scholarly article | Q13442814 |
P2093 | author name string | A Walker | |
E D Kharasch | |||
D Whittington | |||
C Hoffer | |||
P S Bedynek | |||
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Lopinavir/ritonavir reduces bupropion plasma concentrations in healthy subjects | Q79448424 | ||
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Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine | Q40753067 | ||
Ritonavir induces P-glycoprotein expression, multidrug resistance-associated protein (MRP1) expression, and drug transporter-mediated activity in a human intestinal cell line | Q40763015 | ||
Substantial pharmacokinetic interaction between digoxin and ritonavir in healthy volunteers | Q42630554 | ||
Fexofenadine pharmacokinetics are associated with a polymorphism of the SLCO1B1 gene (encoding OATP1B1) | Q42758868 | ||
Methadone blood concentrations are decreased by the administration of abacavir plus amprenavir | Q43760231 | ||
Effect of St John's wort on the pharmacokinetics of fexofenadine | Q44043537 | ||
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Model-based analysis of the pharmacokinetic interactions between ritonavir, nelfinavir, and saquinavir after simultaneous and staggered oral administration | Q44217895 | ||
Opiate-induced analgesia is increased and prolonged in mice lacking P-glycoprotein | Q44312369 | ||
Variable modulation of opioid brain uptake by P-glycoprotein in mice | Q44344008 | ||
Pharmacokinetics and pharmacodynamics of methadone enantiomers after coadministration with amprenavir in opioid-dependent subjects | Q44346900 | ||
The protease inhibitor lopinavir-ritonavir may produce opiate withdrawal in methadone-maintained patients | Q44540993 | ||
Multiple transport mechanisms involved in the intestinal absorption and first-pass extraction of fexofenadine | Q44637319 | ||
Functional Characterization of pH-Sensitive Organic Anion Transporting Polypeptide OATP-B in Human | Q44650608 | ||
Brain penetration of methadone (R)- and (S)-enantiomers is greatly increased by P-glycoprotein deficiency in the blood-brain barrier of Abcb1a gene knockout mice | Q44719752 | ||
Ritonavir and dexamethasone induce expression of CYP3A and P-glycoprotein in rats | Q44777237 | ||
Ritonavir decreases the nonrenal clearance of digoxin in healthy volunteers with known MDR1 genotypes | Q44913929 | ||
Intravenous and oral alfentanil as in vivo probes for hepatic and first-pass cytochrome P450 3A activity: noninvasive assessment by use of pupillary miosis | Q45146008 | ||
Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes | Q45158721 | ||
Evaluation of first-pass cytochrome P4503A (CYP3A) and P-glycoprotein activities using alfentanil and fexofenadine in combination | Q45188831 | ||
Different effects of three transporting inhibitors, verapamil, cimetidine, and probenecid, on fexofenadine pharmacokinetics | Q45215056 | ||
Pharmacogenetic determinants of human liver microsomal alfentanil metabolism and the role of cytochrome P450 3A5. | Q45282861 | ||
Cytochrome P450 enzymes and transporters induced by anti-human immunodeficiency virus protease inhibitors in human hepatocytes: implications for predicting clinical drug interactions | Q45401784 | ||
CYP3A probes can quantitatively predict the in vivo kinetics of other CYP3A substrates and can accurately assess CYP3A induction and inhibition | Q46580820 | ||
Effect of itraconazole on the pharmacokinetics and pharmacodynamics of fexofenadine in relation to the MDR1 genetic polymorphism | Q46638501 | ||
Effect of erythromycin on the absorption of fexofenadine in the jejunum, ileum and colon determined using local intubation in healthy volunteers. | Q46964154 | ||
The effect of short- and long-term administration of verapamil on the disposition of cytochrome P450 3A and P-glycoprotein substrates | Q46972809 | ||
P433 | issue | 4 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | pharmacokinetics | Q323936 |
ritonavir | Q422618 | ||
pharmacodynamics | Q725307 | ||
P304 | page(s) | 506-512 | |
P577 | publication date | 2008-10-01 | |
P1433 | published in | Clinical Pharmacology & Therapeutics | Q1101529 |
P1476 | title | Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities | |
P478 | volume | 84 |
Q34573885 | Assessment of a candidate marker constituent predictive of a dietary substance-drug interaction: case study with grapefruit juice and CYP3A4 drug substrates |
Q50668713 | Clarification of P-glycoprotein inhibition-related drug-drug interaction risks based on a literature search of the clinical information. |
Q30234940 | Clinical Implications of P-Glycoprotein Modulation in Drug-Drug Interactions. |
Q43254867 | Clinically significant adverse events from a drug interaction between quetiapine and atazanavir-ritonavir in two patients |
Q35776626 | Complex drug interactions of the HIV protease inhibitors 3: effect of simultaneous or staggered dosing of digoxin and ritonavir, nelfinavir, rifampin, or bupropion |
Q36646017 | Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil |
Q50682107 | Current Concepts in Methadone Metabolism and Transport. |
Q36036200 | Cyclosporine-inhibitable cerebral drug transport does not influence clinical methadone pharmacodynamics |
Q37325606 | Cytochrome P4503A does not mediate the interaction between methadone and ritonavir-lopinavir |
Q54646435 | Drug interactions with methadone: Time to revise the product label. |
Q36326853 | Effect of HAART on Brain Organization and Function in HIV-Negative Subjects |
Q35000765 | Efflux transporters- and cytochrome P-450-mediated interactions between drugs of abuse and antiretrovirals |
Q46780885 | Enhanced oral bioavailability of felodipine by naringenin in Wistar rats and inhibition of P-glycoprotein in everted rat gut sacs in vitro |
Q37705351 | Evaluation of in vivo P-glycoprotein phenotyping probes: a need for validation |
Q47303894 | Fexofenadine, a Putative In Vivo P-glycoprotein Probe, Fails to Predict Clearance of the Substrate Tacrolimus in Renal Recipients. |
Q37113947 | Influence of drug transport proteins on the pharmacokinetics and drug interactions of HIV protease inhibitors. |
Q42931493 | Inhibition of oral midazolam clearance by boosting doses of ritonavir, and by 4,4-dimethyl-benziso-(2H)-selenazine (ALT-2074), an experimental catalytic mimic of glutathione oxidase |
Q39245872 | Intestinal Drug Interactions Mediated by OATPs: A Systematic Review of Preclinical and Clinical Findings |
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Q26775832 | Management of HIV/AIDS in older patients-drug/drug interactions and adherence to antiretroviral therapy |
Q36693543 | Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics |
Q36641884 | Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: I. Evidence against CYP3A mediation of methadone clearance |
Q48092928 | Mechanisms of pharmacokinetic enhancement between ritonavir and saquinavir; micro/small dosing tests using midazolam (CYP3A4), fexofenadine (p-glycoprotein), and pravastatin (OATP1B1) as probe drugs |
Q38880731 | Membrane Assays to Characterize Interaction of Drugs with ABCB1. |
Q36637864 | Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity |
Q34604652 | Methadone pharmacokinetics are independent of cytochrome P4503A (CYP3A) activity and gastrointestinal drug transport: insights from methadone interactions with ritonavir/indinavir |
Q35087543 | Nerve growth factor β polypeptide (NGFB) genetic variability: association with the methadone dose required for effective maintenance treatment |
Q42941908 | Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir |
Q36578070 | Perioperative pharmacokinetics of methadone in adolescents |
Q46003084 | Plasma 4beta-hydroxycholesterol: an endogenous CYP3A metric? |
Q36072448 | Ritonavir is the best alternative to ketoconazole as an index inhibitor of cytochrome P450-3A in drug-drug interaction studies |
Q33806539 | S-Methadone augments R-methadone induced respiratory depression in the neonatal guinea pig. |
Q38478413 | Transporter-Mediated Disposition of Opioids: Implications for Clinical Drug Interactions |
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