Plasma 4beta-hydroxycholesterol: an endogenous CYP3A metric?

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Plasma 4beta-hydroxycholesterol: an endogenous CYP3A metric? is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1041268147
P356DOI10.1038/CLPT.2009.72
P698PubMed publication ID19458613
P5875ResearchGate publication ID24442817

P2093author name stringD Frank
D Lütjohann
A Jetter
O Doroshyenko
U Fuhr
D Tomalik-Scharte
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Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activitiesQ36641870
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Time course of the increase in 4beta-hydroxycholesterol concentration during carbamazepine treatment of paediatric patients with epilepsyQ36729155
High doses of simvastatin, pravastatin, and cholesterol reduce brain cholesterol synthesis in guinea pigs.Q40541341
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Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.Q40784945
4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicinQ43146767
4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and TanzaniansQ43944775
Influence of propiverine on hepatic microsomal cytochrome p450 enzymes in male ratsQ44447128
Metabolism and elimination of quinine in healthy volunteersQ44550877
In vivo comparisons of constitutive cytochrome P450 3A activity assessed by alprazolam, triazolam, and midazolamQ45095095
Differential mechanism-based inhibition of CYP3A4 and CYP3A5 by verapamilQ45249932
There are no useful CYP3A probes that quantitatively predict the in vivo kinetics of other CYP3A substrates and no expectation that one will be foundQ46430562
No role for the CYP3A5*3 polymorphism in intestinal and hepatic metabolism of midazolamQ46512594
CYP3A probes can quantitatively predict the in vivo kinetics of other CYP3A substrates and can accurately assess CYP3A induction and inhibitionQ46580820
CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levelsQ46610452
Effect of an antiretroviral regimen containing ritonavir boosted lopinavir on intestinal and hepatic CYP3A, CYP2D6 and P-glycoprotein in HIV-infected patientsQ46816943
Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activityQ46856522
P433issue2
P407language of work or nameEnglishQ1860
P921main subject4β-hydroxycholesterolQ27158713
P304page(s)147-153
P577publication date2009-05-20
P1433published inClinical Pharmacology & TherapeuticsQ1101529
P1476titlePlasma 4beta-hydroxycholesterol: an endogenous CYP3A metric?
P478volume86

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