Inhibition of hedgehog signaling ameliorates hepatic inflammation in mice with nonalcoholic fatty liver disease (scientific article published on 16 October 2015)

Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation

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The osteopontin level in liver, adipose tissue and serum is correlated with fibrosis in patients with alcoholic liver disease

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Hedgehog: functions and mechanisms

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Evolution of inflammation in nonalcoholic fatty liver disease: the multiple parallel hits hypothesis

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The role of hedgehog signaling pathway in liver regeneration

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Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis

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Alpha-1 adrenergic receptor transactivates signal transducer and activator of transcription-3 (Stat3) through activation of Src and epidermal growth factor receptor (EGFR) in hepatocytes

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From NAFLD to NASH to cirrhosis-new insights into disease mechanisms.

Q34365079

NAFLD, NASH and liver cancer

Q34374372

Cytosolic phospholipase A2alpha and peroxisome proliferator-activated receptor gamma signaling pathway counteracts transforming growth factor beta-mediated inhibition of primary and transformed hepatocyte growth

Q34455310

Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis.

Q34511187

Vismodegib suppresses TRAIL-mediated liver injury in a mouse model of nonalcoholic steatohepatitis.

Q34876724

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

Q35239565

Elevated Hedgehog/Gli signaling causes beta-cell dedifferentiation in mice

Q35345249

Wnt signaling regulates pancreatic beta cell proliferation

Q35741102

Osteopontin neutralisation abrogates the liver progenitor cell response and fibrogenesis in mice

Q35805769

From fat to inflammation

Q36364153

Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease

Q36402141

NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease

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Increased production of sonic hedgehog by ballooned hepatocytes

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Signals from dying hepatocytes trigger growth of liver progenitors

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Hedgehog pathway and pediatric nonalcoholic fatty liver disease

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Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans

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Smoothened is a master regulator of adult liver repair

Q36890924

Pathophysiological role of osteopontin in hepatic inflammation, toxicity, and cancer

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Elevated expression of osteopontin may be related to adipose tissue macrophage accumulation and liver steatosis in morbid obesity

Q37023005

Obesity, inflammation, and liver cancer

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Hedgehog signaling in the liver

Q37811158

Osteopontin: Versatile modulator of liver diseases

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The mechanisms of Hedgehog signalling and its roles in development and disease

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Interactions among bone, liver, and adipose tissue predisposing to diabesity and fatty liver

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Non-canonical Hedgehog signaling contributes to chemotaxis in cholangiocarcinoma

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Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes

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Protein and mRNA expression of Shh, Smo and Gli1 and inhibition by cyclopamine in hepatocytes of rats with chronic fluorosis

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Nonalcoholic steatohepatitis: association of insulin resistance and mitochondrial abnormalities

Q43552270

Osteopontin delays resolution of liver fibrosis

Q44270823

Upregulation of osteopontin expression is involved in the development of nonalcoholic steatohepatitis in a dietary murine model

Q44814361

Free fatty acids promote hepatic lipotoxicity by stimulating TNF-alpha expression via a lysosomal pathway

Q44967749

Mitochondrial abnormality and oxidative stress in nonalcoholic steatohepatitis.

Q51921309

Osteopontin induces ductular reaction contributing to liver fibrosis.

Q53068016

Osteopontin: A missing link between hedgehog signaling and fibrosis in nonalcoholic steatohepatitis

Q61338068

P433

issue

P407

language of work or name

English

Q1860

P921

main subject

inflammation

Q101991

liver disease

Q929737

metabolic dysfunction–associated steatotic liver disease

Q1546498

fatty liver disease

Q6058862

P304

page(s)

1155-1169

P577

publication date

2015-10-16

P1433

published in

Hepatology

Q15724398

P1476

title

Inhibition of hedgehog signaling ameliorates hepatic inflammation in mice with nonalcoholic fatty liver disease

P478

volume

Reverse relations

cites work (P2860)

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