| scholarly article | Q13442814 |
| P50 | author | Julie Teruya-Feldstein | Q28219585 |
| P2093 | author name string | Hong Zhu | |
| Scott W Lowe | |||
| Jerry Pelletier | |||
| Hans-Guido Wendel | |||
| Takeshi Ueda | |||
| Rie Watanabe-Fukunaga | |||
| Rikiro Fukunaga | |||
| John R Mills | |||
| Ricardo L A Silva | |||
| Abba Malina | |||
| P2860 | cites work | Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2 | Q24532154 |
| Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo | Q24554527 | ||
| Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP | Q27739838 | ||
| Upstream and downstream of mTOR | Q28277365 | ||
| Role of the proto-oncogene Pokemon in cellular transformation and ARF repression | Q28303509 | ||
| Induction of apoptosis in fibroblasts by c-myc protein | Q29614346 | ||
| Does the ribosome translate cancer? | Q29618775 | ||
| Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap | Q29620550 | ||
| Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation | Q33274677 | ||
| Dissecting p53 tumor suppressor functions in vivo | Q34135695 | ||
| Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy | Q34306865 | ||
| Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth | Q34323752 | ||
| Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. | Q34443426 | ||
| Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation? | Q34992458 | ||
| Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development | Q35663786 | ||
| Rapid turnover of mcl-1 couples translation to cell survival and apoptosis | Q35695499 | ||
| Mcl-1 regulation and its role in multiple myeloma | Q35910365 | ||
| Determinants of sensitivity and resistance to rapamycin-chemotherapy drug combinations in vivo | Q36100451 | ||
| Mechanisms of translational deregulation in human tumors and therapeutic intervention strategies. | Q36778676 | ||
| Tethering of eIF4G to adenoviral mRNAs by viral 100k protein drives ribosome shunting | Q37480438 | ||
| Ubiquitination and proteasome-dependent degradation of human eukaryotic translation initiation factor 4E. | Q40276347 | ||
| Apoptosis induced by the kinase inhibitor BAY 43-9006 in human leukemia cells involves down-regulation of Mcl-1 through inhibition of translation | Q40383692 | ||
| Translational control of the antiapoptotic function of Ras. | Q40879734 | ||
| Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. | Q41714456 | ||
| Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities | Q42822974 | ||
| The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis | Q44851701 | ||
| Oncogenic Ras and Akt Signaling Contribute to Glioblastoma Formation by Differential Recruitment of Existing mRNAs to Polysomes | Q47421825 | ||
| Rapamycin selectively inhibits the growth of childhood rhabdomyosarcoma cells through inhibition of signaling via the type I insulin-like growth factor receptor. | Q54214220 | ||
| Methods for studying pro- and antiapoptotic genes in nonimmortal cells | Q73983320 | ||
| P433 | issue | 24 | |
| P304 | page(s) | 3232-3237 | |
| P577 | publication date | 2007-11-30 | |
| P1433 | published in | Genes & Development | Q1524533 |
| P1476 | title | Dissecting eIF4E action in tumorigenesis | |
| P478 | volume | 21 |
| Q36477529 | 4E-BP restrains eIF4E phosphorylation |
| Q24336376 | 4E-BP1 is a target of Smad4 essential for TGFbeta-mediated inhibition of cell proliferation |
| Q36965860 | 4EBP1/c-MYC/PUMA and NF-κB/EGR1/BIM pathways underlie cytotoxicity of mTOR dual inhibitors in malignant lymphoid cells. |
| Q31016573 | A cooperative microRNA-tumor suppressor gene network in acute T-cell lymphoblastic leukemia (T-ALL). |
| Q52370143 | A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1. |
| Q28510855 | A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation |
| Q38988513 | A unique phosphorylation-dependent eIF4E assembly on 40S ribosomes co-ordinated by hepatitis C virus protein NS5A that activates internal ribosome entry site translation |
| Q59355818 | Aberrant regulation of the Akt signaling network by human cytomegalovirus allows for targeting of infected monocytes |
| Q24632768 | Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases |
| Q33419826 | Activation of host translational control pathways by a viral developmental switch |
| Q35597335 | Aerosol delivery of kinase-deficient Akt1 attenuates Clara cell injury induced by naphthalene in the lungs of dual luciferase mice |
| Q26798087 | Amino acid management in cancer |
| Q27009377 | Amino acids and mTORC1: from lysosomes to disease |
| Q45384502 | An oncogenic role of eIF3e/INT6 in human breast cancer |
| Q35212727 | Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer. |
| Q38008847 | Attacking a nexus of the oncogenic circuitry by reversing aberrant eIF4F-mediated translation |
| Q41546726 | BDNF stimulation of protein synthesis in cortical neurons requires the MAP kinase-interacting kinase MNK1. |
| Q90412228 | By reducing global mRNA translation in several ways, 2-deoxyglucose lowers MCL-1 protein and sensitizes hemopoietic tumor cells to BH3 mimetic ABT737 |
| Q58798783 | CD40L/IL-4-stimulated CLL demonstrates variation in translational regulation of DNA damage response genes including ATM |
| Q64104116 | CXCR7 promotes melanoma tumorigenesis via Src kinase signaling |
| Q34962407 | Cancer gene discovery in mouse and man. |
| Q37940415 | Cap and cap-binding proteins in the control of gene expression |
| Q38001940 | Cap-dependent translation initiation factor eIF4E: an emerging anticancer drug target |
| Q33601533 | Cell cycle progression or translation control is not essential for vesicular stomatitis virus oncolysis of hepatocellular carcinoma |
| Q37726436 | Cell signaling in protein synthesis ribosome biogenesis and translation initiation and elongation |
| Q35176396 | Cell-to-cell variability of alternative RNA splicing |
| Q35885183 | Characterization of MNK1b DNA Aptamers That Inhibit Proliferation in MDA-MB231 Breast Cancer Cells |
| Q41615120 | Chemical Inhibitors and microRNAs (miRNA) Targeting the Mammalian Target of Rapamycin (mTOR) Pathway: Potential for Novel Anticancer Therapeutics |
| Q38833185 | Cisplatin-resistant cancer cells are sensitive to Aurora kinase A inhibition by alisertib |
| Q37007347 | Combinatorial effects of lapatinib and rapamycin in triple-negative breast cancer cells |
| Q34069663 | Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development |
| Q28829666 | Cotargeting MNK and MEK kinases induces the regression of NF1-mutant cancers |
| Q37729759 | Coupling 40S ribosome recruitment to modification of a cap-binding initiation factor by eIF3 subunit e. |
| Q39048156 | Developing anti-neoplastic biotherapeutics against eIF4F. |
| Q38514906 | Differential Regulation of ZEB1 and EMT by MAPK-Interacting Protein Kinases (MNK) and eIF4E in Pancreatic Cancer |
| Q33708023 | Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells |
| Q92636553 | Discovery and Preliminary Characterization of Translational Modulators that Impair the Binding of eIF6 to 60S Ribosomal Subunits |
| Q39010703 | Discovery of 5-(2-(phenylamino)pyrimidin-4-yl)thiazol-2(3H)-one derivatives as potent Mnk2 inhibitors: synthesis, SAR analysis and biological evaluation |
| Q37533750 | Down-regulation of eIF4GII by miR-520c-3p represses diffuse large B cell lymphoma development. |
| Q38637354 | Dual abrogation of MNK and mTOR: a novel therapeutic approach for the treatment of aggressive cancers |
| Q48057652 | Dual targeting of eIF4E by blocking MNK and mTOR pathways in leukemia |
| Q39038481 | Dynamical insights of Mnk2 kinase activation by phosphorylation to facilitate inhibitor discovery |
| Q41882870 | ERK1/2 signalling protects against apoptosis following endoplasmic reticulum stress but cannot provide long-term protection against BAX/BAK-independent cell death. |
| Q48412304 | Elevated levels of p-Mnk1, p-eIF4E and p-p70S6K proteins are associated with tumor recurrence and poor prognosis in astrocytomas |
| Q35853794 | Emerging therapeutics targeting mRNA translation |
| Q39774238 | Enhanced mRNA cap methylation increases cyclin D1 expression and promotes cell transformation |
| Q33604979 | Enhancing mTOR-targeted cancer therapy |
| Q90681325 | Estrogen receptor α promotes protein synthesis by fine-tuning the expression of the eukaryotic translation initiation factor 3 subunit f (eIF3f) |
| Q35914014 | Eukaryotic Translation Initiation Factor 4E Is a Feed-Forward Translational Coactivator of Transforming Growth Factor β Early Protransforming Events in Breast Epithelial Cells. |
| Q34240544 | Eukaryotic initiation factor 4F: a vulnerability of tumor cells |
| Q37174030 | Eukaryotic initiation factors (eIF) 2alpha and 4E expression, localization, and phosphorylation in brain tumors |
| Q38857306 | Eukaryotic translation initiation factor 3, subunit C is overexpressed and promotes cell proliferation in human glioma U-87 MG cells |
| Q44380443 | Eukaryotic translation initiation factor 4E (eIF4E) expression is associated with breast cancer tumor phenotype and predicts survival after anthracycline chemotherapy treatment |
| Q38227377 | Eukaryotic translation initiation factor 4E as a novel therapeutic target in hematological malignancies and beyond |
| Q39400409 | Eukaryotic translation initiation factors and cancer |
| Q36545784 | Expression and activity of eIF6 trigger malignant pleural mesothelioma growth in vivo. |
| Q33731418 | Extracellular signal-regulated kinase positively regulates the oncogenic activity of MCT-1 in diffuse large B-cell lymphoma |
| Q37660329 | First MNKs degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines |
| Q38746805 | Galeterone and VNPT55 disrupt Mnk-eIF4E to inhibit prostate cancer cell migration and invasion |
| Q41592725 | Galeterone and its analogs inhibit Mnk-eIF4E axis, synergize with gemcitabine, impede pancreatic cancer cell migration, invasion and proliferation and inhibit tumor growth in mice |
| Q39314466 | Gemcitabine triggers a pro-survival response in pancreatic cancer cells through activation of the MNK2/eIF4E pathway. |
| Q33874396 | Global signatures of protein and mRNA expression levels |
| Q43228472 | Glycolysis inhibition sensitizes tumor cells to death receptors-induced apoptosis by AMP kinase activation leading to Mcl-1 block in translation. |
| Q35762918 | Hepatitis C virus NS5A binds to the mRNA cap-binding eukaryotic translation initiation 4F (eIF4F) complex and up-regulates host translation initiation machinery through eIF4E-binding protein 1 inactivation |
| Q41347243 | Hepatitis C virus core protein targets 4E-BP1 expression and phosphorylation and potentiates Myc-induced liver carcinogenesis in transgenic mice |
| Q54111927 | Human herpesvirus-encoded kinase induces B cell lymphomas in vivo. |
| Q47263046 | Hyperactive mTOR and MNK1 phosphorylation of eIF4E confer tamoxifen resistance and estrogen independence through selective mRNA translation reprogramming |
| Q36967260 | Hypoxia-inducible factor-1α (HIF-1α) promotes cap-dependent translation of selective mRNAs through up-regulating initiation factor eIF4E1 in breast cancer cells under hypoxia conditions |
| Q34227540 | Identification of a gene expression driven progression pathway in myxoid liposarcoma |
| Q40548325 | Identification of expression quantitative trait loci of RPTOR for susceptibility to glioma |
| Q54194644 | Immunohistochemical evaluation of the mTOR pathway in intra-oral minor salivary gland neoplasms. |
| Q38323055 | Immunohistochemistry-based prognostic biomarkers in NSCLC: novel findings on the road to clinical use? |
| Q46713797 | Impact of genetic variations in the MAPK signaling pathway on outcome in metastatic colorectal cancer patients treated with first-line FOLFIRI and bevacizumab: data from FIRE-3 and TRIBE trials |
| Q37552035 | Impact of promoter polymorphisms in key regulators of the intrinsic apoptosis pathway on the outcome of childhood acute lymphoblastic leukemia |
| Q64109270 | Impact of the secretome of activated pancreatic stellate cells on growth and differentiation of pancreatic tumour cells |
| Q92863081 | In silico Methods for Design of Kinase Inhibitors as Anticancer Drugs |
| Q54796100 | Increased expression of MNK1b, the spliced isoform of MNK1, predicts poor prognosis and is associated with triple-negative breast cancer. |
| Q52430693 | Inducible Genome Editing with Conditional CRISPR/Cas9 Mice. |
| Q93183654 | Induction of MNK Kinase-dependent eIF4E Phosphorylation by Inhibitors Targeting BET Proteins Limits Efficacy of BET Inhibitors |
| Q42513156 | Inhibiting ERK/Mnk/eIF4E broadly sensitizes ovarian cancer response to chemotherapy. |
| Q37709399 | Inhibiting the MNK-eIF4E-β-catenin axis increases the responsiveness of aggressive breast cancer cells to chemotherapy |
| Q36573991 | Inhibition of Mitogen-activated Protein Kinase (MAPK)-interacting Kinase (MNK) Preferentially Affects Translation of mRNAs Containing Both a 5'-Terminal Cap and Hairpin |
| Q36814636 | Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursors |
| Q47584869 | Inhibition of eIF4E cooperates with chemotherapy and immunotherapy in renal cell carcinoma. |
| Q39700741 | Inhibition of eIF4E phosphorylation reduces cell growth and proliferation in primary central nervous system lymphoma cells |
| Q37855822 | Inhibitors of translation initiation as cancer therapeutics |
| Q47830442 | Inhibitory effect and molecular mechanism of mesenchymal stem cells on NSCLC cells |
| Q92424256 | Inhibitory effects of SEL201 in acute myeloid leukemia |
| Q92308960 | Intratumoral Heterogeneity Determines the Expression of mTOR-pathway Proteins in Prostate Cancer |
| Q38543715 | Knockdown of eukaryotic translation initiation factor 4E suppresses cell growth and invasion, and induces apoptosis and cell cycle arrest in a human lung adenocarcinoma cell line |
| Q41009946 | LRRK2 in Transcription and Translation Regulation: Relevance for Parkinson's Disease |
| Q38689342 | Lysosomal Biology in Cancer |
| Q41636936 | MAP kinase-interacting serine/threonine kinase 2 promotes proliferation, metastasis, and predicts poor prognosis in non-small cell lung cancer. |
| Q37425601 | MCL-1-dependent leukemia cells are more sensitive to chemotherapy than BCL-2-dependent counterparts |
| Q51743355 | MDM2 is overexpressed and regulated by the eukaryotic translation initiation factor 4E (eIF4E) in human squamous cell carcinoma of esophagus. |
| Q39411394 | MKNK1 is a YB-1 target gene responsible for imparting trastuzumab resistance and can be blocked by RSK inhibition |
| Q37524253 | MNK1 pathway activity maintains protein synthesis in rapalog-treated gliomas |
| Q35142765 | MNK1-induced eIF-4E phosphorylation in myeloma cells: a pathway mediating IL-6-induced expansion and expression of genes involved in metabolic and proteotoxic responses |
| Q47649072 | MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma |
| Q64247410 | MNK1/NODAL Signaling Promotes Invasive Progression of Breast Ductal Carcinoma |
| Q34545783 | MNKs act as a regulatory switch for eIF4E1 and eIF4E3 driven mRNA translation in DLBCL. |
| Q38005668 | Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update |
| Q37117628 | Merestinib blocks Mnk kinase activity in acute myeloid leukemia progenitors and exhibits antileukemic effects in vitro and in vivo |
| Q37890687 | Metformin: a new option in cancer treatment. |
| Q37913018 | MicroRNA regulation by RNA-binding proteins and its implications for cancer |
| Q37691346 | Mitochondrial control of caspase-dependent and -independent cell death |
| Q34594617 | Mitogen-activated protein kinase-interacting kinase regulates mTOR/AKT signaling and controls the serine/arginine-rich protein kinase-responsive type 1 internal ribosome entry site-mediated translation and viral oncolysis. |
| Q86857534 | Mnk Kinases in Cytokine Signaling and Regulation of Cytokine Responses |
| Q39636229 | Mnk Mediates Integrin α6β4–Dependent eIF4E Phosphorylation and Translation of VEGF mRNA |
| Q34069446 | Mnk earmarks eIF4E for cancer therapy |
| Q26865459 | Mnk kinase pathway: Cellular functions and biological outcomes |
| Q37061433 | Modifying chemotherapy response by targeted inhibition of eukaryotic initiation factor 4A. |
| Q33704756 | Mouse models of cancer as biological filters for complex genomic data |
| Q62644763 | NOTCH1 Represses MCL-1 Levels in GSI-resistant T-ALL, Making them Susceptible to ABT-263 |
| Q34310053 | Negative Regulatory Effects of Mnk Kinases in the Generation of Chemotherapy-Induced Antileukemic Responses |
| Q36150711 | Non-germline genetically engineered mouse models for translational cancer research |
| Q36140862 | Notch signaling sustains the expression of Mcl-1 and the activity of eIF4E to promote cell survival in CLL. |
| Q55068343 | Novel C-4 heteroaryl 13-cis-retinamide Mnk/AR degrading agents inhibit cell proliferation and migration and induce apoptosis in human breast and prostate cancer cells and suppress growth of MDA-MB-231 human breast and CWR22Rv1 human prostate tumor x |
| Q34634172 | Novel RNA-binding protein P311 binds eukaryotic translation initiation factor 3 subunit b (eIF3b) to promote translation of transforming growth factor β1-3 (TGF-β1-3). |
| Q90721907 | Oncogenic kinases and perturbations in protein synthesis machinery and energetics in neoplasia |
| Q37389181 | Overcoming mTOR inhibition-induced paradoxical activation of survival signaling pathways enhances mTOR inhibitors' anticancer efficacy |
| Q37447620 | Overexpression of LARP1 predicts poor prognosis of colorectal cancer and is expected to be a potential therapeutic target |
| Q30080017 | PI3K and cancer: lessons, challenges and opportunities |
| Q97531406 | Pan-RAF inhibition induces apoptosis in acute myeloid leukemia cells and synergizes with BCL2 inhibition |
| Q35097767 | Phosphorylated Mnk1 and eIF4E are associated with lymph node metastasis and poor prognosis of nasopharyngeal carcinoma |
| Q33584507 | Phosphorylated eukaryotic translation initiation factor 4 (eIF4E) is elevated in human cancer tissues |
| Q35553279 | Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches |
| Q39936976 | Phosphorylation of eIF4E by MNKs supports protein synthesis, cell cycle progression and proliferation in prostate cancer cells |
| Q37162273 | Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3. |
| Q36750540 | Phosphorylation of eIF4E serine 209 is associated with tumour progression and reduced survival in malignant melanoma |
| Q42793657 | Phosphorylation of eukaryotic translation initiation factor 4G1 (eIF4G1) by protein kinase C{alpha} regulates eIF4G1 binding to Mnk1. |
| Q30009601 | Plakophilin-associated RNA-binding proteins in prostate cancer and their implications in tumor progression and metastasis |
| Q34059200 | Prion protein interaction with stress-inducible protein 1 enhances neuronal protein synthesis via mTOR |
| Q34177252 | Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E. |
| Q35216351 | RNA G-quadruplexes cause eIF4A-dependent oncogene translation in cancer |
| Q36797266 | RNAi screening uncovers Dhx9 as a modifier of ABT-737 resistance in an Eμ-myc/Bcl-2 mouse model. |
| Q40326577 | Rab12 regulates mTORC1 activity and autophagy through controlling the degradation of amino-acid transporter PAT4. |
| Q39129425 | Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a). |
| Q37061781 | Ras and rheb signaling in survival and cell death |
| Q38341049 | Regulation of Eukaryotic Initiation Factor 4E (eIF4E) Phosphorylation by Mitogen-Activated Protein Kinase Occurs through Modulation of Mnk1-eIF4G Interaction |
| Q35642076 | Regulation of cell growth by Notch signaling and its differential requirement in normal vs. tumor-forming stem cells in Drosophila |
| Q26771382 | Regulation of global and specific mRNA translation by the mTOR signaling pathway |
| Q38034202 | Regulation of mRNA translation by signaling pathways |
| Q28111696 | Regulation of translation initiation in eukaryotes: mechanisms and biological targets |
| Q38959287 | Regulatory effects of a Mnk2-eIF4E feedback loop during mTORC1 targeting of human medulloblastoma cells |
| Q39139050 | Repression of microRNA-768-3p by MEK/ERK signalling contributes to enhanced mRNA translation in human melanoma |
| Q34508797 | Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F |
| Q33726390 | Rheb GTPase controls apoptosis by regulating interaction of FKBP38 with Bcl-2 and Bcl-XL |
| Q35758763 | Ribavirin Inhibits the Activity of mTOR/eIF4E, ERK/Mnk1/eIF4E Signaling Pathway and Synergizes with Tyrosine Kinase Inhibitor Imatinib to Impair Bcr-Abl Mediated Proliferation and Apoptosis in Ph+ Leukemia |
| Q47720139 | Ribavirin augments doxorubicin's efficacy in human hepatocellular carcinoma through inhibiting doxorubicin-induced eIF4E activation. |
| Q36068265 | Ribosomal RACK1 promotes chemoresistance and growth in human hepatocellular carcinoma |
| Q38174514 | Ribosomal proteins as novel players in tumorigenesis |
| Q47654911 | Role of hypoxia in Diffuse Large B-cell Lymphoma: Metabolic repression and selective translation of HK2 facilitates development of DLBCL. |
| Q37865381 | Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy. |
| Q34117251 | Sensitivity of global translation to mTOR inhibition in REN cells depends on the equilibrium between eIF4E and 4E-BP1. |
| Q54118148 | Signaling pathways involved in the regulation of mRNA translation. |
| Q26777735 | Signalling to eIF4E in cancer |
| Q38884652 | Significance of MNK1 in prognostic prediction and chemotherapy development of epithelial ovarian cancer |
| Q38918208 | Simultaneous targeting of androgen receptor (AR) and MAPK-interacting kinases (MNKs) by novel retinamides inhibits growth of human prostate cancer cell lines |
| Q36811784 | Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes? |
| Q36020938 | Small-molecule induction of phospho-eIF4E sumoylation and degradation via targeting its phosphorylated serine 209 residue |
| Q38730327 | Sorafenib Inhibition of Mcl-1 Accelerates ATRA-Induced Apoptosis in Differentiation-Responsive AML Cells |
| Q36945305 | Sphingosine-1-Phosphate as a Regulator of Hypoxia-Induced Factor-1α in Thyroid Follicular Carcinoma Cells |
| Q35689148 | Stress granules, P-bodies and cancer. |
| Q24302311 | Sumoylation of eIF4E activates mRNA translation |
| Q54407979 | Superoxide activates mTOR-eIF4E-Bax route to induce enhanced apoptosis in leukemic cells. |
| Q38914858 | Survival control of malignant lymphocytes by anti-apoptotic MCL-1. |
| Q39804531 | Synergistic effect of inhibiting translation initiation in combination with cytotoxic agents in acute myelogenous leukemia cells |
| Q52340912 | Synergistic effects of inhibiting the MNK-eIF4E and PI3K/AKT/ mTOR pathways on cell migration in MDA-MB-231 cells. |
| Q63979742 | Synthetic mRNA capping |
| Q38851407 | Systemic Akt1 Deletion after Tumor Onset in p53(-/-) Mice Increases Lifespan and Regresses Thymic Lymphoma Emulating p53 Restoration |
| Q42837787 | TGFβ-induced PI 3 kinase-dependent Mnk-1 activation is necessary for Ser-209 phosphorylation of eIF4E and mesangial cell hypertrophy |
| Q34148062 | TOR signaling never gets old: aging, longevity and TORC1 activity. |
| Q41144441 | TRIM59 is a novel potential prognostic biomarker in patients with non-small cell lung cancer: A research based on bioinformatics analysis |
| Q40657287 | Targeted cancer therapy: what if the driver is just a messenger? |
| Q53819035 | Targeting BCL-2 regulated apoptosis in cancer. |
| Q93382193 | Targeting EIF4E signaling with ribavirin in infant acute lymphoblastic leukemia |
| Q37990881 | Targeting Mnks for cancer therapy |
| Q35208375 | Targeting cap-dependent translation blocks converging survival signals by AKT and PIM kinases in lymphoma |
| Q34130816 | Targeting eukaryotic translation initiation factor 4E (eIF4E) in cancer |
| Q50046142 | Targeting of phospho-eIF4E by homoharringtonine eradicates a distinct subset of human acute myeloid leukemia |
| Q39172901 | Targeting of protein translation as a new treatment paradigm for prostate cancer |
| Q36950337 | Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell function |
| Q35941539 | Targeting synthetic lethal interactions between Myc and the eIF4F complex impedes tumorigenesis |
| Q84556627 | Targeting the PI3K/AKT/mTOR pathway in non-Hodgkin's lymphoma: results, biology, and development strategies |
| Q36237322 | Targeting the eIF4A RNA helicase blocks translation of the MUC1-C oncoprotein |
| Q34988282 | Targeting the eIF4F translation initiation complex: a critical nexus for cancer development |
| Q38368049 | Targeting the translation machinery in cancer |
| Q33747291 | Targeting the translational machinery as a novel treatment strategy for hematologic malignancies |
| Q37850227 | Targeting translation dependence in cancer |
| Q38699320 | Targeting translation: eIF4E as an emerging anticancer drug target |
| Q26778934 | The La-Related Proteins, a Family with Connections to Cancer |
| Q58580106 | The Natural Compound Homoharringtonine Presents Broad Antiviral Activity In Vitro and In Vivo |
| Q64070603 | The Novel Mnk1/2 Degrader and Apoptosis Inducer VNLG-152 Potently Inhibits TNBC Tumor Growth and Metastasis |
| Q36052399 | The PP242 mammalian target of rapamycin (mTOR) inhibitor activates extracellular signal-regulated kinase (ERK) in multiple myeloma cells via a target of rapamycin complex 1 (TORC1)/eukaryotic translation initiation factor 4E (eIF-4E)/RAF pathway and |
| Q46063833 | The androgen receptor is a negative regulator of eIF4E phosphorylation at S209: implications for the use of mTOR inhibitors in advanced prostate cancer |
| Q37848652 | The biological and therapeutic relevance of mRNA translation in cancer |
| Q39363181 | The cap-translation inhibitor 4EGI-1 induces apoptosis in multiple myeloma through Noxa induction. |
| Q36527188 | The eIF4E RNA regulon promotes the Akt signaling pathway |
| Q29547270 | The mechanism of eukaryotic translation initiation and principles of its regulation |
| Q37726434 | The molecular basis of translational control |
| Q37726457 | The regulation of protein synthesis in cancer |
| Q34978844 | The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival |
| Q38175044 | The role of the dysfunctional akt-related pathway in cancer: establishment and maintenance of a malignant cell phenotype, resistance to therapy, and future strategies for drug development |
| Q30503547 | The sphingosine 1-phosphate receptor S1P₂ maintains the homeostasis of germinal center B cells and promotes niche confinement |
| Q36473355 | Therapeutic interventions to disrupt the protein synthetic machinery in melanoma |
| Q37837732 | Therapeutic resistance resulting from mutations in Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR signaling pathways. |
| Q38408862 | Tissue microarray evidence of association between p16 and phosphorylated eIF4E in tonsillar squamous cell carcinoma. |
| Q44682175 | Transcriptional analysis of left-sided colitis, pancolitis, and ulcerative colitis-associated dysplasia |
| Q90269368 | Translating Translation to Mechanisms of Cardiac Hypertrophy |
| Q36447578 | Translation Inhibition by Rocaglates Is Independent of eIF4E Phosphorylation Status |
| Q38104237 | Translation factors and ribosomal proteins control tumor onset and progression: how? |
| Q36347246 | Translation inhibitors induce cell death by multiple mechanisms and Mcl-1 reduction is only a minor contributor |
| Q34218069 | Translation initiation factor eIF4F modifies the dexamethasone response in multiple myeloma |
| Q37586472 | Translation initiation: a critical signalling node in cancer |
| Q36555212 | Translational control in cancer etiology |
| Q37717999 | Translational control in cancer. |
| Q49790269 | Translational control in the tumor microenvironment promotes lung metastasis: Phosphorylation of eIF4E in neutrophils |
| Q44915601 | Translational control of cell growth and malignancy by the CPEBs |
| Q37369258 | Translational control of long-lasting synaptic plasticity and memory |
| Q33655882 | Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E. |
| Q35579583 | Translational regulation in nutrigenomics |
| Q91329970 | Translational reprogramming marks adaptation to asparagine restriction in cancer |
| Q36843535 | Tumorigenic activity and therapeutic inhibition of Rheb GTPase |
| Q38791406 | Unveiling new chemical scaffolds as Mnk inhibitors. |
| Q102075475 | Venetoclax and pegcrisantaspase for complex karyotype acute myeloid leukemia |
| Q28268118 | Versatility of RNA-Binding Proteins in Cancer |
| Q37726462 | Viral strategies to subvert the mammalian translation machinery |
| Q34069836 | eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression |
| Q28586333 | eIF6 coordinates insulin sensitivity and lipid metabolism by coupling translation to transcription |
| Q41233635 | mTOR in viral hepatitis and hepatocellular carcinoma: function and treatment |
| Q37680565 | mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1. |
| Q24633662 | mTOR: from growth signal integration to cancer, diabetes and ageing |
| Q41840986 | mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition |
| Q36825427 | mTORC1 promotes survival through translational control of Mcl-1. |
| Q37817590 | mTORC1 signaling: what we still don't know |
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