Inhibiting ERK/Mnk/eIF4E broadly sensitizes ovarian cancer response to chemotherapy.

scientific article

Inhibiting ERK/Mnk/eIF4E broadly sensitizes ovarian cancer response to chemotherapy. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S12094-017-1724-0
P698PubMed publication ID28766096

P50authorSanying LiuQ88657342
P2093author name stringM Lei
J Zha
P2860cites workCancer statistics, 2015Q27860576
Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistanceQ28307294
Quantitative analysis of histological staining and fluorescence using ImageJQ28364633
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functionsQ29615216
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HMGB1 promotes differentiation syndrome by inducing hyperinflammation via MEK/ERK signaling in acute promyelocytic leukemia cellsQ33689028
Small‐Molecule Inhibitors of the ERK Signaling Pathway: Towards Novel Anticancer TherapeuticsQ33756524
Inhibition of ERK1/2 Restores GSK3β Activity and Protein Synthesis Levels in a Model of Tuberous SclerosisQ33829976
Second-line treatment of ovarian cancerQ33856411
Phosphorylated Mnk1 and eIF4E are associated with lymph node metastasis and poor prognosis of nasopharyngeal carcinomaQ35097767
Ovarian cancer: strategies for overcoming resistance to chemotherapyQ35166813
Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic ApproachesQ35553279
Ribavirin Inhibits the Activity of mTOR/eIF4E, ERK/Mnk1/eIF4E Signaling Pathway and Synergizes with Tyrosine Kinase Inhibitor Imatinib to Impair Bcr-Abl Mediated Proliferation and Apoptosis in Ph+ LeukemiaQ35758763
Dissecting eIF4E action in tumorigenesisQ36209711
Inhibition of Mnk kinase activity by cercosporamide and suppressive effects on acute myeloid leukemia precursorsQ36814636
eIF4E knockdown decreases breast cancer cell growth without activating Akt signalingQ36920075
Targeting of the MNK-eIF4E axis in blast crisis chronic myeloid leukemia inhibits leukemia stem cell functionQ36950337
Inhibiting the MNK-eIF4E-β-catenin axis increases the responsiveness of aggressive breast cancer cells to chemotherapyQ37709399
Targeting the eIF4E/β-catenin axis sensitizes cervical carcinoma squamous cells to chemotherapyQ37733009
Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.Q37865381
Targeting Mnks for cancer therapyQ37990881
Current management of ovarian cancerQ38434742
Knockdown of eIF4E suppresses cell proliferation, invasion and enhances cisplatin cytotoxicity in human ovarian cancer cellsQ38825129
Significance of MNK1 in prognostic prediction and chemotherapy development of epithelial ovarian cancerQ38884652
Inhibition of MNK pathways enhances cancer cell response to chemotherapy with temozolomide and targeted radionuclide therapyQ39691135
The MEK1-ERK1/2 signaling pathway promotes compensated cardiac hypertrophy in transgenic miceQ40388321
Docetaxel cytotoxicity is enhanced by inhibition of the Raf/MEK/ERK signal transduction pathwayQ40605097
Effect of extracellular signal-regulated kinase on p53 accumulation in response to cisplatinQ40859019
Hydrogen peroxide activation of multiple mitogen-activated protein kinases in an oligodendrocyte cell line: role of extracellular signal-regulated kinase in hydrogen peroxide-induced cell deathQ40981560
Paclitaxel induces prolonged activation of the Ras/MEK/ERK pathway independently of activating the programmed cell death machineryQ43559980
Dual targeting of eIF4E by blocking MNK and mTOR pathways in leukemiaQ48057652
Inhibition of HER2/neu (erbB-2) and mitogen-activated protein kinases enhances tamoxifen action against HER2-overexpressing, tamoxifen-resistant breast cancer cells.Q54031538
Insulin-like growth factor-I protects colon cancer cells from death factor-induced apoptosis by potentiating tumor necrosis factor alpha-induced mitogen-activated protein kinase and nuclear factor kappaB signaling pathwaysQ73679077
Activation of extracellular signal-regulated kinase ERK after hypo-osmotic stress in renal epithelial A6 cellsQ80489507
P433issue3
P921main subjectovarian cancerQ172341
P304page(s)374-381
P577publication date2017-08-01
P1433published inClinical and Translational OncologyQ15754324
P1476titleInhibiting ERK/Mnk/eIF4E broadly sensitizes ovarian cancer response to chemotherapy
P478volume20

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cites work (P2860)
Q65000057ERK is a Pivotal Player of Chemo-Immune-Resistance in Cancer.
Q97419627GRHL2 Upregulation Predicts a Poor Prognosis and Promotes the Resistance of Serous Ovarian Cancer to Cisplatin
Q93183654Induction of MNK Kinase-dependent eIF4E Phosphorylation by Inhibitors Targeting BET Proteins Limits Efficacy of BET Inhibitors
Q52632734MAP Kinase-Interacting Kinase 1 Promotes Proliferation and Invasion of Hepatocellular Carcinoma and Is an Unfavorable Prognostic Biomarker.
Q64247410MNK1/NODAL Signaling Promotes Invasive Progression of Breast Ductal Carcinoma

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