Age-related defects in moesin/ezrin cytoskeletal signals in mouse CD4 T cells

scientific article published on November 2007

Age-related defects in moesin/ezrin cytoskeletal signals in mouse CD4 T cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4049/JIMMUNOL.179.10.6403
P8608Fatcat IDrelease_tbsqtqbitvb4xng5yjfmytxq3m
P932PMC publication ID2441933
P698PubMed publication ID17982027
P5875ResearchGate publication ID5864701

P50authorRichard A. MillerQ92687565
P2093author name stringAmir A Sadighi Akha
Gonzalo G Garcia
P2860cites workRho kinase is required for CCR7‐mediated polarization and chemotaxis of T lymphocytesQ24301001
Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2Q24676628
Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarizationQ24683747
Control of T lymphocyte morphology by the GTPase Rho.Q24806593
Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domainQ27622801
Interaction between two adapter proteins, PAG and EBP50: a possible link between membrane rafts and actin cytoskeletonQ28202663
Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesinQ28208110
CD43 interacts with moesin and ezrin and regulates its redistribution to the uropods of T lymphocytes at the cell-cell contactsQ28272939
A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contactsQ28282813
CD43 regulation of T cell activation is not through steric inhibition of T cell-APC interactions but through an intracellular mechanismQ28505065
Polar redistribution of the sialoglycoprotein CD43: implications for T cell functionQ28506369
ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapseQ28507578
Age-related defects in CD4+ T cell activation reversed by glycoprotein endopeptidaseQ28589044
T cell receptor-proximal signals are sustained in peripheral microclusters and terminated in the central supramolecular activation clusterQ29617556
ERM proteins and merlin: integrators at the cell cortexQ29619893
Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeletonQ29620156
Integrin-mediated adhesion regulates cell polarity and membrane protrusion through the Rho family of GTPasesQ30500235
Regulation of cortical structure by the ezrin-radixin-moesin protein familyQ33536481
Cytoskeletal rearrangement during migration and activation of T lymphocytesQ33650492
Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognitionQ33867251
The immunological synapse and the actin cytoskeleton: molecular hardware for T cell signaling.Q33958592
ERM-Merlin and EBP50 protein families in plasma membrane organization and functionQ34059680
Mastering time and space: immune cell polarization and chemotaxis.Q35975113
The immunological synapse and Rho GTPases.Q36176039
Role of ERM (ezrin-radixin-moesin) proteins in T lymphocyte polarization, immune synapse formation and in T cell receptor-mediated signalingQ36348270
Antigen-independent changes in naive CD4 T cells with agingQ36367675
ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletonsQ36382880
Maintenance and modulation of T cell polarityQ36629861
P-glycoprotein-actin association through ERM family proteins: a role in P-glycoprotein function in human cells of lymphoid originQ38293153
Ezrin mutants affecting dimerization and activationQ39369801
Cholesterol sensitivity of detergent resistance: a rapid flow cytometric test for detecting constitutive or induced raft association of membrane proteins.Q40512992
Raft and cytoskeleton associations of an ABC transporter: P-glycoproteinQ40513001
Age-dependent defects in TCR-triggered cytoskeletal rearrangement in CD4+ T cellsQ40695583
An immunologist's look at the Rho and Rab GTP-binding proteins.Q40769606
Single-cell analyses reveal two defects in peptide-specific activation of naive T cells from aged miceQ40826684
Evidence for ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) self-association through PDZ-PDZ interactionsQ40872990
Rho GTPases control migration and polarization of adhesion molecules and cytoskeletal ERM components in T lymphocytesQ40918897
Ezrin: a protein requiring conformational activation to link microfilaments to the plasma membrane in the assembly of cell surface structuresQ41640261
From naive to effector--alterations with agingQ41708745
Identification and functional analysis of the ezrin-binding site in the hyaluronan receptor, CD44.Q47934778
CD43-independent augmentation of mouse T-cell function by glycoprotein cleaving enzymesQ50079317
Increased Zap-70 association with CD3zeta in CD4 T cells from old miceQ50151247
The two poles of the lymphocyte: specialized cell compartments for migration and recruitmentQ54966424
The Actin Cytoskeleton and Lymphocyte ActivationQ57185350
Determination of GTP loading on RhoQ57446974
Chemokine stimulation of human peripheral blood T lymphocytes induces rapid dephosphorylation of ERM proteins, which facilitates loss of microvilli and polarizationQ58022542
Polarization and interaction of adhesion molecules P-selectin glycoprotein ligand 1 and intercellular adhesion molecule 3 with moesin and ezrin in myeloid cellsQ58064394
ERM proteins regulate cytoskeleton relaxation promoting T cell–APC conjugationQ63408325
Involvement of the lymphocyte cytoskeleton in antigen-receptor signalingQ73112156
Age-dependent alterations in the assembly of signal transduction complexes at the site of T cell/APC interactionQ74027107
The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activationQ77307336
Cutting edge: negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assemblyQ77452189
TCR signaling induces selective exclusion of CD43 from the T cell-antigen-presenting cell contact siteQ77715944
A glycoprotein endopeptidase enhances calcium influx and cytokine production by CD4+ T cells of old and young miceQ80340638
Rac1 mediates collapse of microvilli on chemokine-activated T lymphocytesQ80833051
Age-associated changes in glycosylation of CD43 and CD45 on mouse CD4 T cellsQ81314903
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectcytoskeletonQ154626
P304page(s)6403-6409
P577publication date2007-11-01
P1433published inJournal of ImmunologyQ3521441
P1476titleAge-related defects in moesin/ezrin cytoskeletal signals in mouse CD4 T cells
P478volume179

Reverse relations

cites work (P2860)
Q33765548Age-dependent signature of metallothionein expression in primary CD4 T cell responses is due to sustained zinc signaling
Q37308513Age-related changes in lck-Vav signaling pathways in mouse CD4 T cells
Q34305651Age-related changes in the retinal pigment epithelium (RPE).
Q37639578Age-related defects in the cytoskeleton signaling pathways of CD4 T cells
Q30898592Can blood components with age-related changes influence the ageing of endothelial cells?
Q24601345Ex vivo enzymatic treatment of aged CD4 T cells restores cognate T cell helper function and enhances antibody production in mice
Q33678939Ezrin is highly expressed in early thymocytes, but dispensable for T cell development in mice
Q42868138Identification and functional implication of a Rho kinase-dependent moesin-EBP50 interaction in noradrenaline-stimulated artery
Q36576352Impairment of non-muscle myosin IIA in human CD4+ T cells contributes to functional deficits in the elderly
Q37307472Increased mammalian target of rapamycin complex 2 signaling promotes age-related decline in CD4 T cell signaling and function
Q35874100Integration of immunity with physical and cognitive function in definitions of successful aging.
Q36418550Loss of naive T cells and repertoire constriction predict poor response to vaccination in old primates
Q34104015Nonmalignant clonal expansions of memory CD8+ T cells that arise with age vary in their capacity to mount recall responses to infection
Q34090173Phosphorylation of IRF4 by ROCK2 regulates IL-17 and IL-21 production and the development of autoimmunity in mice
Q38151846Re-defining ERM function in lymphocyte activation and migration
Q39076960Role of the PDZ-scaffold protein NHERF1/EBP50 in cancer biology: from signaling regulation to clinical relevance.
Q47291933The twilight of immunity: emerging concepts in aging of the immune system

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