Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities

scientific article published on October 2008

Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/CLPT.2008.102
P932PMC publication ID3583338
P698PubMed publication ID19238656
P5875ResearchGate publication ID5237783

P2093author name stringA Walker
E D Kharasch
D Whittington
C Hoffer
P S Bedynek
P2860cites workEffect of extended exposure to grapefruit juice on cytochrome P450 3A activity in humans: comparison with ritonavirQ46972814
In vivo activation of human pregnane X receptor tightens the blood-brain barrier to methadone through P-glycoprotein up-regulationQ48473453
Extensive impairment of triazolam and alprazolam clearance by short-term low-dose ritonavir: the clinical dilemma of concurrent inhibition and induction.Q51088676
Ritonavir's role in reducing fentanyl clearance and prolonging its half-life.Q51441513
Time-Dependent Interaction Between Lopinavir/Ritonavir and FexofenadineQ61989765
The long-term effect of verapamil on plasma digoxin concentration and renal digoxin clearance in healthy subjectsQ70399244
St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4Q73443725
Alprazolam-ritonavir interaction: implications for product labelingQ73761350
Ritonavir. Clinical pharmacokinetics and interactions with other anti-HIV agentsQ77542483
Lopinavir/ritonavir reduces bupropion plasma concentrations in healthy subjectsQ79448424
Effect of grapefruit juice volume on the reduction of fexofenadine bioavailability: possible role of organic anion transporting polypeptidesQ28237138
Influence of CYP3A5 genotype on the pharmacokinetics and pharmacodynamics of the cytochrome P4503A probes alfentanil and midazolamQ28305304
Decreased methadone effect after ritonavir initiationQ28368991
OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadineQ28369686
The effect of rifampin administration on the disposition of fexofenadineQ32156844
Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadoneQ34348923
Effects of itraconazole and diltiazem on the pharmacokinetics of fexofenadine, a substrate of P-glycoproteinQ35827580
The effect of ketoconazole on the in vivo intestinal permeability of fexofenadine using a regional perfusion techniqueQ35846680
Treatment of opioid dependence and coinfection with HIV and hepatitis C virus in opioid-dependent patients: the importance of drug interactions between opioids and antiretroviral agentsQ36304438
Pharmacokinetic drug interactions between opioid agonist therapy and antiretroviral medications: implications and management for clinical practiceQ36465406
An update and review of antiretroviral therapyQ36545072
Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearanceQ36641884
Contribution of OATP (organic anion-transporting polypeptide) family transporters to the hepatic uptake of fexofenadine in humansQ40398090
Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadineQ40753067
Ritonavir induces P-glycoprotein expression, multidrug resistance-associated protein (MRP1) expression, and drug transporter-mediated activity in a human intestinal cell lineQ40763015
Substantial pharmacokinetic interaction between digoxin and ritonavir in healthy volunteersQ42630554
Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1)Q42758868
Methadone blood concentrations are decreased by the administration of abacavir plus amprenavirQ43760231
Effect of St John's wort on the pharmacokinetics of fexofenadineQ44043537
Fexofenadine transport in Caco-2 cells: inhibition with verapamil and ritonavirQ44202487
Model-based analysis of the pharmacokinetic interactions between ritonavir, nelfinavir, and saquinavir after simultaneous and staggered oral administrationQ44217895
Opiate-induced analgesia is increased and prolonged in mice lacking P-glycoproteinQ44312369
Variable modulation of opioid brain uptake by P-glycoprotein in miceQ44344008
Pharmacokinetics and pharmacodynamics of methadone enantiomers after coadministration with amprenavir in opioid-dependent subjectsQ44346900
The protease inhibitor lopinavir-ritonavir may produce opiate withdrawal in methadone-maintained patientsQ44540993
Multiple transport mechanisms involved in the intestinal absorption and first-pass extraction of fexofenadineQ44637319
Functional Characterization of pH-Sensitive Organic Anion Transporting Polypeptide OATP-B in HumanQ44650608
Brain penetration of methadone (R)- and (S)-enantiomers is greatly increased by P-glycoprotein deficiency in the blood-brain barrier of Abcb1a gene knockout miceQ44719752
Ritonavir and dexamethasone induce expression of CYP3A and P-glycoprotein in ratsQ44777237
Ritonavir decreases the nonrenal clearance of digoxin in healthy volunteers with known MDR1 genotypesQ44913929
Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosisQ45146008
Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymesQ45158721
Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using alfentanil and fexofenadine in combinationQ45188831
Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokineticsQ45215056
Pharmacogenetic determinants of human liver microsomal alfentanil metabolism and the role of cytochrome P450 3A5.Q45282861
Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactionsQ45401784
CYP3A probes can quantitatively predict the in vivo kinetics of other CYP3A substrates and can accurately assess CYP3A induction and inhibitionQ46580820
Effect of itraconazole on the pharmacokinetics and pharmacodynamics of fexofenadine in relation to the MDR1 genetic polymorphismQ46638501
Effect of erythromycin on the absorption of fexofenadine in the jejunum, ileum and colon determined using local intubation in healthy volunteers.Q46964154
The effect of short- and long-term administration of verapamil on the disposition of cytochrome P450 3A and P-glycoprotein substratesQ46972809
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectpharmacokineticsQ323936
ritonavirQ422618
pharmacodynamicsQ725307
P304page(s)506-512
P577publication date2008-10-01
P1433published inClinical Pharmacology & TherapeuticsQ1101529
P1476titleMechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities
P478volume84

Reverse relations

cites work (P2860)
Q34573885Assessment of a candidate marker constituent predictive of a dietary substance-drug interaction: case study with grapefruit juice and CYP3A4 drug substrates
Q50668713Clarification of P-glycoprotein inhibition-related drug-drug interaction risks based on a literature search of the clinical information.
Q30234940Clinical Implications of P-Glycoprotein Modulation in Drug-Drug Interactions.
Q43254867Clinically significant adverse events from a drug interaction between quetiapine and atazanavir-ritonavir in two patients
Q35776626Complex drug interactions of the HIV protease inhibitors 3: effect of simultaneous or staggered dosing of digoxin and ritonavir, nelfinavir, rifampin, or bupropion
Q36646017Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil
Q50682107Current Concepts in Methadone Metabolism and Transport.
Q36036200Cyclosporine-inhibitable cerebral drug transport does not influence clinical methadone pharmacodynamics
Q37325606Cytochrome P4503A does not mediate the interaction between methadone and ritonavir-lopinavir
Q54646435Drug interactions with methadone: Time to revise the product label.
Q36326853Effect of HAART on Brain Organization and Function in HIV-Negative Subjects
Q35000765Efflux transporters- and cytochrome P-450-mediated interactions between drugs of abuse and antiretrovirals
Q46780885Enhanced oral bioavailability of felodipine by naringenin in Wistar rats and inhibition of P-glycoprotein in everted rat gut sacs in vitro
Q37705351Evaluation of in vivo P-glycoprotein phenotyping probes: a need for validation
Q47303894Fexofenadine, a Putative In Vivo P-glycoprotein Probe, Fails to Predict Clearance of the Substrate Tacrolimus in Renal Recipients.
Q37113947Influence of drug transport proteins on the pharmacokinetics and drug interactions of HIV protease inhibitors.
Q42931493Inhibition of oral midazolam clearance by boosting doses of ritonavir, and by 4,4-dimethyl-benziso-(2H)-selenazine (ALT-2074), an experimental catalytic mimic of glutathione oxidase
Q39245872Intestinal Drug Interactions Mediated by OATPs: A Systematic Review of Preclinical and Clinical Findings
Q36652680Lack of indinavir effects on methadone disposition despite inhibition of hepatic and intestinal cytochrome P4503A (CYP3A).
Q59357868Lopinavir/ritonavir treatment increases the placental transfer of bupivacaine enantiomers in human immunodeficiency virus-infected pregnant women
Q26775832Management of HIV/AIDS in older patients-drug/drug interactions and adherence to antiretroviral therapy
Q36693543Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics
Q36641884Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance
Q48092928Mechanisms of pharmacokinetic enhancement between ritonavir and saquinavir; micro/small dosing tests using midazolam (CYP3A4), fexofenadine (p-glycoprotein), and pravastatin (OATP1B1) as probe drugs
Q38880731Membrane Assays to Characterize Interaction of Drugs with ABCB1.
Q36637864Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity
Q34604652Methadone pharmacokinetics are independent of cytochrome P4503A (CYP3A) activity and gastrointestinal drug transport: insights from methadone interactions with ritonavir/indinavir
Q35087543Nerve growth factor β polypeptide (NGFB) genetic variability: association with the methadone dose required for effective maintenance treatment
Q42941908Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir
Q36578070Perioperative pharmacokinetics of methadone in adolescents
Q46003084Plasma 4beta-hydroxycholesterol: an endogenous CYP3A metric?
Q36072448Ritonavir is the best alternative to ketoconazole as an index inhibitor of cytochrome P450-3A in drug-drug interaction studies
Q33806539S-Methadone augments R-methadone induced respiratory depression in the neonatal guinea pig.
Q38478413Transporter-Mediated Disposition of Opioids: Implications for Clinical Drug Interactions

Search more.