mTOR: A Link from the Extracellular Milieu to Transcriptional Regulation of Oligodendrocyte Development

scientific article published on March 19, 2013

mTOR: A Link from the Extracellular Milieu to Transcriptional Regulation of Oligodendrocyte Development is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1042/AN20120092
P953full work available online athttp://journals.sagepub.com/doi/full-xml/10.1042/AN20120092
http://journals.sagepub.com/doi/pdf/10.1042/AN20120092
https://doi.org/10.1042/an20120092
https://europepmc.org/articles/PMC3601842
https://europepmc.org/articles/PMC3601842?pdf=render
https://www.tandfonline.com/doi/pdf/10.1042/AN20120092
P932PMC publication ID3601842
P698PubMed publication ID23421405

P50authorTeresa L WoodQ87258024
Wendy B MacklinQ88488355
P2093author name stringJinxiang Dai
Jungsoo Min
Kathryn K. Bercury
Lauren E. Mursch
Stacey E. Cifelli
P2860cites workPhosphorylation and regulation of Akt/PKB by the rictor-mTOR complexQ24295120
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeletonQ24299873
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinaseQ24300915
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machineryQ24302549
Dystroglycan promotes filopodial formation and process branching in differentiating oligodendrogliaQ50507092
p38 mitogen-activated protein kinase is required for central nervous system myelinationQ50923980
Insulin-like growth factor type-I receptor internalization and recycling mediate the sustained phosphorylation of Akt.Q50989299
The effect of neonatal thyroidectomy on myelination in the rat brainQ51160395
Expression of the new P2Y-like receptor GPR17 during oligodendrocyte precursor cell maturation regulates sensitivity to ATP-induced deathQ51890411
Wnt signaling regulates the sequential onset of neurogenesis and gliogenesis via induction of BMPsQ52041786
The mitogenic and myogenic actions of insulin-like growth factors utilize distinct signaling pathwaysQ52195728
Effects of Thyroid Hormone on Embryonic Oligodendrocyte Precursor Cell Developmentin Vivoandin VitroQ52197176
Investigations on myelination in vitro. Regulation of sulfolipid synthesis by thyroid hormone in cultures of dissociated brain cells from embryonic mice.Q52294538
Akt-mediated survival of oligodendrocytes induced by neuregulins.Q55475068
Selective survival of neurons from chick embryo sensory ganglionic dissociates utilizing serum-free supplemented mediumQ71129244
In vivo actions of insulin-like growth factor-I (IGF-I) on brain myelination: studies of IGF-I and IGF binding protein-1 (IGFBP-1) transgenic miceQ71511581
A dynamic network model of mTOR signaling reveals TSC-independent mTORC2 regulationQ39372532
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing.Q39616865
mTORC1-activated S6K1 phosphorylates Rictor on threonine 1135 and regulates mTORC2 signalingQ39765614
Thyroid hormone receptor TRbeta1 mediates Akt activation by T3 in pancreatic beta cells.Q40172304
Functional genomics identifies TOR-regulated genes that control growth and divisionQ40277449
regulation of peroxisome proliferator-activated receptor-gamma activity by mammalian target of rapamycin and amino acids in adipogenesisQ40499939
Regulation of oligodendrocyte development and central nervous system myelination by insulin-like growth factorsQ40768915
Mammalian TOR controls one of two kinase pathways acting upon nPKCdelta and nPKCepsilonQ40915855
Neuregulins in developmentQ40943947
Insulin receptor substrate-1 and phosphatidylinositol 3-kinase regulate extracellular signal-regulated kinase-dependent and -independent signaling pathways during myogenic differentiationQ40989063
Insulin-like growth factor I regulates G2/M progression through mammalian target of rapamycin signaling in oligodendrocyte progenitors.Q41035104
Bone morphogenetic proteins induce astroglial differentiation of oligodendroglial-astroglial progenitor cellsQ41108824
The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.Q41120735
Regulation of oligodendrocyte development and CNS myelination by growth factors: prospects for therapy of demyelinating diseaseQ41157691
PI3K: downstream AKTion blocks apoptosisQ41351876
Arrest of myelination and reduced axon growth when Schwann cells lack mTOR.Q41880723
mTOR complex 1 plays critical roles in hematopoiesis and Pten-loss-evoked leukemogenesisQ41910369
Mammalian target of rapamycin protein complex 2 regulates differentiation of Th1 and Th2 cell subsets via distinct signaling pathwaysQ42099912
Igf1 gene disruption results in reduced brain size, CNS hypomyelination, and loss of hippocampal granule and striatal parvalbumin-containing neuronsQ42484843
The transcription factor Yin Yang 1 is essential for oligodendrocyte progenitor differentiation.Q42591243
Cytoplasmic and nuclear distribution of the protein complexes mTORC1 and mTORC2: rapamycin triggers dephosphorylation and delocalization of the mTORC2 components rictor and sin1.Q42810841
Regulation of adipocyte differentiation and insulin action with rapamycin.Q42825624
Elevated phosphatidylinositol 3,4,5-trisphosphate in glia triggers cell-autonomous membrane wrapping and myelination.Q42997819
Initiation of neuronal differentiation requires PI3-kinase/TOR signalling in the vertebrate neural tubeQ43224792
Cytoskeletal reorganization during the formation of oligodendrocyte processes and branchesQ43581929
IGF-I synergizes with FGF-2 to stimulate oligodendrocyte progenitor entry into the cell cycleQ43636472
Insulin-like growth factor I, but not neurotrophin-3, sustains Akt activation and provides long-term protection of immature oligodendrocytes from glutamate-mediated apoptosisQ44078368
Regulation of integrin growth factor interactions in oligodendrocytes by lipid raft microdomainsQ44290613
IGF-I and NT-3 signaling pathways in developing oligodendrocytes: differential regulation and activation of receptors and the downstream effector Akt.Q44383868
Signaling from integrins to Fyn to Rho family GTPases regulates morphologic differentiation of oligodendrocytes.Q44684981
IGF-I prevents glutamate-mediated bax translocation and cytochrome C release in O4+ oligodendrocyte progenitorsQ44813370
Triiodothyronine stimulation of oligodendroglial differentiation and myelination. A developmental studyQ44839318
Investigations on myelination in vitro. Regulation by thyroid hormone in cultures of dissociated brain cells from embryonic miceQ45168538
IGF-1-stimulated protein synthesis in oligodendrocyte progenitors requires PI3K/mTOR/Akt and MEK/ERK pathways.Q46005419
The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification.Q46021705
High cholesterol level is essential for myelin membrane growthQ46406733
Wnt signaling controls the timing of oligodendrocyte development in the spinal cord.Q46541111
Insulin-like growth factor-1 provides protection against psychosine-induced apoptosis in cultured mouse oligodendrocyte progenitor cells using primarily the PI3K/Akt pathwayQ46709267
Characteristics of abnormal diffusivity in normal-appearing white matter investigated with diffusion tensor MR imaging in tuberous sclerosis complex.Q46983617
Temporal control of differentiation by the insulin receptor/tor pathway in DrosophilaQ47070849
IGF-I and FGF-2 coordinately enhance cyclin D1 and cyclin E-cdk2 association and activity to promote G1 progression in oligodendrocyte progenitor cellsQ47920201
GGF/neuregulin induces a phenotypic reversion of oligodendrocytesQ48245409
A central role for RhoA during oligodendroglial maturation in the switch from netrin-1-mediated chemorepulsion to process elaborationQ48248550
IGF-I-induced oligodendrocyte progenitor proliferation requires PI3K/Akt, MEK/ERK, and Src-like tyrosine kinasesQ48248963
Insulin-like growth factor I increases brain growth and central nervous system myelination in transgenic miceQ48313440
Transgenic overexpression of BMP4 increases astroglial and decreases oligodendroglial lineage commitmentQ48373791
Magnetic resonance imaging and diffusion-weighted imaging of normal-appearing white matter in children and young adults with tuberous sclerosis complexQ48522540
Myelination is altered in insulin-like growth factor-I null mutant mice.Q48546118
The basic helix-loop-helix factor olig2 is essential for the development of motoneuron and oligodendrocyte lineages.Q48546876
Molecular basis of thyroid hormone regulation of myelin basic protein gene expression in rodent brainQ48612039
GGF/neuregulin is a neuronal signal that promotes the proliferation and survival and inhibits the differentiation of oligodendrocyte progenitorsQ48956089
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR actionQ24302566
Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cellsQ24303535
Identification of Protor as a novel Rictor-binding component of mTOR complex-2Q24303936
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitiveQ24306328
SREBP activity is regulated by mTORC1 and contributes to Akt-dependent cell growthQ24309283
mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1Q24319851
Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signallingQ24323370
Identification of a proline-rich Akt substrate as a 14-3-3 binding partnerQ24338582
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin.Q24540159
Fat cell-specific ablation of rictor in mice impairs insulin-regulated fat cell and whole-body glucose and lipid metabolismQ24608263
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensationQ24616946
Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancerQ24617184
Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapyQ24632296
Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucineQ24633679
Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1Q24645183
mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in miceQ24658113
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activityQ24680264
Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null miceQ27324246
TOR signaling in growth and metabolismQ27860757
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTORQ28115142
A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cellsQ28141706
Type III neuregulin-1 promotes oligodendrocyte myelinationQ28261097
The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelinationQ28261757
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1Q28276788
Molecular and cellular aspects of the insulin-like growth factor I receptorQ28288023
Rictor/mTORC2 is essential for maintaining a balance between beta-cell proliferation and cell sizeQ28304000
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKBQ28306356
Axonal neuregulin-1 regulates myelin sheath thicknessQ28504655
Multiple roles of Id4 in developmental myelination: predicted outcomes and unexpected findingsQ28505437
A genome-wide screen for spatially restricted expression patterns identifies transcription factors that regulate glial developmentQ28507109
Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidneyQ28507177
A novel role for thyroid hormone, glucocorticoids and retinoic acid in timing oligodendrocyte developmentQ72048609
Distinct roles for PI3K in proliferation and survival of oligodendrocyte progenitor cellsQ73131749
Stage-specific effects of bone morphogenetic proteins on the oligodendrocyte lineageQ73650552
Axonal regulation of Schwann cell proliferation and survival and the initial events of myelination requires PI 3-kinase activityQ73870801
Bone morphogenetic proteins negatively control oligodendrocyte precursor specification in the chick spinal cordQ78424874
p38 MAP kinase regulation of oligodendrocyte differentiation with CREB as a potential targetQ79604064
Platelet-derived growth factor-AA mediates oligodendrocyte lineage differentiation through activation of extracellular signal-regulated kinase signaling pathwayQ80233774
Synergistic induction of cyclin D1 in oligodendrocyte progenitor cells by IGF-I and FGF-2 requires differential stimulation of multiple signaling pathwaysQ80348606
Oligodendrocyte maturation is inhibited by bone morphogenetic proteinQ80382762
Severe impairment of cerebellum development in mice expressing a dominant-negative mutation inactivating thyroid hormone receptor alpha1 isoformQ84215036
Wnt signaling is sufficient to perturb oligodendrocyte maturationQ84260240
Identification of Akt-independent regulation of hepatic lipogenesis by mammalian target of rapamycin (mTOR) complex 2Q34286779
The oligodendrocyte and its many cellular processesQ34290907
Neuregulins and their receptors: a versatile signaling module in organogenesis and oncogenesisQ34431223
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activityQ34598209
Rheb1 is required for mTORC1 and myelination in postnatal brain developmentQ34665970
An 'oligarchy' rules neural developmentQ34750265
Emergence of the PI3-kinase pathway as a central modulator of normal and aberrant B cell differentiationQ34762309
The splicing factor SF2/ASF regulates translation initiation by enhancing phosphorylation of 4E-BP1.Q34774397
Regulation of oligodendrocyte development in the vertebrate CNS.Q34973857
Molecular crosstalk between p70S6k and MAPK cell signaling pathwaysQ34975063
Yy1 as a molecular link between neuregulin and transcriptional modulation of peripheral myelinationQ35126078
Axin2 as regulatory and therapeutic target in newborn brain injury and remyelinationQ35132066
Canonical Wnt Signalling Requires the BMP Pathway to Inhibit Oligodendrocyte MaturationQ35161679
The mammalian target of rapamycin regulates cholesterol biosynthetic gene expression and exhibits a rapamycin-resistant transcriptional profile.Q35216878
Constitutively active Akt induces enhanced myelination in the CNSQ35394901
YY1 negatively regulates mouse myelin proteolipid protein (Plp1) gene expression in oligodendroglial cellsQ35513380
Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complexQ35546651
The mTOR (mammalian target of rapamycin) kinase maintains integrity of mTOR complex 2.Q35562825
Insulin-like growth factor I/somatomedin C: a potent inducer of oligodendrocyte developmentQ35589345
Insulin-like growth factor type 1 receptor signaling in the cells of oligodendrocyte lineage is required for normal in vivo oligodendrocyte development and myelinationQ35597565
TOR in the immune systemQ35621941
Erk1/2 MAPK and mTOR signaling sequentially regulates progression through distinct stages of oligodendrocyte differentiationQ35693398
Interactions between ID and OLIG proteins mediate the inhibitory effects of BMP4 on oligodendroglial differentiationQ28511485
Activation of the mammalian target of rapamycin (mTOR) is essential for oligodendrocyte differentiationQ28568907
A role for the helix-loop-helix protein Id2 in the control of oligodendrocyte developmentQ28579332
The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase CQ28587901
Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiationQ28588209
Dysregulation of the Wnt pathway inhibits timely myelination and remyelination in the mammalian CNSQ28589814
Dlg1-PTEN interaction regulates myelin thickness to prevent damaging peripheral nerve overmyelinationQ28591752
HDAC1 and HDAC2 regulate oligodendrocyte differentiation by disrupting the beta-catenin-TCF interactionQ28593397
Common developmental requirement for Olig function indicates a motor neuron/oligodendrocyte connectionQ28594759
Regulation of Oligodendrocyte Differentiation and MyelinationQ29542652
Regulation of neuronal survival by the serine-threonine protein kinase AktQ29614185
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1Q29614563
Activation of a metabolic gene regulatory network downstream of mTOR complex 1Q29615179
Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissueQ29615225
Growing roles for the mTOR pathwayQ29616212
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40Q29617097
mTOR controls mitochondrial oxidative function through a YY1-PGC-1alpha transcriptional complexQ29617214
The nuts and bolts of AGC protein kinasesQ29617465
The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinaseQ29618387
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathwayQ30425628
Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteinsQ30438876
Muscle-specific deletion of rictor impairs insulin-stimulated glucose transport and enhances Basal glycogen synthase activityQ30442556
Deletion of Rictor in neural progenitor cells reveals contributions of mTORC2 signaling to tuberous sclerosis complexQ30529898
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathyQ33589972
A bimodal influence of thyroid hormone on cerebellum oligodendrocyte differentiation.Q33636657
Two-tier transcriptional control of oligodendrocyte differentiationQ33677363
mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of actionQ33706924
Oligodendrocyte development and thyroid hormone.Q33714940
Insulin-like growth factor-I-stimulated Akt phosphorylation and oligodendrocyte progenitor cell survival require cholesterol-enriched membranesQ33910877
Targeted disruption of mouse Yin Yang 1 transcription factor results in peri-implantation lethality.Q33959870
mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar transcription factor UBF.Q33973841
Proteomic identification of novel targets regulated by the mammalian target of rapamycin pathway during oligodendrocyte differentiationQ34000315
Control of fibroblast fibronectin expression and alternative splicing via the PI3K/Akt/mTOR pathwayQ34077087
Focal adhesion kinase can play unique and opposing roles in regulating the morphology of differentiating oligodendrocytesQ34130047
Oligodendrocyte PTEN is required for myelin and axonal integrity, not remyelinationQ34253257
The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivationQ34283579
Glial specification in the vertebrate neural tubeQ35752440
Expression of thyroid hormone receptor isoforms in the oligodendrocyte lineage.Q35771238
Kinome-wide selectivity profiling of ATP-competitive mammalian target of rapamycin (mTOR) inhibitors and characterization of their binding kineticsQ35879915
Mechanisms of regulation of oligodendrocyte development by p38 mitogen-activated protein kinaseQ35892864
Integrin-growth factor interactions as regulators of oligodendroglial development and functionQ35971762
mTORC1 is essential for leukemia propagation but not stem cell self-renewalQ36005418
A Critical Role for Rictor in T LymphopoiesisQ36141169
Axonal neuregulin signals cells of the oligodendrocyte lineage through activation of HER4 and Schwann cells through HER2 and HER3.Q36274058
ERK1/ERK2 MAPK Signaling is Required to Increase Myelin Thickness Independent of Oligodendrocyte Differentiation and Initiation of MyelinationQ36464562
Olig gene function in CNS development and diseaseQ36465466
The amino acid sensitive TOR pathway from yeast to mammals.Q36473396
Defining Akt actions in muscle differentiation.Q36494504
Axonal regulation of myelination by neuregulin 1.Q36589639
The ERK2 mitogen-activated protein kinase regulates the timing of oligodendrocyte differentiationQ36600067
Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPaseQ36623662
Integration of nutritional and stress signaling pathways by Maf1.Q36686250
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2Q36710799
p38 Mitogen-activated protein kinase regulates myelinationQ36997755
Neuregulin-1/ErbB signaling serves distinct functions in myelination of the peripheral and central nervous system.Q37066557
A matter of identity: transcriptional control in oligodendrocytesQ37134194
The mTOR signaling network: insights from its role during embryonic developmentQ37160816
The Yin and Yang of YY1 in the nervous systemQ37165666
Bone morphogenetic protein signaling and olig1/2 interact to regulate the differentiation and maturation of adult oligodendrocyte precursor cellsQ37344179
Developmental profiles of lipogenic enzymes and their regulators in the neonatal mouse brainQ37352030
Mammalian target of rapamycin complex 1: signalling inputs, substrates and feedback mechanisms.Q37376549
Akt signals through the mammalian target of rapamycin pathway to regulate CNS myelination.Q37377107
An emerging role of mTOR in lipid biosynthesis.Q37641438
Transcriptional and post-transcriptional control of CNS myelinationQ37765990
Nrg1/ErbB signaling networks in Schwann cell development and myelinationQ37787450
Differing effects of rapamycin and mTOR kinase inhibitors on protein synthesisQ37856368
Glia unglued: How signals from the extracellular matrix regulate the development of myelinating gliaQ37915435
ID2: A negative transcription factor regulating oligodendroglia differentiationQ37976660
The RAS/RAF/MEK/ERK and the PI3K/AKT signalling pathways: role in cancer pathogenesis and implications for therapeutic approaches.Q37996420
A novel heterodimerization partner for thyroid hormone receptor. Peroxisome proliferator-activated receptor.Q38308944
Characterization of myelin basic protein thyroid hormone response element and its function in the context of native and heterologous promoterQ38326873
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectregulation of gene expressionQ411391
oligodendrocyteQ916698
nervous systemQ9404
cellQ7868
developmental gene expression regulationQ70697639
serine/threonine-protein kinase TORQ24723029
enzymeQ8047
P304page(s)e00108
P577publication date2013-03-19
P13046publication type of scholarly workreview articleQ7318358
P1433published inASN NeuroQ20312578
P1476titlemTOR: a link from the extracellular milieu to transcriptional regulation of oligodendrocyte development
mTOR: A Link from the Extracellular Milieu to Transcriptional Regulation of Oligodendrocyte Development
P478volume5

Reverse relations

cites work (P2860)
Q41211684A brain proteomic investigation of rapamycin effects in the Tsc1+/- mouse model
Q33631202A mutation in the canine gene encoding folliculin-interacting protein 2 (FNIP2) associated with a unique disruption in spinal cord myelination
Q38122225Akt/mTOR signalling in myelination
Q55073612Balanced mTORC1 activity in oligodendrocytes is required for accurate CNS myelination.
Q35202359CNS myelination requires cytoplasmic dynein function
Q36480281Clemastine Enhances Myelination in the Prefrontal Cortex and Rescues Behavioral Changes in Socially Isolated Mice.
Q88188972Clemastine effects in rat models of a myelination disorder
Q35594174Dimethyl fumarate modulates antioxidant and lipid metabolism in oligodendrocytes
Q41560440Dual function of the PI3K-Akt-mTORC1 axis in myelination of the peripheral nervous system
Q98772165EED-mediated histone methylation is critical for CNS myelination and remyelination by inhibiting WNT, BMP, and senescence pathways
Q36254079Fbxw7 Limits Myelination by Inhibiting mTOR Signaling.
Q35559678Gas6 enhances axonal ensheathment by MBP+ membranous processes in human DRG/OL promyelinating co-cultures
Q40413443Impaired oligodendroglial turnover is associated with myelin pathology in focal cortical dysplasia and tuberous sclerosis complex.
Q91564490Independent and cooperative roles of the Mek/ERK1/2-MAPK and PI3K/Akt/mTOR pathways during developmental myelination and in adulthood
Q37592138Integrin-Linked Kinase (ILK) Deletion Disrupts Oligodendrocyte Development by Altering Cell Cycle
Q47687993Interactions Between the Canonical WNT/Beta-Catenin Pathway and PPAR Gamma on Neuroinflammation, Demyelination, and Remyelination in Multiple Sclerosis.
Q38766318Intracellular signaling pathway regulation of myelination and remyelination in the CNS.
Q26744655Mammalian Target of Rapamycin: Its Role in Early Neural Development and in Adult and Aged Brain Function
Q37663142Mammalian target of rapamycin promotes oligodendrocyte differentiation, initiation and extent of CNS myelination.
Q30355283Nudging oligodendrocyte intrinsic signaling to remyelinate and repair: Estrogen receptor ligand effects.
Q36339174Olig1 Acetylation and Nuclear Export Mediate Oligodendrocyte Development
Q35707945Olig1 function is required for oligodendrocyte differentiation in the mouse brain
Q28508935Oligodendrocyte precursor cell-intrinsic effect of Rheb1 controls differentiation and mediates mTORC1-dependent myelination in brain
Q37127817Optimal myelin elongation relies on YAP activation by axonal growth and inhibition by Crb3/Hippo pathway.
Q49815600PTEN negatively regulates the cell lineage progression from NG2+ glial progenitor to oligodendrocyte via mTOR-independent signaling.
Q48272328Schwann cell-specific deletion of the endosomal PI 3-kinase Vps34 leads to delayed radial sorting of axons, arrested myelination, and abnormal ErbB2-ErbB3 tyrosine kinase signaling.
Q38943983Serine/threonine-protein kinase PFTK1 modulates oligodendrocyte differentiation via PI3K/AKT pathway
Q90021339Spatiotemporal Control of CNS Myelination by Oligodendrocyte Programmed Cell Death through the TFEB-PUMA Axis
Q31162298Structures Showing Negative Correlations of Signal Intensity with Postnatal Age on T1-weighted Imaging of the Brain of Newborns and Infants
Q41157649The Wnt effector transcription factor 7-like 2 positively regulates oligodendrocyte differentiation in a manner independent of Wnt/β-catenin signaling.
Q38705961Transcription factor 7 like 2 promotes oligodendrocyte differentiation and remyelination
Q35625755Translational control of myelin basic protein expression by ERK2 MAP kinase regulates timely remyelination in the adult brain
Q35035474mTOR kinase: a possible pharmacological target in the management of chronic pain

Search more.