Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases.

scientific article published on June 2007

Matrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1038/NRD2308
P2888exact matchhttps://scigraph.springernature.com/pub.10.1038/nrd2308
P698PubMed publication ID17541420
P5875ResearchGate publication ID6295749

P50authorGhislain OpdenakkerQ37065855
Philippe E Van den SteenQ42369206
P2093author name stringJialiang Hu
Qing-Xiang A Sang
P2860cites workLoss of MMP 13 attenuates murine hepatic injury and fibrosis during cholestasisQ80002082
Medial collateral ligament healing in macrophage metalloelastase (MMP-12)-deficient miceQ80201774
Cold preservation of isolated sinusoidal endothelial cells in MMP 9 knockout mice: effect on morphology and platelet adhesionQ80610463
Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient miceQ80833094
Role of matrix metalloproteinase-9 in endothelial apoptosis in chronic heart failure in miceQ81008508
Matrix metalloproteinase-9 modulation by resident arterial cells is responsible for injury-induced accelerated atherosclerotic plaque development in apolipoprotein E-deficient miceQ81475505
Inhibition of obliterative airway disease development in murine tracheal allografts by matrix metalloproteinase-9 deficiencyQ81507537
Stromelysin-3 is a potent negative regulator of adipogenesis participating to cancer cell-adipocyte interaction/crosstalk at the tumor invasive frontQ81562221
Surfactant protein-D regulates soluble CD14 through matrix metalloproteinase-12Q81621923
Hematopoietic progenitor cell mobilization by granulocyte colony-stimulating factor and erythropoietin in the absence of matrix metalloproteinase-9Q81875550
Effect of MMP-2 deficiency on atherosclerotic lesion formation in apoE-deficient miceQ82928035
The cysteine switch: a principle of regulation of metalloproteinase activity with potential applicability to the entire matrix metalloproteinase gene familyQ24557562
Targeted gene disruption of matrix metalloproteinase-9 (gelatinase B) suppresses development of experimental abdominal aortic aneurysmsQ24623052
MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytesQ24628843
Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligandQ24644662
Low-dose irradiation promotes tissue revascularization through VEGF release from mast cells and MMP-9-mediated progenitor cell mobilizationQ24646424
Inflammation and cancerQ24649640
Macrophage metalloelastase (MMP-12) deficiency does not alter bleomycin-induced pulmonary fibrosis in miceQ25256719
Structure of human pro-matrix metalloproteinase-2: activation mechanism revealedQ27618464
X-ray structures of human neutrophil collagenase complexed with peptide hydroxamate and peptide thiol inhibitors. Implications for substrate binding and rational drug designQ27730217
Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitorQ27731527
Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3Q28144040
Regulation of intestinal alpha-defensin activation by the metalloproteinase matrilysin in innate host defenseQ28145389
Molecular Recognition of Protein−Ligand Complexes:  Applications to Drug DesignQ28202151
Biochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9)Q28204521
Design and therapeutic application of matrix metalloproteinase inhibitorsQ28212260
Gelatinase B deficiency protects against endotoxin shockQ28220536
Gelatinase B is required for alveolar bronchiolization after intratracheal bleomycinQ28395498
Increased susceptibility to LPS-induced endotoxin shock in secretory leukoprotease inhibitor (SLPI)-deficient miceQ28588786
Galectin-3 is a downstream regulator of matrix metalloproteinase-9 function during endochondral bone formationQ28595005
The ADAMTS metalloproteinasesQ29544428
Matrix Metalloproteinase Inhibitors and Cancer--Trials and TribulationsQ29544430
New functions for the matrix metalloproteinases in cancer progressionQ29547738
The pathophysiology and treatment of sepsisQ29619103
The immunopathogenesis of sepsisQ29622909
Selection of a histidine-containing inhibitor of gelatinases through deconvolution of combinatorial tetrapeptide librariesQ42803020
Suppression of adjuvant arthritis of rats by a novel matrix metalloproteinase-inhibitorQ43264390
Inhibition of bleomycin-induced pulmonary fibrosis in mice by the matrix metalloproteinase inhibitor batimastatQ43558010
Inhibition of matrix metalloproteinases and tumour necrosis factor alpha converting enzyme as adjuvant therapy in pneumococcal meningitisQ43719854
A combination of a chemically modified doxycycline and a bisphosphonate synergistically inhibits endotoxin-induced periodontal breakdown in ratsQ43721782
Inhibition of matrix metalloproteinases blocks lethal hepatitis and apoptosis induced by tumor necrosis factor and allows safe antitumor therapyQ43786938
A murine model of toluene diisocyanate-induced asthma can be treated with matrix metalloproteinase inhibitorQ43821994
Cleavage of denatured natural collagen type II by neutrophil gelatinase B reveals enzyme specificity, post-translational modifications in the substrate, and the formation of remnant epitopes in rheumatoid arthritisQ43903188
Targeting leukocyte MMPs and transmigration: minocycline as a potential therapy for multiple sclerosisQ44002202
Design and synthesis of novel inhibitors of gelatinase B.Q44071209
Gelatinase B is diabetogenic in acute and chronic pancreatitis by cleaving insulin.Q44355278
Matrix Metalloproteinases Inhibition Attenuates Tobacco Smoke-Induced Emphysema in Guinea PigsQ44436336
Urokinase-type plasminogen activator potentiates lipopolysaccharide-induced neutrophil activationQ44448903
Loss of collagenase-2 confers increased skin tumor susceptibility to male mice.Q44601270
Identification and characterization of 4-[[4-(2-butynyloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-(3S)thiomorpholinecarboxamide (TMI-1), a novel dual tumor necrosis factor-alpha-converting enzyme/matrix metalloprotease inhibitor for the treatment oQ44725424
Inhibitors of gelatinase B/matrix metalloproteinase-9 activity comparison of a peptidomimetic and polyhistidine with single-chain derivatives of a neutralizing monoclonal antibodyQ44855768
Matrix metalloproteinase-9 deficiency impairs host defense mechanisms against Streptococcus pneumoniae in a mouse model of bacterial meningitisQ44882363
Doxycycline reduces airway inflammation and hyperresponsiveness in a murine model of toluene diisocyanate-induced asthmaQ44886971
Generation of glycosylated remnant epitopes from human collagen type II by gelatinase B.Q45018699
The expression of matrix metalloproteinase-12 by oligodendrocytes regulates their maturation and morphological differentiation.Q45041113
Gelatinase B/matrix metalloproteinase-9 contributes to cellular infiltration in a murine model of zymosan peritonitisQ45092937
Matrix metalloproteinase-9 deficiency impairs host defense against abdominal sepsisQ45131662
Mmp-9 deficiency enhances collagenase-induced intracerebral hemorrhage and brain injury in mutant miceQ45141100
In vivo activation of gelatinase B/MMP-9 by trypsin in acute pancreatitis is a permissive factor in streptozotocin-induced diabetesQ45147489
Minocycline protects against permanent cerebral ischemia in wild type but not in matrix metalloprotease-9-deficient miceQ45240483
Matrix metalloproteinase 9 facilitates collagen remodeling and angiogenesis for vascular constructsQ45288039
Loss of matrix metalloproteinase-9 or matrix metalloproteinase-12 protects apolipoprotein E-deficient mice against atherosclerotic media destruction but differentially affects plaque growthQ45873353
Formation of the dentino-enamel interface in enamelysin (MMP-20)-deficient mouse incisorsQ46281901
Retinal vascular development and pathologic retinal angiogenesis are not impaired in matrix metalloproteinase-2 deficient miceQ46432753
Design, synthesis, and evaluation of a mechanism-based inhibitor for gelatinase A.Q46576483
The brain-specific tissue-type plasminogen activator inhibitor, neuroserpin, protects neurons against excitotoxicity both in vitro and in vivoQ46739636
Myocardial ischemia induces interleukin-6 and tissue factor production in patients with coronary artery disease: a dobutamine stress echocardiography studyQ46802784
An Adverse Role for Matrix Metalloproteinase 12 after Spinal Cord Injury in MiceQ47400562
Regulation by C5a of neutrophil activation during sepsisQ47672797
Impaired alveolization in mice deficient in membrane-type matrix metalloproteinase 1 (MT1-MMP).Q47729507
Matrix metalloproteinase-8 deficiency promotes granulocytic allergen-induced airway inflammationQ47752298
Gelatinase B/matrix metalloproteinase-9 cleaves interferon-beta and is a target for immunotherapyQ47891881
The effect of adjunctive low-dose doxycycline therapy on clinical parameters and gingival crevicular fluid matrix metalloproteinase-8 levels in chronic periodontitisQ47941807
Phase I trial of Marimastat, a novel matrix metalloproteinase inhibitor, administered orally to patients with advanced lung cancerQ47976225
Matrix metalloproteinase-mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat.Q48468454
Role of matrix metalloproteinases in delayed cortical responses after stroke.Q48604373
Myelin formation during development of the CNS is delayed in matrix metalloproteinase-9 and -12 null mice.Q48640163
Matrix metalloproteinase-9-mediated dendritic cell recruitment into the airways is a critical step in a mouse model of asthma.Q49027198
Resistance of collagenase-2 (matrix metalloproteinase-8)-deficient mice to TNF-induced lethal hepatitis.Q49099417
Role for matrix metalloproteinase 9 after focal cerebral ischemia: effects of gene knockout and enzyme inhibition with BB-94.Q49133201
Selective ablation of matrix metalloproteinase-2 exacerbates experimental colitis: contrasting role of gelatinases in the pathogenesis of colitis.Q50077344
Transforming growth factor (TGF)-beta1 stimulates pulmonary fibrosis and inflammation via a Bax-dependent, bid-activated pathway that involves matrix metalloproteinase-12.Q50232161
Matrix metalloproteinase (MMP)-8 and MMP-9 in cerebrospinal fluid during bacterial meningitis: association with blood-brain barrier damage and neurological sequelae.Q50495245
Delayed inflammation-associated corneal neovascularization in MMP-2-deficient mice.Q51549098
The involvement of matrix metalloproteinases in basement membrane injury in a murine model of acute allergic airway inflammation.Q51701514
Matrix metalloproteinase-9 is required for adequate angiogenic revascularization of ischemic tissues: potential role in capillary branching.Q51786158
Tumor targeting with a selective gelatinase inhibitorQ30747366
MMP-2 and MMP-9 synergize in promoting choroidal neovascularizationQ31013160
Corneal neovascularization after excimer keratectomy wounds in matrilysin-deficient miceQ31123069
Reduced choroidal neovascular membrane formation in matrix metalloproteinase-2-deficient mice.Q31123109
Absence of mechanical allodynia and Abeta-fiber sprouting after sciatic nerve injury in mice lacking membrane-type 5 matrix metalloproteinaseQ33197078
Simulation of evolution-selected propeptide by high-throughput selection of a peptidomimetic inhibitor on a capillary DNA sequencer platform.Q33213420
Inhibition of lethal endotoxin shock with an L-pyridylalanine containing metalloproteinase inhibitor selected by high-throughput screening of a new peptide libraryQ33259227
Decreased allergic lung inflammatory cell egression and increased susceptibility to asphyxiation in MMP2-deficiencyQ33622543
Plasminogen activators and matrix metalloproteases, mediators of extracellular proteolysis in inflammatory demyelination of the central nervous system.Q33665742
Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humansQ34028910
Elastin degradation and calcification in an abdominal aorta injury model: role of matrix metalloproteinasesQ34092968
Inhibition of autoimmune encephalomyelitis by a tetracycline.Q34113359
Tissue plasminogen activator and plasminogen mediate stress-induced decline of neuronal and cognitive functions in the mouse hippocampusQ34212891
Gelatinase B/MMP-9 and neutrophil collagenase/MMP-8 process the chemokines human GCP-2/CXCL6, ENA-78/CXCL5 and mouse GCP-2/LIX and modulate their physiological activities.Q34226948
Metalloproteinases in biology and pathology of the nervous system.Q34297141
Stromal matrix metalloproteinase-9 regulates the vascular architecture in neuroblastoma by promoting pericyte recruitmentQ34302655
Elastin fragments drive disease progression in a murine model of emphysemaQ34338306
Diet-induced obesity and reduced skin cancer susceptibility in matrix metalloproteinase 19-deficient miceQ34346225
Toll-like receptors: how they work and what they do.Q34468201
Strategies for MMP inhibition in cancer: innovations for the post-trial era.Q34810420
Neutralizing antibodies in gene-defective hostsQ35053404
Matrix metalloproteinase-9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eyeQ35083557
New frontiers in cardiology: drug-eluting stents: Part II.Q35125882
Functional roles and therapeutic targeting of gelatinase B and chemokines in multiple sclerosisQ35592638
Prevention of interleukin-8-induced mobilization of hematopoietic progenitor cells in rhesus monkeys by inhibitory antibodies against the metalloproteinase gelatinase B (MMP-9).Q35634821
Matrix metalloproteinases promote inflammation and fibrosis in asbestos-induced lung injury in miceQ35676548
Matrix metalloproteinase-9 deficiency impairs cellular infiltration and bronchial hyperresponsiveness during allergen-induced airway inflammationQ35747617
Cytokines and proteases in invasive processes: molecular similarities between inflammation and cancer.Q35779496
Matrilysin (matrix metalloproteinase-7) mediates E-cadherin ectodomain shedding in injured lung epitheliumQ35791414
Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteasesQ35824305
The role of metalloelastase in immune complex-induced acute lung injury.Q35842301
Matrix metalloproteinases as modulators of inflammation and innate immunityQ35852281
Chemically modified tetracyclines as inhibitors of matrix metalloproteinasesQ35856969
The countercurrent principle in invasion and metastasis of cancer cells. Recent insights on the roles of chemokines.Q35878919
Matrix metalloproteinases (MMPs) in oral diseases.Q35943087
Matrix metalloproteinase inhibitors: a review on pharmacophore mapping and (Q)SARs resultsQ36050642
Crystal structures of MMPs in complex with physiological and pharmacological inhibitorsQ36076479
Matrix metalloproteinases in coronary artery disease: clinical and therapeutic implications and pathological significanceQ36107510
Matrix metalloproteinases and free radicals in cerebral ischemiaQ36144616
Metalloproteinases: mediators of pathology and regeneration in the CNS.Q36313201
Vascular remodeling and protease inhibition--bench to bedsideQ36357530
What has been learned about the cardiovascular effects of matrix metalloproteinases from mouse models?Q36373670
Matrix metalloproteinase deficiencies affect contact hypersensitivity: stromelysin-1 deficiency prevents the response and gelatinase B deficiency prolongs the responseQ36384927
Gelatinase B-deficient mice are resistant to experimental bullous pemphigoidQ36401533
Matrix metalloproteinase inhibitors as prospective agents for the prevention and treatment of cardiovascular and neoplastic diseasesQ36447419
Novel functions of TIMPs in cell signalingQ36471132
The immune response in atherosclerosis: a double-edged swordQ36508676
Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation.Q36580334
A tetracycline derivative, minocycline, reduces inflammation and protects against focal cerebral ischemia with a wide therapeutic windowQ36678875
Metalloelastase is required for macrophage-mediated proteolysis and matrix invasion in miceQ36799271
Proteomic identification of in vivo substrates for matrix metalloproteinases 2 and 9 reveals a mechanism for resolution of inflammationQ36967346
Matrix metalloproteinase-2 facilitates wound healing events that promote functional recovery after spinal cord injuryQ37138010
Matrix metalloproteinase-3-dependent generation of a macrophage chemoattractant in a model of herniated disc resorptionQ37174699
MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs.Q37370581
Matrilysin expression and function in airway epitheliumQ37385157
Altered endochondral bone development in matrix metalloproteinase 13-deficient miceQ37407318
Overlapping and independent contributions of MMP2 and MMP9 to lung allergic inflammatory cell egression through decreased CC chemokinesQ37407320
Loss or inhibition of uPA or MMP-9 attenuates LV remodeling and dysfunction after acute pressure overload in miceQ38584976
Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodelingQ39735936
Matrix metalloproteinases 2 and 9 work in concert to produce aortic aneurysmsQ39738340
A monoclonal antibody inhibits gelatinase B/MMP-9 by selective binding to part of the catalytic domain and not to the fibronectin or zinc binding domainsQ40264843
Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cellsQ40277201
Targeted deletion of metalloproteinase 9 attenuates experimental colitis in mice: central role of epithelial-derived MMP.Q40340860
The contribution of bone marrow-derived cells to the tumor vasculature in neuroblastoma is matrix metalloproteinase-9 dependent.Q40434427
Reduced retinal angiogenesis in MMP-2-deficient miceQ40547231
Matrix metalloproteinase-7-dependent release of tumor necrosis factor-alpha in a model of herniated disc resorptionQ40716553
Resistance of young gelatinase B-deficient mice to experimental autoimmune encephalomyelitis and necrotizing tail lesions.Q40857787
Matrix metalloproteinase inhibitors in the treatment of cancerQ40901330
Targeted deletion or pharmacological inhibition of MMP-2 prevents cardiac rupture after myocardial infarction in miceQ41051040
The molecular basis of leukocytosisQ41759585
Inhibition of cartilage and bone destruction in adjuvant arthritis in the rat by a matrix metalloproteinase inhibitorQ41839052
Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitisQ41895463
Enamelysin (matrix metalloproteinase 20)-deficient mice display an amelogenesis imperfecta phenotype.Q52113450
Gelatinase B is present in the cerebrospinal fluid during experimental autoimmune encephalomyelitis and cleaves myelin basic protein.Q52507299
Targeted disruption of the matrix metalloproteinase-9 gene impairs smooth muscle cell migration and geometrical arterial remodeling.Q52548108
The metalloproteinase MT1-MMP is required for normal development and maintenance of osteocyte processes in bone.Q52561730
MMP-12 has a role in abdominal aortic aneurysms in mice.Q52563459
Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy.Q53348981
Membrane-type 1 matrix metalloproteinase is required for normal alveolar development.Q53625816
Matrix metalloproteinase-9 gene deletion facilitates angiogenesis after myocardial infarction.Q53659623
Matrilysin shedding of syndecan-1 regulates chemokine mobilization and transepithelial efflux of neutrophils in acute lung injury.Q53662097
Time-dependent changes in myocardial structure following discrete injury in mice deficient of matrix metalloproteinase-3.Q53676019
Different roles for matrix metalloproteinase-2 and matrix metalloproteinase-9 in the pathogenesis of cardiac allograft rejection.Q53688825
The serpin alpha1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo.Q54035460
Inhibition of alveolar bone loss by matrix metalloproteinase inhibitors in experimental periodontal disease.Q54550703
The gelatinase inhibitory activity of tetracyclines and chemically modified tetracycline analogues as measured by a novel microtiter assay for inhibitors.Q54585384
An elevated matrix metalloproteinase (MMP) in an animal model of multiple sclerosis is protective by affecting Th1/Th2 polarization.Q54650311
Earlier Onset of Tumoral Angiogenesis in Matrix Metalloproteinase-19–Deficient MiceQ57082637
Role of matrix metalloproteinase-9 in a mouse model for amyotrophic lateral sclerosisQ57244961
Prevention of acute autoimmune encephalomyelitis and abrogation of relapses in murine models of multiple sclerosis by the protease inhibitor D-penicillamineQ57247191
Enhanced early vascular permeability in gelatinase B (MMP-9)-deficient mice: putative contribution of COX-1-derived PGE2 of macrophage originQ57584340
Matrix metalloproteinase-9 (gelatinase B) deficiency leads to increased severity of Staphylococcus aureus-triggered septic arthritisQ57584350
Targeting neutrophil collagenase/matrix metalloproteinase-8 and gelatinase B/matrix metalloproteinase-9 with a peptidomimetic inhibitor protects against endotoxin shockQ57584404
Structural Characterization of the Catalytic Active Site in the Latent and Active Natural Gelatinase B from Human NeutrophilsQ57584591
Evaluation of gelatinases and IL-6 in the cerebrospinal fluid of patients with optic neuritis, multiple sclerosis and other inflammatory neurological diseasesQ57584769
The metalloproteinase matrilysin proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosisQ59276652
The influence of transforming growth factor beta 1 on the expression of genes coding for matrix metalloproteinases and tissue inhibitors of metalloproteinases during regeneration from cerulein-induced pancreatitisQ60609544
Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failureQ62383757
Minocycline reduces gingival collagenolytic activity during diabetes. Preliminary observations and a proposed new mechanism of actionQ70176370
Suppression of experimental allergic encephalomyelitis in the Lewis rat by the matrix metalloproteinase inhibitor Ro31-9790Q70951168
Preclinical antiarthritic activity of matrix metalloproteinase inhibitorsQ72853061
Tissue inhibitor of matrix metalloproteinases-1 impairs arterial neointima formation after vascular injury in miceQ73254517
Accelerated neointima formation after vascular injury in mice with stromelysin-3 (MMP-11) gene inactivationQ73257355
Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-alpha inhibitorQ73270598
Anti-arthritic activity of hydroxamic acid-based pseudopeptide inhibitors of matrix metalloproteinases and TNF alpha processingQ73556798
Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbitsQ73589806
X-ray absorption studies of human matrix metalloproteinase-2 (MMP-2) bound to a highly selective mechanism-based inhibitor. comparison with the latent and active forms of the enzymeQ73694165
Requirement for macrophage elastase for cigarette smoke-induced emphysema in miceQ73709481
Role of stromelysin 1 and gelatinase B in experimental acute lung injuryQ73877425
Susceptibility of stromelysin 1-deficient mice to collagen-induced arthritis and cartilage destructionQ74060223
Persistence of atherosclerotic plaque but reduced aneurysm formation in mice with stromelysin-1 (MMP-3) gene inactivationQ74514976
Design and synthesis of cyclic inhibitors of matrix metalloproteinases and TNF-alpha productionQ74583501
The role of matrix metalloproteinase-2 and matrix metalloproteinase-9 in antibody-induced arthritisQ74650599
Matrix metalloproteinase-9 deficiency results in enhanced allergen-induced airway inflammationQ75424883
Malonyl alpha-mercaptoketones and alpha-mercaptoalcohols, a new class of matrix metalloproteinase inhibitorsQ77744501
The asymmetric synthesis and in vitro characterization of succinyl mercaptoalcohol and mercaptoketone inhibitors of matrix metalloproteinasesQ77744504
Design and synthesis of phosphinamide-based hydroxamic acids as inhibitors of matrix metalloproteinasesQ77795461
Matrix metalloproteinases 9 and 2 are necessary for the migration of Langerhans cells and dermal dendritic cells from human and murine skinQ77995830
Matrix metalloproteinase-9 is necessary for the regulation of smooth muscle cell replication and migration after arterial injuryQ78460679
Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha releaseQ78773775
Matrix metalloproteinase-9 facilitates remyelination in part by processing the inhibitory NG2 proteoglycanQ79346630
P433issue6
P304page(s)480-498
P577publication date2007-06-01
P1433published inNature Reviews Drug DiscoveryQ45998
P1476titleMatrix metalloproteinase inhibitors as therapy for inflammatory and vascular diseases
P478volume6

Reverse relations

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Q89944633Expression of MMP-2, MMP-9, and NGAL in Tissue and Serum of Patients with Vascular Aneurysms and Their Modulation by Statin Treatment: A Pilot Study
Q33694487Extracellular matrix molecules: potential targets in pharmacotherapy.
Q37939732Extracellular proteolysis in macrophage migration: losing grip for a breakthrough
Q35086168FRET-based and other fluorescent proteinase probes.
Q48543248Fell‐Muir Lecture: Metalloproteinases: from demolition squad to master regulators
Q36078299Fragment-Based Discovery of 5-Arylisatin-Based Inhibitors of Matrix Metalloproteinases 2 and 13.
Q39645443Free energy calculations on snake venom metalloproteinase BaP1.
Q26779933Friends or Foes: Matrix Metalloproteinases and Their Multifaceted Roles in Neurodegenerative Diseases
Q60951598Galangin Inhibits Thrombin-Induced MMP-9 Expression in SK-N-SH Cells via Protein Kinase-Dependent NF-κB Phosphorylation
Q33887938Gelatin degradation assay reveals MMP-9 inhibitors and function of O-glycosylated domain
Q24568374Gelatinase B/MMP-9 in Tumour Pathogenesis and Progression
Q59136611Gelatinase B/Matrix Metalloproteinase-9 as Innate Immune Effector Molecule in Achalasia
Q57061847Gelatinase B/matrix metalloproteinase-9 is a phase-specific effector molecule, independent from Fas, in experimental autoimmune encephalomyelitis
Q37193691Gene deletion of the kinin receptor B1 attenuates cardiac inflammation and fibrosis during the development of experimental diabetic cardiomyopathy
Q46757984Gingival crevicular fluid and serum matrix metalloproteinase-8 and tissue inhibitor of matrix metalloproteinase-1 levels in renal transplant patients undergoing different immunosuppressive therapy
Q37353175Glomerular matrix metalloproteinases and their regulators in the pathogenesis of lupus nephritis
Q26745510Glycosylation of matrix metalloproteases and tissue inhibitors: present state, challenges and opportunities
Q41048068Grafting MAP peptide to dental polymer inhibits MMP-8 activity
Q52900205Hemorrhagic metalloproteinase, Cc HSM-III, isolated from Cerastes cerastes venom: Purification and biochemical characterization.
Q27316480Hepatoprotective effect of MMP-19 deficiency in a mouse model of chronic liver fibrosis
Q37595298Heterogeneity of serum gelatinases MMP-2 and MMP-9 isoforms and charge variants.
Q38182192Host matrix metalloproteinases in cerebral malaria: new kids on the block against blood-brain barrier integrity?
Q38350129Human rhinovirus infection up-regulates MMP-9 production in airway epithelial cells via NF-{kappa}B.
Q27311200Hydrophilic extract from Posidonia oceanica inhibits activity and expression of gelatinases and prevents HT1080 human fibrosarcoma cell line invasion
Q38014073Hydroxamic acids as matrix metalloproteinase inhibitors
Q33806982IL-6 and high glucose synergistically upregulate MMP-1 expression by U937 mononuclear phagocytes via ERK1/2 and JNK pathways and c-Jun
Q35635079Identification of matrix metalloproteinase inhibitors by chemical arrays
Q48434563Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier.
Q37564195Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models
Q51017366In silico study combining docking and QSAR methods on a series of matrix metalloproteinase 13 inhibitors.
Q34175711Including receptor flexibility and induced fit effects into the design of MMP-2 inhibitors
Q36990163Incorporation of Bulky and Cationic Cyclam-Triazole Moieties into Marimastat Can Generate Potent MMP Inhibitory Activity without Inducing Cytotoxicity
Q44195273Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9.
Q36618438Increased matrix metalloproteinase (MMPs) levels do not predict disease severity or progression in emphysema
Q84110434Increased serum levels of matrix metalloproteinase-9 in acute graft-versus-host disease after allogeneic haematopoietic stem cell transplantation
Q57265309Infliximab Restores the Dysfunctional Matrix Remodeling Protein and Growth Factor Gene Expression in Patients with Inflammatory Bowel Disease
Q42571243Inhibition of MMP-9-dependent Degradation of Gelatin, but Not Other MMP-9 Substrates, by the MMP-9 Hemopexin Domain Blades 1 and 4.
Q43253807Inhibition of enzymatic degradation of adhesive-dentin interfaces
Q37171756Inhibition of matrix metalloproteinases enhances in vitro repair of the meniscus
Q34696039Inhibition of neutrophil collagenase/MMP-8 and gelatinase B/MMP-9 and protection against endotoxin shock.
Q42726346Inhibitor of PI3Kγ ameliorates TNBS-induced colitis in mice by affecting the functional activity of CD4+CD25+FoxP3+ regulatory T cells
Q28547985Inhibitory Effect of Aqueous Extracts from Marine Sponges on the Activity and Expression of Gelatinases A (MMP-2) and B (MMP-9) in Rat Astrocyte Cultures
Q28477370Insights into the complex formed by matrix metalloproteinase-2 and alloxan inhibitors: molecular dynamics simulations and free energy calculations
Q27313841Insufficiently defined genetic background confounds phenotypes in transgenic studies as exemplified by malaria infection in Tlr9 knockout mice
Q40112560Integrative studies implicate matrix metalloproteinase-12 as a culprit gene for large-artery atherosclerotic stroke
Q39080263Interplay of extracellular matrix and leukocytes in lung inflammation.
Q53173976Intracellular Wnt/Beta-Catenin Signaling Underlying 17beta-Estradiol-Induced Matrix Metalloproteinase 9 Expression in Human Endometriosis.
Q37456901Intracellular regulation of matrix metalloproteinase-2 activity: new strategies in treatment and protection of heart subjected to oxidative stress
Q37784801Intracellular substrate cleavage: a novel dimension in the biochemistry, biology and pathology of matrix metalloproteinases.
Q26744390Involvement of matrix metalloproteinases (MMPs) and inflammasome pathway in molecular mechanisms of fibrosis
Q38265674Is there new hope for therapeutic matrix metalloproteinase inhibition?
Q44086832Isolation and characterization of human monoclonal antibodies specific to MMP-1A, MMP-2 and MMP-3.
Q36943114Keratinocyte expression of MMP3 enhances differentiation and prevents tumor establishment
Q36395757Ligand-induced expansion of the S1' site in the anthrax toxin lethal factor
Q92443818Lipopolysaccharide-Induced Matrix Metalloproteinase-9 Expression Associated with Cell Migration in Rat Brain Astrocytes
Q37866602Lung cancer in pulmonary fibrosis: tales of epithelial cell plasticity
Q41176062MMP-12 catalytic domain recognizes triple helical peptide models of collagen V with exosites and high activity
Q41099760MMP-2, MMP-9, and TIMP-4 and Response to Aspirin in Diabetic and Nondiabetic Patients with Stable Coronary Artery Disease: A Pilot Study.
Q33340257MMP19 is essential for T cell development and T cell-mediated cutaneous immune responses
Q33727374Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis.
Q92502869Matrix Metalloproteases as Influencers of the Cells' Social Media
Q40464605Matrix Metalloproteinase 1 Causes Vasoconstriction and Enhances Vessel Reactivity to Angiotensin II via Protease-Activated Receptor 1.
Q50916304Matrix Metalloproteinase Inhibitors as Investigational and Therapeutic Tools in Unrestrained Tissue Remodeling and Pathological Disorders.
Q91644631Matrix Metalloproteinase Triple-Helical Peptide Inhibitors: Potential Cross-Reactivity with Caspase-11
Q92479030Matrix Metalloproteinase in Abdominal Aortic Aneurysm and Aortic Dissection
Q36088748Matrix Metalloproteinase-1 and Matrix Metalloproteinase-9 in the Aqueous Humor of Diabetic Macular Edema Patients.
Q27678085Matrix Metalloproteinase-10 (MMP-10) Interaction with Tissue Inhibitors of Metalloproteinases TIMP-1 and TIMP-2: BINDING STUDIES AND CRYSTAL STRUCTURE
Q41908742Matrix Metalloproteinase-9 and Haemozoin: Wedding Rings for Human Host and Plasmodium falciparum Parasite in Complicated Malaria
Q36316444Matrix Metalloproteinases as Regulators of Vein Structure and Function: Implications in Chronic Venous Disease
Q51055817Matrix Metalloproteinases in Remodeling of Lower Extremity Veins and Chronic Venous Disease.
Q47223491Matrix Metalloproteinases, Vascular Remodeling, and Vascular Disease
Q43100620Matrix metalloprotease regulation of neuropathic pain
Q34138756Matrix metalloproteinase 9 opposes diet-induced muscle insulin resistance in mice
Q34667430Matrix metalloproteinase activity and glycosaminoglycans in chronic venous disease: the linkage among cell biology, pathology and translational research
Q38431602Matrix metalloproteinase collagenolysis in health and disease
Q37983293Matrix metalloproteinase inhibition therapy for vascular diseases
Q33947243Matrix metalloproteinase inhibitor batimastat alleviates pathology and improves skeletal muscle function in dystrophin-deficient mdx mice
Q37253560Matrix metalloproteinase inhibitors (MMPIs) from marine natural products: the current situation and future prospects
Q38237471Matrix metalloproteinase inhibitors: a patent review (2011 - 2013).
Q37150788Matrix metalloproteinase-12 deficiency worsens relapsing-remitting experimental autoimmune encephalomyelitis in association with cytokine and chemokine dysregulation
Q37239871Matrix metalloproteinase-9 inhibition ameliorates pathogenesis and improves skeletal muscle regeneration in muscular dystrophy.
Q24299490Matrix metalloproteinase-9 promotes chronic lymphocytic leukemia b cell survival through its hemopexin domain
Q37264609Matrix metalloproteinases 2 and 9 are differentially expressed in patients with indeterminate and cardiac clinical forms of Chagas disease
Q37375110Matrix metalloproteinases and their multiple roles in neurodegenerative diseases
Q47875381Matrix metalloproteinases and their tissue inhibitors (TIMPs) in Plasmodium falciparum malaria: serum levels of TIMP-1 are associated with disease severity
Q37444400Matrix metalloproteinases as drug targets in infections caused by gram-negative bacteria and in septic shock
Q36644577Matrix metalloproteinases as potential targets in the venous dilation associated with varicose veins
Q37242419Matrix metalloproteinases in diabetic retinopathy: potential role of MMP-9.
Q50184676Matrix metalloproteinases in emphysema.
Q28080664Matrix metalloproteinases in inflammatory bowel disease: an update
Q36210614Matrix metalloproteinases in neuropathic pain and migraine: friends, enemies, and therapeutic targets
Q34199345Matrix metalloproteinases in tumorigenesis: an evolving paradigm.
Q39162423Matrix metalloproteinases inhibition promotes the polyfunctionality of human natural killer cells in therapeutic antibody-based anti-tumour immunotherapy
Q38151704Matrix metalloproteinases, new insights into the understanding of neurodegenerative disorders
Q37308645Matrix metalloproteinases: drug targets for myocardial infarction
Q40830357Mechanistic investigations of matrix metalloproteinase-8 inhibition by metal abstraction peptide
Q35586223Membrane type-1 matrix metalloproteinase (MT1-MMP) correlates with the expression and activation of matrix metalloproteinase-2 (MMP-2) in inflammatory breast cancer
Q39817857Membrane-bound FRET probe visualizes MMP12 activity in pulmonary inflammation.
Q41899118Metalloproteases and tendinopathy
Q28512433Metalloproteinase MT5-MMP is an essential modulator of neuro-immune interactions in thermal pain stimulation
Q36219151Metalloproteinases and their inhibitors are influenced by inhalative glucocorticoid therapy in combination with environmental dust reduction in equine recurrent airway obstruction
Q33660754Metalloproteinases and their inhibitors-diagnostic and therapeutic opportunities in orthopedics
Q62515266Metal–ligand interactions in drug design
Q54952381Microbial production of novel sulphated alkaloids for drug discovery.
Q34035175Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
Q44327938Minocycline suppresses experimental autoimmune encephalomyelitis by increasing tissue inhibitors of metalloproteinases
Q43137867Minocycline with aspirin: a therapeutic approach in the treatment of diabetic neuropathy.
Q50516083Mobilization of bone marrow cells by CSF3 protects mice from bleomycin-induced lung injury.
Q36059874Modeling Structural Coordination and Ligand Binding in Zinc Proteins with a Polarizable Potential
Q58865283Modulation of Brain Injury as a Target of Adjunctive Therapy in Bacterial Meningitis
Q41048038Monitoring proteolytic processing events by quantitative mass spectrometry.
Q52682069Monoclonal antibodies against metzincin targets.
Q28083906Multifaceted role of matrix metalloproteinases (MMPs)
Q88886710Multimodal Molecular Imaging Demonstrates Myeloperoxidase Regulation of Matrix Metalloproteinase Activity in Neuroinflammation
Q47775396Multiple molecular modelling studies on some derivatives and analogues of glutamic acid as matrix metalloproteinase-2 inhibitors.
Q46487703Natural antioxidant polyphenols on inflammation management: Anti-glycation activity vs metalloproteinases inhibition
Q39517254Natural haemozoin modulates matrix metalloproteinases and induces morphological changes in human microvascular endothelium
Q35378782Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for Toll-like receptor activation and cellular signaling.
Q41968510Neural functions of matrix metalloproteinases: plasticity, neurogenesis, and disease
Q37037317Neuroimmunology of central nervous system viral infections: the cells, molecules and mechanisms involved.
Q37976564Neurological diseases in relation to the blood-brain barrier
Q38950036Neutrophils in ulcerative colitis: a review of selected biomarkers and their potential therapeutic implications.
Q50047875Neutrophils: a cornerstone of liver ischemia and reperfusion injury.
Q42239363New and paradoxical roles of matrix metalloproteinases in the tumor microenvironment.
Q35544060New strategies for targeting matrix metalloproteinases
Q37532557New treatments for chronic obstructive pulmonary disease and viable formulation/device options for inhalation therapy
Q58802393Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, Tc-labeling, and Evaluation
Q41175771Novel bis-(arylsulfonamide) hydroxamate-based selective MMP inhibitors
Q30986676Optimization of total protein and activity assays for the detection of MMP-12 in induced human sputum
Q84313370Orally active, antimetastatic, nontoxic diphenyl ether-derived carbamoylphosphonate matrix metalloproteinase inhibitors
Q35175749Osteopontin-stimulated expression of matrix metalloproteinase-9 causes cardiomyopathy in the mdx model of Duchenne muscular dystrophy
Q48098141Overcoming neurite-inhibitory chondroitin sulfate proteoglycans in the astrocyte matrix.
Q34490917PEGylation extends circulation half-life while preserving in vitro and in vivo activity of tissue inhibitor of metalloproteinases-1 (TIMP-1)
Q30499011POVME: an algorithm for measuring binding-pocket volumes
Q36919032Peptide-based selective inhibitors of matrix metalloproteinase-mediated activities
Q37017515Plasma and brain matrix metalloproteinase-9 after acute focal cerebral ischemia in rats
Q35252779Plasma matrix metalloproteinases in neonates having surgery for congenital heart disease
Q81654439Poly(ADP-ribose) polymerase mediates inflammation in a mouse model of contact hypersensitivity
Q45905073Potentiation of aspirin-induced cerebroprotection by minocycline: a therapeutic approach to attenuate exacerbation of transient focal cerebral ischaemia.
Q39005974Preparation and evaluation of the effect of Fe3 O4 @piroctone olamine magnetic nanoparticles on matrix metalloproteinase-2: a preliminary in vitro study.
Q38972238Pro-Inflammatory and Pro-Fibrogenic Effects of Ionic and Particulate Arsenide and Indium-Containing Semiconductor Materials in the Murine Lung.
Q33608536Progress in matrix metalloproteinase research
Q38850914Prospects for the therapeutic application of sulfated polysaccharides of brown algae in diseases of the cardiovascular system: review
Q43753094Protective role of bortezomib in steatotic liver ischemia/reperfusion injury through abrogation of MMP activation and YKL-40 expression.
Q38783636Pyridazinone: an attractive lead for anti-inflammatory and analgesic drug discovery
Q30039761Pyrone-Based Inhibitors of Metalloproteinase Types 2 and 3 May Work as Conformation-Selective Inhibitors
Q34144797Recombinant TIMP-1-GPI inhibits growth of fibrosarcoma and enhances tumor sensitivity to doxorubicin
Q39239228Regulation of intestinal permeability: The role of proteases
Q30530312Regulation of the basement membrane by epithelia generated forces
Q43483685Relationship between leukocyte kinetics and behavioral tests changes in the inflammatory process of hemorrhagic stroke recovery
Q35083186Relationship between vitreous levels of matrix metalloproteinases and vascular endothelial growth factor in proliferative diabetic retinopathy
Q35007289Reversal of West Nile virus-induced blood-brain barrier disruption and tight junction proteins degradation by matrix metalloproteinases inhibitor
Q49569343Role of DDX3 in the pathogenesis of inflammatory bowel disease.
Q38626384Role of Matrix Metalloproteinases in the Pathogenesis of Traumatic Brain Injury
Q36468930Role of matrix metalloproteinase-2 and -9 in the development of diabetic retinopathy
Q36713661Role of metabolic modulator Bet-CA in altering mitochondrial hyperpolarization to suppress cancer associated angiogenesis and metastasis
Q39959867Role of the hemopexin domain of matrix metalloproteinases in cell migration
Q88165814Salvianolic acid A attenuates ischemia reperfusion induced rat brain damage by protecting the blood brain barrier through MMP-9 inhibition and anti-inflammation
Q37629036Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention
Q38095854Secreted proteases of Trypanosoma brucei gambiense: possible targets for sleeping sickness control?
Q39249230Seeking for Non-Zinc-Binding MMP-2 Inhibitors: Synthesis, Biological Evaluation and Molecular Modelling Studies.
Q92692565Selected TLR7/8 agonist and type I interferon (IFN-α) cooperatively redefine the microglia transcriptome
Q27306938Selective Allosteric Inhibition of MMP9 Is Efficacious in Preclinical Models of Ulcerative Colitis and Colorectal Cancer
Q34513677Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2).
Q35308826Selective water-soluble gelatinase inhibitor prodrugs.
Q42816439Self-Assembled Wound Dressings Silence MMP-9 and Improve Diabetic Wound Healing In Vivo
Q37714909Small molecules for bone diseases
Q39145232Spatial mismatch, non-additive binding energies and selectivity in supramolecular complexes.
Q38318458Spinal cord injury induced neuropathic pain: Molecular targets and therapeutic approaches
Q47241630Spine-on-a-chip: Human annulus fibrosus degeneration model for simulating the severity of intervertebral disc degeneration
Q39329438Synergic and antagonistic relationship between MMP-2 and MMP-9 with fibrosis and inflammation in Chagas' cardiomyopathy.
Q27727742Synthesis and in Vitro and in Vivo Evaluation of MMP-12 Selective Optical Probes
Q53744193Synthesis, Antiphospholipase A₂, Antiprotease, Antibacterial Evaluation and Molecular Docking Analysis of Certain Novel Hydrazones.
Q39573243Target-Activated Prodrugs (TAPs) for the Autoregulated Inhibition of MMP12.
Q36963155Targeting MMPs in acute and chronic neurological conditions
Q35760031Targeting Matrix Metalloproteinases in Cancer: Bringing New Life to Old Ideas
Q37849424Tetracyclines and pain
Q24338163The Anti-inflammatory Role of Endometase/Matrilysin-2 in Human Prostate Cancer Cells
Q30486745The Concise Guide to PHARMACOLOGY 2013/14: enzymes.
Q26773190The Function and Roles of ADAMTS-7 in Inflammatory Diseases
Q36079853The Influence of Differentially Expressed Tissue-Type Plasminogen Activator in Experimental Autoimmune Encephalomyelitis: Implications for Multiple Sclerosis.
Q37310730The Kazal motifs of RECK protein inhibit MMP-9 secretion and activity and reduce metastasis of lung cancer cells in vitro and in vivo
Q24309142The Rap80-BRCC36 de-ubiquitinating enzyme complex antagonizes RNF8-Ubc13-dependent ubiquitination events at DNA double strand breaks
Q92959736The Rebirth of Matrix Metalloproteinase Inhibitors: Moving Beyond the Dogma
Q37589671The biology of NK cells and their receptors affects clinical outcomes after hematopoietic cell transplantation (HCT).
Q34980526The dual role of thymidine phosphorylase in cancer development and chemotherapy
Q46860326The efficient expression of human fibroblast collagenase in Escherichia coli and the discovery of flavonoid inhibitors.
Q37358106The emerging roles of ADAMTS-7 and ADAMTS-12 matrix metalloproteinases.
Q38014071The gelatinases and their inhibitors: the structure-activity relationships
Q28294058The impact of the extracellular matrix on inflammation
Q38881849The molecular biology of matrix metalloproteinases and tissue inhibitors of metalloproteinases in inflammatory bowel diseases
Q42052538The role of manganese superoxide dismutase in skin aging
Q37693493The role of matrix metalloproteinases in colorectal cancer
Q38136195The role of microglia and matrix metalloproteinases involvement in neuroinflammation and gliomas
Q45337859The role of the macrophage in the development of aortic dissection
Q64940065Therapeutic efficacy of anti-MMP9 antibody in combination with nab-paclitaxel-based chemotherapy in pre-clinical models of pancreatic cancer.
Q47371190Thrombin/Matrix Metalloproteinase-9-Dependent SK-N-SH Cell Migration is Mediated Through a PLC/PKC/MAPKs/NF-κB Cascade
Q37709748Towards a safe and effective chlamydial vaccine: lessons from the eye
Q39191612Towards integrating extracellular matrix and immunological pathways.
Q34607259Trachoma: protective and pathogenic ocular immune responses to Chlamydia trachomatis
Q37311960Treg depletion-enhanced IL-2 treatment facilitates therapy of established tumors using systemically delivered oncolytic virus
Q37029277Tuberculosis immunopathology: the neglected role of extracellular matrix destruction.
Q34132341Tumor necrosis factor-alpha augments matrix metalloproteinase-9 production in skeletal muscle cells through the activation of transforming growth factor-beta-activated kinase 1 (TAK1)-dependent signaling pathway
Q30449753Ultrasound enhanced matrix metalloproteinase-9 triggered release of contents from echogenic liposomes.
Q41544769Understanding the binding of inhibitors of matrix metalloproteinases by molecular docking, quantum mechanical calculations, molecular dynamics simulations, and a MMGBSA/MMBappl study
Q64275021Upregulated MMP28 in Hepatocellular Carcinoma Promotes Metastasis via Notch3 Signaling and Predicts Unfavorable Prognosis
Q42978654Upregulated expression of matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in BALB/c mouse brain challenged with Japanese encephalitis virus
Q59136160Utility of Glycosylated TIMP3 molecules: Inhibition of MMPs and TACE to improve cardiac function in rat myocardial infarct model
Q30528882VEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue
Q37138490Wasting mechanisms in muscular dystrophy.
Q34329995Zymography methods for visualizing hydrolytic enzymes.
Q42286935dCas9-mediated transcriptional activation of tissue inhibitor of metalloproteinases
Q42784361sFRP2 activates Wnt/β-catenin signaling in cardiac fibroblasts: differential roles in cell growth, energy metabolism, and extracellular matrix remodeling

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