An essential role for SRC-activated STAT-3 in 14,15-EET-induced VEGF expression and angiogenesis

scientific article published on 11 April 2008

An essential role for SRC-activated STAT-3 in 14,15-EET-induced VEGF expression and angiogenesis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1182/BLOOD-2007-11-126680
P932PMC publication ID2424155
P698PubMed publication ID18408167
P5875ResearchGate publication ID5444850

P2093author name stringDong Wang
Baolin Zhang
Richard C Venema
Gadiparthi N Rao
Manjula Karpurapu
Sergey Y Cheranov
P2860cites workSignal transducer and activator of transcription 3 is required for glycoprotein 130-mediated induction of vascular endothelial growth factor in cardiac myocytesQ22253414
Activation and association of Stat3 with Src in v-Src-transformed cell linesQ24650319
Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesisQ28288381
Mechanism by which H-2g, a glucose analog of blood group H antigen, mediates angiogenesisQ45119313
Characterization of 5,6- and 8,9-epoxyeicosatrienoic acids (5,6- and 8,9-EET) as potent in vivo angiogenic lipidsQ46510528
Fibroblast growth factor-2 is a downstream mediator of phosphatidylinositol 3-kinase-Akt signaling in 14,15-epoxyeicosatrienoic acid-induced angiogenesisQ46802698
Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acidsQ46939863
Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injuryQ47359646
Nuclear translocation of phosphorylated STAT3 is essential for vascular endothelial growth factor-induced human dermal microvascular endothelial cell migration and tube formationQ47745076
AMP-activated protein kinase (AMPK) signaling in endothelial cells is essential for angiogenesis in response to hypoxic stressQ47858200
Protective effects of epoxyeicosatrienoic acids on human endothelial cells from the pulmonary and coronary vasculature.Q50480074
Peroxisomal proliferator-activated receptor-alpha-dependent inhibition of endothelial cell proliferation and tumorigenesis.Q53335014
Hyperactivation of Stat3 in gp130 mutant mice promotes gastric hyperproliferation and desensitizes TGF-beta signaling.Q54652087
15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires STAT3-dependent expression of VEGFQ64377130
Endothelium-derived hyperpolarizing factors and vascular cytochrome P450 metabolites of arachidonic acid in the regulation of toneQ74583497
Anti-inflammatory properties of cytochrome P450 epoxygenase-derived eicosanoids.Q28343514
Cytochrome P450 2C is an EDHF synthase in coronary arteriesQ28374241
Novel role for STAT-5B in the regulation of Hsp27-FGF-2 axis facilitating thrombin-induced vascular smooth muscle cell growth and motilityQ28571912
An essential role for gp130 in neointima formation following arterial injuryQ28572064
Vascular endothelial growth factor and basic fibroblast growth factor differentially modulate early postnatal coronary angiogenesisQ28577598
Involvement of EGF receptor and c-Src in the survival signals induced by TGF-beta1 in hepatocytesQ28577954
An essential role of the Jak-2/STAT-3/cytosolic phospholipase A(2) axis in platelet-derived growth factor BB-induced vascular smooth muscle cell motilityQ28582726
Angiogenesis in cancer, vascular, rheumatoid and other diseaseQ29547165
c-Src and cooperating partners in human cancerQ30434520
A1 adenosine receptor activation promotes angiogenesis and release of VEGF from monocytesQ30444620
Cytochrome p450 epoxygenase metabolism of arachidonic acid inhibits apoptosisQ33182344
Overexpression of C-terminal Src kinase blocks 14, 15-epoxyeicosatrienoic acid-induced tyrosine phosphorylation and mitogenesisQ33900024
The role of STATs in transcriptional control and their impact on cellular functionQ33941346
The role of FGF and VEGF in angioblast induction and migration during vascular developmentQ34123470
Epoxygenase pathways of arachidonic acid metabolismQ34307877
Epoxide hydrolase and epoxygenase metabolites as therapeutic targets for renal diseasesQ34442004
Action of epoxyeicosatrienoic acids on cellular functionQ34567484
Hypoxia-inducible factors, stem cells, and cancerQ34625782
Angiogenesis in human coronary atherosclerotic plaquesQ35833812
Hypoxic induction of an HIF-1alpha-dependent bFGF autocrine loop drives angiogenesis in human endothelial cellsQ35848595
Constitutively activated Stat3 induces tumorigenesis and enhances cell motility of prostate epithelial cells through integrin beta 6Q35857048
Suppression of activation of signal transducer and activator of transcription-5B signaling in the vessel wall reduces balloon injury-induced neointima formationQ36007499
Growth regulation of the vascular system: an emerging role for adenosineQ36193019
Role of angiogenesis in cardiovascular disease: a critical appraisal.Q36261464
Endothelial extracellular matrix: biosynthesis, remodeling, and functions during vascular morphogenesis and neovessel stabilizationQ36321628
Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitroQ37385294
Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis.Q38318726
Cytochrome p450 epoxygenase promotes human cancer metastasisQ40105564
Divergent roles of c-Src in controlling platelet-derived growth factor-dependent signaling in fibroblastsQ40379214
HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas.Q40453583
Inhibition of gp130 signaling in breast cancer blocks constitutive activation of Stat3 and inhibits in vivo malignancyQ40508006
Src-dependent phosphorylation of the EGF receptor Tyr-845 mediates Stat-p21waf1 pathway in A431 cellsQ40594374
c-Src regulation of fibroblast growth factor-induced proliferation in murine embryonic fibroblastsQ40666026
Cytochrome P450 2C9-derived epoxyeicosatrienoic acids induce angiogenesis via cross-talk with the epidermal growth factor receptor (EGFR).Q40670711
Activation of the Stat3 signaling pathway is required for differentiation by interleukin-6 in PC12-E2 cellsQ40906010
Src kinase activates endothelial nitric-oxide synthase by phosphorylating Tyr-83.Q42483154
Hypoxic induction of human vascular endothelial growth factor expression through c-Src activationQ42826789
Epoxygenase-driven angiogenesis in human lung microvascular endothelial cellsQ44185550
Cytochrome p-450 epoxygenase products contribute to attenuated vasoconstriction after chronic hypoxiaQ44353639
11,12-Epoxyeicosatrienoic acid-induced inhibition of FOXO factors promotes endothelial proliferation by down-regulating p27Kip1.Q44457864
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectangiogenesisQ539568
P1104number of pages11
P304page(s)5581-5591
P577publication date2008-04-11
P1433published inBloodQ885070
P1476titleAn essential role for SRC-activated STAT-3 in 14,15-EET-induced VEGF expression and angiogenesis
P478volume111

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