Non-redundant function of the MEK5-ERK5 pathway in thymocyte apoptosis

scientific article published on 12 June 2008

Non-redundant function of the MEK5-ERK5 pathway in thymocyte apoptosis is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/EMBOJ.2008.114
P932PMC publication ID2486421
P698PubMed publication ID18548009
P5875ResearchGate publication ID5309234

P2093author name stringAstar Winoto
Gavin M Lewis
Sue J Sohn
P2860cites workBMK1/ERK5 regulates serum-induced early gene expression through transcription factor MEF2CQ24532869
Erk5 null mice display multiple extraembryonic vascular and embryonic cardiovascular defectsQ24534817
Knockout of ERK5 causes multiple defects in placental and embryonic developmentQ24791222
BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytesQ28203083
Bmk1/Erk5 is required for cell proliferation induced by epidermal growth factorQ28286729
Targeted deletion of mek5 causes early embryonic death and defects in the extracellular signal-regulated kinase 5/myocyte enhancer factor 2 cell survival pathwayQ28508107
Transcriptional activation of known and novel apoptotic pathways by Nur77 orphan steroid receptorQ28512848
ERK5 MAPK regulates embryonic angiogenesis and acts as a hypoxia-sensitive repressor of vascular endothelial growth factor expressionQ28591302
Production of high-titer helper-free retroviruses by transient transfectionQ29547802
T cell receptor antagonist peptides induce positive selectionQ29618820
ERK5 is a novel type of mitogen-activated protein kinase containing a transcriptional activation domainQ33605384
A requirement for sustained ERK signaling during thymocyte positive selection in vivoQ34015960
Nuclear hormone receptors in T lymphocytesQ34126046
Positive and negative selection of T cellsQ34157557
Apoptosis during lymphoid developmentQ35084288
In vivo and in vitro clonal deletion of double-positive thymocytesQ36231231
Rapid deletion of rearranged T cell antigen receptor (TCR) Valpha-Jalpha segment by secondary rearrangement in the thymus: role of continuous rearrangement of TCR alpha chain gene and positive selection in the T cell repertoire formation.Q36322809
Positive and negative selection invoke distinct signaling pathways.Q36367050
c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferationQ36376229
Positive and negative selection in transgenic mice expressing a T-cell receptor specific for influenza nucleoprotein and endogenous superantigenQ36511048
During negative selection, Nur77 family proteins translocate to mitochondria where they associate with Bcl-2 and expose its proapoptotic BH3 domainQ36639961
Targeted deletion of BMK1/ERK5 in adult mice perturbs vascular integrity and leads to endothelial failure.Q37370471
Thymic selection threshold defined by compartmentalization of Ras/MAPK signallingQ39773899
Regulation of osteoclast apoptosis by ubiquitylation of proapoptotic BH3-only Bcl-2 family member Bim.Q40323778
A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activityQ40862851
Transcriptional regulation of tissue-specific genes by the ERK5 mitogen-activated protein kinaseQ42590095
Effects of MAP kinase cascade inhibitors on the MKK5/ERK5 pathwayQ43691664
Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes.Q43967840
Differential roles of ERK and p38 MAP kinase pathways in positive and negative selection of T lymphocytes.Q44556255
A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selectionQ44593628
GATA-3 expression is controlled by TCR signals and regulates CD4/CD8 differentiationQ46044258
Suppressor of cytokine signaling 1 is required for the differentiation of CD4+ T cells.Q46697159
Susceptibility and resistance to antigen-induced apoptosis in the thymus of transgenic miceQ48032387
The role of erk1 and erk2 in multiple stages of T cell development.Q50954940
The Central Tolerance Response to Male Antigen in Normal Mice Is Deletion and Not Receptor EditingQ53854162
Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim.Q53877408
T cell tolerance by clonal elimination in the thymusQ56922465
Failure of HY-Specific Thymocytes to Escape Negative Selection by Receptor EditingQ57078475
Duration and Strength of Extracellular Signal-Regulated Kinase Signals Are Altered During Positive Versus Negative Thymocyte SelectionQ59123070
B7 expression on thymic medullary epithelium correlates with epithelium-mediated deletion of V beta 5+ thymocytesQ71616339
Receptor editing in developing T cellsQ73035421
Degree of ERK activation influences both positive and negative thymocyte selectionQ73666616
LKLF: A transcriptional regulator of single-positive T cell quiescence and survivalQ73709468
CD3delta couples T-cell receptor signalling to ERK activation and thymocyte positive selectionQ74144662
Defective central tolerance induction in NOD mice: genomics and geneticsQ81552095
P433issue13
P407language of work or nameEnglishQ1860
P921main subjectthymocyteQ7799635
P304page(s)1896-1906
P577publication date2008-06-12
P1433published inThe EMBO JournalQ1278554
P1476titleNon-redundant function of the MEK5-ERK5 pathway in thymocyte apoptosis
P478volume27

Reverse relations

cites work (P2860)
Q33523813A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathway
Q89978308ASK1 Mediates Nur77 Expression in T-Cell Receptor Mediated Thymocyte Apoptosis
Q54636641Activation of p38 mitogen-activated protein kinase by norepinephrine in T-lineage cells
Q42378808Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity
Q34662225CBAP promotes thymocyte negative selection by facilitating T-cell receptor proximal signaling
Q35874330CCR7/CCL19 controls expression of EDG-1 in T cells
Q92957674Caenorhabditis elegans and its applicability to studies on restless legs syndrome
Q36862130Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site
Q38841260Dual role of ERK5 in the regulation of T cell receptor expression at the T cell surface
Q37618290ERK and cell death: ERK location and T cell selection
Q37618297ERK and cell death: mechanisms of ERK-induced cell death--apoptosis, autophagy and senescence
Q37977186ERK5 and its role in tumour development
Q35651895Identification and validation of dysregulated MAPK7 (ERK5) as a novel oncogenic target in squamous cell lung and esophageal carcinoma
Q42051316Increased T-cell Infiltration Elicited by Erk5 Deletion in a Pten-Deficient Mouse Model of Prostate Carcinogenesis.
Q54611374Injury-induced activation of the MAPK/CREB pathway triggers apoptosis-induced compensatory proliferation in hydra head regeneration.
Q34361180Life and death in the thymus—cell death signaling during T cell development
Q39816876MEK5 and ERK5 are mediators of the pro-myogenic actions of IGF-2.
Q61796855MEK5/ERK5 activation regulates colon cancer stem-like cell properties
Q34769445Modulation of protein kinase signaling cascades by palytoxin
Q37801270Molecular and genetic parameters defining T-cell clonal selection
Q36850002Protein Kinase C ζ Interacts with a Novel Binding Region of Gαq to Act as a Functional Effector
Q34790083Protein kinase C regulates mitochondrial targeting of Nur77 and its family member Nor-1 in thymocytes undergoing apoptosis
Q37376338Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.
Q37395668TGF-β receptor maintains CD4 T helper cell identity during chronic viral infections
Q41263307Trx1/TrxR1 system regulates post-selected DP thymocytes survival by modulating ASK1-JNK/p38 MAPK activities