Hypoxia-mediated autophagic flux inhibits silver nanoparticle-triggered apoptosis in human lung cancer cells.

scientific article published on 12 February 2016

Hypoxia-mediated autophagic flux inhibits silver nanoparticle-triggered apoptosis in human lung cancer cells. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/SREP21688
P932PMC publication ID4751501
P698PubMed publication ID26867977
P5875ResearchGate publication ID294289288

P50authorJin-Hoi KimQ56761554
Ssang-Goo ChoQ57190964
P2093author name stringChankyu Park
Yun-Jung Choi
Hyuk Song
Min-Hee Kang
Han Geuk Seo
Jae-Kyo Jeong
Deug-Nam Kwon
Sangiliyandi Gurunathan
Jae Woong Han
Joydeep Das
P2860cites workHypoxia induces protection against etoposide-induced apoptosis: molecular profiling of changes in gene expression and transcription factor activityQ21245725
Identification of the hypoxia-inducible factor 1 alpha-responsive HGTD-P gene as a mediator in the mitochondrial apoptotic pathwayQ24336803
mir-210: a sensor for hypoxic stress during tumorigenesisQ24619437
The VHL tumor suppressor: master regulator of HIFQ24634592
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domainsQ28114920
HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleusQ28191456
Tumor hypoxia: definitions and current clinical, biologic, and molecular aspectsQ28200181
Hypoxia and nitric oxide treatment confer tolerance to glucose starvation in a 5'-AMP-activated protein kinase-dependent mannerQ28208032
Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alphaQ28259513
Exposure of silver-nanoparticles and silver-ions to lung cells in vitro at the air-liquid interfaceQ29248681
Hypoxia--a key regulatory factor in tumour growthQ29547318
Autophagy regulates lipid metabolismQ29547421
Cytotoxicity and genotoxicity of silver nanoparticles in human cellsQ29615488
Rapamycin up-regulation of autophagy reduces infarct size and improves outcomes in both permanent MCAL, and embolic MCAO, murine models of strokeQ30412044
Anti-proliferative activity of silver nanoparticlesQ33504392
Overcoming hypoxic-resistance of tumor cells to TRAIL-induced apoptosis through melatoninQ34072314
Antitumor activity of silver nanoparticles in Dalton's lymphoma ascites tumor modelQ34231168
Interactions between autophagy receptors and ubiquitin-like proteins form the molecular basis for selective autophagy.Q34399968
JC-1: alternative excitation wavelengths facilitate mitochondrial membrane potential cytometryQ34484892
Monitoring autophagic degradation of p62/SQSTM1.Q50603624
Hypoxia inhibition of apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL).Q52594169
Dose-dependent in-vivo toxicity assessment of silver nanoparticle in Wistar rats.Q53289194
Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis.Q53597468
Silica and titanium dioxide nanoparticles cause pregnancy complications in miceQ83772051
Hypoxia-induced autophagy: a new player in cancer immunotherapy?Q95467535
Autophagy, inflammation and neurodegenerative diseaseQ34686890
LC3 and AutophagyQ34772075
Knockdown of autophagy-related protein 5, ATG5, decreases oxidative stress and has an opposing effect on camptothecin-induced cytotoxicity in osteosarcoma cellsQ35026243
Hypoxia-inducible factor and its biomedical relevanceQ35086124
Role and regulation of autophagy in cancerQ35161917
Continuous hypoxia attenuates paraquat-induced cytotoxicity in the human A549 lung carcinoma cell lineQ35463874
Differential effects of hypoxia on etoposide-induced apoptosis according to the cancer cell linesQ36177149
Hypoxia-inducible factors: central regulators of the tumor phenotypeQ36701590
Nanosilver: a nanoproduct in medical applicationQ37006108
Green synthesis of silver nanoparticles using Ganoderma neo-japonicum Imazeki: a potential cytotoxic agent against breast cancer cells.Q37323343
Potential theranostics application of bio-synthesized silver nanoparticles (4-in-1 system).Q37558875
p62/SQSTM1/A170: physiology and pathologyQ38030264
Silver nanoparticle-induced oxidative stress, genotoxicity and apoptosis in cultured cells and animal tissuesQ38039366
Interaction domains of p62: a bridge between p62 and selective autophagyQ38093208
New prospects for drug development: the hedgehog pathway revealed. Focus on hematologic malignanciesQ38104413
Sequestosome1/p62: a regulator of redox-sensitive voltage-activated potassium channels, arterial remodeling, inflammation, and neurite outgrowthQ38116302
The Atg8 family: multifunctional ubiquitin-like key regulators of autophagyQ38144277
Selective autophagyQ38144281
Emerging role of selective autophagy in human diseasesQ38270177
Autophagy inhibition sensitizes colon cancer cells to antiangiogenic and cytotoxic therapyQ39185200
Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastomaQ39374075
Inhibition of hypoxia-inducible factor-1 function enhances the sensitivity of multiple myeloma cells to melphalanQ39813872
Hypoxia signals autophagy in tumor cells via AMPK activity, independent of HIF-1, BNIP3, and BNIP3L.Q39972651
A life-span extending form of autophagy employs the vacuole-vacuole fusion machineryQ40061500
Hypoxia inhibits TRAIL-induced tumor cell apoptosis: involvement of lysosomal cathepsinsQ40202626
Modulation of TRAIL-induced tumor cell apoptosis in a hypoxic environmentQ40350114
Hypoxia and drug resistanceQ40630925
The role of the selective adaptor p62 and ubiquitin-like proteins in autophagy.Q41470238
The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.Q41736480
Cytotoxicity, oxidative stress, apoptosis and the autophagic effects of silver nanoparticles in mouse embryonic fibroblastsQ42805360
Apoptosis induction in human leukemic cells by a novel protein Bengalin, isolated from Indian black scorpion venom: through mitochondrial pathway and inhibition of heat shock proteinsQ43242372
Calpain mediates a von Hippel-Lindau protein-independent destruction of hypoxia-inducible factor-1alphaQ43252221
Antiangiogenic properties of silver nanoparticlesQ43287968
Expression of genes related to oxidative stress in the mouse brain after exposure to silver-25 nanoparticles.Q46017996
Can silver nanoparticles be useful as potential biological labels?Q47654721
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectlung cancerQ47912
nanoparticleQ61231
hypoxiaQ105688
autophagyQ288322
silver nanoparticleQ905762
P304page(s)21688
P577publication date2016-02-12
P1433published inScientific ReportsQ2261792
P1476titleHypoxia-mediated autophagic flux inhibits silver nanoparticle-triggered apoptosis in human lung cancer cells
P478volume6

Reverse relations

cites work (P2860)
Q90009724A Current Overview of the Biological and Cellular Effects of Nanosilver
Q57928617A systematic review on silver nanoparticles-induced cytotoxicity: Physicochemical properties and perspectives
Q46385282Activation of autophagy by elevated reactive oxygen species rather than released silver ions promotes cytotoxicity of polyvinylpyrrolidone-coated silver nanoparticles in hematopoietic cells.
Q58567784Apoptotic role of marine sponge symbiont Bacillus subtilis NMK17 through the activation of caspase-3 in human breast cancer cell line
Q42736018Asymmetric dumbbell-shaped silver nanoparticles and spherical gold nanoparticles green-synthesized by mangosteen (Garcinia mangostana) pericarp waste extracts
Q55717899Biosynthesized Protein-Capped Silver Nanoparticles Induce ROS-Dependent Proapoptotic Signals and Prosurvival Autophagy in Cancer Cells.
Q58692747Combination Effect of Silver Nanoparticles and Histone Deacetylases Inhibitor in Human Alveolar Basal Epithelial Cells
Q59798927Cytotoxicity and Transcriptomic Analysis of Silver Nanoparticles in Mouse Embryonic Fibroblast Cells
Q42656462Dual functions of silver nanoparticles in F9 teratocarcinoma stem cells, a suitable model for evaluating cytotoxicity- and differentiation-mediated cancer therapy
Q90636031Effects of Green Silver Nanoparticles on Apoptosis and Oxidative Stress in Normal and Cancerous Human Hepatic Cells in vitro
Q92244146Exploiting Nanomaterial-mediated Autophagy for Cancer Therapy
Q64374734HIF1A and NFAT5 coordinate Na-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting
Q89341688Inhibition of autophagy enhanced cobalt chloride‑induced apoptosis in rat alveolar type II epithelial cells
Q47839200LincRNA-p21 knockdown enhances radiosensitivity of hypoxic tumor cells by reducing autophagy through HIF-1/Akt/mTOR/P70S6K pathway
Q90363475Microcellular Environmental Regulation of Silver Nanoparticles in Cancer Therapy: A Critical Review
Q64241922Microwave induced synthesis of ZnO nanorods and their efficacy as a drug carrier with profound anticancer and antibacterial properties
Q90041357Mitochondrial Peptide Humanin Protects Silver Nanoparticles-Induced Neurotoxicity in Human Neuroblastoma Cancer Cells (SH-SY5Y)
Q89769994Modulation of bone turnover aberration: A target for management of primary osteoporosis in experimental rat model
Q36229006Polyethylenimine-functionalized silver nanoparticle-based co-delivery of paclitaxel to induce HepG2 cell apoptosis
Q40071681Quercetin-mediated synthesis of graphene oxide-silver nanoparticle nanocomposites: a suitable alternative nanotherapy for neuroblastoma
Q64900721Recent Progress in the Theranostics Application of Nanomedicine in Lung Cancer.
Q28079043Silver Nanoparticle-Mediated Cellular Responses in Various Cell Lines: An in Vitro Model
Q60959037Silver Nanoparticles Potentiates Cytotoxicity and Apoptotic Potential of Camptothecin in Human Cervical Cancer Cells
Q36229000Silver nanoparticles inhibit the function of hypoxia-inducible factor-1 and target genes: insight into the cytotoxicity and antiangiogenesis
Q89985480Silver nanoparticles selectively treat triple-negative breast cancer cells without affecting non-malignant breast epithelial cells in vitro and in vivo
Q46345734Surface modification minimizes the toxicity of silver nanoparticles: an in vitro and in vivo study.
Q92290679Tangeretin-Assisted Platinum Nanoparticles Enhance the Apoptotic Properties of Doxorubicin: Combination Therapy for Osteosarcoma Treatment
Q64976486Targeting autophagy using metallic nanoparticles: a promising strategy for cancer treatment.
Q38717240The Antiproliferative and Colony-suppressive Activities of STAT3 Inhibitors in Human Cancer Cells Is Compromised Under Hypoxic Conditions
Q58089089The impact of nanoparticle-driven lysosomal alkalinization on cellular functionality
Q55005742The role of HIF-1α in chemo-/radioresistant tumors.
Q38917270Toxicity evaluation of silver nanoparticles synthesized by chemical and green route in different experimental models

Search more.