Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery

scientific article published on April 2013

Recent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2013PNAS..110.6494P
P356DOI10.1073/PNAS.1221955110
P932PMC publication ID3631617
P698PubMed publication ID23576744

P50authorAndreia C LinoQ54938111
Ana E. SousaQ39972525
Jocelyne DemengeotQ47410059
Iris CaramalhoQ50617263
Marie-Louise BergmanQ51765641
Santiago ZelenayQ51765647
P2093author name stringRicardo S Paiva
P2860cites workA requisite role for induced regulatory T cells in tolerance based on expanding antigen receptor diversityQ24622687
Regulatory T cell lineage specification by the forkhead transcription factor foxp3Q28510328
Extrathymic generation of regulatory T cells in placental mammals mitigates maternal-fetal conflictQ28728365
Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acidQ29619479
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self.Q55035366
Integrated T-cell receptor and costimulatory signals determine TGF-β-dependent differentiation and maintenance of Foxp3+ regulatory T cellsQ56987319
Establishment of tissue-specific tolerance is driven by regulatory T cells selected by thymic epitheliumQ59652622
Cutting Edge: Intrathymic Differentiation of Adaptive Foxp3+ Regulatory T Cells upon Peripheral Proinflammatory ImmunizationQ61053507
Sub-optimal CD4+ T-cell activation triggers autonomous TGF-β-dependent conversion to Foxp3+ regulatory T cellsQ61907019
Differential contribution of thymic outputs and peripheral expansion in the development of peripheral T cell poolsQ72416092
Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune diseaseQ73542905
Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptideQ73688337
A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cellsQ81157115
"Default" generation of neonatal regulatory T cellsQ84291731
Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responsesQ29619908
Retinoic acid can enhance conversion of naive into regulatory T cells independently of secreted cytokinesQ33500916
Genomic definition of multiple ex vivo regulatory T cell subphenotypesQ33778238
Oral tolerance in the absence of naturally occurring TregsQ33840440
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fateQ33908130
Identification of an immediate Foxp3(-) precursor to Foxp3(+) regulatory T cells in peripheral lymphoid organs of nonmanipulated miceQ33979866
Actively acquired tolerance of foreign cellsQ34233179
In vivo instruction of suppressor commitment in naive T cellsQ34548023
Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancerQ34729938
Retinoic acid enhances Foxp3 induction indirectly by relieving inhibition from CD4+CD44hi CellsQ35117509
Post-thymic maturation: young T cells assert their individualityQ35620794
Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiencyQ35992006
An N-terminal mutation of the Foxp3 transcription factor alleviates arthritis but exacerbates diabetesQ36067669
Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cellsQ36156864
Smad3 binding to the foxp3 enhancer is dispensable for the development of regulatory T cells with the exception of the gut.Q36193512
Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigenQ36403106
A two-step process for thymic regulatory T cell development.Q36470183
Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire.Q36725004
IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cellsQ36985100
Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control.Q37223249
Thymus-homing peripheral dendritic cells constitute two of the three major subsets of dendritic cells in the steady-state thymusQ37234298
A central role for induced regulatory T cells in tolerance induction in experimental colitisQ37390209
Two subsets of naive T helper cells with distinct T cell receptor excision circle content in human adult peripheral bloodQ42944731
DNA methylation controls Foxp3 gene expressionQ46391168
Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factorQ47740353
Continued maturation of thymic emigrants in the peripheryQ48022294
Maintenance of peripheral naive T cells is sustained by thymus output in mice but not humans.Q51415097
The thymus plays a role in oral tolerance in experimental autoimmune encephalomyelitis.Q51980902
P433issue16
P407language of work or nameEnglishQ1860
P304page(s)6494-6499
P577publication date2013-04-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleRecent thymic emigrants are the preferential precursors of regulatory T cells differentiated in the periphery
P478volume110

Reverse relations

cites work (P2860)
Q35180524BST2/Tetherin is constitutively expressed on human thymocytes with the phenotype and function of Treg cells
Q35601082CD11c-mediated deletion of Flip promotes autoreactivity and inflammatory arthritis
Q36247816CD25+CD127+Foxp3- Cells Represent a Major Subpopulation of CD8+ T Cells in the Eye Chambers of Normal Mice
Q27321353CD4+ Recent Thymic Emigrants Are Recruited into Granulomas during Leishmania donovani Infection but Have Limited Capacity for Cytokine Production
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Q39096604Critical influence of the thymus on peripheral T cell homeostasis
Q39808834Distinct IL-7 signaling in recent thymic emigrants versus mature naïve T cells controls T-cell homeostasis
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