The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland.

scientific article published on 5 June 2015

The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/CDD.2015.61
P932PMC publication ID4815977
P698PubMed publication ID26045049
P5875ResearchGate publication ID277778797

P50authorLothar HennighausenQ51971727
Victoria KlepschQ57444157
Piotr TymoszukQ48030718
P2093author name stringS Oh
A Villunger
C J Watson
F Schuler
E Müller-Holzner
W Doppler
F Baumgartner
M Chamson
P2860cites workHormonal control of insulin-like growth factor-binding protein-5 production in the involuting mammary gland of the ratQ73923087
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikisQ24291662
FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawalQ24676637
Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesisQ24681265
Structural insights into the degradation of Mcl-1 induced by BH3 domainsQ27644256
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunityQ28138855
The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complexQ28141249
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxaQ28204059
Cellular actions of the insulin-like growth factor binding proteinsQ28216659
Gain of Bcl-2 is more potent than bax loss in regulating mammary epithelial cell survival in vivoQ28506179
BIM regulates apoptosis during mammary ductal morphogenesis, and its absence reveals alternative cell death mechanismsQ28510331
The NOXA-MCL1-BIM axis defines lifespan on extended mitotic arrestQ30648719
Apoptosis in normal and neoplastic mammary gland developmentQ31911459
Transforming growth factor-(beta)s and mammary gland involution; functional roles and implications for cancer progressionQ33553226
Prolactin inhibits BCL6 expression in breast cancer through a Stat5a-dependent mechanismQ33658181
Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1.Q33877581
The role of Stat3 in apoptosis and mammary gland involution. Conditional deletion of Stat3.Q34014065
The PI3K regulatory subunits p55α and p50α regulate cell death in vivo.Q34035704
Interleukin 15-mediated survival of natural killer cells is determined by interactions among Bim, Noxa and Mcl-1.Q34184126
BH3-only protein Bmf mediates apoptosis upon inhibition of CAP-dependent protein synthesisQ34191999
Keeping killers on a tight leash: transcriptional and post-translational control of the pro-apoptotic activity of BH3-only proteinsQ34612753
Developmental regulation of Bcl-2 family protein expression in the involuting mammary glandQ34629005
Stat3 controls lysosomal-mediated cell death in vivoQ48530601
Socs 3 modulates the activity of the transcription factor Stat3 in mammary tissue and controls alveolar homeostasis.Q51997629
Regulation and function of the cytokine-inducible SH-2 domain proteins, CIS and SOCS3, in mammary epithelial cells.Q52118105
Transforming growth factor beta3 induces cell death during the first stage of mammary gland involution.Q52167469
Mammary gland involution is delayed by activated Akt in transgenic mice.Q52543083
Overexpression of Bcl-2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice.Q53439560
p53 mediates a default programme of mammary gland involution in the absence of STAT3Q57557282
Rapid modulation of the apoptosis regulatory genes, bcl-2 and bax by prolactin in rat Nb2 lymphoma cellsQ71826203
Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3.Q35207498
c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3.Q35222270
Bad-deficient mice develop diffuse large B cell lymphomaQ35234507
The BCL-2 family reunionQ35568029
Bim and Bmf in tissue homeostasis and malignant diseaseQ35737865
Combined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in TACI-Ig transgenic miceQ35941499
Mammary-derived signals activate programmed cell death during the first stage of mammary gland involutionQ36086481
Information networks in the mammary gland.Q36289108
Glucocorticoid and progesterone inhibit involution and programmed cell death in the mouse mammary glandQ36382841
Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates gamma irradiation-induced thymic lymphoma developmentQ36509870
Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentrationQ36580933
Multisite phosphorylation regulates Bim stability and apoptotic activityQ36756298
BAD: undertaker by night, candyman by day.Q37566231
Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf.Q37723472
Lysosomal-mitochondrial cross-talk during cell deathQ37778889
Remodeling mechanisms of the mammary gland during involution.Q37967577
Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy.Q38172752
Molecular analysis of neutrophil spontaneous apoptosis reveals a strong role for the pro-apoptotic BH3-only protein Noxa.Q38666072
Upregulation of two BH3-only proteins, Bmf and Bim, during TGF beta-induced apoptosisQ40243666
Prolactin inhibits cell loss and decreases matrix metalloproteinase expression in the involuting mouse mammary gland but fails to prevent cell loss in the mammary glands of mice expressing IGFBP-5 as a mammary transgeneQ40276292
Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit compositionQ40442177
Mutual antagonism of TGF-beta and Interleukin-2 in cell survival and lineage commitment of induced regulatory T cells.Q41825885
Role of STAT5 in controlling cell survival and immunoglobulin gene recombination during pro-B cell developmentQ42175565
Conditional deletion of the bcl-x gene from mouse mammary epithelium results in accelerated apoptosis during involution but does not compromise cell function during lactation.Q43814258
Deletion of Stat3 blocks mammary gland involution and extends functional competence of the secretory epithelium in the absence of lactogenic stimuli.Q44112935
A dual, non-redundant, role for LIF as a regulator of development and STAT3-mediated cell death in mammary glandQ44480678
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikisQ44502162
The role of cathepsins in involution and breast cancer.Q47815769
Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune responseQ48030659
P275copyright licenseCreative Commons Attribution-NonCommercial-ShareAlike 4.0 InternationalQ42553662
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageJQ1659584
P433issue1
P304page(s)41-51
P577publication date2015-06-05
P1433published inCell Death & DifferentiationQ2943974
P1476titleThe BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland
P478volume23

Reverse relations

cites work (P2860)
Q92399928Checkpoint kinase 1 is essential for fetal and adult hematopoiesis
Q37383229Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis
Q37122579Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling.
Q93193962Molecular mechanism of mammary gland involution: An update
Q26781203Regulation of Bim in Health and Disease
Q91100188Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins
Q54122849The cJUN NH2-terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution.
Q89018067cIAP2 Is an Independent Signaling and Survival Factor during Mammary Lactational Involution and Tumorigenesis

Search more.