4β-Hydroxycholesterol Level in Patients With Rheumatoid Arthritis Before vs. After Initiation of bDMARDs and Correlation With Inflammatory State

scientific article

4β-Hydroxycholesterol Level in Patients With Rheumatoid Arthritis Before vs. After Initiation of bDMARDs and Correlation With Inflammatory State is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/CTS.12431
P932PMC publication ID5351010
P698PubMed publication ID27991741

P50authorEspen MoldenQ43075786
P2093author name stringS W Syversen
E Lie
I C Olsen
B M Wollmann
C Gjestad
L L Mehus
P2860cites workA validated liquid chromatography-tandem mass spectrometry method for the quantitative determination of 4β-hydroxycholesterol in human plasmaQ33450215
Comparison of two endogenous biomarkers of CYP3A4 activity in a drug-drug interaction study between midostaurin and rifampicinQ33870649
4β-Hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humansQ34580565
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Immunological response as a source to variability in drug metabolism and transportQ35749503
Decreased dromotropic response to verapamil despite pronounced increased drug concentration in rheumatoid arthritisQ36055358
Drug metabolism and variability among patients in drug responseQ36139862
Gene-specific effects of inflammatory cytokines on cytochrome P450 2C, 2B6 and 3A4 mRNA levels in human hepatocytes.Q36320257
Regulation of drug metabolism and disposition during inflammation and infectionQ36544874
Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" ProblemQ36634077
4β-hydroxycholesterol correlates with dose but not steady-state concentration of carbamazepine: indication of intestinal CYP3A in biomarker formation?Q36802040
A comparison of 4β-hydroxycholesterol : cholesterol and 6β-hydroxycortisol : cortisol as markers of CYP3A4 inductionQ36948140
Cancer, inflammation, and therapy: effects on cytochrome p450-mediated drug metabolism and implications for novel immunotherapeutic agents.Q38225574
Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans: evidence for involvement of cytochrome p450 3A4.Q40784945
4beta-hydroxycholesterol as an endogenous marker for CYP3A4/5 activity. Stability and half-life of elimination after induction with rifampicinQ43146767
Impact of OATP1B1, MDR1, and CYP3A4 expression in liver and intestine on interpatient pharmacokinetic variability of atorvastatin in obese subjectsQ43571907
Endogenous 4β-hydroxycholesterol-to-cholesterol ratio is not a validated biomarker for the assessment of CYP3A activityQ43768274
4Beta-hydroxycholesterol is a new endogenous CYP3A marker: relationship to CYP3A5 genotype, quinine 3-hydroxylation and sex in Koreans, Swedes and TanzaniansQ43944775
Serum levels of 25-hydroxyvitamin D and the CYP3A biomarker 4β-hydroxycholesterol in a high-dose vitamin D supplementation studyQ45188059
Plasma 4beta-hydroxycholesterol: an endogenous CYP3A metric?Q46003084
Cytochrome P450 induction by rifampicin in healthy subjects: determination using the Karolinska cocktail and the endogenous CYP3A4 marker 4beta-hydroxycholesterolQ46466256
Evaluation of endogenous metabolic markers of hepatic CYP3A activity using metabolic profiling and midazolam clearance.Q46495913
Genotype-phenotype associations of cytochrome P450 3A4 and 3A5 polymorphism with midazolam clearance in vivoQ46496009
CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levelsQ46610452
Evaluation of disease-mediated therapeutic protein-drug interactions between an anti-interleukin-6 monoclonal antibody (sirukumab) and cytochrome P450 activities in a phase 1 study in patients with rheumatoid arthritis using a cocktail approachQ47692758
Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancerQ80546801
Disease-drug-drug interaction involving tocilizumab and simvastatin in patients with rheumatoid arthritisQ83692598
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectrheumatoid arthritisQ187255
P304page(s)42-49
P577publication date2016-11-05
P1433published inClinical and Translational ScienceQ5133809
P1476title4β-Hydroxycholesterol Level in Patients With Rheumatoid Arthritis Before vs. After Initiation of bDMARDs and Correlation With Inflammatory State
P478volume10

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cites work (P2860)
Q92613362A five-year follow-up study of antioxidants, oxidative stress and polyunsaturated fatty acids in schizophrenia
Q97561664Inflammation is a major regulator of drug metabolizing enzymes and transporters: Consequences for the personalization of drug treatment