Activator of G protein signaling 3 null mice: I. Unexpected alterations in metabolic and cardiovascular function

scientific article published on May 2008

Activator of G protein signaling 3 null mice: I. Unexpected alterations in metabolic and cardiovascular function is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1210/EN.2008-0050
P932PMC publication ID2488243
P698PubMed publication ID18450958
P5875ResearchGate publication ID5401613

P50authorThomas L SaundersQ40082893
Kurt VarnerQ42775321
Stephen M. LanierQ54867228
Alejandra M PacchioniQ57046269
Joe B BlumerQ57339491
P2093author name stringEric Lazartigues
Thomas W Gettys
Kevin Lord
Cory Black
P2860cites workMammalian Pins is a conformational switch that links NuMA to heterotrimeric G proteinsQ24313402
Pertussis toxin-sensitive G-proteins and regulation of blood pressure in the spontaneously hypertensive ratQ28138361
A mammalian Partner of inscuteable binds NuMA and regulates mitotic spindle organizationQ28214962
FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistanceQ28215944
Genetically lean mice result from targeted disruption of the RII beta subunit of protein kinase AQ28507570
Adenosine A2a blockade prevents synergy between mu-opiate and cannabinoid CB1 receptors and eliminates heroin-seeking behavior in addicted ratsQ28566486
Receptor-independent activators of heterotrimeric G-protein signaling pathwaysQ28569590
Lysosomal phospholipase A2 and phospholipidosisQ28584862
Impaired vascular contractility and blood pressure homeostasis in the smooth muscle alpha-actin null mouseQ28586468
Efficient in vivo manipulation of mouse genomic sequences at the zygote stageQ29547306
Promotion of lipolysis in rat adipocytes by pertussis toxin: reversal of endogenous inhibitionQ30449717
Identification of a truncated form of the G-protein regulator AGS3 in heart that lacks the tetratricopeptide repeat domains.Q30661459
Activator of G protein signaling 3 regulates opiate activation of protein kinase A signaling and relapse of heroin-seeking behaviorQ33841606
The GoLoco motif: a Galphai/o binding motif and potential guanine-nucleotide exchange factorQ33872778
Expression analysis and subcellular distribution of the two G-protein regulators AGS3 and LGN indicate distinct functionality. Localization of LGN to the midbody during cytokinesis.Q34113092
Altered expression of inhibitory guanine nucleotide regulatory proteins (Gi alpha) in spontaneously hypertensive ratsQ67771443
A new approach to analysis of the arterial baroreflexQ69855739
Increase in myocardial Gi-proteins in heart failureQ69925044
DOCA-salt hypertensive rat hearts exhibit altered expression of G-proteinsQ70547335
Selective activation of inhibitory G-protein alpha-subunits by partial agonists of the human 5-HT1A receptorQ72357768
Tumor necrosis factor alpha stimulates lipolysis in adipocytes by decreasing Gi protein concentrationsQ74485215
Growth hormone and dexamethasone stimulate lipolysis and activate adenylyl cyclase in rat adipocytes by selectively shifting Gi alpha2 to lower density membrane fractionsQ74586448
Overexpression of Gi-proteins precedes the development of DOCA-salt-induced hypertension: relationship with adenylyl cyclaseQ77498235
Desensitization of cardiac beta-adrenoceptor signaling with heart failure produced by myocardial infarction in the rat. Evidence for the role of Gi but not Gs or phosphorylating proteinsQ77890681
Resistance to inhibitors of cholinesterase 8A catalyzes release of Galphai-GTP and nuclear mitotic apparatus protein (NuMA) from NuMA/LGN/Galphai-GDP complexesQ34133413
Return of the GDI: the GoLoco motif in cell division.Q34326049
Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessmentQ34441265
Progressive vascular smooth muscle cell defects in a mouse model of Hutchinson-Gilford progeria syndromeQ34480435
Increase of the 40,000-mol wt pertussis toxin substrate (G protein) in the failing human heartQ34557266
Inhibitory G-proteins and their role in desensitization of the adenylyl cyclase pathway in heart failure.Q35601874
Beta-adrenergic receptors and regulation of energy expenditure: a family affairQ35639145
Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesityQ35768964
The effect of pertussis toxin on beta-adrenoceptor responses in isolated cardiac myocytes from noradrenaline-treated guinea-pigs and patients with cardiac failureQ35870521
Mechanistic pathways and biological roles for receptor-independent activators of G-protein signaling.Q35995003
Fat cells: afferent and efferent messages define new approaches to treat obesityQ36094559
A specific role of AGS3 in the surface expression of plasma membrane proteinsQ36156809
Beta-adrenoceptor blocker treatment and the cardiac beta-adrenoceptor-G-protein(s)-adenylyl cyclase system in chronic heart failureQ36704776
Activator of G protein signaling 3: a gatekeeper of cocaine sensitization and drug seeking.Q36747977
Alterations in mRNA levels, expression, and function of GTP-binding regulatory proteins in adipocytes from obese mice (C57BL/6J-ob/ob).Q38333739
Asymmetrically distributed C. elegans homologs of AGS3/PINS control spindle position in the early embryoQ38353471
Increase of Gi alpha in human hearts with dilated but not ischemic cardiomyopathyQ41889181
Enhanced expression of Gi-protein precedes the development of blood pressure in spontaneously hypertensive ratsQ42438496
G protein betagamma subunits and AGS3 control spindle orientation and asymmetric cell fate of cerebral cortical progenitorsQ42481073
A protein complex containing Inscuteable and the Galpha-binding protein Pins orients asymmetric cell divisions in DrosophilaQ42486222
Modulation of basal and receptor-induced GIRK potassium channel activity and neuronal excitability by the mammalian PINS homolog LGN.Q42495400
The Partner of Inscuteable/Discs-large complex is required to establish planar polarity during asymmetric cell division in DrosophilaQ42508762
Heterotrimeric G proteins direct two modes of asymmetric cell division in the Drosophila nervous systemQ42511782
Inactivation of enhanced expression of G(i) proteins by pertussis toxin attenuates the development of high blood pressure in spontaneously hypertensive ratsQ44095813
Desensitization of adenylate cyclase and increase of Gi alpha in cardiac hypertrophy due to acquired hypertensionQ44525278
Rapsynoid/partner of inscuteable controls asymmetric division of larval neuroblasts in Drosophila.Q47072851
Analysis of partner of inscuteable, a novel player of Drosophila asymmetric divisions, reveals two distinct steps in inscuteable apical localizationQ47881793
Distinct roles for Galpha and Gbetagamma in regulating spindle position and orientation in Caenorhabditis elegans embryosQ48561935
The G-protein regulatory (GPR) motif-containing Leu-Gly-Asn-enriched protein (LGN) and Gialpha3 influence cortical positioning of the mitotic spindle poles at metaphase in symmetrically dividing mammalian cells.Q51803692
Establishment and chimera analysis of 129/SvEv- and C57BL/6-derived mouse embryonic stem cell lines.Q52833036
P433issue8
P407language of work or nameEnglishQ1860
P304page(s)3842-3849
P577publication date2008-05-01
P1433published inEndocrinologyQ3054009
P1476titleActivator of G protein signaling 3 null mice: I. Unexpected alterations in metabolic and cardiovascular function
P478volume149

Reverse relations

cites work (P2860)
Q39048563A role for activator of G-protein signaling 3 (AGS3) in multiple myeloma
Q35180330AGS-3 alters Caenorhabditis elegans behavior after food deprivation via RIC-8 activation of the neural G protein G αo.
Q52995668Activator of G protein signaling 3 forms a complex with resistance to inhibitors of cholinesterase-8A without promoting nucleotide exchange on Gα(i3).
Q28513014Activator of G protein signaling 8 (AGS8) is required for hypoxia-induced apoptosis of cardiomyocytes: role of G betagamma and connexin 43 (CX43)
Q36738441Activator of G-Protein Signaling 3-Induced Lysosomal Biogenesis Limits Macrophage Intracellular Bacterial Infection
Q26999408Activators of G protein signaling exhibit broad functionality and define a distinct core signaling triad
Q33528947An inhibitory role of the G-protein regulator AGS3 in mTOR-dependent macroautophagy
Q27302329B Lymphocyte-Specific Loss of Ric-8A Results in a Gα Protein Deficit and Severe Humoral Immunodeficiency
Q38578735Cell Division Modes and Cleavage Planes of Neural Progenitors during Mammalian Cortical Development.
Q33675851Defective chemokine signal integration in leukocytes lacking activator of G protein signaling 3 (AGS3)
Q33705006Distribution of activator of G-protein signaling 3 within the aggresomal pathway: role of specific residues in the tetratricopeptide repeat domain and differential regulation by the AGS3 binding partners Gi(alpha) and mammalian inscuteable.
Q36504457G-protein signaling modulator 1 deficiency accelerates cystic disease in an orthologous mouse model of autosomal dominant polycystic kidney disease
Q37214389Genetic Determinants of Type 2 Diabetes in Asians
Q29417014Genome-wide association study identifies three novel loci for type 2 diabetes
Q37880248Group II activators of G-protein signalling and proteins containing a G-protein regulatory motif.
Q35558398Heterotrimeric G protein-mediated signaling and its non-canonical regulation in the heart
Q33543785Identification of a deubiquitinating enzyme as a novel AGS3-interacting protein
Q34978973Identification of transcription factor E3 (TFE3) as a receptor-independent activator of Gα16: gene regulation by nuclear Gα subunit and its activator
Q39195304Increased expression of AGS3 in rat brain cortex after traumatic brain injury
Q35204630Localization and expression profile of Group I and II Activators of G-protein Signaling in the kidney
Q35003246Loss of activator of G-protein signaling 3 impairs renal tubular regeneration following acute kidney injury in rodents
Q38799056Mouse inscuteable induces apical-basal spindle orientation to facilitate intermediate progenitor generation in the developing neocortex
Q35060770Normal autophagic activity in macrophages from mice lacking Gαi3, AGS3, or RGS19.
Q33966889Receptor-regulated interaction of activator of G-protein signaling-4 and Galphai
Q37664759Regulation of Chemokine Signal Integration by Activator of G-Protein Signaling 4 (AGS4).
Q34232074Regulation of the AGS3·G{alpha}i signaling complex by a seven-transmembrane span receptor.
Q36579455Regulation of the G-protein regulatory-Gαi signaling complex by nonreceptor guanine nucleotide exchange factors.
Q42147924Ric-8A catalyzes guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3.
Q58565715Role of G-proteins and S/T phosphorylation sites in the transition of Activator of G-Protein signaling 3 to cell puncta
Q27666097Structural Determinants of Affinity Enhancement between GoLoco Motifs and G-Protein   Subunit Mutants
Q27675508Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN)
Q42130839Structural basis for self-renewal of neural progenitors in cortical neurogenesis.
Q41383720The G protein regulator AGS-3 allows C. elegans to alter behaviors in response to food deprivation
Q37598759The G-protein regulator LGN modulates the activity of the NO receptor soluble guanylate cyclase
Q37099770Translocation of activator of G-protein signaling 3 to the Golgi apparatus in response to receptor activation and its effect on the trans-Golgi network.

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