Genetic evidence that acute morphologic transformation, induction of cellular DNA synthesis, and focus formation are mediated by a single activity of the bovine papillomavirus E5 protein

scientific article published on December 1989

Genetic evidence that acute morphologic transformation, induction of cellular DNA synthesis, and focus formation are mediated by a single activity of the bovine papillomavirus E5 protein is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.9.12.5563
P932PMC publication ID363726
P698PubMed publication ID2555701

P2093author name stringJ Settleman
D DiMaio
A Fazeli
B H Horwitz
J Malicki
P2860cites workMutational Analysis of Simian Virus 40 T Antigen: Isolation and Characterization of Mutants with Deletions in the T-Antigen GeneQ36936356
Mutational analysis of simian virus 40 T antigen: stimulation of cellular DNA synthesis and activation of rRNA genes by mutants with deletions in the T-antigen geneQ36936373
New host cell system for regulated simian virus 40 DNA replicationQ36951834
Multiple functional domains in the adenovirus E1A geneQ39480678
The simian virus 40 large T antigen. A lot packed into a littleQ39511498
Mutants of polyomavirus middle-T antigenQ39677582
Stimulation of cellular DNA synthesis by wild type and mutant bovine papillomavirus DNA.Q43430573
Hormonal regulation of the Rous sarcoma virus src gene via a heterologous promoter defines a threshold dose for cellular transformationQ45807430
Transactivation of a bovine papilloma virus transcriptional regulatory element by the E2 gene productQ45838465
The E5 gene of bovine papillomavirus type 1 is sufficient for complete oncogenic transformation of mouse fibroblasts.Q53522602
Demonstration that a chemically synthesized BPV1 oncoprotein and its C-terminal domain function to induce cellular DNA synthesis.Q53525847
A transcriptional repressor encoded by BPV-1 shares a common carboxy-terminal domain with the E2 transactivator.Q53528217
E5 open reading frame of bovine papillomavirus type 1 encodes a transforming geneQ28286988
Efficient transactivation and morphologic transformation by bovine papillomavirus genes expressed from a bovine papillomavirus/simian virus 40 recombinant virusQ33678641
Genetic and biochemical definition of the bovine papillomavirus E5 transforming proteinQ33929466
Translation of open reading frame E5 of bovine papillomavirus is required for its transforming activityQ35595257
Bovine papillomavirus contains multiple transforming genesQ36422987
Transforming activity of a 16-amino-acid segment of the bovine papillomavirus E5 protein linked to random sequences of hydrophobic amino acids.Q36831412
44-amino-acid E5 transforming protein of bovine papillomavirus requires a hydrophobic core and specific carboxyl-terminal amino acidsQ36846314
Nonsense mutation in open reading frame E2 of bovine papillomavirus DNA.Q36857407
Bovine papillomavirus E2 gene regulates expression of the viral E5 transforming geneQ36872874
Mutational analysis of open reading frame E4 of bovine papillomavirus type 1.Q36886812
Two classes of transformation-deficient, immortalization-positive simian virus 40 mutants constructed by making three-base insertions in the T antigen geneQ36896709
Mutational analysis of the 3' open reading frames and the splice junction at nucleotide 3225 of bovine papillomavirus type 1.Q36920313
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)5563-5572
P577publication date1989-12-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleGenetic evidence that acute morphologic transformation, induction of cellular DNA synthesis, and focus formation are mediated by a single activity of the bovine papillomavirus E5 protein
P478volume9

Reverse relations

cites work (P2860)
Q36656196A glutamine residue in the membrane-associating domain of the bovine papillomavirus type 1 E5 oncoprotein mediates its binding to a transmembrane component of the vacuolar H(+)-ATPase
Q41080345Activation of the platelet-derived growth factor receptor by the bovine papillomavirus E5 transforming protein
Q36797281Biologic properties and nucleotide sequence analysis of human papillomavirus type 51
Q36797809Biological properties of the deer papillomavirus E5 gene in mouse C127 cells: growth transformation, induction of DNA synthesis, and activation of the platelet-derived growth factor receptor
Q36801595Bovine papillomavirus E2 repressor mutant displays a high-copy-number phenotype and enhanced transforming activity
Q43581315Bovine papillomavirus oncoprotein E5 affects the arachidonic acid metabolism in cells.
Q37163604Bovine papillomaviruses, papillomas and cancer in cattle.
Q35256418Cellular transformation by a transmembrane peptide: structural requirements for the bovine papillomavirus E5 oncoprotein
Q42641810Characterization of human papillomavirus type 57b: transforming activity and comparative sequence analysis as probes for biological determinants associated with high-risk oncogenic viruses
Q40543709Expression cloning of multiple human cDNAs that complement the phenotypic defects of ataxia-telangiectasia group D fibroblasts
Q42803602Expression of the bovine papillomavirus type 1 E5B gene reveals a protein-protein interaction of the E5A and E5B gene products
Q36648153Genetic definition of a new bovine papillomavirus type 1 open reading frame, E5B, that encodes a hydrophobic protein involved in altering host-cell protein processing.
Q35990329Hydrophobic Mismatch Drives the Interaction of E5 with the Transmembrane Segment of PDGF Receptor
Q35895171Identification of amino acids in the transmembrane and juxtamembrane domains of the platelet-derived growth factor receptor required for productive interaction with the bovine papillomavirus E5 protein
Q36649427Inhibition of cervical carcinoma cell line proliferation by the introduction of a bovine papillomavirus regulatory gene
Q37071223Localization of bovine papillomavirus type 1 E5 protein to transformed basal keratinocytes and permissive differentiated cells in fibropapilloma tissue
Q33183198Mechanisms of cell transformation by papillomavirus E5 proteins
Q41650748Molecular cloning, analysis, and chromosomal localization of a mouse genomic sequence related to the human papillomavirus type 18 E5 region
Q35861099Mutational analysis of human papillomavirus type 11 E5a oncoprotein
Q35846414Mutational analysis of the interaction between the bovine papillomavirus E5 transforming protein and the endogenous beta receptor for platelet-derived growth factor in mouse C127 cells.
Q41485266Oncogenes and antioncogenes in the development of HPV associated tumors
Q36690316Platelet-derived growth factor receptor can mediate tumorigenic transformation by the bovine papillomavirus E5 protein
Q40571030SV40 virus expression vectors.
Q36634049Specific interaction between the bovine papillomavirus E5 transforming protein and the beta receptor for platelet-derived growth factor in stably transformed and acutely transfected cells
Q37119249Stable association between the bovine papillomavirus E5 transforming protein and activated platelet-derived growth factor receptor in transformed mouse cells
Q34134605Structural role of the conserved cysteines in the dimerization of the viral transmembrane oncoprotein E5.
Q36685093The E5 gene product of rhesus papillomavirus is an activator of endogenous Ras and phosphatidylinositol-3'-kinase in NIH 3T3 cells
Q33932448The bovine papillomavirus constitutive enhancer is essential for viral transformation, DNA replication, and the maintenance of latency
Q36656359The central hydrophobic domain of the bovine papillomavirus E5 transforming protein can be functionally replaced by many hydrophobic amino acid sequences containing a glutamine
Q33180948The platelet-derived growth factor beta receptor as a target of the bovine papillomavirus E5 protein
Q40281053The putative E5 open reading frame of cottontail rabbit papillomavirus is dispensable for papilloma formation in domestic rabbits
Q80356586The role of HPV oncoproteins and cellular factors in maintenance of hTERT expression in cervical carcinoma cells
Q41374895Virocrine transformation

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