Activation of the Stat3 signaling pathway is required for differentiation by interleukin-6 in PC12-E2 cells

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Activation of the Stat3 signaling pathway is required for differentiation by interleukin-6 in PC12-E2 cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.275.3.2147
P698PubMed publication ID10636920

P2093author name stringR A Bradshaw
Y Y Wu
P2860cites workInduction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6Q24297617
Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesisQ24316448
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathwayQ24531184
Leukemia inhibitory factor, a cytokine at the interface between neurobiology and immunologyQ24564233
STAT3 serine phosphorylation by ERK-dependent and -independent pathways negatively modulates its tyrosine phosphorylationQ24644334
Targeted disruption of the mouse Stat3 gene leads to early embryonic lethalityQ24685515
High-efficiency transformation of mammalian cells by plasmid DNAQ27860469
Rapid and efficient site-specific mutagenesis without phenotypic selectionQ27860628
Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activationQ28131755
Jak2 is essential for signaling through a variety of cytokine receptorsQ28270987
Dominant negative stat3 mutant inhibits interleukin-6-induced Jak-STAT signal transductionQ28278147
Cytokines and the nervous system. I: Expression and recognitionQ28287817
Cytokines and the nervous system II: Actions and mechanisms of actionQ28301619
Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elementsQ28571255
Requirement of serine phosphorylation for formation of STAT-promoter complexesQ28637366
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6Q28637521
Differential activation of acute phase response factor/Stat3 and Stat1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. II. Src homology SH2 domains define the specificity of stat factor activationQ28637692
STATs and gene regulationQ29547796
Production of high-titer helper-free retroviruses by transient transfectionQ29547802
Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral diseaseQ29615967
Jaks and STATs: biological implicationsQ29619657
STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinaseQ34087183
Neuroendocrine-immune system interactions and autoimmunityQ34300053
Disruption of the Jak1 gene demonstrates obligatory and nonredundant roles of the Jaks in cytokine-induced biologic responsesQ34468309
Mapping of Stat3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of Stat1 and Stat3.Q34629986
Sympathetic neurons can produce and respond to interleukin 6Q35985223
Induction of the Ly-6A/E gene by interferon alpha/beta and gamma requires a DNA element to which a tyrosine-phosphorylated 91-kDa protein bindsQ36432406
Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosisQ36571893
Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cellsQ36728456
Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor- mediated cell growth In vitroQ37385294
Reflections on STAT3, STAT5, and STAT6 as fat STATsQ37508544
STAT3 activation is a critical step in gp130-mediated terminal differentiation and growth arrest of a myeloid cell lineQ37625031
Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domainQ38354217
Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinaseQ39575287
Stat3 activation by Src induces specific gene regulation and is required for cell transformationQ39583802
Differentiation-regulated serine phosphorylation of STAT1 promotes GAF activation in macrophagesQ40016551
Stat1 serine phosphorylation occurs independently of tyrosine phosphorylation and requires an activated Jak2 kinaseQ40023873
Cytokine receptor signallingQ40416594
Neuronal differentiation factors/cytokines and synaptic plasticityQ40873394
STATs: signal transducers and activators of transcriptionQ40974978
Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspasesQ41075291
STAT3 is a serine kinase target in T lymphocytes. Interleukin 2 and T cell antigen receptor signals converge upon serine 727.Q41090036
The neurotrophins and CNTF: two families of collaborative neurotrophic factorsQ41132721
Gp130-mediated signal transduction in embryonic stem cells involves activation of Jak and Ras/mitogen-activated protein kinase pathwaysQ41150318
Two signals are necessary for cell proliferation induced by a cytokine receptor gp130: involvement of STAT3 in anti-apoptosis.Q41153893
Expression of interleukin-6 receptor (IL-6R) and gp130 mRNA in PC12 cells and sympathetic neurons: modulation by tumor necrosis factor alpha (TNF-alpha).Q41240165
PC12-E2 cells: a stable variant with altered responses to growth factor stimulationQ41306757
CNTF, FGF, and NGF collaborate to drive the terminal differentiation of MAH cells into postmitotic neuronsQ41449903
Interleukin 6 and its receptor: ten years laterQ41722189
Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factorQ41978360
Dual control of neurite outgrowth by STAT3 and MAP kinase in PC12 cells stimulated with interleukin-6.Q42628720
Interleukin-6 as a neurotrophic factor for promoting the survival of cultured catecholaminergic neurons in a chemically defined medium from fetal and postnatal rat midbrainsQ45227108
Induction of neurite outgrowth by interleukin-6 is accompanied by activation of Stat3 signaling pathway in a variant PC12 cell (E2) lineQ46485002
Synergistic induction of neurite outgrowth by nerve growth factor or epidermal growth factor and interleukin-6 in PC12 cellsQ46545637
STATs as activators of apoptosisQ47721568
Increasing complexity of the Ras signaling pathwayQ47762067
Interleukin-6 protects cultured rat hippocampal neurons against glutamate-induced cell deathQ48139177
Sequence of protein disulphide isomerase and implications of its relationship to thioredoxinQ48375261
Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathwayQ48617330
Differential Activation of Acute Phase Response Factor/STAT3 and STAT1 via the Cytoplasmic Domain of the Interleukin 6 Signal Transducer gp130Q56690299
Not just another meeting: the coming of age of JAKs and STATsQ56933132
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectinterleukinsQ194908
P304page(s)2147-2156
P577publication date2000-01-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleActivation of the Stat3 signaling pathway is required for differentiation by interleukin-6 in PC12-E2 cells
P478volume275

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cites work (P2860)
Q43073859Activation of STAT3 by pituitary adenylate cyclase-activating polypeptide (PACAP) during PACAP-promoted neurite outgrowth of PC12 cells
Q60594494Activation of Stat-3 as one of the early events in tobacco chewing-mediated oral carcinogenesis
Q30650799An automated fluorescence based assay of neurite formation
Q36713529An essential role for SRC-activated STAT-3 in 14,15-EET-induced VEGF expression and angiogenesis
Q28582726An essential role of the Jak-2/STAT-3/cytosolic phospholipase A(2) axis in platelet-derived growth factor BB-induced vascular smooth muscle cell motility
Q28566936Cannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowth
Q35003859Chemical genetic screening approaches to neurobiology
Q64904616Chemotherapy-Induced Peripheral Neuropathy and Changes in Cytoskeleton.
Q33919760Chronically increased ciliary neurotrophic factor and fibroblast growth factor-2 expression after spinal contusion in rats
Q44279253Cytosolic phospholipase A2 is an effector of Jak/STAT signaling and is involved in platelet-derived growth factor BB-induced growth in vascular smooth muscle cells
Q39439940Diabetes impairs an interleukin-1β-dependent pathway that enhances neurite outgrowth through JAK/STAT3 modulation of mitochondrial bioenergetics in adult sensory neurons
Q35780674Effects of Reducing Suppressors of Cytokine Signaling-3 (SOCS3) Expression on Dendritic Outgrowth and Demyelination after Spinal Cord Injury
Q44658021Expression of galectin‐3 in neuronally differentiating PC12 cells is regulated both via Ras/MAPK‐dependent and –independent signalling pathways
Q38290665Fibroblast growth factor-1 induced promatrilysin expression through the activation of extracellular-regulated kinases and STAT3.
Q42836193Functional whole-genome analysis identifies Polo-like kinase 2 and poliovirus receptor as essential for neuronal differentiation upstream of the negative regulator alphaB-crystallin.
Q34334392Impact of cell swelling on proliferative signal transduction in the liver
Q38361170Independent roles of SOCS-3 and SHP-2 in the regulation of neuronal gene expression by leukemia inhibitory factor.
Q42798316Insulin induces epidermal growth factor (EGF) receptor clustering and potentiates EGF-stimulated DNA synthesis in swiss 3T3 cells: a mechanism for costimulation in mitogenic synergy
Q37331339Interleukin-10 provides direct trophic support to neurons.
Q28344474Interleukin-1beta-induced promatrilysin expression is mediated by NFkappaB-regulated synthesis of interleukin-6 in the prostate carcinoma cell line, LNCaP
Q42508217Interleukin-6 protects rat PC12 cells from serum deprivation or chemotherapeutic agents through the phosphatidylinositol 3-kinase and STAT3 pathways
Q28571934Leukemia inhibitory factor receptor signaling negatively modulates nerve growth factor-induced neurite outgrowth in PC12 cells and sympathetic neurons
Q36026076Mechanisms of action of antidepressants: from neurotransmitter systems to signaling pathways
Q33955275Mitochondrial localized STAT3 is involved in NGF induced neurite outgrowth
Q43746975Nerve growth factor uses Ras/ERK and phosphatidylinositol 3-kinase cascades to up-regulate the N-methyl-D-aspartate receptor 1 promoter
Q48187789Peripheral nerve induces macrophage neurotrophic activities: regulation of neuronal process outgrowth, intracellular signaling and synaptic function
Q40345587ROS via BTK-p300-STAT1-PPARγ signaling activation mediates cholesterol crystals-induced CD36 expression and foam cell formation.
Q28115789Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation
Q33969194Regulation of Id gene expression by type I insulin-like growth factor: roles of Stat3 and the tyrosine 950 residue of the receptor
Q34746354Regulation of neurite outgrowth by G(i/o) signaling pathways
Q36602612Role of the Go/i signaling network in the regulation of neurite outgrowth.
Q45153426STAT-3-dependent cytosolic phospholipase A2 expression is required for thrombin-induced vascular smooth muscle cell motility
Q47074089STAT3-dependent pathfinding and control of axonal branching and target selection
Q36007499Suppression of activation of signal transducer and activator of transcription-5B signaling in the vessel wall reduces balloon injury-induced neointima formation
Q40232250Suppressor of cytokine signaling-3 suppresses the ability of activated signal transducer and activator of transcription-3 to stimulate neurite growth in rat primary sensory neurons.
Q46186932TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity
Q37237506The 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Janus kinase 2-signal transducer and activator of transcription-5B-dependent expression of interleukin-8.

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