighted sequence in patients with ischemia-reperfusion injury: a semi-automated image processing technique
Q38377369Quantitative cardiac phosphoproteomics profiling during ischemia-reperfusion in an immature swine model
Q37371205Quercetin postconditioning attenuates myocardial ischemia/reperfusion injury in rats through the PI3K/Akt pathway
Q42703908ROCK-dependent ATP5D modulation contributes to the protection of notoginsenoside NR1 against ischemia-reperfusion-induced myocardial injury
Q49896899Radiolabeled Duramycin: Promising Translational Imaging of Myocardial Apoptosis.
Q90355066Real-time local oxygen measurements for high resolution cellular imaging
Q38648760Recent Advances in Developing Inhibitors for Hypoxia-Inducible Factor Prolyl Hydroxylases and Their Therapeutic Implications.
Q57807470Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target
Q49788549Recombinant Human ADAMTS13 Treatment Improves Myocardial Remodeling and Functionality After Pressure Overload Injury in Mice.
Q64065918Regenerative Cardiovascular Therapies: Stem Cells and Beyond
Q35064243Regulation of heat shock proteins 27 and 70, p-Akt/p-eNOS and MAPKs by Naringin Dampens myocardial injury and dysfunction in vivo after ischemia/reperfusion
Q89753006Regulation of metabolism by mitochondrial enzyme acetylation in cardiac ischemia-reperfusion injury
Q58563445Relationships between circulating branched chain amino acid concentrations and risk of adverse cardiovascular events in patients with STEMI treated with PCI
Q38940630Relaxin' the Heart: A Novel Therapeutic Modality
Q89978268Remote Ischemic Preconditioning induces Cardioprotective Autophagy and Signals through the IL-6-Dependent JAK-STAT Pathway
Q38249023Remote conditioning the heart overview: translatability and mechanism
Q36532517Remote ischaemic conditioning: cardiac protection from afar.
Q58566940Remote ischemic conditioning in ST-segment elevation myocardial infarction - an update
Q89367256Reperfusing the myocardium - a damocles Sword
Q37714720Reperfusion Therapy with Rapamycin Attenuates Myocardial Infarction through Activation of AKT and ERK.
Q45050521Reperfusion therapy with recombinant human relaxin-2 (Serelaxin) attenuates myocardial infarct size and NLRP3 inflammasome following ischemia/reperfusion injury via eNOS-dependent mechanism
Q33861937Restoration of autophagic flux in myocardial tissues is required for cardioprotection of sevoflurane postconditioning in rats
Q64269543Resveratrol alleviates hypoxia/reoxygenation injury‑induced mitochondrial oxidative stress in cardiomyocytes
Q58725811Revisiting the Cardioprotective Effects of Acetylcholine Receptor Activation against Myocardial Ischemia/Reperfusion Injury
Q36194029Role of Trimetazidine in Ischemic Preconditioning in Patients With Symptomatic Coronary Artery Disease
Q33847421Role of angiopoietin-2 in the cardioprotective effect of fibroblast growth factor 21 on ischemia/reperfusion-induced injury in H9c2 cardiomyocytes
Q39249816Role of glycogen synthase kinase following myocardial infarction and ischemia-reperfusion.
Q53136063Roles of MicroRNA-195 in cardiomyocyte apoptosis induced by myocardial ischemia-reperfusion injury.
Q47098725Roles of mitochondrial dynamics modulators in cardiac ischaemia/reperfusion injury
Q38256778Roles of obese-insulin resistance and anti-diabetic drugs on the heart with ischemia-reperfusion injury
Q28076837SIRT3 in Cardiac Physiology and Disease
Q98778877SNHG16 accelerates the proliferation of primary cardiomyocytes by targeting miRNA-770-5p
Q51810981Safety and feasibility of local myocardial hypothermia.
Q36211215Salvage of nicotinamide adenine dinucleotide plays a critical role in the bioenergetic recovery of post-hypoxic cardiomyocytes
Q52561276Salvia miltiorrhizaBurge (Danshen): A golden herbal medicine in cardiovascular therapeutics.
Q89536625Sappanone A Protects Against Myocardial Ischemia Reperfusion Injury by Modulation of Nrf2
Q89870664Sappanone A alleviates hypoxia/reoxygenation-induced cardiomyocytes injury through inhibition of mitochondrial apoptosis and activation of PI3K-Akt-Gsk-3β pathway
Q42068530Sauchinone augments cardiomyocyte viability by enhancing autophagy proteins -PI3K, ERK(1/2), AMPK and Beclin-1 during early ischemia-reperfusion injury in vitro
Q91643357Sevoflurane postconditioning alleviates hypoxia-reoxygenation injury of cardiomyocytes by promoting mitochondrial autophagy through the HIF-1/BNIP3 signaling pathway
Q92136696Significant reduction of ischemia-reperfusion cell death in mouse myocardial infarcts using the immediate-acting PrC-210 ROS-scavenger
Q55411204Sirt1 Activation by Post-ischemic Treatment With Lumbrokinase Protects Against Myocardial Ischemia-Reperfusion Injury.
Q89176614Size-Dependent Ability of Liposomes to Accumulate in the Ischemic Myocardium and Protect the Heart
Q91942070Slit2 Protects Hearts Against Ischemia-Reperfusion Injury by Inhibiting Inflammatory Responses and Maintaining Myofilament Contractile Properties
Q47614023Sodium Thiosulfate Preconditioning Ameliorates Ischemia/Reperfusion Injury in Rat Hearts Via Reduction of Oxidative Stress and Apoptosis.
Q37648367Spliced X-box binding protein 1 couples the unfolded protein response to hexosamine biosynthetic pathway
Q64080446Stromal cell-derived factor-1α signals via the endothelium to protect the heart against ischaemia-reperfusion injury
Q38202410Stromal derived factor 1α: a chemokine that delivers a two-pronged defence of the myocardium.
Q30851880Structure-redox-relaxivity relationships for redox responsive manganese-based magnetic resonance imaging probes
Q39901435Succinate Accumulation and Ischemia-Reperfusion Injury: Of Mice but Not Men, a Study in Renal Ischemia-Reperfusion.
Q46618771Succinate dehydrogenase inhibition with malonate during reperfusion reduces infarct size by preventing mitochondrial permeability transition.
Q34527213Succinate metabolism: a new therapeutic target for myocardial reperfusion injury.
Q38717638Surface-modified particles loaded with CaMKII inhibitor protect cardiac cells against mitochondrial injury.
Q87034029Systemic toll-like receptor and interleukin-18 pathway activation in patients with acute ST elevation myocardial infarction
Q92305799Systems Network Genomic Analysis Reveals Cardioprotective Effect of MURC/Cavin-4 Deletion Against Ischemia/Reperfusion Injury
Q36040487T lymphocytes and fractalkine contribute to myocardial ischemia/reperfusion injury in patients.
Q90650189TAT-dextran-mediated mitochondrial transfer enhances recovery from models of reperfusion injury in cultured cardiomyocytes
Q38826190TGF-β improves myocardial function and prevents apoptosis induced by anoxia-reoxygenation, through the reduction of endoplasmic reticulum stress
Q55342846TGF-β/Smad3 pathway enhances the cardio-protection of S1R/SIPR1 in in vitro ischemia-reperfusion myocardial cell model.
Q38383096TNNI3K in cardiovascular disease and prospects for therapy.
Q35155010Targeted NGF siRNA delivery attenuates sympathetic nerve sprouting and deteriorates cardiac dysfunction in rats with myocardial infarction.
Q90862847Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles
Q92823429Targeting Mitochondrial Fission Using Mdivi-1 in A Clinically Relevant Large Animal Model of Acute Myocardial Infarction: A Pilot Study
Q46243656Targeting Oxidative Stress Using Nanoparticles as a Theranostic Strategy for Cardiovascular Diseases.
Q39039959Targeting TRAF3IP2 by Genetic and Interventional Approaches Inhibits Ischemia/Reperfusion-induced Myocardial Injury and Adverse Remodeling
Q38595544Targeting danger-associated molecular patterns after myocardial infarction
Q36094149Targeting delivery of Radix Ophiopogonis polysaccharide to ischemic/reperfused rat myocardium by long-circulating macromolecular and liposomal carriers
Q38206842Targeting mitochondria for cardioprotection: examining the benefit for patients.
Q37738596Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations.
Q99629091Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury
Q26744359Targeting the Innate Immune Response to Improve Cardiac Graft Recovery after Heart Transplantation: Implications for the Donation after Cardiac Death
Q91808620The Association of Ascorbic Acid, Deferoxamine and N-Acetylcysteine Improves Cardiac Fibroblast Viability and Cellular Function Associated with Tissue Repair Damaged by Simulated Ischemia/Reperfusion
Q57175391The Effects of Potassium Cyanide on the Functional Recovery of Isolated Rat Hearts after Ischemia and Reperfusion: The Role of Oxidative Stress
Q64230739The Guizhi Gancao Decoction Attenuates Myocardial Ischemia-Reperfusion Injury by Suppressing Inflammation and Cardiomyocyte Apoptosis
Q89736120The Pomace Extract Taurisolo Protects Rat Brain From Ischemia-Reperfusion Injury
Q99615238The Rationale of Neprilysin Inhibition in Prevention of Myocardial Ischemia-Reperfusion Injury during ST-Elevation Myocardial Infarction
Q42368418The Role of Hydrogen Sulfide on Cardiovascular Homeostasis: An Overview with Update on Immunomodulation
Q90232213The Role of Lipopolysaccharide-Induced Extracellular Vesicles in Cardiac Cell Death
Q90568414The Role of Mitochondria in the Mechanisms of Cardiac Ischemia-Reperfusion Injury
Q26747310The Role of Mitochondrial Reactive Oxygen Species in Cardiovascular Injury and Protective Strategies
Q51395640The cardioprotective effect of dihydromyricetin prevents ischemia-reperfusion-induced apoptosis in vivo and in vitro via the PI3K/Akt and HIF-1α signaling pathways.
Q55316827The cardioprotective effects of secretory leukocyte protease inhibitor against myocardial ischemia/reperfusion injury.
Q38705817The challenges and impact of microvascular injury in ST-elevation myocardial infarction
Q64097624The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury
Q36342106The interferon regulatory factors as novel potential targets in the treatment of cardiovascular diseases
Q91846247The lymphocyte adapter protein: A negative regulator of myocardial ischemia/reperfusion injury
Q38274962The mitochondrial permeability transition pore and its role in myocardial ischemia reperfusion injury.
Q38245433The mitochondrial permeability transition: a current perspective on its identity and role in ischaemia/reperfusion injury.
Q33823814The modified Yi qi decoction protects cardiac ischemia-reperfusion induced injury in rats
Q90092681The optimal model of reperfusion injury in vitro using H9c2 transformed cardiac myoblasts
Q37366133The physiological role of mitochondrial calcium revealed by mice lacking the mitochondrial calcium uniporter.
Q38775962The potential for nanotechnology to improve delivery of therapy to the acute ischemic heart
Q34486554The protective effect of microRNA-320 on left ventricular remodeling after myocardial ischemia-reperfusion injury in the rat model
Q37139158The role of antioxidation and immunomodulation in postnatal multipotent stem cell-mediated cardiac repair
Q47288476The selective NLRP3-inflammasome inhibitor MCC950 reduces infarct size and preserves cardiac function in a pig model of myocardial infarction
Q52730972The unfolded protein response in ischemic heart disease.
Q49942720Therapeutic Effects of Ischemic-Preconditioned Exosomes in Cardiovascular Diseases
Q90344406Therapeutic Hypothermia Protects Against Heat Stroke-Induced Arterial Hypotension via Promoting Left Ventricular Performance in Rats
Q54988971Therapeutic Potential of Annexin A1 in Ischemia Reperfusion Injury.
Q38866803Therapeutic targeting of autophagy in myocardial infarction and heart failure.
Q30589568Three-dimensional myocardial scarring along myofibers after coronary ischemia-reperfusion revealed by computerized images of histological assays
Q91530211Thrombo-inflammation in acute ischaemic stroke - implications for treatment
Q28541982Toll-like receptor 9-activation during onset of myocardial ischemia does not influence infarct extension
Q37393468Tongxinluo modulates cytokine secretion by cardiac microvascular endothelial cells in ischemia/reperfusion injury
Q92711721Traditional Chinese Medicine for Coronary Heart Disease: Clinical Evidence and Possible Mechanisms
Q58697406Trichosanthis Pericarpium Aqueous Extract Protects H9c2 Cardiomyocytes from Hypoxia/Reoxygenation Injury by Regulating PI3K/Akt/NO Pathway
Q26864088Troponin I-interacting protein kinase: a novel cardiac-specific kinase, emerging as a molecular target for the treatment of cardiac disease
Q47348883Umbelliferone Alleviates Myocardial Ischemia: the Role of Inflammation and Apoptosis
Q37577025Uncoupling of increased cellular oxidative stress and myocardial ischemia reperfusion injury by directed sarcolemma stabilization
Q36395058Unfolded protein response plays a critical role in heart damage after myocardial ischemia/reperfusion in rats
Q92840305Upregulation of miR-202-5p promotes cell apoptosis and suppresses cell viability of hypoxia-induced myocardial H9c2 cells by targeting SOX6 to inhibit the activation of the PI3K/AKT/FOXO3a pathway
Q60953149Upregulation of miR-335 ameliorates myocardial ischemia reperfusion injury via targeting hypoxia inducible factor 1-alpha subunit inhibitor
Q36188738Urocortin Treatment Improves Acute Hemodynamic Instability and Reduces Myocardial Damage in Post-Cardiac Arrest Myocardial Dysfunction.
Q36956766Variant Aldehyde Dehydrogenase 2 (ALDH2*2) Is a Risk Factor for Coronary Spasm and ST-Segment Elevation Myocardial Infarction
Q52677026Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise.
Q89182402Vascular endothelial growth factor regulation of endothelial nitric oxide synthase phosphorylation is involved in isoflurane cardiac preconditioning
Q38803474Vascular endothelial growth factor-C protects heart from ischemia/reperfusion injury by inhibiting cardiomyocyte apoptosis
Q40348381Virus-Mimetic Fusogenic Exosomes for Direct Delivery of Integral Membrane Proteins to Target Cell Membranes
Q37397458Water-soluble acacetin prodrug confers significant cardioprotection against ischemia/reperfusion injury
Q90676339circDLPAG4/HECTD1 mediates ischaemia/reperfusion injury in endothelial cells via ER stress
Q64226437extract-761 protects myocardium by regulating Akt/Nrf2 signal pathway
Q91712167lncRNA H19 Alleviated Myocardial I/RI via Suppressing miR-877-3p/Bcl-2-Mediated Mitochondrial Apoptosis
Q64281625l‐α‐Lysophosphatidylinositol ( LPI ) aggravates myocardial ischemia/reperfusion injury via a GPR 55/ ROCK ‐dependent pathway
Q93024751miR-26a-5p protects against myocardial ischemia/reperfusion injury by regulating the PTEN/PI3K/AKT signaling pathway
Q36661786miR-429 regulates the transition between Hypoxia-Inducible Factor (HIF)1A and HIF3A expression in human endothelial cells
Q92545603miR‑155 inhibition represents a potential valuable regulator in mitigating myocardial hypoxia/reoxygenation injury through targeting BAG5 and MAPK/JNK signaling
Q90276033mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury
Q47671228β-arrestin 2 mediates cardiac ischemia-reperfusion injury via inhibiting GPCR-independent cell survival signalling

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