Structural analysis of wild-type and mutant human immunodeficiency virus type 1 Tat proteins

scientific article published on December 1990

Structural analysis of wild-type and mutant human immunodeficiency virus type 1 Tat proteins is …
instance of (P31):
scholarly articleQ13442814

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P932PMC publication ID248775
P698PubMed publication ID2243385

P2093author name stringA P Rice
F Carlotti
P2860cites workMutational analysis of the conserved basic domain of human immunodeficiency virus tat proteinQ24656004
Structural and functional characterization of human immunodeficiency virus tat proteinQ24656163
Transcriptional regulation in mammalian cells by sequence-specific DNA binding proteinsQ27861094
RNA-binding proteins as developmental regulatorsQ28237577
A novel human immunodeficiency virus type 1 protein, tev, shares sequences with tat, env, and rev proteinsQ28246228
Anti-termination of transcription within the long terminal repeat of HIV-1 by tat gene productQ29615049
HIV-1 Tat protein increases transcriptional initiation and stabilizes elongationQ29620799
A tripartite HIV-1 tat-env-rev fusion proteinQ33918908
Structural and functional characterization of the short acidic transcriptional activation region of yeast GCN4 proteinQ34172416
HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA.Q34186306
Cooperative activation of a eukaryotic transcription factor: interaction between Cu(I) and yeast ACE1 proteinQ34289491
Human immunodeficiency virus 1 tat protein binds trans-activation-responsive region (TAR) RNA in vitroQ34303073
Trans-activation of human immunodeficiency virus gene expression is mediated by nuclear eventsQ34344850
Trans-acting transcriptional regulation of human T-cell leukemia virus type III long terminal repeatQ34563887
The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeatQ34564367
Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III.Q34564460
Multiple functional domains of Tat, the trans-activator of HIV-1, defined by mutational analysisQ35226113
5'-3' exonucleases in phosphorothioate-based oligonucleotide-directed mutagenesisQ35943171
Mutational analysis of the conserved cysteine-rich region of the human immunodeficiency virus type 1 Tat proteinQ36804564
Temporal aspects of DNA and RNA synthesis during human immunodeficiency virus infection: evidence for differential gene expressionQ36830303
trans activation of human immunodeficiency virus type 1 is sequence specific for both the single-stranded bulge and loop of the trans-acting-responsive hairpin: a quantitative analysis.Q36832567
Synthesis of the complete trans-activation gene product of human T-lymphotropic virus type III in Escherichia coli: demonstration of immunogenicity in vivo and expression in vitroQ37398372
Human immunodeficiency virus type 1 LTR TATA and TAR region sequences required for transcriptional regulationQ38345116
Functional domains required for tat-induced transcriptional activation of the HIV-1 long terminal repeatQ38346354
Regulatory pathways governing HIV-1 replicationQ38360638
Mutational effects on protein stabilityQ38686707
HIV TAR: an RNA enhancer?Q38708348
Genetic studies of protein stability and mechanisms of foldingQ39653536
Mutational analysis of the trans-activation-responsive region of the human immunodeficiency virus type I long terminal repeatQ40129795
A discrete element 3' of human immunodeficiency virus 1 (HIV-1) and HIV-2 mRNA initiation sites mediates transcriptional activation by an HIV trans activatorQ40650101
Transcriptional but not translational regulation of HIV-1 by the tat gene product.Q44298589
Transactivation induced by human T-lymphotropic virus type III (HTLV III) maps to a viral sequence encoding 58 amino acids and lacks tissue specificityQ44335635
HIV-1 tat trans-activation requires the loop sequence within tar.Q44349676
Regulation of mRNA accumulation by a human immunodeficiency virus trans-activator proteinQ45830211
Trans-activation of human immunodeficiency virus occurs via a bimodal mechanismQ45830933
Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genesQ45831871
Trans-activator gene of human T-lymphotropic virus type III (HTLV-III).Q45838520
Tat protein from human immunodeficiency virus forms a metal-linked dimerQ45841752
Tat trans-activates the human immunodeficiency virus through a nascent RNA targetQ45847022
Structure, sequence, and position of the stem-loop in tar determine transcriptional elongation by tat through the HIV-1 long terminal repeatQ46674379
HIV-1 TAT "activates" presynthesized RNA in the nucleusQ48291503
Genes-in-pieces revisited.Q53728552
Site-directed mutagenesis of two trans-regulatory genes (tat-III,trs) of HIV-1Q68126223
Functional substitution of the basic domain of the HIV-1 trans-activator, Tat, with the basic domain of the functionally heterologous RevQ68505951
The acidic amino-terminal region of the HIV-1 Tat protein constitutes an essential activating domainQ69366191
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)6018-6026
P577publication date1990-12-01
P1433published inJournal of VirologyQ1251128
P1476titleStructural analysis of wild-type and mutant human immunodeficiency virus type 1 Tat proteins
P478volume64

Reverse relations

cites work (P2860)
Q34593969A phase I trial of preventive HIV vaccination with heterologous poxviral-vectors containing matching HIV-1 inserts in healthy HIV-uninfected subjects
Q35870516Cooperation between herpes simplex virus type 1-encoded ICP0 and Tat to support transcription of human immunodeficiency virus type 1 long terminal repeat in vivo can occur in the absence of the TAR binding site.
Q54225233Defining the molecular mechanisms of HIV-1 Tat secretion: PtdIns(4,5)P2 at the epicenter.
Q34888756Exon2 of HIV-2 Tat contributes to transactivation of the HIV-2 LTR by increasing binding affinity to HIV-2 TAR RNA.
Q40676905Exosome-associated release, uptake, and neurotoxicity of HIV-1 Tat protein.
Q24548355FBI-1 can stimulate HIV-1 Tat activity and is targeted to a novel subnuclear domain that includes the Tat-P-TEFb-containing nuclear speckles
Q40047125Functional analysis of interactions between Tat and the trans-activation response element of human immunodeficiency virus type 1 in cells.
Q36326743Functional relevance of nonsynonymous mutations in the HIV-1 tat gene within an epidemiologically-linked transmission cohort
Q39619066Genetic and functional heterogeneity of CNS-derived tat alleles from patients with HIV-associated dementia
Q24543241HIV-1 Tat targets microtubules to induce apoptosis, a process promoted by the pro-apoptotic Bcl-2 relative Bim.
Q33815080Human and rodent transcription elongation factor P-TEFb: interactions with human immunodeficiency virus type 1 tat and carboxy-terminal domain substrate
Q38317787Identification of specific molecular structures of human immunodeficiency virus type 1 Tat relevant for its biological effects on vascular endothelial cells
Q33930741Inhibition of human immunodeficiency virus type 1 Tat activity by coexpression of heterologous trans activators
Q24676286Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor
Q39877972RNA-targeted activators, but not DNA-targeted activators, repress the synthesis of short transcripts at the human immunodeficiency virus type 1 long terminal repeat.
Q33192810Random mutagenesis of the human immunodeficiency virus type-1 trans-activator of transcription (HIV-1 Tat)
Q40273841Sequence variation within the dominant amino terminus epitope affects antibody binding and neutralization of human immunodeficiency virus type 1 Tat protein
Q35059684Specific interaction of Tat with the human but not rodent P-TEFb complex mediates the species-specific Tat activation of HIV-1 transcription
Q36642378TAR RNA binding properties and relative transactivation activities of human immunodeficiency virus type 1 and 2 Tat proteins.
Q33957746Tat activates human immunodeficiency virus type 1 transcriptional elongation independent of TFIIH kinase
Q24682531The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function
Q29614788Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro
Q39272683Transition step during assembly of HIV Tat:P-TEFb transcription complexes and transfer to TAR RNA.

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