Hedgehog signaling in the liver

scientific article published on 14 October 2010

Hedgehog signaling in the liver is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/J.JHEP.2010.10.003
P932PMC publication ID3053023
P698PubMed publication ID21093090
P5875ResearchGate publication ID49624336

P50authorAlessia OmenettiQ37829246
Gregory MichelottiQ37830916
P2093author name stringAnna Mae Diehl
Steve Choi
P2860cites workGli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and functionQ21145277
The dynamic cilium in human diseasesQ21202039
Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIPQ24308894
A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitroQ24315704
mir-29 regulates Mcl-1 protein expression and apoptosisQ24652606
All Mammalian Hedgehog Proteins Interact with Cell Adhesion Molecule, Down-regulated by Oncogenes (CDO) and Brother of CDO (BOC) in a Conserved MannerQ27662102
Vertebrate Smoothened functions at the primary ciliumQ27919682
Intraflagellar transport (IFT) role in ciliary assembly, resorption and signalling.Q27967638
Hedgehog signaling in animal development: paradigms and principlesQ28208463
Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivoQ28237073
Cholesterol modification of hedgehog signaling proteins in animal developmentQ28291005
Divergence of hedgehog signal transduction mechanism between Drosophila and mammalsQ28295678
Isolation and characterization of a putative liver progenitor population after treatment of fetal rat hepatocytes with TGF-betaQ28582698
Patched1 regulates hedgehog signaling at the primary ciliumQ29547515
Molecular requirements for epithelial-mesenchymal transition during tumor progressionQ29618960
Cloning of the human GLI2 Promoter: transcriptional activation by transforming growth factor-beta via SMAD3/beta-catenin cooperationQ33553631
TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transitionQ33734595
Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosisQ33771703
Role of Wnt/β-catenin signaling in liver metabolism and cancerQ33940403
Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in miceQ34060199
Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease.Q34060210
Transcriptional suppression of mir-29b-1/mir-29a promoter by c-Myc, hedgehog, and NF-kappaB.Q34070947
A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblastsQ34125363
Functional genomics reveals a BMP-driven mesenchymal-to-epithelial transition in the initiation of somatic cell reprogrammingQ34125369
Role for hedgehog pathway in regulating growth and function of invariant NKT cells.Q34247943
Communicating with HedgehogsQ34407911
Hedgehog signaling in gastrointestinal development and diseaseQ34566828
Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signalingQ34574774
The initiation of liver development is dependent on Foxa transcription factorsQ34650705
Signals that determine Schwann cell identityQ34713829
Transitions between epithelial and mesenchymal states in development and diseaseQ34761972
Evolving concepts of liver fibrogenesis provide new diagnostic and therapeutic optionsQ36014644
Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humansQ36726189
Signals from dying hepatocytes trigger growth of liver progenitorsQ36785147
Death receptor 5 mediated-apoptosis contributes to cholestatic liver diseaseQ36825315
Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humansQ36890842
Non-canonical activation of GLI transcription factors: implications for targeted anti-cancer therapyQ36921866
Liver cell-derived microparticles activate hedgehog signaling and alter gene expression in hepatic endothelial cells.Q37047177
The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancerQ37064698
Control of cholangiocyte adaptive responses by visceral hormones and neuropeptidesQ37067699
New insights on the molecular and cell biology of human cholangiopathiesQ37071294
Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA (review).Q37242474
Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseasesQ37265621
Repair-related activation of hedgehog signaling promotes cholangiocyte chemokine productionQ37294219
Modeling ciliopathies: Primary cilia in development and diseaseQ37383076
Hedgehog signalling: emerging evidence for non-canonical pathwaysQ37462651
Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease.Q37504561
Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activationQ37622323
Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in miceQ38297119
A cellular memory module conveys epigenetic inheritance of hedgehog expression during Drosophila wing imaginal disc developmentQ38361920
An in vivo comparative study of sonic, desert and Indian hedgehog reveals that hedgehog pathway activity regulates epidermal stem cell homeostasisQ38861297
Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferationQ38869247
Purification and bioassay of hedgehog ligands for the study of cell death and survivalQ39219577
Comparative biological responses to human Sonic, Indian, and Desert hedgehogQ39342519
A developmental study of the Desert hedgehog-null mouse testisQ39355851
Hedgehog signaling in mouse ovary: Indian hedgehog and desert hedgehog from granulosa cells induce target gene expression in developing theca cellsQ39592664
GLI3-dependent repression of DR4 mediates hedgehog antagonism of TRAIL-induced apoptosisQ39690748
Increased expression of the hedgehog signaling pathway in pediatric solid malignanciesQ39740299
Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease.Q39829317
Down-regulation of hedgehog-interacting protein through genetic and epigenetic alterations in human hepatocellular carcinoma.Q39971688
Hedgehog signaling maintains resident hepatic progenitors throughout lifeQ40345226
Role for hedgehog signaling in hepatic stellate cell activation and viabilityQ40371810
Mcl-1 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in human cholangiocarcinoma cells.Q40554408
Bcl-2 is overexpressed and alters the threshold for apoptosis in a cholangiocarcinoma cell lineQ41085962
Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cellsQ41980364
Activation of Rac1 promotes hedgehog-mediated acquisition of the myofibroblastic phenotype in rat and human hepatic stellate cellsQ42171771
Integrative genomic analyses on GLI1: positive regulation of GLI1 by Hedgehog-GLI, TGFbeta-Smads, and RTK-PI3K-AKT signals, and negative regulation of GLI1 by Notch-CSL-HES/HEY, and GPCR-Gs-PKA signalsQ42455142
Unmasking of epigenetically silenced genes reveals DNA promoter methylation and reduced expression of PTCH in breast cancerQ42508201
Global gene expression profiling reveals a key role of CD44 in hepatic oval-cell reaction after 2-AAF/CCl4 injury in rodents.Q43276136
The ESC-E(Z) complex participates in the hedgehog signaling pathwayQ45225683
Regulation and function of the sonic hedgehog signal transduction pathway in isolated gastric parietal cellsQ45251271
Non-alcoholic steatohepatitis pathogenesis: role of repair in regulating the disease progressionQ45394733
Hedgehog signal activation coordinates proliferation and differentiation of fetal liver progenitor cells.Q45950325
Blocking the hedgehog pathway inhibits hepatoblastoma growth.Q46141818
Dysregulation of the Hedgehog pathway in human hepatocarcinogenesisQ46843790
Identification of adult hepatic progenitor cells capable of repopulating injured rat liverQ46893464
The product of hedgehog autoproteolytic cleavage active in local and long-range signallingQ47072400
Transcriptional mechanisms of WNT5A based on NF-kappaB, Hedgehog, TGFbeta, and Notch signaling cascadesQ47855910
Integrative genomic analyses of ZEB2: Transcriptional regulation of ZEB2 based on SMADs, ETS1, HIF1alpha, POU/OCT, and NF-kappaB.Q47855994
The phenotypes of pluripotent human hepatic progenitors.Q52020121
Reduced pepsin A processing of sonic hedgehog in parietal cells precedes gastric atrophy and transformation.Q53527573
Bile ductules and stromal cells express hedgehog ligands and/or hedgehog target genes in primary biliary cirrhosis.Q53556864
The hedgehog pathway regulates remodelling responses to biliary obstruction in rats.Q54539811
Activation of the hedgehog pathway in human hepatocellular carcinomas.Q54616323
Primary cilia and signaling pathways in mammalian development, health and disease.Q55443025
Correlation between Shh expression and DNA methylation status of the limb-specific Shh enhancer region during limb regeneration in amphibiansQ57709964
Hedgehog-mediated mesenchymal–epithelial interactions modulate hepatic response to bile duct ligationQ61050018
Cholangiocarcinomas express Fas ligand and disable the Fas receptorQ73208576
The stem cell niche of human livers: symmetry between development and regenerationQ79758183
Zonal hierarchy of differentiation markers and nestin expression during oval cell mediated rat liver regenerationQ79886544
When fibroblasts MET iPSCsQ84557506
P433issue2
P304page(s)366-373
P577publication date2010-10-14
P1433published inJournal of HepatologyQ15724402
P1476titleHedgehog signaling in the liver
P478volume54

Reverse relations

cites work (P2860)
Q87912961A Patient with Non-alcoholic Steatohepatitis Complicated by Multiple Myeloma
Q37031700A review on the diagnosis and treatment of hepatocellular carcinoma with a focus on the role of Wnts and the dickkopf family of Wnt inhibitors
Q58077797Adult Hepatocytes Are Hedgehog-Responsive Cells in the Setting of Liver Injury: Evidence for Smoothened-Mediated Activation of NF-κB/Epidermal Growth Factor Receptor/Akt in Hepatocytes that Counteract Fas-Induced Apoptosis
Q38223202Advances in liver regeneration
Q83065990After goodbye? Dead hepatocytes as a biomarker for fibrosis and steatohepatitis
Q33745654Alcohol activates the hedgehog pathway and induces related procarcinogenic processes in the alcohol-preferring rat model of hepatocarcinogenesis.
Q34446710Attenuation of early liver fibrosis by herbal compound "Diwu Yanggan" through modulating the balance between epithelial-to-mesenchymal transition and mesenchymal-to-epithelial transition
Q50973238Canonical hedgehog signalling regulates hepatic stellate cell-mediated angiogenesis in liver fibrosis.
Q35153098Capsaicin treatment attenuates cholangiocarcinoma carcinogenesis
Q38311151Cellular and molecular functions of hepatic stellate cells in inflammatory responses and liver immunology
Q47618775Chronic liver injury alters driver mutation profiles in hepatocellular carcinoma in mice.
Q40979935Curcumin regulates cell fate and metabolism by inhibiting hedgehog signaling in hepatic stellate cells
Q100994709Drug discovery and treatment paradigms in nonalcoholic steatohepatitis
Q38155507Emerging signaling pathways in hepatocellular carcinoma.
Q37440129Evidence for and against epithelial-to-mesenchymal transition in the liver
Q37584658Expression of vascular endothelial growth factors and their receptors by hepatic progenitor cells in human liver diseases.
Q42709926Forskolin, a hedgehog signalling inhibitor, attenuates carbon tetrachloride-induced liver fibrosis in rats
Q36348318Genomic Profiling Reveals Unique Molecular Alterations in Hepatoblastomas and Adjacent Hepatocellular Carcinomas in B6C3F1 Mice.
Q34620012Gli1 activation and protection against hepatic encephalopathy is suppressed by circulating transforming growth factor β1 in mice.
Q27302934Growth Arrest Specific 1 (Gas1) Gene Overexpression in Liver Reduces the In Vivo Progression of Murine Hepatocellular Carcinoma and Partially Restores Gene Expression Levels
Q52646732HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers.
Q38739400Hedgehog Signaling Activation in Hepatic Stellate Cells Promotes Angiogenesis and Vascular Mimicry in Hepatocellular Carcinoma
Q36345406Hedgehog controls hepatic stellate cell fate by regulating metabolism
Q33695543Hedgehog inhibition reduces angiogenesis by downregulation of tumoral VEGF-A expression in hepatocellular carcinoma
Q36402141Hedgehog pathway activation parallels histologic severity of injury and fibrosis in human nonalcoholic fatty liver disease
Q36799703Hedgehog pathway and pediatric nonalcoholic fatty liver disease
Q52877592Hedgehog pathway as a potential treatment target in human cholangiocarcinoma.
Q36955776Hedgehog signaling and radiation induced liver injury: a delicate balance
Q27322930Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer
Q36463282Hedgehog signaling blockade delays hepatocarcinogenesis induced by hepatitis B virus X protein
Q40706711Hedgehog signaling influences gender-specific response of liver to radiation in mice
Q36908863Hedgehog signaling is a potent regulator of liver lipid metabolism and reveals a GLI-code associated with steatosis.
Q38707438Hedgehog signaling pathway affects the sensitivity of hepatoma cells to drug therapy through the ABCC1 transporter
Q38220772Hedgehog signaling pathway as key player in liver fibrosis: new insights and perspectives
Q36997036Hedgehog signaling pathway regulates autophagy in human hepatocellular carcinoma cells
Q37965128Hedgehog signalling in gut development, physiology and cancer
Q36677171Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation
Q46250177Hepatic Fibrosis in Dogs
Q28504728Hepatic Hedgehog signaling contributes to the regulation of IGF1 and IGFBP1 serum levels
Q37595392Hepatic alterations are accompanied by changes to bile acid transporter-expressing neurons in the hypothalamus after traumatic brain injury
Q38941908Hepatic stellate cells: fibrogenic, regenerative or both? Heterogeneity and context are key.
Q61099995Hepatocyte Lethal and Nonlethal Lipotoxic Injury
Q91999281Hepatoprotective Effect of Kombucha Tea in Rodent Model of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis
Q64275574High Risk of Hepatocellular Carcinoma Development in Fibrotic Liver: Role of the Hippo-YAP/TAZ Signaling Pathway
Q38940706How to Face Chronic Liver Disease: The Sinusoidal Perspective.
Q45061974Human germline hedgehog pathway mutations predispose to fatty liver.
Q55491884Identification and characterization of long noncoding RNAs and mRNAs expression profiles related to postnatal liver maturation of breeder roosters using Ribo-zero RNA sequencing.
Q51077092Induced MiR-1249 expression by aberrant activation of Hedegehog signaling pathway in hepatocellular carcinoma.
Q40272590Induction of autophagy and apoptosis by miR-148a through the sonic hedgehog signaling pathway in hepatic stellate cells
Q38134486Inhibition of Hedgehog signaling in the gastrointestinal tract: targeting the cancer microenvironment.
Q36723148Inhibition of hedgehog signaling ameliorates hepatic inflammation in mice with nonalcoholic fatty liver disease
Q37109402Liver Injury and the Activation of the Hepatic Myofibroblasts
Q60950062Liver Regeneration: Different Sub-Populations of Parenchymal Cells at Play Choreographed by an Injury-Specific Microenvironment
Q64968927Liver Zonation in Health and Disease: Hypoxia and Hypoxia-Inducible Transcription Factors as Concert Masters.
Q33587672Loss of pericyte smoothened activity in mice with genetic deficiency of leptin
Q36457220Macrophage-derived Hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni
Q90799544Manipulating the mechanics of extracellular matrix to study effects on the nucleus and its structure
Q53150028Mechanism of pancreatic and liver malformations in human fetuses with short-rib polydactyly syndrome.
Q39294420Mechanisms of hepatic stellate cell activation
Q37050843MicroRNA Expression Profiling in CCl₄-Induced Liver Fibrosis of Mus musculus
Q38909043MicroRNA-370 Attenuates Hepatic Fibrogenesis by Targeting Smoothened
Q36719130MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression
Q36059842MicroRNA125b-mediated Hedgehog signaling influences liver regeneration by chorionic plate-derived mesenchymal stem cells
Q26740198MicroRNAs in liver fibrosis: Focusing on the interaction with hedgehog signaling
Q39114556Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy.
Q83823098Neighborhood watch orchestrates liver regeneration
Q92112806Nocturnal Hypoxia Activation of the Hedgehog Signaling Pathway Affects Pediatric Nonalcoholic Fatty Liver Disease Severity
Q57050806Oncogenic Signaling Induced by HCV Infection
Q36801010Osteopontin is a novel downstream target of SOX9 with diagnostic implications for progression of liver fibrosis in humans
Q34985968PNPLA3 I148M variant in nonalcoholic fatty liver disease: demographic and ethnic characteristics and the role of the variant in nonalcoholic fatty liver fibrosis
Q36476413Paracrine Hedgehog signaling drives metabolic changes in hepatocellular carcinoma
Q35928495Pathogenesis of nonalcoholic steatohepatitis
Q38759957Pentoxifylline inhibits liver fibrosis via hedgehog signaling pathway
Q43793566Potential role of Hedgehog signaling and microRNA-29 in liver fibrosis of IKKβ-deficient mouse
Q27003833Potential role of thymosin Beta 4 in liver fibrosis
Q34347580Principles of liver regeneration and growth homeostasis
Q94564532Pro- and Anti-fibrogenic Functions of Gram-Negative Bacterial Lipopolysaccharide in the Liver
Q35943663RNA-sequencing analysis of 5' capped RNAs identifies many new differentially expressed genes in acute hepatitis C virus infection
Q37720268Reelin expression in human liver of patients with chronic hepatitis C infection.
Q46374706Resveratrol inhibits hepatocellular carcinoma progression driven by hepatic stellate cells by targeting Gli-1.
Q37291238Role of hepatic progenitor cells in nonalcoholic fatty liver disease development: cellular cross-talks and molecular networks
Q54275100Roles of myofibroblasts and notch and hedgehog signaling pathways in the formation of intrahepatic bile duct lesions in polycystic kidney rats.
Q40499678Serum osteopontin is a biomarker of severe fibrosis and portal hypertension in human and murine schistosomiasis mansoni
Q47102009Single-cell RNA-Seq analysis reveals dynamic trajectories during mouse liver development
Q36890924Smoothened is a master regulator of adult liver repair
Q38831994Statins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension.
Q36464512Suppression of hedgehog signaling regulates hepatic stellate cell activation and collagen secretion
Q37946756TGF-β in progression of liver disease
Q27002288Targeted therapy for hepatocellular carcinoma: novel agents on the horizon
Q95270458Targeting Hepatic Stellate Cells for the Treatment of Liver Fibrosis by Natural Products: Is It the Dawning of a New Era?
Q64245542The Importance of the Hedgehog Signaling Pathway in Tumorigenesis of Spinal and Cranial Chordoma
Q47126762The Injury-Related Activation of Hedgehog Signaling Pathway Modulates the Repair-Associated Inflammation in Liver Fibrosis
Q35690783The Protective Effect of Resveratrol on Concanavalin-A-Induced Acute Hepatic Injury in Mice
Q36036483The development of hepatic stellate cells in normal and abnormal human fetuses - an immunohistochemical study
Q60047391The molecular connection of histopathological heterogeneity in hepatocellular carcinoma: A role of Wnt and Hedgehog signaling pathways
Q33812502Thymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling.
Q92875878Transforming Growth Factor-Beta (TGFβ) Signaling Pathway in Cholangiocarcinoma
Q34560114Treatment response in the PIVENS trial is associated with decreased Hedgehog pathway activity
Q38584340Tumor Microenvironment Versus Cancer Stem Cells in Cholangiocarcinoma: Synergistic Effects?
Q91406319Understanding susceptibility and targeting treatment in non-alcoholic fatty liver disease in children; moving the fulcrum
Q36277100Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease
Q39003705Wound healing - A literature review.

Search more.