| scholarly article | Q13442814 |
| P2093 | author name string | Robert E Rhoads | |
| Anren Song | |||
| Hermann Gram | |||
| Nadejda L Korneeva | |||
| Mary Ann Edens | |||
| P2860 | cites work | ATP-dependent unwinding of messenger RNA structure by eukaryotic initiation factors | Q69802631 |
| Translational regulation of vascular permeability factor by eukaryotic initiation factor 4E: implications for tumor angiogenesis | Q71081146 | ||
| Serine 209, not serine 53, is the major site of phosphorylation in initiation factor eIF-4E in serum-treated Chinese hamster ovary cells | Q72036803 | ||
| Phosphorylation of eukaryotic protein synthesis initiation factor 4E at Ser-209 | Q72315799 | ||
| Characterization of the two eIF4A-binding sites on human eIF4G-1 | Q73145418 | ||
| Phosphorylation of eIF-4E on Ser 209 in response to mitogenic and inflammatory stimuli is faithfully detected by specific antibodies | Q73984086 | ||
| The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1 | Q81089022 | ||
| Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases | Q83201881 | ||
| Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2 | Q24291466 | ||
| Human Eukaryotic Translation Initiation Factor 4G (eIF4G) Possesses Two Separate and Independent Binding Sites for eIF4A | Q24308808 | ||
| Essential Role for Mnk Kinases in Type II Interferon (IFNγ) Signaling and Its Suppressive Effects on Normal Hematopoiesis | Q24315357 | ||
| MNK1 and MNK2 regulation in HER2-overexpressing breast cancer lines | Q24320171 | ||
| MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates | Q24322852 | ||
| Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2 | Q24532154 | ||
| Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E | Q24533512 | ||
| The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells | Q24551026 | ||
| Physical association of eukaryotic initiation factor 4G (eIF4G) with eIF4A strongly enhances binding of eIF4G to the internal ribosomal entry site of encephalomyocarditis virus and is required for internal initiation of translation | Q24552462 | ||
| A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes | Q24552529 | ||
| Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo | Q24554527 | ||
| Structural basis for competitive inhibition of eIF4G-Mnk1 interaction by the adenovirus 100-kilodalton protein | Q24564094 | ||
| The selectivity of protein kinase inhibitors: a further update | Q24654622 | ||
| Mnk kinase pathway: Cellular functions and biological outcomes | Q26865459 | ||
| The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure. | Q27472955 | ||
| Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G | Q27618954 | ||
| Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins | Q27639133 | ||
| Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure | Q27860806 | ||
| Regulation of translation initiation in eukaryotes: mechanisms and biological targets | Q28111696 | ||
| Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma | Q28202140 | ||
| Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus | Q28263838 | ||
| Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk | Q28270295 | ||
| Synthesis and properties of mRNAs containing the novel "anti-reverse" cap analogs 7-methyl(3'-O-methyl)GpppG and 7-methyl (3'-deoxy)GpppG | Q28362678 | ||
| Loss of MNK function sensitizes fibroblasts to serum-withdrawal induced apoptosis | Q28512029 | ||
| Two-stage translational control of dentate gyrus LTP consolidation is mediated by sustained BDNF-TrkB signaling to MNK | Q28564985 | ||
| p38α Mitogen-Activated Protein Kinase Depletion and Repression of Signal Transduction to Translation Machinery by miR-124 and -128 in Neurons | Q28710107 | ||
| Molecular mechanisms of mTOR-mediated translational control | Q29615529 | ||
| Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (eIF4G) with picornaviral proteases. Implications for cap-dependent and cap-independent translational initiation | Q29615969 | ||
| Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation | Q29620293 | ||
| Mass spectrometric analysis of the N terminus of translational initiation factor eIF4G-1 reveals novel isoforms | Q31037125 | ||
| Interaction between the NH2-terminal domain of eIF4A and the central domain of eIF4G modulates RNA-stimulated ATPase activity | Q31125745 | ||
| Characterization of the role of eIF4G in stimulating cap- and IRES-dependent translation in aplysia neurons | Q31137829 | ||
| Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions | Q33633701 | ||
| BDNF induces translocation of initiation factor 4E to mRNA granules: Evidence for a role of synaptic microfilaments and integrins | Q33717423 | ||
| Sindbis virus translation is inhibited by a PKR/RNase L-independent effector induced by alpha/beta interferon priming of dendritic cells | Q33718551 | ||
| The roles of individual eukaryotic translation initiation factors in ribosomal scanning and initiation codon selection | Q33962536 | ||
| Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs | Q34007902 | ||
| Retracted: Simultaneous Inhibition of mTOR-Containing Complex 1 (mTORC1) and MNK Induces Apoptosis of Cutaneous T-Cell Lymphoma (CTCL) Cells | Q34031521 | ||
| Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development | Q34069663 | ||
| eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression | Q34069836 | ||
| Translation initiation on mammalian mRNAs with structured 5'UTRs requires DExH-box protein DHX29. | Q34168375 | ||
| Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E. | Q34177252 | ||
| Generation of multiple isoforms of eukaryotic translation initiation factor 4GI by use of alternate translation initiation codons | Q34282753 | ||
| Cap-independent translation of mRNA conferred by encephalomyocarditis virus 5' sequence improves the performance of the vaccinia virus/bacteriophage T7 hybrid expression system | Q34296022 | ||
| Novel "anti-reverse" cap analogs with superior translational properties | Q34365285 | ||
| Phosphorylation of eukaryotic initiation factor 4E (eIF4E) at Ser209 is not required for protein synthesis in vitro and in vivo | Q34518466 | ||
| MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL. | Q34545783 | ||
| Induction of viral, 7-methyl-guanosine cap-independent translation and oncolysis by mitogen-activated protein kinase-interacting kinase-mediated effects on the serine/arginine-rich protein kinase | Q34594574 | ||
| Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis. | Q34594617 | ||
| Phosphorylated Mnk1 and eIF4E are associated with lymph node metastasis and poor prognosis of nasopharyngeal carcinoma | Q35097767 | ||
| MNK1-induced eIF-4E phosphorylation in myeloma cells: a pathway mediating IL-6-induced expansion and expression of genes involved in metabolic and proteotoxic responses | Q35142765 | ||
| Activation of p38 MAPK in CD4 T cells controls IL-17 production and autoimmune encephalomyelitis | Q35230209 | ||
| mTOR Signaling to Translation | Q35560378 | ||
| Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development | Q35663786 | ||
| Ribosome-messenger recognition in the absence of the Shine-Dalgarno interactions. | Q43561466 | ||
| Protection of cap-dependent protein synthesis in vivo and in vitro with an eIF4G-1 variant highly resistant to cleavage by Coxsackievirus 2A protease | Q44244859 | ||
| mTOR signaling pathway in penile squamous cell carcinoma: pmTOR and peIF4E over expression correlate with aggressive tumor behavior. | Q44321698 | ||
| Mnk is a negative regulator of cap-dependent translation in Aplysia neurons | Q51984345 | ||
| Bi-polarized translation of ascidian maternal mRNA determinant pem-1 associated with regulators of the translation machinery on cortical Endoplasmic Reticulum (cER). | Q52723743 | ||
| The ATP requirement for initiation of eukaryotic translation varies according to the mRNA species | Q67969563 | ||
| A polypeptide in eukaryotic initiation factors that crosslinks specifically to the 5'-terminal cap in mRNA | Q35994504 | ||
| Dissecting eIF4E action in tumorigenesis | Q36209711 | ||
| Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors | Q36814636 | ||
| Heterogeneous nuclear ribonucleoprotein A1 regulates cyclin D1 and c-myc internal ribosome entry site function through Akt signaling | Q36838764 | ||
| The Oncogene eIF4E: Using Biochemical Insights to Target Cancer | Q36842143 | ||
| Targeting of the MNK–eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function | Q36950337 | ||
| Inhibition of polysome assembly enhances imatinib activity against chronic myelogenous leukemia and overcomes imatinib resistance | Q36959906 | ||
| The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner | Q37072152 | ||
| The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases). | Q37175518 | ||
| MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas | Q37524253 | ||
| Mitotic phosphorylation of eukaryotic initiation factor 4G1 (eIF4G1) at Ser1232 by Cdk1:cyclin B inhibits eIF4A helicase complex binding with RNA. | Q37546968 | ||
| First MNKs degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines | Q37660329 | ||
| Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E. | Q37729445 | ||
| Cap and cap-binding proteins in the control of gene expression | Q37940415 | ||
| The scanning mechanism of eukaryotic translation initiation | Q38185457 | ||
| Mnks, eIF4E phosphorylation and cancer | Q38275721 | ||
| Stopped-flow kinetic analysis of eIF4E and phosphorylated eIF4E binding to cap analogs and capped oligoribonucleotides: evidence for a one-step binding mechanism | Q38314964 | ||
| Differential inhibition of mRNA degradation pathways by novel cap analogs | Q38319346 | ||
| Translational activation of uncapped mRNAs by the central part of human eIF4G is 5' end-dependent | Q38335396 | ||
| Regulation of Eukaryotic Initiation Factor 4E (eIF4E) Phosphorylation by Mitogen-Activated Protein Kinase Occurs through Modulation of Mnk1-eIF4G Interaction | Q38341049 | ||
| The ATP-dependent interaction of eukaryotic initiation factors with mRNA. | Q38349548 | ||
| Pharmacologic co-inhibition of Mnks and mTORC1 synergistically suppresses proliferation and perturbs cell cycle progression in blast crisis-chronic myeloid leukemia cells. | Q38926797 | ||
| Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway. | Q39314466 | ||
| MNK kinases facilitate c-myc IRES activity in rapamycin-treated multiple myeloma cells | Q39389252 | ||
| MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition | Q39411394 | ||
| The effect of p-4E-BP1 and p-eIF4E on cell proliferation in a breast cancer model. | Q39507749 | ||
| Mnk Mediates Integrin α6β4–Dependent eIF4E Phosphorylation and Translation of VEGF mRNA | Q39636229 | ||
| The involvement of mRNA secondary structure in protein synthesis | Q39689165 | ||
| Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells | Q39936976 | ||
| Phosphorylation of eIF-4E positively regulates formation of the eIF-4F translation initiation complex following DNA damage | Q40029572 | ||
| A novel mechanism for integrin-mediated ras activation in breast carcinoma cells: the alpha6beta4 integrin regulates ErbB2 translation and transactivates epidermal growth factor receptor/ErbB2 signaling | Q40309797 | ||
| Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties | Q40373561 | ||
| Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA. | Q40766564 | ||
| Insulin and phorbol ester stimulate initiation factor eIF-4E phosphorylation by distinct pathways in Chinese hamster ovary cells overexpressing the insulin receptor | Q41228182 | ||
| Novel translational control in Arc-dependent long term potentiation consolidation in vivo | Q41813558 | ||
| Regulation of protein synthesis by eIF4E phosphorylation in adult cardiocytes: the consequence of secondary structure in the 5'-untranslated region of mRNA. | Q41849529 | ||
| Phosphorylation of Eukaryotic Translation Initiation Factor 4G1 (eIF4G1) by Protein Kinase Cα Regulates eIF4G1 Binding to Mnk1 | Q42793657 | ||
| TGFβ‐induced PI 3 kinase‐dependent Mnk‐1 activation is necessary for Ser‐209 phosphorylation of eIF4E and mesangial cell hypertrophy | Q42837787 | ||
| P433 | issue | 7 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 3455-3467 | |
| P577 | publication date | 2015-12-14 | |
| P1433 | published in | Journal of Biological Chemistry | Q867727 |
| P1476 | title | Inhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5'-Terminal Cap and Hairpin | |
| P478 | volume | 291 |
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